ER alpha36 [cytosol]

Stable Identifier
R-HSA-9020981
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
ESR1(36), Estrogen receptor, ESR1_HUMAN, ER36
ER alpha36 [cytosol] icon
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
ESR1, ESR, NR3A1
Other Identifiers
0000360020
0104540528
11721785_a_at
11721786_a_at
11736904_a_at
11750485_a_at
11756042_x_at
1298_at
1681_at
17013809
1893_s_at
205225_at
2099
211233_x_at
211234_x_at
211235_s_at
215552_s_at
217163_at
217190_x_at
2931764
2931765
2931774
2931775
2931776
2931779
2931780
2931781
2931782
2931783
2931784
2931785
2931798
2931799
2931812
2931821
2931839
2931840
2931850
2931859
2931860
2931861
2931862
2931863
33670_at
8122840
8122843
A_14_P136162
A_23_P309739
A_24_P325215
A_24_P383478
A_33_P3379356
FUNCTION Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032).SUBUNIT Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with FOXC2, MAP1S, SLC30A9, UBE1C and NCOA3 coactivator (By similarity). Interacts with PELP1, the interaction is enhanced by 17-beta-estradiol, the interaction increases ESR1 transcriptional activity (PubMed:11481323, PubMed:14963108). Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with CITED1; the interaction is estrogen-dependent. Interacts with NCOA5 and NCOA6 coactivators. Interacts with NCOA7; the interaction is a ligand-inducible. Interacts with PHB2, and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ESR1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with KMT2D/MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol. Interacts with KIF18A and LDB1. Interacts with RLIM (via C-terminus). Interacts with MACROD1. Interacts with SH2D4A and PLCG. Interaction with SH2D4A blocks binding to PLCG and inhibits estrogen-induced cell proliferation. Interacts with DYNLL1. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with DNAAF4. Interacts with PRMT2. Interacts with RBFOX2. Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D. Interacts with NCOA2; NCOA2 can interact with ESR1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy. Interacts with DDX5 (PubMed:11682626). Interacts with NCOA1; the interaction seems to require a self-association of N-terminal and C-terminal regions. Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3. Interacts with NRIP1 (By similarity). Interacts with GPER1; the interaction occurs in an estrogen-dependent manner. Interacts with CLOCK and the interaction is stimulated by estrogen. Interacts with BCAS3. Interacts with TRIP4 (ufmylated); estrogen dependent. Interacts with LMTK3; the interaction phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with ZFHX3. Interacts with SFR1 in a ligand-dependent and -independent manner (PubMed:23874500). Interacts with DCAF13, LATS1 and DCAF1; regulates ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation (PubMed:28068668). Interacts (via DNA-binding domain) with POU4F2 (C-terminus); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner (By similarity). Interacts with ESRRB isoform 1 (PubMed:19755138). Interacts with UBE3A and WBP2 (PubMed:16772533). Interacts with GTF2B (PubMed:1517211). Interacts with RBM39 (By similarity). In the absence of hormonal ligand, interacts with TACC1 (PubMed:20078863). Interacts with PI3KR1 or PI3KR2 and PTK2/FAK1 (PubMed:18657504). Interacts with SRC (PubMed:14963108, PubMed:18657504).TISSUE SPECIFICITY Widely expressed (PubMed:10970861). Not expressed in the pituitary gland (PubMed:10970861).DOMAIN Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner. AF-1 seems to provide the major transactivation function in differentiated cells.PTM Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Self-association induces phosphorylation. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity. Phosphorylated by LMTK3 in vitro.PTM Glycosylated; contains N-acetylglucosamine, probably O-linked.PTM Ubiquitinated; regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation (PubMed:21602804, PubMed:28068668). Deubiquitinated by OTUB1 (PubMed:19383985).PTM Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization (PubMed:18657504, PubMed:24498420). Demethylated by JMJD6 at Arg-260 (PubMed:24498420).PTM Palmitoylated (isoform 3). Not biotinylated (isoform 3).PTM Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor.POLYMORPHISM Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.MISCELLANEOUS Selective estrogen receptor modulators (SERMs), such as tamoxifen, raloxifene, toremifene, lasofoxifene, clomifene, femarelle and ormeloxifene, have tissue selective agonistic and antagonistic effects on the estrogen receptor (ER). They interfere with the ER association with coactivators or corepressors, mainly involving the AF-2 domain.SIMILARITY Belongs to the nuclear hormone receptor family. NR3 subfamily.CAUTION Was reported to be activated by DDX5. However, this study has been retracted due to concerns of image manipulation.
