Reactome | BECN1 [cytosol]

BECN1 [cytosol]

Stable Identifier

R-HSA-1632841

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Beclin-1, BECN1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP13 deubiquitinates BECN1,USP10 (Homo sapiens)
        
        USP13:BECN1,USP10 [cytosol] (Homo sapiens)
        
        BECN1,USP10 [cytosol] (Homo sapiens)
        
        BECN1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14457 BECN1

Gene Names

BECN1, GT197

Chain

chain:1-450, chain:134-450, chain:150-450

Reference Genes

BioGPS Gene:8678 BECN1

COSMIC (genes):BECN1 BECN1

CTD Gene:8678 BECN1

dbSNP Gene:8678 BECN1

ENSEMBL:ENSG00000126581 BECN1

HGNC:1034 BECN1

KEGG:hsa:8678 BECN1

Monarch:8678 BECN1

NCBI Gene:8678 BECN1

OMIM:604378 BECN1

UCSC:Q14457 BECN1

Reference Transcript

Other Identifiers

11743587_a_at

11743588_x_at

11745483_s_at

11746790_a_at

11746791_s_at

11746792_x_at

1561652_PM_at

1561652_at

16845263

208945_PM_s_at

208945_s_at

208946_PM_s_at

208946_s_at

3758158

3758159

3758160

3758161

3758162

3758163

3758164

3758165

3758166

3758167

3758168

3758169

3758170

3758171

3758172

3758173

3758174

3758175

3758176

3758177

3758178

3758179

3758180

3758181

3758182

3758183

3758184

3758185

3758186

3758187

3758188

3758189

3758190

3758191

3758192

39378_at

8015715

8678

A_23_P433071

A_23_P89410

A_24_P313597

GE660198

GE79828

GE84671

GO:0000045

GO:0000407

GO:0000423

GO:0001666

GO:0002376

GO:0002753

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005768

GO:0005773

GO:0005776

GO:0005783

GO:0005789

GO:0005794

GO:0005802

GO:0005829

GO:0006622

GO:0006629

GO:0006886

GO:0006897

GO:0006914

GO:0006915

GO:0006968

GO:0006995

GO:0007005

GO:0007040

GO:0007080

GO:0007254

GO:0008285

GO:0009410

GO:0010008

GO:0010040

GO:0010288

GO:0010506

GO:0010507

GO:0010508

GO:0010613

GO:0012501

GO:0016020

GO:0016192

GO:0016236

GO:0016241

GO:0016604

GO:0019901

GO:0030425

GO:0030674

GO:0031410

GO:0031625

GO:0031667

GO:0031966

GO:0032465

GO:0032473

GO:0032801

GO:0032991

GO:0033197

GO:0034198

GO:0034271

GO:0034272

GO:0035032

GO:0036092

GO:0038066

GO:0039521

GO:0042149

GO:0042802

GO:0043066

GO:0043069

GO:0043226

GO:0043548

GO:0043652

GO:0045022

GO:0045324

GO:0045335

GO:0048666

GO:0048856

GO:0050435

GO:0051020

GO:0051301

GO:0051607

GO:0051707

GO:0051897

GO:0060090

GO:0060395

GO:0061024

GO:0062029

GO:0065003

GO:0070301

GO:0071275

GO:0071280

GO:0071364

GO:0090650

GO:0097352

GO:0098542

GO:0098780

GO:1902425

GO:1902902

GO:1905672

GO:2000378

GO:2000786

GO:2001244

HMNXSV003004505

Hs.12272.0.S1_3p_a_at

Hs2.372893.1.S1_3p_at

ILMN_1744822

L38932_at

PH_hs_0001156

TC17001545.hg

g4680380_3p_a_at

Participates

as a member of

as an input of

ISGylation of BECN1 (Homo sapiens)

as a component of

Other forms of this molecule

p-S15-BECN1 [cytosol]

ISG15-K-BECN1 [cytosol]

K63polyUb-BECN1 [cytosol]

Inferred To

atg6 [cytosol] (Schizosaccharomyces pombe)

Becn1 [cytosol] (Mus musculus)

Becn1 [cytosol] (Rattus norvegicus)

Atg6 [cytosol] (Drosophila melanogaster)

BECN1 [cytosol] (Bos taurus)

BECN1 [cytosol] (Canis familiaris)

BECN1 [cytosol] (Gallus gallus)

BECN1 [cytosol] (Sus scrofa)

bec-1 [cytosol] (Caenorhabditis elegans)

atg6B [cytosol] (Dictyostelium discoideum)

VPS30 [cytosol] (Saccharomyces cerevisiae)

becn1 [cytosol] (Danio rerio)

becn1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_003757.1, NP_001300929.1, NP_001300927.1, NP_001300928.1

