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PTPRC [plasma membrane]
Stable Identifier
R-HSA-197931
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Leukocyte common antigen precursor, CD45_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Other semaphorin interactions (Homo sapiens)
SEMA4D interacts with CD45 (Homo sapiens)
PTPRC [plasma membrane] (Homo sapiens)
SEMA4D:PTPRC [plasma membrane] (Homo sapiens)
PTPRC [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
CD45,CD148 [plasma membrane] (Homo sapiens)
PTPRC [plasma membrane] (Homo sapiens)
Inactivation of Lck by Csk (Homo sapiens)
CD45,CD148 [plasma membrane] (Homo sapiens)
PTPRC [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
PTPRC [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08575 PTPRC
Gene Names
PTPRC, CD45
Chain
signal peptide:1-25, chain:26-1306
Reference Genes
BioGPS Gene:5788 PTPRC
COSMIC (genes):PTPRC PTPRC
CTD Gene:5788 PTPRC
dbSNP Gene:5788 PTPRC
ENSEMBL:ENSG00000081237 PTPRC
ENSEMBL_homo_sapiens_GENE:ENSG00000081237.21 PTPRC
ENSEMBL_homo_sapiens_GENE:ENSG00000262418.5 PTPRC
HGNC:9666 PTPRC
KEGG Gene (Homo sapiens):5788 PTPRC
Monarch:5788 PTPRC
NCBI Gene:5788 PTPRC
OMIM:151460 PTPRC
UCSC:P08575 PTPRC
Reference Transcript
RefSeq:NM_080921.3 PTPRC
RefSeq:XM_006711474.3 PTPRC
RefSeq:NM_002838.4 PTPRC
RefSeq:XM_006711473.3 PTPRC
RefSeq:XM_006711472.3 PTPRC
Other Identifiers
11739334_a_at
11743559_a_at
11743560_a_at
11743561_a_at
11752095_a_at
16675578
207238_PM_s_at
207238_s_at
212587_PM_s_at
212587_s_at
212588_PM_at
212588_at
2373853
2373855
2373856
2373875
2373878
2373879
2373882
2373884
2373887
2373888
2373889
2373891
2373893
2373895
2373898
2373900
2373901
2373907
2373908
2373910
2373911
2373912
2373914
2373915
2373916
2373919
2373921
2373923
2373924
2373925
2373928
2373929
2373930
2373931
2373933
2373934
2373936
2373937
2373938
2373939
2373940
2373941
2373942
2373943
40518_at
40520_g_at
5788
7908553
A_14_P136733
A_23_P125451
A_33_P3309526
A_33_P3364808
A_33_P3364811
A_33_P3364821
GE60225
GO:0000165
GO:0001779
GO:0001915
GO:0001916
GO:0001960
GO:0002244
GO:0002376
GO:0002639
GO:0002711
GO:0002923
GO:0002925
GO:0003824
GO:0004721
GO:0004725
GO:0005001
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0005925
GO:0006310
GO:0006469
GO:0006470
GO:0006933
GO:0006954
GO:0007155
GO:0007159
GO:0007166
GO:0008092
GO:0008201
GO:0009897
GO:0009898
GO:0009986
GO:0010332
GO:0010468
GO:0012501
GO:0016020
GO:0016192
GO:0016311
GO:0016787
GO:0016791
GO:0019901
GO:0023052
GO:0030154
GO:0030183
GO:0030217
GO:0030506
GO:0030507
GO:0030667
GO:0030890
GO:0031410
GO:0031668
GO:0031953
GO:0032059
GO:0032677
GO:0032703
GO:0032743
GO:0032760
GO:0034113
GO:0035584
GO:0036211
GO:0042098
GO:0042100
GO:0042102
GO:0042110
GO:0042492
GO:0043226
GO:0043395
GO:0043410
GO:0044770
GO:0044855
GO:0045059
GO:0045060
GO:0045121
GO:0045582
GO:0045588
GO:0045860
GO:0046425
GO:0046633
GO:0046641
GO:0048304
GO:0048539
GO:0048856
GO:0048864
GO:0048870
GO:0050731
GO:0050732
GO:0050764
GO:0050766
GO:0050852
GO:0050853
GO:0050857
GO:0051209
GO:0051607
GO:0051726
GO:0055065
GO:0055085
GO:0060089
GO:0060369