GE59651
GO:0000003
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001093
GO:0001223
GO:0001226
GO:0001228
GO:0001547
GO:0002064
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0003707
GO:0004879
GO:0005496
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0006338
GO:0006355
GO:0006357
GO:0006367
GO:0006464
GO:0006629
GO:0006950
GO:0007165
GO:0007200
GO:0007204
GO:0007267
GO:0008013
GO:0008134
GO:0008150
GO:0008209
GO:0008219
GO:0008270
GO:0008283
GO:0008289
GO:0008584
GO:0009058
GO:0010629
GO:0010863
GO:0016020
GO:0016021
GO:0016579
GO:0017025
GO:0019899
GO:0019901
GO:0022607
GO:0030111
GO:0030154
GO:0030234
GO:0030235
GO:0030284
GO:0030331
GO:0030518
GO:0030520
GO:0030522
GO:0032355
GO:0032991
GO:0033146
GO:0034056
GO:0034121
GO:0034641
GO:0035327
GO:0040007
GO:0042592
GO:0042802
GO:0042981
GO:0043124
GO:0043167
GO:0043226
GO:0043401
GO:0043433
GO:0043565
GO:0043627
GO:0045893
GO:0045899
GO:0045944
GO:0046872
GO:0048146
GO:0048856
GO:0048863
GO:0050727
GO:0051091
GO:0051117
GO:0051276
GO:0051897
GO:0060065
GO:0060068
GO:0060523
GO:0060527
GO:0060687
GO:0060745
GO:0060749
GO:0060750
GO:0065003
GO:0071168
GO:0071391
GO:0071392
GO:0097550
GO:1903799
GO:1990837
HMNXSV003001759
Hs.247938.0.S1_3p_at
Hs.247976.0.S1_3p_s_at
ILMN_1678535
TC06001104.hg
TC06003132.hg
TC06003133.hg
X03635_at
X86816_at
g11907834_3p_a_at
g4503602_3p_at
Participates
Other forms of this molecule
Inferred To
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
620
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
GlyGen
PDB
4PXM, 7RS8, 2POG, 6IAR, 6HHP, 5TN5, 7RS2, 5ACC, 5E19, 6PFM, 3L03, 5WGQ, 7BA3, 1GWQ, 1PCG, 4IW8, 5TN6, 2LLO, 5DLR, 2I0J, 5TLU, 5KCC, 5KRO, 2JF9, 1A52, 4MGC, 4JDD, 2QZO, 6HKF, 2QSE, 5DMC, 6HKB, 5TLT, 4MGD, 5KR9, 5WGD, 4ZNU, 6VPK, 5KRL, 5TLO, 5EIT, 2QXM, 6SUO, 5TLP, 5KRK, 1ERR, 5AAU, 4TUZ, 1ERE, 6B0F, 5AAV, 3CBM, 6TJM, 6CZN, 4MGA, 5TM4, 5TMS, 5FQT, 3HM1, 7RRZ, 7RS0, 7KCA, 1HCQ, 4IVY, 5EI1, 5TM5, 5FQS, 5DWG, 2QXS, 5DKS, 5DWI, 5DXR, 4IVW, 3ERT, 6CHZ, 1QKU, 5DXQ, 5DL4, 4ZNT, 5TMR, 7KBS, 5E1C, 5KD9, 2Q70, 3UUC, 6CHW, 