Reactome | PolyUb-SNX3 [endosome membrane]

PolyUb-SNX3 [endosome membrane]

Stable Identifier

R-HSA-6782993

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

SNX3, SDP3, retromer

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP10 deubiquitinates SNX3, CFTR (Homo sapiens)
        
        USP10:PolyUb-SNX3,PolyUb-CTFR [endosome membrane] (Homo sapiens)
        
        PolyUb-SNX3,PolyUb-CTFR [endosome membrane] (Homo sapiens)
        
        PolyUb-SNX3 [endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60493 SNX3

Gene Names

SNX3

Chain

initiator methionine:1, chain:2-162

Reference Genes

BioGPS Gene:8724 SNX3

COSMIC - genes:SNX3 SNX3

CTD Gene:8724 SNX3

dbSNP Gene:8724 SNX3

ENSEMBL:ENSG00000112335 SNX3

HGNC:11174 SNX3

KEGG:hsa:8724 SNX3

Monarch:8724 SNX3

NCBI Gene:8724 SNX3

OMIM:605930 SNX3

UCSC:O60493 SNX3

Reference Transcript

Other Identifiers

11715738_s_at

11728533_a_at

11754173_a_at

17022349

18670525

18670526

18670527

18670528

18670529

18670530

18670531

18670532

18670533

200067_PM_x_at

200067_x_at

208781_PM_x_at

210648_PM_x_at

210648_x_at

213545_PM_x_at

213545_x_at

2968244

2968245

2968246

2968247

2968249

2968250

2968257

2968258

2968259

2968260

2968331

39360_at

7892770

7893585

7893777

7894157

7894771

7895231

7895478

7895544

7896605

8128683

8724

A_23_P42498

A_24_P277807

A_33_P3345796

GE61205

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0008289

GO:0009617

GO:0010008

GO:0010314

GO:0010324

GO:0010976

GO:0015031

GO:0016192

GO:0019903

GO:0022615

GO:0030111

GO:0030136

GO:0030904

GO:0031410

GO:0031901

GO:0032009

GO:0032266

GO:0032456

GO:0034499

GO:0035091

GO:0042177

GO:0045335

GO:0046597

GO:0050765

GO:0051224

GO:0061024

GO:0070062

GO:0070273

GO:0070676

GO:0080025

GO:1901981

GO:1905394

GO:2000642

HMNXSV003000660

HMNXSV003014364

ILMN_1740180

ILMN_1795557

PH_hs_0001136

TC06001994.hg

g12957159_3p_a_at

g3126978_3p_a_at

Participates

as a member of

PolyUb-SNX3,PolyUb-CTFR [endosome membrane] (Homo sapiens)

Other forms of this molecule

SNX3 [cytosol]

SNX3 [endosome membrane]

Inferred To

SNX3 [endosome membrane] (Gallus gallus)

SNX3 [endosome membrane] (Sus scrofa)

snx3 [endosome membrane] (Danio rerio)

PolyUb-SNX3 [endosome membrane] (Canis familiaris)

PolyUb-SNX3 [endosome membrane] (Mus musculus)

PolyUb-SNX3 [endosome membrane] (Rattus norvegicus)

PolyUb-SNX3 [endosome membrane] (Saccharomyces cerevisiae)

PolyUb-SNX3 [endosome membrane] (Schizosaccharomyces pombe)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001287858.1, NP_690040.1, NP_003786.1

OpenTargets

ENSG00000112335

ENSEMBL

ENST00000230085, ENSP00000401779, ENST00000349379, ENSG00000112335, ENSP00000357975, ENST00000426155, ENSP00000230085, ENST00000368979, ENSP00000296991

HPA

ENSG00000112335-SNX3

GeneCards

SNX3

PRO

O60493

Pharos - Targets

O60493

GlyGen

O60493

PDB

5F0J, 7BLO, 2MXC, 5F0L, 5F0P, 5F0M, 2YPS

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96QK1 VPS35	1	VPS35 [cytosol] (R-HSA-3247740)	0.643	4
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.577	4
ChEBI:17283 PI3P			0.564	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q15041 AR6P1			0.556	3
UniProt:P56539 CAV3	1	CAV3 [plasma membrane] (R-HSA-1368135)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:Q9BWG6 SCNM1			0.527	2
UniProt:P04798 CYP1A1	1	CYP1A1 [endoplasmic reticulum membrane] (R-HSA-52623)	0.527	2
UniProt:P43005 SLC1A1	4	SLC1A1 [plasma membrane] (R-HSA-210414) SLC1A1 R445W [plasma membrane] (R-HSA-5625045) SLC1A1 84kb_del [plasma membrane] (R-HSA-5625040) SLC1A1 I395del [plasma membrane] (R-HSA-5625023)	0.527	2
UniProt:Q9H8J5 MANS1			0.527	2
UniProt:P02675 FGB	5	FGB [extracellular region] (R-HSA-140584) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [plasma membrane] (R-HSA-140917) FGB(31-491) [extracellular region] (R-HSA-140846) FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921)	0.527	2
UniProt:Q4G0F5 VP26B			0.527	3
UniProt:Q9UBQ0 VPS29	1	VPS29 [cytosol] (R-HSA-3247738)	0.527	2
UniProt:O75436 VPS26A	1	VPS26A [cytosol] (R-HSA-3247739)	0.527	3
UniProt:P59536 TAS2R41	1	TAS2R41 [plasma membrane] (R-HSA-3299622)	0.527	2
UniProt:Q9UMY4 SNX12			0.527	3

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