EGFR D770_N771insNPG [plasma membrane]

Stable Identifier
R-HSA-1996322
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Epidermal Growth Factor Receptor D770_N771insNPG, EGFR Asp770_Asn771insAsnProGly
Icon
EGFR D770_N771insNPG [plasma membrane] icon
EGFR D770_N771insNPG [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
24353160 Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer

Huberman, MS, Moran, T, Kobayashi, SS, Oxnard, GR, Cohen, DW, Costa, DB, Yamaguchi, N, Yun, CH, Eck, MJ, Arcila, ME, Ishioka, K, Yeo, WL, Lathan, CS, Hanna, M, Meyerson, M, Lucena-Araujo, AR, Soo, RA, Sequist, LV, Yasuda, H, Sng, NJ, Riely, GJ, Park, E, Chaft, JE, Nakayama, S

Sci Transl Med 2013
External Reference Information
External Reference
UniProt:P00533 EGFR
Gene Names
EGFR, ERBB, ERBB1, HER1
Chain
signal peptide:1-24, chain:25-1210
Reference Genes
COSMIC (genes):EGFR EGFR
dbSNP Gene:1956 EGFR
ENSEMBL:ENSG00000146648 EGFR
Participates
as a candidate of
Other forms of this molecule
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
p-5Y-EGFRvIII [plasma membrane]
EGFRvIII [plasma membrane]
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
p-6Y-EGFR L858R;T790M [plasma membrane]
p-6Y-EGFR A767_V769dup [plasma membrane]
p-6Y-EGFR N771_H773dup [plasma membrane]
p-6Y-EGFR K739_I744dup [plasma membrane]
p-6Y-EGFR D770_N771insNPG [plasma membrane]
p-6Y-EGFR E746_A750del [plasma membrane]
p-6Y-EGFR L858R [plasma membrane]
p-6Y-EGFR G719S [plasma membrane]
p-6Y-EGFR L747_P753delinsS [plasma membrane]
p-6Y-EGFR L747_A750delinsP [plasma membrane]
p-6Y-EGFR L747_T751del [plasma membrane]
p-6Y-EGFR L747_S752del [plasma membrane]
p-6Y-EGFR L747_T751delinsP [plasma membrane]
p-6Y-EGFR E746_T751delinsA [plasma membrane]
p-6Y-EGFR E746_S752delinsV [plasma membrane]
p-6Y-EGFR L861Q [plasma membrane]
p-6Y-EGFR A289V [plasma membrane]
p-6Y-EGFR T263P [plasma membrane]
p-6Y-EGFR G598V [plasma membrane]
p-6Y-EGFR R108K [plasma membrane]
p-6Y-EGFR A289T [plasma membrane]
p-6Y-EGFR G719C [plasma membrane]
p-6Y-EGFR A289D [plasma membrane]
p-6Y-EGFR G719A [plasma membrane]
EGFR L858R;T790M [plasma membrane]
EGFR E746_A750del;T790M [plasma membrane]
EGFR K739_I744dup [plasma membrane]
EGFR A767_V769dup [plasma membrane]
EGFR N771_H773dup [plasma membrane]
EGFR L858R [plasma membrane]
EGFR G719S [plasma membrane]
EGFR E746_A750del [plasma membrane]
p-6Y-EGFR [plasma membrane]
p-Y1086,Y1101-EGFR [plasma membrane]
EGFR [plasma membrane]
p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]
EGFR [endosome membrane]