7BAB, 5TMO, 5FQP, 7RS3, 5TMQ, 5DVV, 5E14, 5TM2, 5DKE, 7RS9, 5DXM, 6VGH, 7NFB, 5EHJ, 5E15, 5DKG, 5FQR, 4ZNH, 5N10, 4IV4, 6PIT, 6VJD, 5TN3, 6C42, 4MGB, 3OSA, 6ZOS, 6SBO, 6TL3, 4IV2, 6VMU, 4JC3, 6D0F, 5TN4, 6ZOR, 6PET, 3UUD, 6VJ1, 5EGV, 4MG8, 6ZOQ, 1QKT, 5DUH, 2P15, 4MG9, 2Q6J, 6VPF, 2YAT, 6VIG, 3ERD, 5TLM, 6OWC, 7NDO, 5T1Z, 5KCW, 5KRI, 1HCP, 5DZH, 5DWE, 3HLV, 6DFN, 4ZNS, 5DXP, 7RRY, 5TLL, 5KCU, 5W9C, 5TM3, 5KRJ, 7RRX, 2AYR, 5W9D, 1XQC, 7NFW, 5DZI, 1YIN, 1X7E, 4ZN9, 5TM1, 5TLY, 7RS4, 3OS8, 5DXK, 5DZ3, 5E0X, 5DXG, 5KCF, 5DZ1, 6DF6, 5DKB, 6V87, 3UUA, 3Q95, 5TML, 7BAA, 5KRF, 4IU7, 5KCT, 5TMM, 3UU7, 4AA6, 2QH6, 1SJ0, 7BA9, 1XP9, 3DT3, 2QGW, 2QA8, 5TN1, 1ZKY, 5E0W, 5DK9, 2R6Y, 7NEL, 5DVS, 4O6F, 4Q13, 4ZN7, 5AK2, 5TMZ, 1X7R, 4IUI, 3OS9, 4Q50, 5TMV, 2YJA, 5DUG, 5TM8, 4XI3, 5TMW, 1XPC, 2QAB, 5JMM, 5UFX, 2QE4, 5TLG, 6V8T, 1UOM, 1L2I, 7MSA, 5U2D, 6PSJ, 5T0X, 7BA8, 1R5K, 5TNB, 5KRH, 5UFW, 7B9T, 4MG6, 5DUE, 5U2B, 2B23, 5T97, 7BA7, 5TLF, 5DIE, 4MG7, 5DIG, 6VVP, 5TN9, 2LLQ, 5KRC, 4IWC, 1GWR, 4PPS, 5TLD, 7BA5, 1XP1, 5TN7, 5KRA, 5DMF, 7B9M, 2IOK, 5DTV, 2G44, 2OUZ, 6WOK, 5DI7, 5GS4, 5TLX, 7JHD, 5DU5, 5KCD, 5DXB, 5TLV, 5GTR, 2JFA, 5DYD, 5DZ0, 5TM9, 2QA6, 1XP6, 2B1Z, 2R6W, 4IWF, 5KCE, 5DXE, 4PPP, 2QGT, 5DRM, 5DY8, 2B1V, 6CBZ, 5DWJ, 5HYR, 4ZNV, 3CBP, 2BJ4, 1G50, 4TV1, 2G5O, 4DMA, 5DYB, 4ZNW, 5TM6, 5TMU, 5DX3, 3CBO, 2OCF, 5KRM, 7KCD, 4MG5, 4PP6, 7RS1, 6HMU, 1YIM, 5TM7, 5DP0, 4IW6, 5T92, 2QR9, 5DID, 5TMT, 2IOG, 2FAI, 5TN8, 6SQ0, 5FQV, 7RS7, 7BA6, 7B9R, 5DRJ
ZINC - Investigational
ZINC - Metabolites
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
Interactors (256)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P03372 ESR1  8 0.87 11
 UniProt:P12931 SRC  6 0.848 12
 UniProt:Q15788 NCOA1  3 0.835 8
 UniProt:Q04206 RELA  6 0.832 9
 UniProt:P38398 BRCA1  20 0.811 16
 IntAct:EBI-5590876 TFF1      0.788 6
 UniProt:P06401 PGR  3 0.774 20
 UniProt:P55345 ANM2      0.75 9
 UniProt:Q6PL18 ATAD2  1 0.737 5
 UniProt:Q9H1R3 MYLK2      0.725 5
 UniProt:P60709 ACTB  5 0.723 6
 UniProt:P62701 RPS4X  2 0.69 4
 UniProt:P05388 RPLP0  1 0.69 4
