Ligand-responsive EGFR mutants resistant to non-covalent TKIs

Stable Identifier
R-HSA-1182967
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
17085664 Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors

Balak, MN, Gong, Y, Riely, GJ, Somwar, R, Li, AR, Zakowski, MF, Chiang, A, Yang, G, Ouerfelli, O, Kris, MG, Ladanyi, M, Miller, VA, Pao, W

Clin Cancer Res 2006
18227510 The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

Yun, CH, Mengwasser, KE, Toms, AV, Woo, MS, Greulich, H, Wong, KK, Meyerson, M, Eck, MJ

Proc Natl Acad Sci U S A 2008
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer