Reactome | HCK [cytosol]

HCK [cytosol]

Stable Identifier

R-HSA-167708

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Hck-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08631 HCK

Gene Names

HCK

Chain

initiator methionine:1, chain:2-526

Reference Genes

BioGPS Gene:3055 HCK

COSMIC (genes):HCK HCK

CTD Gene:3055 HCK

dbSNP Gene:3055 HCK

ENSEMBL:ENSG00000101336 HCK

ENSEMBL_homo_sapiens_GENE:ENSG00000101336 HCK

HGNC:4840 HCK

KEGG Gene (Homo sapiens):3055 HCK

Monarch:3055 HCK

NCBI Gene:3055 HCK

OMIM:142370 HCK

UCSC:P08631 HCK

Reference Transcript

Other Identifiers

0005270162

04660+2.7.10.2

11718861_a_at

16912472

1AD5

1BU1

1QCF

2045_s_at

208018_s_at

2C0I

2C0O

2C0T

2HCK

2HK5

2OI3

2OJ2

3055

3881655

3881656

3881657

3881661

3881663

3881664

3881665

3881666

3881670

3881671

3881672

3881673

3881676

3881679

3881681

3881682

3HCK

3NHN

3RBB

3REA

3REB

3VRY

3VRZ

3VS0

3VS1

3VS2

3VS3

3VS4

3VS5

3VS6

3VS7

40742_at

4HCK

4LUD

4LUE

4ORZ

4U5W

5195

5H09

5H0B

5H0E

5H0G

5H0H

5HCK

5NUH

5ZJ6

63768

8061668

AAA52643

AAA52644

AAH14435

AAH94847

AAI08931

AAI08932

AAI13855

AAI14464

AK026432

AK289896

AK298726

AL049539

AL353092

BAB15482

BAF82585

BAG60878

BC014435

BC094847

BC108930

BC108931

BC113854

BC114463

CAA41565

CAB005195

CAI19694

CAI19695

CAI22966

CAI22967

CCDS33460

CCDS54453

CCDS54455

CCDS54456

CH471077

EAW76392

EAW76393

ENSG00000101336

ENSP00000427757

ENSP00000429848

ENSP00000441169

ENSP00000444986

ENSP00000486627

ENSP00000491964

ENST00000518730

ENST00000520553

ENST00000534862

ENST00000538448

ENST00000629881

ENST00000639405

EntrezGene:3055

F6SF04

g4504356_3p_a_at

GO:0000166

GO:0000902

GO:0001784

GO:0002376

GO:0002522

GO:0002758

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005773

GO:0005794

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005901

GO:0005925

GO:0006464

GO:0006468

GO:0006810

GO:0006887

GO:0006909

GO:0006950

GO:0006954

GO:0007010

GO:0007155

GO:0007165

GO:0007169

GO:0007229

GO:0007498

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008360

GO:0009058

GO:0016020

GO:0016032

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019221

GO:0022607

GO:0030054

GO:0030133

GO:0030154

GO:0030838

GO:0031234

GO:0031410

GO:0031663

GO:0034641

GO:0038083

GO:0038096

GO:0040011

GO:0042995

GO:0043066

GO:0043167

GO:0043226

GO:0043299

GO:0044403

GO:0045087

GO:0045728

GO:0046777

GO:0048856

GO:0048870

GO:0050690

GO:0050727

GO:0050764

GO:0051090

GO:0060333

GO:0065003

GO:0071801

GO:2000251

H0Y3C5

H7BXG4

H7C5P9

HCK

HCK-206

HCK-207

HCK-208

HCK-209

HCK-210

HCK-211

HGNC:4840

HPA063768

ILMN_1791771

IPR000719

IPR000980

IPR001245

IPR001452

IPR008266

IPR011009

IPR017441

IPR020635

IPR035851

IPR036028

IPR036860

J3KPD6

M16591

M16591_s_at

M16592

MIM:142370

NM_001172129

NM_001172131

NM_001172132

NM_001172133

NP_001165600

NP_001165602

NP_001165603

NP_001165604

PF00017

PF00018

PF07714

PH_hs_0004996

PR00109

PR00401

PR00452

SM00219

SM00252

SM00326

TC20000206.hg

uc002wxi.4

uc021wbv.2

uc061wdo.1

uc061wdq.1

uc061wds.1

UPI000012C34E

UPI000015C528

UPI00004709D1

UPI0001C4365F

X58741

X58742

X58743

Participant Of

hasComponent

Hck-1:Nef [cytosol]