 UniProt:P62854 RPS26  2 0.69 5
 UniProt:Q969Q0 RPL36AL  1 0.69 5
 UniProt:Q9BQ69 MACD1      0.69 6
 UniProt:Q9Y6Q9 NCOA3  2 0.688 4
 UniProt:P29279 CCN2  1 0.682 7
 UniProt:P19838-PRO_0000030311 NFKB1      0.676 3
 UniProt:Q02447 SP3  3 0.667 4
 UniProt:Q6NYC1 JMJD6  1 0.649 8
 UniProt:Q9Y294 ASF1A  1 0.647 4
 UniProt:P06576 ATP5F1B  6 0.643 4
 UniProt:P17844 DDX5  4 0.643 4
 UniProt:P60660 MYL6  2 0.642 3
 UniProt:O15164 TRIM24  4 0.641 3
 UniProt:P60763 RAC3  3 0.639 5
 UniProt:Q8N895 ZN366      0.633 6
 UniProt:O43524 FOXO3  9 0.632 7
 UniProt:Q03989 ARI5A      0.625 9
 UniProt:P53041 PPP5C  2 0.625 4
 UniProt:P23771 GATA3  2 0.623 4
 UniProt:P05627 Jun  5 0.616 6
 UniProt:Q9Y3R0 GRIP1  2 0.609 2
 UniProt:P35579 MYH9  3 0.597 3
 UniProt:Q5JTH9 RRP12      0.597 4
 UniProt:P11142 HSPA8  10 0.597 3
 UniProt:Q01130 SRSF2  1 0.597 4
 UniProt:P61513 RPL37A  1 0.597 4
 UniProt:P27635 RPL10  1 0.597 4
 UniProt:P06396 GSN  7 0.597 3
 UniProt:Q13547 HDAC1  2 0.597 4
 UniProt:P21333 FLNA  3 0.597 3
 UniProt:Q96GQ7 DDX27      0.597 4
 UniProt:Q92841 DDX17  2 0.597 3
 UniProt:Q9BVP2 GNL3  1 0.597 4
 UniProt:O43823 AKAP8      0.597 4
 UniProt:P10276 RARA  3 0.597 4
 UniProt:P62263 RPS14  2 0.597 3
 UniProt:P06401-1 PGR      0.593 4
 UniProt:Q12802 AKAP13  1 0.593 3
 UniProt:Q9Y6C7 L3R2A      0.593 3
 UniProt:O60869 EDF1      0.59 3
 UniProt:P18846 ATF1  2 0.59 3
 UniProt:P17676 CEBPB  3 0.59 2
 UniProt:Q93009 USP7  2 0.59 3
 UniProt:Q15596 NCOA2  3 0.584 5
 UniProt:O43251 RBFOX2  1 0.581 4
 UniProt:Q96AQ6-1 PBXIP1      0.576 3
 IntAct:EBI-10099285 VITA2      0.576 5
 UniProt:Q86Y37 CACL1      0.571 5
 UniProt:P36873 PPP1CC  1 0.564 3
 UniProt:P48552 NRIP1  2 0.564 3
 UniProt:Q9UHF7 TRPS1      0.564 4
 UniProt:P00523 SRC  9 0.564 2
 UniProt:Q15648 MED1  1 0.564 3
 UniProt:P08047 SP1  1 0.558 2
 UniProt:O76024 WFS1  3 0.556 3
 UniProt:Q6ZQX7-4 Q6ZQX74      0.556 3
 UniProt:Q16881-4 TXNRD1      0.556 4
 UniProt:P62962 Pfn1  2 0.556 3
 UniProt:Q6XD76 ASCL4      0.556 3
 UniProt:Q9UBK2 PPARGC1A  4 0.553 2
 UniProt:Q9BZ95 NSD3  1 0.547 3