GO:0061024
GO:0061097
GO:0061099
GO:0070062
GO:0070373
GO:0070374
GO:0071944
GO:0097191
GO:0098542
GO:0098857
GO:0140096
GO:1903615
GO:1903979
GO:1904044
GO:1904155
GO:2000473
GO:2000648
GO:2001236
GO:2001238
HMNXSV003006596
HMNXSV003040906
HMNXSV003046238
Hs.170121.1.A1_3p_a_at
Hs.170121.1.A3_3p_at
ILMN_1804279
PH_hs_0025956
TC01001640.hg
Y00062_at
g4506306_3p_a_at
Participates
as a member of
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
CD45,CD148 [plasma membrane] (Homo sapiens)
as a component of
SEMA4D:PTPRC [plasma membrane] (Homo sapiens)
as an input of
SEMA4D interacts with CD45 (Homo sapiens)
Other forms of this molecule
PTPRC [secretory granule membrane]
Inferred To
PTP3 [plasma membrane]
(Saccharomyces cerevisiae)
Ptp52F [plasma membrane]
(Drosophila melanogaster)
Homologues of PTPRC [plasma membrane]
(Dictyostelium discoideum)
Homologues of PTPRC [plasma membrane]
(Drosophila melanogaster)
Homologues of PTPRC [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of PTPRC [plasma membrane]
(Schizosaccharomyces pombe)
pyp2 [plasma membrane]
(Schizosaccharomyces pombe)
PTP1 [plasma membrane]
(Saccharomyces cerevisiae)
ptpA1-2 [plasma membrane]
(Dictyostelium discoideum)
pyp1 [plasma membrane]
(Schizosaccharomyces pombe)
ptpB [plasma membrane]
(Dictyostelium discoideum)
pyp3 [plasma membrane]
(Schizosaccharomyces pombe)
ptpC [plasma membrane]
(Dictyostelium discoideum)
PTP2 [plasma membrane]
(Saccharomyces cerevisiae)
PTPRC [plasma membrane]
(Bos taurus)
PTPRC [plasma membrane]
(Caenorhabditis elegans)
PTPRC [plasma membrane]
(Canis familiaris)
PTPRC [plasma membrane]
(Drosophila melanogaster)
PTPRC [plasma membrane]
(Gallus gallus)
PTPRC [plasma membrane]
(Mus musculus)
PTPRC [plasma membrane]
(Rattus norvegicus)
PTPRC [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
XP_006711536.1
,
XP_006711535.1
,
XP_006711537.1
,
NP_563578.2
,
NP_002829.3
Guide to Pharmacology - Targets
1852
OpenTargets
ENSG00000081237
ZINC - Substances
PTPRC_HUMAN
ZINC target
P08575
ZINC - Biogenic
PTPRC_HUMAN
PRO
P08575
PDB
5FN7
,
5FMV
,
5FN6
,
1YGR
,
1YGU
HPA
ENSG00000081237-PTPRC
GeneCards
P08575
Ensembl
ENSP00000458322
,
ENST00000442510
,
ENSP00000411355
,
ENSP00000461074
,
ENSG00000262418
,
ENST00000697631
,
ENST00000573679
,
ENSP00000513363
,
ENST00000348564
,
ENSP00000306782
,
ENSG00000081237
,
ENST00000573477
Pharos - Targets
P08575
ZINC - Predictions - Purchasable
PTPRC_HUMAN
Orphanet
15171
HMDB Protein
HMDBP02584
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.851
7
UniProt:P41240 CSK
2
CSK [plasma membrane]
(R-HSA-180499)
CSK [cytosol]
(R-HSA-203776)
0.623
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.609
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.592
2
UniProt:P09382 LGALS1
2
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
0.558
2
UniProt:P08575 PTPRC
2
PTPRC [secretory granule membrane]
(R-HSA-6806150)
PTPRC [plasma membrane]
(R-HSA-197931)
0.509
2
UniProt:P20701 ITGAL
2
ITGAL [specific granule membrane]
(R-HSA-6799536)
ITGAL [plasma membrane]
(R-HSA-198013)
0.508
2
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