Reactome | SNAP25(199-206) [cytosol]

SNAP25(199-206) [cytosol]

Stable Identifier

R-HSA-5244501

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Synaptosomal-associated protein 25, residues 199-206

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Literature References

PubMed ID	Title	Journal	Year
9886085	Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage Niemann, H, Nauenburg, S, Dorries, C, Binz, T, Jahnz, M, Bade, S, Yoshino, K, Vaidyanathan, VV	J Neurochem	1999

External Reference Information

External Reference

UniProt:P60880 SNAP25

Gene Names

SNAP25, SNAP

Chain

chain:1-206

Reference Genes

COSMIC (genes):SNAP25 SNAP25

dbSNP Gene:6616 SNAP25

ENSEMBL:ENSG00000132639 SNAP25

Participates

as an output of

Other forms of this molecule

SNAP25(1-197) [plasma membrane]

SNAP25(198-206) [cytosol]

SNAP25(1-198) [plasma membrane]

SNAP25 [tertiary granule membrane]

SNAP25 [specific granule membrane]

SNAP25 [plasma membrane]

Disease

Name	Identifier	Synonyms
botulism	DOID:11976	Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449622 REP			0.556	3
UniProt:O75558 STX11			0.553	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.547	3
UniProt:P61764 STXBP1	2	STXBP1 [plasma membrane] (R-HSA-2980862) STXBP1 [cytosol] (R-HSA-6794256)	0.527	2
UniProt:P84077 ARF1	2	ARF1 [Golgi membrane] (R-HSA-199971) ARF1 [cytosol] (R-HSA-200826)	0.512	5
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.502	2
UniProt:Q8IUH5 ZDH17			0.489	3
UniProt:Q9Y3C0 WASC3			0.488	2

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