Reactome | p-CRKL [cytosol]

p-CRKL [cytosol]

Stable Identifier

R-HSA-9024730

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Crk-like protein, CRKL_HUMAN

Icon

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Erythropoietin (Homo sapiens)
  - Erythropoietin activates RAS (Homo sapiens)
    - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:SHC1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1,p-Y-VAV1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:p-Y-VAV1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
    - JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:SHC1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
    - JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:p-Y-VAV1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)
    - LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 (Homo sapiens)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)
        
        p-CRKL [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
11443118	CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling Arai, A, Miura, O, Nosaka, Y, Kanda, E, Miyasaka, N	J. Biol. Chem.	2001

External Reference Information

External Reference

UniProt:P46109 CRKL

Gene Names

CRKL

Chain

chain:1-303

Reference Genes

BioGPS Gene:1399 CRKL

COSMIC (genes):CRKL CRKL

CTD Gene:1399 CRKL

dbSNP Gene:1399 CRKL

ENSEMBL:ENSG00000099942 CRKL

ENSEMBL_homo_sapiens_GENE:ENSG00000099942.13 CRKL

HGNC:2363 CRKL

KEGG Gene (Homo sapiens):1399 CRKL

Monarch:1399 CRKL

NCBI Gene:1399 CRKL

OMIM:602007 CRKL

UCSC:P46109 CRKL

Reference Transcript

RefSeq:NM_005207.3 CRKL

Other Identifiers

11718993_at

11718994_x_at

11752708_a_at

1399

16927401

206184_PM_at

206184_at

212180_PM_at

212180_at

33524_at

35301_at

3937683

3937788

3937789

3937790

3937791

3937792

3937793

3937794

3937795

3937796

3937797

3937798

3937799

3937809

3937810

415_at

8071434

A_23_P40535

A_24_P935009

GE55439

GE59847

GO:0001558

GO:0001568

GO:0001655

GO:0001764

GO:0001783

GO:0001784

GO:0001933

GO:0001934

GO:0002376

GO:0002685

GO:0003151

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0005886

GO:0006629

GO:0007155

GO:0007163

GO:0007165

GO:0007167

GO:0007254

GO:0007265

GO:0007283

GO:0007338

GO:0007389

GO:0007507

GO:0008284

GO:0008543

GO:0008584

GO:0009887

GO:0009952

GO:0010468

GO:0010629

GO:0012501

GO:0016358

GO:0016477

GO:0021766

GO:0021987

GO:0022414

GO:0023052

GO:0030010

GO:0030154

GO:0030971

GO:0031594

GO:0032991

GO:0033628

GO:0034330

GO:0035022

GO:0035556

GO:0035591

GO:0035685

GO:0036211

GO:0038026

GO:0042802

GO:0043226

GO:0043410

GO:0045202

GO:0045296

GO:0048384

GO:0048538

GO:0048856

GO:0048870

GO:0050773

GO:0050852

GO:0060017

GO:0060090

GO:0060326

GO:0061024

GO:0061629

GO:0070374

GO:0071466

GO:0071560

GO:0071774

GO:0086100

GO:0095500

GO:0098698

GO:0098749

GO:0098761

GO:0098890

GO:0160093

GO:1900026

GO:1903977

GO:1904393

GO:1904395

GO:1904888

GO:2000145

GO:2000404

HMNXSV003027912

HMNXSV003041118

Hs.5613.0.S1_3p_at

Hs.5613.0.S1_3p_x_at

ILMN_1690122

ILMN_1723165

PH_hs_0000573

TC22000074.hg

TC22000983.hg

X59656_at

g4885152_3p_at

Participates

as a component of

p-CRKL:RAPGEF1 [cytosol] (Homo sapiens)

Other forms of this molecule

CRKL [cytosol]