p-4Y-EGFR [plasma membrane]
EGFR L747_S752del [plasma membrane]
EGFR G598V [plasma membrane]
EGFR T263P [plasma membrane]
EGFR G719C [plasma membrane]
EGFR E746_S752delinsV [plasma membrane]
EGFR A289T [plasma membrane]
EGFR G719A [plasma membrane]
EGFR E746_T751delinsA [plasma membrane]
EGFR L747_A750delinsP [plasma membrane]
EGFR R108K [plasma membrane]
EGFR L861Q [plasma membrane]
EGFR A289D [plasma membrane]
EGFR L747_T751del [plasma membrane]
EGFR L747_T751delinsP [plasma membrane]
EGFR A289V [plasma membrane]
EGFR L747_P753delinsS [plasma membrane]
Modified Residues
Name
Replacement of residues 770 to 771 by DNPGN
Disease
Name Identifier Synonyms
lung cancer DOID:1324
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Interactors (324)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P62993 GRB2  1 0.983 59
 UniProt:P00533 EGFR  20 0.981 29
 UniProt:P29353 SHC1  5 0.976 44
 UniProt:P01133 EGF  5 0.973 29
 UniProt:P22681 CBL  20 0.964 26
 UniProt:P04626 ERBB2  20 0.954 25
 UniProt:P21860 ERBB3      0.919 14
 UniProt:P40763 STAT3  12 0.919 15
 UniProt:P12931 SRC  6 0.9 9
 UniProt:Q9UJM3 ERRFI      0.9 15
 UniProt:P18031 PTPN1  2 0.898 9
 UniProt:P08238 HSP90AB1  6 0.89 10
 UniProt:P27348 YWHAQ  1 0.854 7
 UniProt:P19174 PLCG1  6 0.85 6
 UniProt:P31947 SFN  1 0.833 9
 UniProt:P62158 CALM      0.828 6
 UniProt:Q96CW1 AP2M1  6 0.828 8
 UniProt:P16333 NCK1  2 0.823 6
 UniProt:Q06124 PTPN11  4 0.821 8
 UniProt:P07948 LYN  7 0.82 7
 UniProt:P15941 MUC1  19 0.819 6
 UniProt:Q03135 CAV1  5 0.813 7
 UniProt:O00750 PIK3C2B  1 0.811 10
 UniProt:P27986 PIK3R1  16 0.81 7
 UniProt:Q9UBN7 HDAC6  4 0.809 12
 UniProt:Q05209 PTPN12  2 0.807 5
 UniProt:P11142 HSPA8  10 0.803 7
 UniProt:P20417  2 0.802 11
 UniProt:P08581 MET  7 0.8 8
 UniProt:P08107 HSP71      0.799 6
 UniProt:Q92625 ANS1A      0.793 7
 UniProt:P16885 PLCG2  8 0.793 6
 UniProt:Q16543 CDC37  1 0.786 13
 UniProt:P04406 GAPDH  1 0.785 7
 UniProt:P10599 TXN  4 0.785 5
 UniProt:P01135 TGFA  5 0.779 4
 UniProt:P07900 HSP90AA1  8 0.778 7
 UniProt:P42224 STAT1  8 0.774 7
 UniProt:Q9NRF2 SH2B1  1 0.773 4
 UniProt:P63104 YWHAZ  2 0.772 6
 UniProt:P04083 ANXA1  2 0.772 5
 UniProt:Q92569 PIK3R3  2 0.76 7
 UniProt:O00459 PIK3R2  3 0.76 5
 UniProt:P46109 CRKL  2 0.749 5
 UniProt:Q71U36 TUBA1A  9 0.745 4
 UniProt:O60716 CTNND1  1 0.745 5
 UniProt:Q05397 PTK2  11 0.745 7
 UniProt:P38646 HSPA9  6 0.745 5
 UniProt:Q96JA1 LRIG1  2 0.743 6
 UniProt:P26447 S10A4      0.743 6
 UniProt:Q92870 APBB2      0.737 7
 UniProt:Q9NSE2 CISH  1 0.737 4