 IntAct:EBI-2695616 ERE      0.544 2
 UniProt:Q96Q04 LMTK3      0.544 3
 UniProt:Q14151 SAFB2      0.544 2
 UniProt:Q09472 EP300  5 0.536 2
 UniProt:Q92731 ESR2  5 0.532 3
 UniProt:P06748 NPM1  10 0.532 3
 UniProt:P82673 MRPS35  1 0.527 3
 UniProt:P62269 RPS18  2 0.527 2
 UniProt:Q99832 CCT7  1 0.527 2
 UniProt:P68363 TUBA1B  9 0.527 3
 UniProt:P05109 S100A8  3 0.527 2
 UniProt:Q96SB4 SRPK1  1 0.527 3
 UniProt:Q9HCM4 EPB41L5  1 0.527 3
 UniProt:Q9NX58 LYAR      0.527 3
 UniProt:Q8NI36 WDR36  1 0.527 3
 UniProt:O00165 HAX1      0.527 2
 IntAct:EBI-1265559 MYC      0.527 3
 UniProt:Q13823 NOG2      0.527 3
 UniProt:P08865 RPSA  2 0.527 3
 UniProt:P62244 RPS15A  2 0.527 3
 UniProt:Q14684 RRP1B      0.527 3
 UniProt:P60866 RPS20  2 0.527 2
 UniProt:Q9NPD3 EXOSC4  2 0.527 3
 UniProt:Q7Z406 MYH14  1 0.527 2
 UniProt:O95793 STAU1      0.527 2
 UniProt:P27708 CAD  1 0.527 3
 UniProt:Q9Y399 MRPS2  1 0.527 3
 UniProt:Q15084 PDIA6  3 0.527 3
 UniProt:Q9BUF5 TUBB6  6 0.527 3
 UniProt:Q9NPJ6 MED4  1 0.527 3
 UniProt:P56192 MARS1  1 0.527 3
 UniProt:P42224 STAT1  7 0.527 3
 UniProt:Q96L91 EP400  1 0.527 3
 UniProt:P46940 IQGAP1  3 0.527 3
 UniProt:O75110 ATP9A  1 0.527 3
 UniProt:P82650 MRPS22  1 0.527 3
 UniProt:P12268 IMPDH2  4 0.527 3
 UniProt:Q92665 MRPS31  1 0.527 3
 UniProt:O43432 EIF4G3  1 0.527 3
 UniProt:Q96EY7 PTCD3  1 0.527 3
 UniProt:Q8IYT4 KATL2      0.527 2
 UniProt:Q9UBF2 COPG2  4 0.527 3
 UniProt:Q92552 MRPS27  1 0.527 3
 UniProt:P62952 BLCAP      0.527 2
 UniProt:O60568 PLOD3  1 0.527 2
 UniProt:P12814 ACTN1  3 0.527 3
 UniProt:Q9Y4P3 TBL2      0.527 3
 UniProt:Q9NQZ2 UTP3  1 0.527 3
 UniProt:Q9BRD0 BUD13      0.527 3
 UniProt:Q9UN36 NDRG2      0.527 2
 UniProt:Q7Z2W4 ZC3HAV1  2 0.527 3
 UniProt:O43175 PHGDH  1 0.527 3
 UniProt:Q15291 RBBP5  1 0.527 4
 UniProt:P05089 ARG1  4 0.527 2
 UniProt:Q8WUY1 THEM6      0.527 3
 UniProt:Q9Y2R5 MRPS17  1 0.527 2
 UniProt:Q8NHW5 RLA0L      0.527 2
 UniProt:Q9BVJ6 UTP14A  1 0.527 3
 UniProt:Q9UBL3 ASH2L  1 0.527 4
 UniProt:Q9H3U1 UN45A      0.527 3
 UniProt:P62191 PSMC1  2 0.527 3