Inferred To

phospho-p-CRKL [cytosol] (Sus scrofa)

phospho-Crkl [cytosol] (Rattus norvegicus)

p-Crkl [cytosol] (Mus musculus)

phospho-CRKL [cytosol] (Bos taurus)

phospho-CRKL [cytosol] (Canis familiaris)

phospho-Crk [cytosol] (Drosophila melanogaster)

Ghost homologue of p-CRKL [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005198.1

OpenTargets

ENSG00000099942

HPA

ENSG00000099942-CRKL

GeneCards

P46109

Ensembl

ENSP00000346300, ENST00000354336, ENSG00000099942, ENSP00000396646, ENST00000411769

PRO

P46109

Pharos - Targets

P46109

Orphanet

21835

PDB

2DBK, 2BZX, 2LQW, 2LQN, 2EO3, 2BZY

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.868	9
UniProt:Q13480 GAB1	4	GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.753	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.749	5
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.743	4
UniProt:Q13905 RAPGEF1	2	RAPGEF1 [cytosol] (R-HSA-913472) RAPGEF1 [endosome] (R-HSA-3008667)	0.723	4
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.719	4
UniProt:Q08460 Kcnma1	2	Kcnma1 [plasma membrane] (R-MMU-9667781) KCNMA1 [plasma membrane] (R-MMU-418462)	0.639	5
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.621	4
UniProt:P16234 PDGFRA	20	PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA I843_D846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974)	0.569	3
UniProt:Q70EK8 UBP53			0.556	5
UniProt:A2A3K4 PTPC1			0.556	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.556	3
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.556	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.556	5
UniProt:Q63HR2 TENS2			0.553	2
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.547	2
UniProt:Q8TB24 RIN3	1	RIN3 [cytosol] (R-HSA-8875292)	0.547	2
UniProt:Q12774 ARHGEF5	1	ARHGEF5 [cytosol] (R-HSA-8873909)	0.547	2
IntAct:EBI-15753371 YRCPEPTIDE			0.544	3
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.536	2
UniProt:Q9H792 PEAK1	1	PEAK1 [cytosol] (R-HSA-9715162)	0.527	2
UniProt:Q6P2E9 EDC4	1	EDC4 [cytosol] (R-HSA-429963)	0.527	2
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.527	2
UniProt:Q14185 DOCK1	1	DOCK1 [cytosol] (R-HSA-372654)	0.527	2
UniProt:Q86YV5 SGK223	1	PRAG1 [cytosol] (R-HSA-9696532)	0.527	2
UniProt:Q9H7D0 DOCK5	1	DOCK5 [cytosol] (R-HSA-1012991)	0.527	2
UniProt:Q13325 IFIT5	1	IFIT5 [cytosol] (R-HSA-9684472)	0.527	2
UniProt:Q92918 M4K1			0.524	5
UniProt:Q9EQG6 Kidins220	3	ARMS/KIDINS220 protein [cytosol] (R-RNO-182094) phospho-Kidins220 [cytosol] (R-RNO-169869) Kidins220 [cytosol] (R-RNO-169880)	0.499	2
UniProt:Q96PD2 DCBD2			0.499	3
UniProt:O15524 SOCS1	1	SOCS1 [cytosol] (R-HSA-204910)	0.488	2
UniProt:Q9H0V1 TM168			0.488	2
UniProt:Q99704 DOK1	2	p-Y362-DOK1 [cytosol] (R-HSA-8848784) DOK1 [cytosol] (R-HSA-74763)	0.488	2
UniProt:O15033 AREL1	1	AREL1 [cytosol] (R-HSA-8851648)	0.488	2
UniProt:O60496 DOK2	1	DOK2 [cytosol] (R-HSA-204823)	0.488	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.483	3
UniProt:P17948 FLT1	1	VEGFR1 [plasma membrane] (R-HSA-3004464)	0.471	9
UniProt:P42229 STAT5A	4	STAT5A [nucleoplasm] (R-HSA-9701901) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) p-Y694-STAT5A [cytosol] (R-HSA-507936) STAT5A [cytosol] (R-HSA-380747)	0.462	2

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