 UniProt:P12830 CDH1  8 0.735 4
 UniProt:Q13480 GAB1  4 0.735 5
 UniProt:Q9UQB8 BAIAP2  1 0.735 4
 UniProt:Q13322 GRB10  2 0.729 4
 UniProt:Q9UNE7 STUB1  1 0.721 4
 UniProt:Q12929 EPS8  1 0.713 4
 UniProt:Q9P0L0 VAPA  4 0.713 4
 UniProt:Q96B97 SH3KBP1  3 0.695 4
 UniProt:Q13387 JIP2      0.692 5
 UniProt:P46108 CRK  1 0.692 4
 UniProt:P23467 PTPRB  3 0.692 3
 UniProt:P43403 ZAP70  3 0.692 3
 UniProt:P00519 ABL1  6 0.692 3
 UniProt:P51451 BLK  2 0.692 3
 UniProt:Q13239 SLA  1 0.692 3
 UniProt:P42684 ABL2  1 0.692 9
 UniProt:Q8TF42 UBS3B      0.69 7
 UniProt:Q14318 FKBP8  2 0.683 4
 UniProt:Q68CZ2 TNS3  1 0.683 5
 UniProt:P16234 PDGFRA  20 0.683 4
 UniProt:Q99962 SH3GL2  4 0.681 4
 UniProt:O75368 SH3L1      0.681 3
 UniProt:Q8WUM4 PDCD6IP  1 0.681 4
 UniProt:P41240 CSK  2 0.681 3
 UniProt:O60603 TLR2  3 0.681 3
 UniProt:P35221 CTNNA1  2 0.68 5
 UniProt:Q9UKV8 AGO2  2 0.679 11
 UniProt:O95782 AP2A1  5 0.671 6
 UniProt:Q9UQC2 GAB2  5 0.669 3
 UniProt:Q07889 SOS1  3 0.669 3
 UniProt:P34932 HSPA4  2 0.668 3
 UniProt:P23528 CFL1  3 0.668 3
 UniProt:Q09666 AHNK      0.667 4
 UniProt:P51636 CAV2  2 0.667 3
 UniProt:P06493 CDK1  11 0.667 3
 UniProt:Q9NZM3 ITSN2  1 0.653 3
 UniProt:Q15750 TAB1  6 0.653 3
 UniProt:P14923 JUP  6 0.653 3
 UniProt:P15311 EZR  3 0.653 3
 UniProt:P08631 HCK  2 0.653 3
 UniProt:Q10567 AP1B1  5 0.649 4
 UniProt:Q8NBJ4 GOLM1  2 0.644 13
 UniProt:P08195 SLC3A2  1 0.643 5
 UniProt:P16615 ATP2A2  2 0.643 3
 UniProt:P60520 GABARAPL2  3 0.635 3
 UniProt:P04150 NR3C1  3 0.635 3
 UniProt:P18433 PTPRA  1 0.635 3
 UniProt:Q9Y2H9 MAST1      0.635 3
 UniProt:P42229 STAT5A  4 0.635 4
 UniProt:P17252 PRKCA  8 0.635 3
 UniProt:P49069 CAMLG  1 0.635 3
 UniProt:Q6S5L8 SHC4      0.635 3
 UniProt:Q9Y2R2 PTPN22  1 0.635 3
 UniProt:Q8WUI4 HDAC7  1 0.635 3
 UniProt:Q02952 AKAP12  1 0.635 3
 UniProt:Q9BRG2 SH23A      0.635 3
 UniProt:P09936 UCHL1  1 0.635 3
 UniProt:P31948 STIP1  1 0.635 3
 UniProt:O43561 LAT  3 0.635 3
 UniProt:Q14247 CTTN  2 0.635 4
 UniProt:Q13094 LCP2  2 0.635 3
 UniProt:P09769 FGR  3 0.635 3
 UniProt:O75791 GRAP2  1 0.635 3
 UniProt:Q12933 TRAF2  5 0.635 4
 UniProt:Q14457 BECN1  4 0.628 7
 UniProt:P46940 IQGAP1  3 0.626 4
 UniProt:Q13438 OS9  1 0.623 3
 UniProt:Q12852 M3K12      0.621 3
 UniProt:Q6UW88 EPGN  2 0.618 3
 UniProt:O14944 EREG  2 0.618 3
 UniProt:P04792 HSBP1  3 0.615 3
 UniProt:Q99075 HBEGF  8 0.609 3
 UniProt:Q9UJ41 RABGEF1  2 0.599 4
 UniProt:Q86VI4 LAP4B      0.599 10
 UniProt:P60033 CD81  1 0.597 6
 UniProt:P08575 PTPRC  2 0.592 2
 UniProt:P14174 MIF  3 0.591 3
