Reactome | SOS1 [plasma membrane]

SOS1 [plasma membrane]

Stable Identifier

R-HSA-983559

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Son of sevenless homolog 1, SOS1_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - SARS-CoV Infections (Homo sapiens)
    - Potential therapeutics for SARS (Homo sapiens)
      - BTK binds BTK inhibitors (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
      - BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
        
        BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
      - BTK autophosphorylates (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
      - BTK binds BTK inhibitors (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
      - Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
      - Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
      - p-6Y-SYK phosphorylates BLNK (SLP65) (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
      - p-SYK and LYN phosphorylate BTK (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)
        
        LYN, p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)
        
        SOS1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07889 SOS1

Gene Names

SOS1

Chain

chain:1-1333

Reference Genes

BioGPS Gene:6654 SOS1

COSMIC (genes):SOS1 SOS1

CTD Gene:6654 SOS1

dbSNP Gene:6654 SOS1

ENSEMBL:ENSG00000115904 SOS1

HGNC:11187 SOS1

KEGG Gene (Homo sapiens):6654 SOS1

Monarch:6654 SOS1

NCBI Gene:6654 SOS1

OMIM:182530 SOS1

UCSC:Q07889 SOS1

Reference Transcript

RefSeq:NM_005633.3 SOS1

Other Identifiers

0006130692

11720892_at

11720893_s_at

11720894_a_at

11720895_at

16896710

212777_PM_at

212777_at

212780_PM_at

212780_at

227426_PM_at

227426_at

2548968

2549093

2549094

2549095

2549096

2549097

2549098

2549099

2549100

2549101

2549102

2549103

2549106

2549109

2549110

2549111

2549112

2549113

2549114

2549115

2549116

2549117

2549118

2549119

2549122

2549123

2549125

2549126

2549128

2549131

2549132

2549133

2549134

2549147

2549148

2549149

2549150

2549215

303_at

33260_at

46678_at

6654

69184_at

8051670

A_23_P343808

A_33_P3356406

GE57636

GO:0000003

GO:0000902

GO:0001782

GO:0001942

GO:0002260

GO:0002376

GO:0003007

GO:0003209

GO:0003344

GO:0003674

GO:0003677

GO:0005085

GO:0005096

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0006357

GO:0006464

GO:0007165

GO:0007173

GO:0007264

GO:0007265

GO:0007296

GO:0007411

GO:0008150

GO:0008283

GO:0009058

GO:0009790

GO:0014069

GO:0017124

GO:0019221

GO:0030154

GO:0030234

GO:0032991

GO:0033081

GO:0034641

GO:0035264

GO:0038095

GO:0040007

GO:0040011

GO:0042127

GO:0042129

GO:0042592

GO:0043025

GO:0043226

GO:0043405

GO:0043547

GO:0045742

GO:0046982

GO:0048011

GO:0048514

GO:0048856

GO:0048870

GO:0050900

GO:0051057

GO:0060021

GO:0061029

GO:0061384

GO:1904693

GO:1905360

GO:2000973

HMNXSV003049615

Hs.326392.1.A1_3p_at

Hs.326392.1.A2_3p_at

Hs.7312.0.A1_3p_at

ILMN_1767135

PH_hs_0016186

PH_hs_0032906

TC02001761.hg

Participates

as a component of

p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-4S-SOS1 [cytosol]

SOS1 [cytosol]

Inferred To

SOS1 [plasma membrane] (Bos taurus)

SOS1 [plasma membrane] (Canis familiaris)

SOS1 [plasma membrane] (Gallus gallus)

SOS1 [plasma membrane] (Sus scrofa)

sos1 [plasma membrane] (Xenopus tropicalis)

Ghost homologue of SOS1 [plasma membrane] (Danio rerio)

Sos1 [plasma membrane] (Mus musculus)

Sos1 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_005624.2

ZINC - World Drugs

SOS1_HUMAN

Guide to Pharmacology - Targets

3096

OpenTargets

ENSG00000115904

ZINC - FDA approved

SOS1_HUMAN

ZINC target

Q07889

PRO

Q07889

PDB

1XD4, 6BVJ, 6D5M, 4NYI, 6CUR, 6SFR, 4NYJ, 6D5E, 6D5V, 6D5G, 4URV, 5OVH, 6V9M, 6V94, 4URW, 4URX, 6SCM, 1AWE, 6F08, 6V9N, 1DBH, 4US1, 6D5W, 4URZ, 1NVU, 6D5J, 4US2, 1BKD, 7AVL, 6D5L, 1NVV, 7AVT, 5WFO, 1NVW, 6EPN, 3KSY, 5WFQ, 6V9O, 1XD2, 1NVX, 7AVS, 5OVE, 5WFR, 5OVF, 6V9J, 6Y44, 6CUP, 6BVK, 6BVM, 5OVG, 7AVU, 6BVL, 6EPO, 7AVV, 5OVI, 4URU, 6EPP, 4NYM, 7AVI, 6D55, 6V9L, 6EPL, 4US0, 6D56, 7KFZ, 6D5H, 4URY, 1XDV, 1Q9C, 6D59, 6V9F, 2II0, 6EPM, 6BVI, 5WFP, 5OVD, 6CUO

ZINC - Investigational

SOS1_HUMAN

GeneCards

Q07889

HPA

ENSG00000115904-SOS1

Ensembl

ENSG00000115904, ENST00000402219, ENSP00000384675

Pharos - Targets

Q07889

Orphanet

15537

HMDB Protein

HMDBP08580

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.97	27
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.938	11
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.816	7
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.692	4
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.667	3
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.636	7
UniProt:P20929 NEB	1	NEB [cytosol] (R-HSA-390569)	0.618	3
UniProt:Q5TCZ1-2			0.611	5
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.589	5
UniProt:Q9UNS2 COPS3	2	COPS3 [cytosol] (R-HSA-416973) COPS3 [nucleoplasm] (R-HSA-5697017)	0.581	3
UniProt:P29353 SHC1	5	SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.564	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.564	2
UniProt:P57075-2 UBASH3A			0.556	3
UniProt:O60239 3BP5			0.553	2
UniProt:Q8IZP0 ABI1	2	p-5S-ABI1 [cytosol] (R-HSA-2029034) ABI1 [cytosol] (R-HSA-1671643)	0.544	2
UniProt:P27986 PIK3R1	15	PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.536	3
UniProt:Q9Y5X1 SNX9	3	SNX9 [cytosol] (R-HSA-8867737) SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.524	2
UniProt:Q9UKS6 PACSIN3	1	PACSIN3 [cytosol] (R-HSA-8868270)	0.524	2