Reactome | PDGFRA S601P [plasma membrane]

PDGFRA S601P [plasma membrane]

Stable Identifier

R-HSA-9673600

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Alpha platelet-derived growth factor receptor, PGDS_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
19210352	A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndrome Salemi, S, Yousefi, S, Simon, D, Schmid, I, Moretti, L, Scapozza, L, Simon, HU	Allergy	2009

External Reference Information

External Reference

UniProt:P16234 PDGFRA

Gene Names

PDGFRA, PDGFR2, RHEPDGFRA

Chain

signal peptide:1-23, chain:24-1089

Reference Genes

COSMIC (genes):PDGFRA PDGFRA

dbSNP Gene:5156 PDGFRA

ENSEMBL:ENSG00000134853 PDGFRA

Participates

as a member of

Other forms of this molecule

PDGFRA L629P [plasma membrane]

PDGFRA N659K [plasma membrane]

PDGFRA T674I [plasma membrane]

PDGFRA Y288C [endoplasmic reticulum membrane]

PDGFRA Y375_K455del [endoplasmic reticulum membrane]

p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]

p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]

PDGFRA D842_M844del [plasma membrane]

PDGFRA D842Y [plasma membrane]

PDGFRA D842V [plasma membrane]

PDGFRA I843_D846del [plasma membrane]

PDGFRA D842_H845del [plasma membrane]

PDGFRA D842del [plasma membrane]

PDGFRA D842_I843delinsV [plasma membrane]

PDGFRA D846Y [plasma membrane]

PDGFRA D843_845del [plasma membrane]

PDGFRA D842_D846del [plasma membrane]

PDGFRA N848K [plasma membrane]

PDGFRA Y849C [plasma membrane]

PDGFRA D843_844del [plasma membrane]

PDGFRA D846V [plasma membrane]

PDGFRA D842L [plasma membrane]

PDGFRA V561D [plasma membrane]

PDGFRA V561A [plasma membrane]

PDGFRA V536E [plasma membrane]

PDGFRA V536M [plasma membrane]

p-11Y PDGFRA D842V [plasma membrane]

p-11Y PDGFRA D846Y [plasma membrane]

p-11Y-PDGFRA [plasma membrane]

PDGFRA [plasma membrane]

p-11Y PDGFRA V561A [plasma membrane]

p-11Y PDGFRA V561D [plasma membrane]

p-11Y PDGFRA V536M [plasma membrane]

p-11Y PDGFRA V536E [plasma membrane]

p-11Y PDGFRA D846V [plasma membrane]

p-11Y PDGFRA D842L dimer [plasma membrane]

p-11Y PDGFRA N848K [plasma membrane]

p-11Y PDGFRA D843_845del [plasma membrane]

p-10Y PDGFRA Y849C [plasma membrane]

p-11Y PDGFRA D842_D846del [plasma membrane]

p-11Y PDGFRA D842_H845del [plasma membrane]

p-11Y PDGFRA D842Y [plasma membrane]

p-11Y PDGFRA D843_846del [plasma membrane]

p-11Y-PDGFRA D842_I843delinsV [plasma membrane]

p-11Y PDGFRA D843_844del [plasma membrane]

p-11Y PDGFRA D842del [plasma membrane]

Modified Residues

Name

L-serine 601 replaced with L-proline

Coordinate

601

PsiMod

L-serine removal [MOD:01646]

A protein modification that effectively removes or replaces an L-serine.

L-proline residue [MOD:00024]

A protein modification that effectively converts a source amino acid residue to L-proline.

Disease

Name	Identifier	Synonyms
hypereosinophilic syndrome	DOID:999	Eosinophilic leukocytosis, eosinophilia
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

Mondo

0004992, 0015691

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.774	6
UniProt:P01127 PDGFB	8	PDGFB (82-190) [extracellular region] (R-HSA-184201) PDGFB(82-241) [extracellular region] (R-HSA-381904) PDGFB(1-241) [endoplasmic reticulum lumen] (R-HSA-381903) PDGFB(1-241) [Golgi membrane] (R-HSA-380740) PDGFB(1-81) [Golgi lumen] (R-HSA-389058) PDGFB(191-241) [Golgi lumen] (R-HSA-396945) PDGFB(21-81) [platelet alpha granule lumen] (R-HSA-184200) PDGFB(82-241) [platelet alpha granule lumen] (R-HSA-387075)	0.733	11
UniProt:P04085 PDGFA	1	PDGFA [extracellular region] (R-HSA-2426265)	0.691	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.683	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.671	4
UniProt:Q9NRA1 PDGFC			0.656	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.569	3
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.544	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.483	2
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.483	2

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