 UniProt:Q8IZW8 TNS4  1 0.59 2
 UniProt:P07355 ANXA2  6 0.583 4
 UniProt:O75886 STAM2  2 0.583 3
 UniProt:P29353-7 SHC1      0.581 4
 UniProt:O14965 AURKA  6 0.581 4
 UniProt:Q01973 ROR1  2 0.576 8
 UniProt:P23470 PTPRG      0.573 3
 UniProt:Q9UKG1 APPL1  1 0.571 3
 UniProt:Q9Y6R0 NUMBL      0.571 2
 UniProt:P49757 NUMB  1 0.571 2
 UniProt:P07992 ERCC1  2 0.571 21
 UniProt:P63010 AP2B1  4 0.569 5
 UniProt:P53680 AP2S1  4 0.569 3
 UniProt:O94973 AP2A2  6 0.569 4
 UniProt:hspa1a_hspa1b_human-1 EBI-11820565      0.569 3
 UniProt:Q9UBS4 DNAJB11  1 0.569 3
 UniProt:Q92622 RUBIC      0.564 3
 UniProt:Q15303 ERBB4      0.564 3
 UniProt:P07947 YES1  2 0.564 3
 UniProt:Q13451 FKBP5  2 0.564 2
 UniProt:P62994 Grb2  3 0.564 5
 UniProt:Q8IZV2 CKLF8      0.556 3
 UniProt:O75674 TM1L1      0.556 6
 UniProt:Q05513 PRKCZ  5 0.553 2
 UniProt:P05107 ITGB2  4 0.553 2
 UniProt:P40925 MDH1  1 0.553 2
 UniProt:Q99608 NDN  1 0.553 2
 UniProt:Q9H299 SH3L3      0.553 2
 UniProt:Q8N111 CEND      0.553 2
 UniProt:Q59GR8 Q59GR8      0.553 2
 UniProt:Q14204 DYNC1H1  3 0.553 2
 UniProt:P16930 FAH  1 0.553 2
 UniProt:Q59G22 Q59G22      0.553 2
 UniProt:Q13491 GPM6B      0.553 2
 UniProt:A4FU49 SH321      0.553 2
 UniProt:P60174 TPI1  1 0.553 2
 UniProt:O95433 AHSA1      0.553 2
 UniProt:Q7L273 KCTD9      0.553 2
 UniProt:Q4KWH8 PLCH1  1 0.553 2
 UniProt:O15511 ARPC5  4 0.553 2
 UniProt:Q99759 MAP3K3  1 0.553 2
 UniProt:P31321 PRKAR1B  2 0.553 2
 UniProt:P19438 TNFRSF1A  2 0.553 2
 UniProt:Q16186 ADRM1  2 0.553 2
 UniProt:P06132 UROD  1 0.553 2
 UniProt:P04075 ALDOA  6 0.553 2
 UniProt:P41222 PTGDS  1 0.553 2
 UniProt:Q8TDI0 CHD5      0.553 2
 UniProt:Q02790 FKBP4  3 0.553 2
 UniProt:P06396 GSN  7 0.553 2
 UniProt:Q8N2Y8 RUSC2      0.553 2
 UniProt:P05067 APP  20 0.553 2
 UniProt:Q13561 DCTN2  1 0.553 2
 UniProt:Q53GZ6 Q53GZ6      0.553 2
 UniProt:P17600 SYN1  2 0.553 2
 UniProt:P31939 ATIC  5 0.553 2
 UniProt:Q08881 ITK  3 0.553 2
 UniProt:P54368 OAZ1  1 0.553 2
 UniProt:Q9UPY6 WASF3  3 0.553 2
 UniProt:P17174 GOT1  1 0.553 2
 UniProt:Q9NNZ3 DNJC4      0.553 2
 UniProt:Q9Y5X1 SNX9  3 0.553 2
 UniProt:Q14050 COL9A3  20 0.553 2
 UniProt:O94992 HEXI1      0.553 2
 UniProt:O43639 NCK2  1 0.553 2
 UniProt:Q9Y3A3 PHOCN      0.553 2
 UniProt:Q96AD5 PNPLA2  4 0.553 2
 UniProt:O94875 SRBS2      0.553 2
 UniProt:P07949 RET  2 0.553 2
 UniProt:Q15819 UBE2V2  2 0.553 2
 UniProt:P45984 MAPK9  3 0.553 2
 UniProt:Q6UWJ1 TMCO3      0.553 2
 UniProt:Q99784 NOE1      0.553 2
 UniProt:Q92918 M4K1      0.553 2
 UniProt:Q07890 SOS2  1 0.553 2
