Reactome | FKBP4 [nucleoplasm]

FKBP4 [nucleoplasm]

Stable Identifier

R-HSA-5324621

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

FKBP52, Peptidyl-prolyl cis-trans isomerase FKBP4, Immunophilin FKBP52

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q02790 FKBP4

Gene Names

FKBP4, FKBP52

Chain

chain:1-459, initiator methionine:, chain:2-459

Reference Genes

BioGPS Gene:2288 FKBP4

COSMIC (genes):FKBP4 FKBP4

CTD Gene:2288 FKBP4

dbSNP Gene:2288 FKBP4

ENSEMBL:ENSG00000004478 FKBP4

ENSEMBL_homo_sapiens_GENE:ENSG00000004478.8 FKBP4

HGNC:3720 FKBP4

KEGG Gene (Homo sapiens):2288 FKBP4

Monarch:2288 FKBP4

NCBI Gene:2288 FKBP4

OMIM:600611 FKBP4

UCSC:Q02790 FKBP4

Reference Transcript

RefSeq:NM_002014.3 FKBP4

Other Identifiers

11736021_a_at

11736022_at

11744683_s_at

1560303_PM_at

1560303_at

1560305_PM_x_at

1560305_x_at

16746808

200894_PM_s_at

200894_s_at

200895_PM_s_at

200895_s_at

2288

3171319

3171330

3171664

3401100

3401101

3401104

3401105

3401106

3401108

3401109

3401110

3401111

3401112

3401113

3401114

3401116

3401117

3401118

3401120

3401121

3401122

3401123

3401124

38729_at

4051399

7953100

A_23_P128372

A_32_P71788

GE58127

GE82381

GO:0003723

GO:0003755

GO:0003824

GO:0005515

GO:0005524

GO:0005525

GO:0005528

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005874

GO:0006457

GO:0006463

GO:0006825

GO:0007010

GO:0007566

GO:0008092

GO:0010977

GO:0016853

GO:0022414

GO:0023052

GO:0030154

GO:0030424

GO:0030521

GO:0030674

GO:0030850

GO:0031072

GO:0031111

GO:0031115

GO:0031503

GO:0032767

GO:0032991

GO:0035259

GO:0042995

GO:0043025

GO:0043226

GO:0044295

GO:0046661

GO:0048156

GO:0048471

GO:0048608

GO:0048856

GO:0051219

GO:0060090

GO:0061077

GO:0065003

GO:0070062

GO:0140096

HMNXSV003021650

Hs.848.0.A1_3p_a_at

Hs2.407281.1.S1_3p_s_at

ILMN_1782045

M88279_at

PH_hs_0000103

TC12000028.hg

g4503728_3p_a_at

Participates

as an output of

as a component of

Other forms of this molecule

FKBP4 [nucleoplasm]

FKBP4 [cytosol]

Inferred To

FKBP35 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of FKBP4 [nucleoplasm] (Danio rerio)

Ghost homologue of FKBP4 [nucleoplasm] (Xenopus tropicalis)

Fkbp4 [nucleoplasm] (Mus musculus)

Fkbp4 [nucleoplasm] (Rattus norvegicus)

Fkbp59 [nucleoplasm] (Drosophila melanogaster)

FKBP4 [nucleoplasm] (Bos taurus)

FKBP4 [nucleoplasm] (Canis familiaris)

FKBP4 [nucleoplasm] (Gallus gallus)

FKBP4 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_002005.1

ZINC - World Drugs

FKBP4_HUMAN

Guide to Pharmacology - Targets

3176

OpenTargets

ENSG00000004478

ZINC - Substances

FKBP4_HUMAN

ZINC target

Q02790

PRO

Q02790

PDB

1QZ2, 1N1A, 4LAV, 4LAW, 4DRJ, 1Q1C, 6RCY, 4LAY, 1P5Q, 8FFV, 4TW8, 4LAX

GeneCards

Q02790

HPA

ENSG00000004478-FKBP4

Ensembl

ENSP00000001008, ENST00000001008, ENSG00000004478

Pharos - Targets

Q02790

ZINC - Predictions - Purchasable

FKBP4_HUMAN

HMDB Protein

HMDBP10689

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.793	6
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.784	9
UniProt:P35467	1	S100A1 [extracellular region] (R-RNO-6805991)	0.753	7
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.742	5
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.629	7
UniProt:P29034 S10A2			0.591	3
UniProt:P06703 S10A6			0.591	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.527	2
UniProt:Q8NG41 NPB	2	NPB(25-48) [extracellular region] (R-HSA-374794) NPB(25-53) [extracellular region] (R-HSA-374790)	0.527	2
UniProt:Q58FG0 HS905			0.527	2
UniProt:Q58FF6 H90B4			0.527	2
UniProt:Q9BQP7 MGME1			0.527	2
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.508	2
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.499	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.499	3
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.499	2

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