Reactome | SOS1 [plasma membrane]

SOS1

Stable Identifier

R-HSA-983559

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Son of sevenless homolog 1, SOS1_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
      - BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
        
        BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
      - BTK autophosphorylates (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
      - Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
      - Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
      - p-6Y-SYK phosphorylates BLNK (SLP65) (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
      - p-SYK and LYN phosphorylate BTK (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        LYN, p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07889 SOS1

Gene Names

SOS1

Chain

chain:1-1333

Reference Genes

BioGPS Gene:6654 SOS1

COSMIC (genes):SOS1 SOS1

CTD Gene:6654 SOS1

dbSNP Gene:6654 SOS1

ENSEMBL:ENSG00000115904 SOS1

HGNC:11187 SOS1

KEGG Gene (Homo sapiens):hsa:6654 SOS1

Monarch:6654 SOS1

NCBI Gene:6654 SOS1

OMIM:182530 SOS1

UCSC:Q07889 SOS1

Reference Transcript

RefSeq:NM_005633.3 SOS1

Other Identifiers

0006130692

11720892_at

11720893_s_at

11720894_a_at

11720895_at

12613

16896710

1AWE

1BKD

1DBH

1NVU

1NVV

1NVW

1NVX

1Q9C

1XD2

1XD4

1XDV

212777_at

212780_at

227426_at

2549093

2549094

2549095

2549096

2549097

2549098

2549099

2549100

2549101

2549102

2549103

2549106

2549109

2549110

2549111

2549112

2549113

2549114

2549115

2549116

2549117

2549118

2549119

2549122

2549123

2549125

2549126

2549128

2549131

2549132

2549133

2549134

2549147

2II0

303_at

33260_at

3KSY

46678_at

4NYI

4NYJ

4NYM

4URU

4URV

4URW

4URX

4URY

4URZ

4US0

4US1

4US2

5396

6654

6F08

8051670

A_23_P343808

A_33_P3356406

AAA35913

AC019171

AC092672

AK290228

AK301960

BAF82917

BAG63374

C9K0N6

CAB005396

CCDS1802

CH471053

EAX00351

ENSG00000115904

ENSP00000384675

ENSP00000387784

ENST00000402219

ENST00000426016

EntrezGene:6654

G5E9C8

GE57636

GO:0000003

GO:0000165

GO:0000786

GO:0000902

GO:0001782

GO:0001942

GO:0002260

GO:0002376

GO:0003007

GO:0003209

GO:0003344

GO:0003674

GO:0003677

GO:0005085

GO:0005088

GO:0005089

GO:0005096

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006464

GO:0007155

GO:0007165

GO:0007173

GO:0007186

GO:0007264

GO:0007265

GO:0007296

GO:0007411

GO:0008150

GO:0008219

GO:0008283

GO:0008286

GO:0009790

GO:0014069

GO:0017124

GO:0019221

GO:0019899

GO:0030154

GO:0030234

GO:0032991

GO:0033081

GO:0035023

GO:0035264

GO:0038095

GO:0038128

GO:0040007

GO:0040011

GO:0042129

GO:0042592

GO:0043025

GO:0043065

GO:0043226

GO:0043547

GO:0045742

GO:0046982

GO:0048011

GO:0048514

GO:0048856

GO:0048870

GO:0050900

GO:0051056

GO:0051057

GO:0060021

GO:0061029

GO:0061384

GO:1904693

GO:2000973

HGNC:11187

HPA012613

Hs.326392.1.A1_3p_at

Hs.326392.1.A2_3p_at

Hs.7312.0.A1_3p_at

ILMN_1767135

IPR000219

IPR000651

IPR001849

IPR001895

IPR007125

IPR009072

IPR011993

IPR019804

IPR023578

IPR035899

IPR036964

L13857

LRG_754

LRG_754t1

MIM:135300

MIM:182530

MIM:610733

NM_005633

NP_005624

PF00125

PF00169

PF00617

PF00618

PF00621

PH_hs_0016186

SM00147

SM00229

SM00233

SM00325

SOS1

SOS1-202

SOS1-203

TC02001761.hg

uc002rrk.5

uc061ikm.1

UPI0000135CF0

XM_011533062

XM_011533064

XM_011533066

XP_011531364

XP_011531366

XP_011531368

Participant Of

hasComponent

p-BLNK:GRB2:SOS1:CIN85 [plasma membrane]

Other forms of this molecule

p-4S-SOS1 [cytosol]

SOS1 [cytosol]

Inferred To

SOS1 [plasma membrane] (Bos taurus)

SOS1 [plasma membrane] (Canis familiaris)

SOS1 [plasma membrane] (Mus musculus)

SOS1 [plasma membrane] (Rattus norvegicus)

SOS1 [plasma membrane] (Sus scrofa)

SOS1 [plasma membrane] (Xenopus tropicalis)

Ghost homologue of SOS1 [plasma membrane] (Danio rerio)

Homologues of SOS1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_005624.2

GeneCards

Q07889

ZINC target

Q07889

PRO

Q07889

Orphanet

15537

HMDB Protein

HMDBP08580

PDB

1XD4, 1DBH, 4URX, 2II0, 3KSY, 1NVX, 4URW, 1AWE, 1XD2, 1NVW, 4URV, 4URU, 1XDV, 1NVV, 6F08, 4NYM, 4US2, 1Q9C, 4US1, 4NYJ, 4NYI, 1NVU, 4URZ, 4US0, 1BKD, 4URY

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.965	23
UniProt:P01112 HRAS	8	Q61L HRAS [plasma membrane] (R-HSA-6802452) Q61R HRAS [plasma membrane] (R-HSA-6802458) Q61K HRAS [plasma membrane] (R-HSA-6802442) G12V HRAS [plasma membrane] (R-HSA-6802350) G13R HRAS [plasma membrane] (R-HSA-6802368) G12S HRAS [plasma membrane] (R-HSA-6802343) HRAS [cytosol] (R-HSA-205771) HRAS [plasma membrane] (R-HSA-62717)	0.938	11
UniProt:P08631 HCK	1	HCK [cytosol] (R-HSA-167708)	0.713	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.688	3
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.667	3
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.636	7
UniProt:P20929 NEB	1	NEB [cytosol] (R-HSA-390569)	0.618	3
UniProt:Q5TCZ1-2			0.611	5
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.589	5
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.589	3
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.564	2
UniProt:Q8IZP0 ABI1	2	p-5S-ABI1 [cytosol] (R-HSA-2029034) ABI1 [cytosol] (R-HSA-1671643)	0.544	2
UniProt:Q9Y5X1 SNX9	3	SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytosol] (R-HSA-8867737) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.524	2
UniProt:Q9UKS6 PACSIN3	1	PACSIN3 [cytosol] (R-HSA-8868270)	0.524	2
UniProt:P57075-2 UBASH3A			0.488	2