 UniProt:P49798 RGS4  1 0.553 2
 UniProt:O75095 MEGF6      0.553 2
 UniProt:Q15120 PDK3  1 0.553 2
 UniProt:O43707 ACTN4  3 0.553 2
 UniProt:Q8N5H7 SH2D3      0.553 2
 UniProt:Q02297 NRG1  1 0.553 2
 UniProt:P62330 ARF6  2 0.553 2
 UniProt:P52306 RAP1GDS1  1 0.553 2
 UniProt:Q15005 SPCS2  1 0.553 2
 UniProt:Q92733 PRCC  1 0.553 2
 UniProt:Q9Y6K9 IKBKG  12 0.553 2
 UniProt:Q59EJ3 Q59EJ3      0.553 2
 UniProt:P43243 MATR3      0.553 2
 UniProt:P53041 PPP5C  2 0.553 2
 UniProt:P49908 SELENOP  2 0.553 2
 UniProt:Q8TDB4 HUMMR      0.553 2
 UniProt:Q02156 PRKCE  2 0.553 2
 UniProt:Q9Y237 PIN4      0.553 2
 UniProt:Q07954 LRP1  2 0.553 2
 UniProt:Q14155 ARHGEF7  1 0.553 2
 UniProt:P42685 FRK  4 0.553 2
 UniProt:P20336 RAB3A  9 0.553 2
 UniProt:P52630 STAT2  4 0.553 2
 UniProt:P60880 SNAP25  7 0.553 2
 UniProt:P15498 VAV1  5 0.553 2
 UniProt:P21291 CSRP1  1 0.553 2
 UniProt:Q13153 PAK1  5 0.553 2
 UniProt:O14818 PSMA7  2 0.553 2
 UniProt:Q13905 RAPGEF1  2 0.553 2
 UniProt:Q99952 PTPN18  2 0.553 2
 UniProt:Q99704 DOK1  2 0.553 2
 UniProt:P55036 PSMD4  1 0.553 2
 UniProt:P30307 CDC25C  8 0.553 2
 UniProt:Q02246 CNTN2  1 0.553 2
 UniProt:O14543 SOCS3  1 0.553 2
 UniProt:P26641 EEF1G  3 0.553 2
 UniProt:Q9UGK3 STAP2  2 0.553 2
 UniProt:P10636 MAPT  3 0.553 2
 UniProt:P37840 SNCA  5 0.553 2
 UniProt:Q9H6Q3 SLA2  1 0.553 2
 UniProt:Q99963 SH3GL3  1 0.553 2
 UniProt:P49407 ARRB1  6 0.553 2
 UniProt:O14544 SOCS6  1 0.553 2
 UniProt:Q06830 PRDX1  3 0.553 2
 UniProt:P32121 ARRB2  3 0.553 2
 UniProt:Q16620 NTRK2  6 0.553 2
 UniProt:P31946 YWHAB  1 0.553 2
 UniProt:O00170 AIP  2 0.553 2
 UniProt:P11309 PIM1  1 0.553 2
 UniProt:O00401 WASL  4 0.553 2
 UniProt:P31749 AKT1  14 0.553 2
 UniProt:P04049 RAF1  20 0.553 2
 UniProt:P16152 CBR1  1 0.553 2
 UniProt:P14625 HSP90B1  4 0.553 2
 UniProt:P45983 MAPK8  3 0.553 2
 UniProt:P10586 PTPRF  2 0.547 2
 UniProt:P29350 PTPN6  5 0.547 2
 UniProt:P23468 PTPRD  1 0.547 2
 UniProt:Q14956-1 GPNMB      0.544 2
 UniProt:P07948-1 LYN      0.544 2
 UniProt:Q38SD2 LRRK1      0.544 2
 UniProt:P17936 IGFBP3  15 0.539 3
 UniProt:P0DTC2 S  20 0.537 4
 UniProt:O14964 HGS  2 0.536 2
 UniProt:P68366 TUBA4A  9 0.527 2
 UniProt:P55060 XPO2      0.527 2
 UniProt:Q6XE38 SG1D4      0.527 2
 UniProt:P40855 PEX19  1 0.527 2
 UniProt:Q00325 S25A3      0.527 3
 UniProt:O60884 DNAJA2  1 0.527 2
 UniProt:O00483 NDUFA4  1 0.527 2
 UniProt:P31943 HNRNPH1  1 0.527 2
 UniProt:P11021 HSPA5  6 0.527 5
 UniProt:O43592 XPOT  2 0.527 2
 UniProt:Q9H0D6 XRN2  2 0.527 5
 UniProt:Q9Y4L1 HYOU1  3