OpenTargets

ENSG00000126581

ENSEMBL

ENST00000361523, ENSP00000465364, ENSP00000355231, ENST00000590099

HPA

ENSG00000126581-BECN1

PRO

Q14457

Pharos - Targets

Q14457

GlyGen

Q14457

PDB

4DDP, 8SOR, 5VAU, 6HOK, 6DCO, 6HOI, 6HOJ, 5VAX, 8SRQ, 2P1L, 2PON, 5EFM, 7BL1, 6DCN, 5VAY, 5HHE, 3DVU, 4MI8

Interactors (76)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6ZNE5 ATG14	3	ATG14 [phagophore assembly site membrane] (R-HSA-5682389) ATG14 [endoplasmic reticulum membrane] (R-HSA-5679263) ATG14 [cytosol] (R-HSA-5668893)	0.979	51
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.971	47
UniProt:Q8NEB9 PIK3C3	2	PIK3C3 [cytosol] (R-HSA-188011) PIK3C3 [phagocytic vesicle membrane] (R-HSA-6798182)	0.97	43
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.951	18
UniProt:Q92622 RUBIC			0.922	16
UniProt:Q99570 PIK3R4	2	PIK3R4 [phagocytic vesicle membrane] (R-HSA-6798171) PIK3R4 [cytosol] (R-HSA-188010)	0.875	10
UniProt:Q9C0C7 AMBRA1	2	p-AMBRA1 [cytosol] (R-HSA-1632854) AMBRA1 [cytosol] (R-HSA-1632831)	0.868	9
UniProt:Q96F24 NRBF2			0.855	10
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.766	15
UniProt:P89884 ARBH			0.75	4
UniProt:O95229 ZWINT	1	ZWINT [cytosol] (R-HSA-376254)	0.75	6
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.709	8
UniProt:Q07817-1 BCL2L1			0.704	5
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.666	4
UniProt:Q9NYJ8 TAB2	4	TAB2 [cytosol] (R-HSA-168117) TAB2 [endosome membrane] (R-HSA-450279) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323)	0.655	11
UniProt:Q8N5C8 TAB3	3	TAB3 [plasma membrane] (R-HSA-446879) TAB3 [endosome membrane] (R-HSA-450247) TAB3 [cytosol] (R-HSA-450264)	0.655	9
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.643	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.643	3
UniProt:P54252-1 ATXN3			0.632	10
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.628	7
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.599	4
UniProt:Q2GJL5 Q2GJL5			0.593	4
UniProt:P53355 DAPK1	1	DAPK1 [cytosol] (R-HSA-418262)	0.591	4
UniProt:Q91ZQ0 VMP1			0.571	6
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.564	2
UniProt:Q9Y371 SHLB1			0.564	2
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.556	3
UniProt:P14679-2 P146792			0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.556	3
UniProt:P38398-6 BRCA1			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P31930 UQCRC1	1	UQCRC1 [mitochondrial inner membrane] (R-HSA-164284)	0.556	3
UniProt:P42261 GRIA1	6	GRIA1 [plasma membrane] (R-HSA-3004495) GRIA1 [endocytic vesicle membrane] (R-HSA-3004479) p-S849-GRIA1 [plasma membrane] (R-HSA-9620488) GRIA1 [endoplasmic reticulum membrane] (R-HSA-5689460) GRIA1 [ER to Golgi transport vesicle membrane] (R-HSA-5689810) GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689811)	0.556	3
UniProt:P50440 GATM	1	GATM [mitochondrial intermembrane space] (R-HSA-71267)	0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:P17752 TPH1	1	TPH1 [cytosol] (R-HSA-976250)	0.556	3
UniProt:P14678-2 SNRPB			0.556	3
UniProt:P14927 UQCRB	1	UQCRB [mitochondrial inner membrane] (R-HSA-164287)	0.556	3
UniProt:P21333-2 FLNA			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P61758 VBP1	1	VBP1 [cytosol] (R-HSA-379543)	0.556	3
UniProt:P54253 ATX1			0.556	6
UniProt:Q13885 TUBB2A	6	TUBB2A folding intermediate [cytosol] (R-HSA-392802) TUBB2A unfolded [cytosol] (R-HSA-392776) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) TUBB2A [axonemal microtubule] (R-HSA-5610431) TUBB2A [cytosol] (R-HSA-191699)	0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613) p-T774-PKN1 [nucleoplasm] (R-HSA-5625721)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:O75190-2 DNAJB6			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:Q96A83-2 Q96A832			0.556	3
UniProt:P10276-2 RARA			0.556	3
UniProt:Q13449 LSAMP	2	cleaved GPI-LSAMP [extracellular region] (R-HSA-8941032) GPI-LSAMP [plasma membrane] (R-HSA-8940809)	0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.556	3
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.556	3
UniProt:P60891 PRPS1	1	PRPS1 [cytosol] (R-HSA-73483)	0.556	3
UniProt:Q9H714 PACER			0.527	4
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.527	4
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) BIRC5 [nucleoplasm] (R-HSA-4655344) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.524	3
IntAct:EBI-14080447 ISOLATED POLYQ STRETCH			0.524	4
UniProt:Q14964 RAB39A	4	RAB39A [Golgi membrane] (R-HSA-8849601) GGC-RAB39A [Golgi membrane] (R-HSA-8877794) GGC-RAB39A [cytosol] (R-HSA-8874001) RAB39A [cytosol] (R-HSA-8873700)	0.524	2
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.499	2
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.499	3
UniProt:Q96GC9 VMP1			0.499	3
UniProt:Q9H714-3 RUBCNL			0.499	3
UniProt:Q9QUM4 SLAF1			0.499	8
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.488	2
UniProt:Q9Y4W6 AFG3L2	1	AFG3L2 [mitochondrial inner membrane] (R-HSA-8949650)	0.483	3
UniProt:A8K0Z3 WASH1			0.463	3
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.463	2
UniProt:Q8UZC1 Q8UZC1			0.463	2
UniProt:O54921	2	Exoc2 [cytosol] (R-RNO-5623376) Exoc2 [plasma membrane] (R-RNO-264887)	0.463	2

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