input

Nef Binds and activates the Src-family tyrosine kinase Hck

hasCandidate

FYN-like kinases [cytosol]

hasMember

Src family kinases (SFKs) [cytosol]

Inferred To

HCK [cytosol] (Bos taurus)

HCK [cytosol] (Caenorhabditis elegans)

HCK [cytosol] (Canis familiaris)

HCK [cytosol] (Danio rerio)

HCK [cytosol] (Gallus gallus)

HCK [cytosol] (Mus musculus)

HCK [cytosol] (Rattus norvegicus)

HCK [cytosol] (Sus scrofa)

HCK [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001165601.1, NP_001165604.1, NP_001165600.1, NP_002101.2, NP_001165602.1

ZINC - World Drugs

HCK_HUMAN

OpenTargets

ENSG00000101336

ZINC - FDA approved

HCK_HUMAN

ZINC - Substances

HCK_HUMAN

ZINC target

P08631

ZINC - Biogenic

HCK_HUMAN

PRO

P08631

PDB

2HCK, 4LUE, 3VS6, 5H0E, 4ORZ, 1AD5, 2OI3, 5H0B, 3VS5, 3HCK, 4LUD, 3VS4, 2HK5, 2C0T, 5HCK, 3NHN, 3RBB, 3VS3, 5H09, 2OJ2, 3VS2, 2C0O, 5NUH, 2C0I, 3REB, 3VS1, 1BU1, 3REA, 3VRZ, 3VS0, 5ZJ6, 5H0H, 3VRY, 5H0G, 1QCF, 4U5W, 3VS7, 4HCK

GeneCards

P08631

DOCK Blaster

4U5W, 4LUE, 3REB, 4LUD, 3REA, 2HCK, 3VS7, 2C0O, 3VS6, 2C0T, 3VS5, 3VS4, 3VS3, 3VRZ, 3VRY, 3NHN, 2C0I, 3VS2, 3VS1, 3VS0, 1QCF, 1BU1, 2HK5, 1AD5, 3RBB, 4ORZ

BRENDA (Homo sapiens)

2.7.10.2

ZINC - Predictions - Purchasable

HCK_HUMAN

HMDB Protein

HMDBP01256

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.78	4
UniProt:P27958 Genome polyprotein	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.729	5
UniProt:P42768 WAS	2	p-Y291-WAS [cytosol] (R-HSA-2197668) WAS [cytosol] (R-HSA-201879)	0.718	9
UniProt:Q07889 SOS1	3	SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [cytosol] (R-HSA-64847)	0.713	4
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.709	4
UniProt:P03407 NEF			0.646	4
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.609	2
UniProt:O92972 POLG			0.589	2
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.589	3
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.573	2
UniProt:P04324 NEF			0.558	2
IntAct:EBI-7149158 PD1			0.558	2
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9HD26 GOPC	3	GOPC [plasma membrane] (R-HSA-5626572) GOPC [lysosomal membrane] (R-HSA-5627281) GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067)	0.556	3
UniProt:P03406 NEF			0.542	2
UniProt:P12504 VIF			0.524	3
IntAct:EBI-7355238 Q85737			0.524	3
UniProt:Q9QPN3 NEF			0.524	3
UniProt:Q90VU7 Q90VU7			0.524	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873)	0.524	2
UniProt:Q92556 ELMO1	1	ELMO1 [cytosol] (R-HSA-200932)	0.524	4