 UniProt:O00429 DNM1L  2 0.527 2
 UniProt:P60842 EIF4A1  1 0.527 3
 UniProt:P25398 RPS12  2 0.527 2
 UniProt:Q15233 NONO      0.527 3
 UniProt:P78362 SRPK2  1 0.527 3
 UniProt:Q96HI0 SENP5  1 0.527 2
 UniProt:Q7L2E3 DHX30      0.527 3
 UniProt:Q99575 POP1  1 0.527 3
 UniProt:Q9BQ39 DDX50      0.527 3
 UniProt:Q9Y3U8 RPL36  1 0.527 3
 UniProt:P50454 SERPINH1  1 0.527 3
 UniProt:Q8N201 INTS1  1 0.527 3
 UniProt:Q8IXJ9 ASXL1  1 0.527 2
 UniProt:Q9Y230 RUVBL2  1 0.527 2
 UniProt:Q16576 RBBP7  1 0.527 3
 UniProt:Q04637 EIF4G1  2 0.527 3
 UniProt:Q92754 TFAP2C  3 0.527 3
 UniProt:O14686 KMT2D  1 0.525 3
 UniProt:Q99966 CITED1  1 0.524 3
 UniProt:P42229 STAT5A  6 0.524 2
 UniProt:Q9H467 CUED2      0.524 2
 UniProt:Q9BTK6 PAGR1  1 0.524 5
 UniProt:Q00987 MDM2  11 0.508 2
 UniProt:Q9JLI4 NCOA6      0.508 2
 UniProt:Q60974 Ncor1  3 0.508 2
 UniProt:Q99623 PHB2  1 0.508 4
 UniProt:P59598  1 0.508 2
 UniProt:P20290-2 BTF3      0.508 5
 UniProt:Q12778 FOXO1  5 0.508 2
 UniProt:Q9NV06 DCAF13  1 0.499 2
 UniProt:O95835 LATS1  2 0.499 2
 UniProt:PGR ENSG00000082175      0.499 3
 UniProt:Q9NPJ4 PNRC2  1 0.488 2
 UniProt:P27986 PIK3R1  15 0.483 7
 UniProt:Q925T6  2 0.482 2
 UniProt:P83881 RPL36A  1 0.462 2
 UniProt:O76021 RL1D1      0.462 2
 UniProt:P38159 RBMX  2 0.462 2
 UniProt:Q9NYF8 BCLF1      0.462 2
 UniProt:Q07020 RPL18  1 0.462 2
 UniProt:Q92769 HDAC2  2 0.462 2
 UniProt:P61978 HNRNPK  2 0.462 2
 UniProt:Q01844 EWS      0.462 2
 UniProt:Q8IYB3 SRRM1  2 0.462 2
 UniProt:P39023 RPL3  1 0.462 2
 UniProt:P62249 RPS16  2 0.462 2
 UniProt:O00159 MYO1C  1 0.462 2
 UniProt:P62241 RPS8  2 0.462 2
 UniProt:Q08211 DHX9  2 0.462 2
 UniProt:P0CG47 UBB  20 0.462 2
 UniProt:Q16629 SRSF7  1 0.462 2
 UniProt:Q14444 CAPR1      0.462 2
 UniProt:P17480 UBTF  2 0.462 2
 UniProt:Q6PJG2 MDEAS      0.462 2
 UniProt:P05141 SLC25A5  1 0.462 2
 UniProt:Q00610 CLTC  10 0.462 2
 UniProt:Q9NVP1 DDX18      0.462 2
 UniProt:P02786 TFRC  5 0.462 2
 UniProt:Q96PK6 RBM14  1 0.462 2
 UniProt:P62917 RPL8  1 0.462 2
 UniProt:P04843 RPN1  1 0.462 2
 UniProt:P04844 RPN2  1 0.462 2
 UniProt:P09874 PARP1  4 0.462 2
 UniProt:P36578 RPL4  1 0.462 2
 UniProt:P46013 KI67      0.462 2
 UniProt:Q14669 TRIP12  1 0.462 2
 UniProt:Q9P035 HACD3  1 0.462 2
 UniProt:P15880 RPS2  3 0.462 2
 UniProt:P11388 TOP2A  3 0.462 2
 UniProt:P83731 RPL24  1 0.462 2
 UniProt:P11940 PABPC1  1 0.462 2
 UniProt:P68032 ACTC1  1 0.462 2
 UniProt:Q02543 RPL18A  1 0.462 2
 UniProt:P19338 NCL  1 0.462 2
 UniProt:O43795 MYO1B      0.462 2
 UniProt:P52597 HNRNPF  2 0.462 2
 UniProt:Q12905 ILF2  4 0.462 2
 UniProt:P18124 RPL7  1 0.462 2
 UniProt:O00571 DDX3X  3 0.462 2
 UniProt:P62424 RPL7A  1 0.462 2
 UniProt:Q32P51 RA1L2      0.462 2
 UniProt:Q14980 NUMA1  3 0.462 2
 UniProt:Q8IZL8 PELP1  1 0.462 2
 UniProt:Q9BZE4 GTPB4      0.462 2
 UniProt:O00567 NOP56  2 0.462 2
 UniProt:Q9NVI7 ATD3A      0.462 2
 UniProt:P61313 RPL15  1 0.462 2
 UniProt:P35268 RPL22  1 0.462 2
 UniProt:A0A024RC46 A0A024RC46      0.462 2
 UniProt:P14923 JUP  6 0.462 2
 UniProt:Q96HS1 PGAM5      0.462 2
 UniProt:P52272 HNRNPM  1 0.462 2
 UniProt:Q02878 RPL6  1 0.462 2
 UniProt:P51991 HNRNPA3  1 0.462 2
 UniProt:O60832 DKC1  1 0.462 2
 UniProt:P50914 RPL14  1 0.462 2
 UniProt:P18621 RPL17  1 0.462 2
 UniProt:P26373 RPL13  1 0.462 2
 UniProt:P84098 RPL19  1 0.462 2
 UniProt:P26368 U2AF2  1 0.462 2
 UniProt:P46776 RPL27A  1 0.462 2
 UniProt:O43390 HNRNPR  1 0.462 2
 UniProt:P61247 RPS3A  2 0.462 2
 UniProt:Q8TDD1 DDX54      0.462 2
 UniProt:P46781 RPS9  2 0.462 2
 UniProt:O43143 DHX15  1 0.462 2
 UniProt:Q07955 SRSF1  1 0.462 2
 UniProt:Q9H0A0 NAT10  1 0.462 2
 UniProt:P35637 FUS  1 0.462 2
 UniProt:Q14498 RBM39      0.462 2
 UniProt:P40429 RPL13A  2 0.462 2
 UniProt:P11387 TOP1  2 0.462 2
 UniProt:P62266 RPS23  2 0.462 2
 UniProt:P02787 TF  6 0.462 2
 UniProt:Q9NR30 DDX21  1 0.462 2
 UniProt:P62753 RPS6  3 0.462 2
 UniProt:Q9Y2W1 THRAP3  1 0.462 2
 UniProt:Q9BQG0 MYBBP1A  1 0.462 2
 UniProt:P09651 HNRNPA1  1 0.462 2
 UniProt:Q02880 TOP2B  2 0.462 2
 UniProt:Q8IY81 FTSJ3  1 0.462 2
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