Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
HCK [cytosol]
Stable Identifier
R-HSA-167708
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Hck-1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
Nef and signal transduction (Homo sapiens)
Nef Binds and activates the Src-family tyrosine kinase Hck (Homo sapiens)
HCK [cytosol] (Homo sapiens)
Hck-1:Nef [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK (Homo sapiens)
Src family kinases (SFKs) [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers (Homo sapiens)
Src family kinases (SFKs) [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK (Homo sapiens)
Src family kinases (SFKs) [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers (Homo sapiens)
Src family kinases (SFKs) [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
FLT3 signaling through SRC family kinases (Homo sapiens)
Active FLT3 binds HCK (Homo sapiens)
Active FLT3:HCK [plasma membrane] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
HCK [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL is tyrosine phosphorylated (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
CBL ubiquitinates PI3K (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
FCGR activation (Homo sapiens)
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Homo sapiens)
Src family kinases (SFKs) [cytosol] (Homo sapiens)
HCK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08631 HCK
Gene Names
HCK
Chain
initiator methionine:1, initiator methionine:, chain:2-526
Reference Genes
BioGPS Gene:3055 HCK
COSMIC (genes):HCK HCK
CTD Gene:3055 HCK
dbSNP Gene:3055 HCK
ENSEMBL:ENSG00000101336 HCK
HGNC:4840 HCK
KEGG Gene (Homo sapiens):3055 HCK
Monarch:3055 HCK
NCBI Gene:3055 HCK
OMIM:142370 HCK
UCSC:P08631 HCK
Reference Transcript
RefSeq:NM_001172133.1 HCK
RefSeq:NM_001172130.1 HCK
RefSeq:NM_001172129.1 HCK
RefSeq:NM_001172131.1 HCK
RefSeq:NM_002110.3 HCK
Other Identifiers
0005270162
11718861_a_at
16912472
2045_s_at
208018_s_at
3055
3881655
3881656
3881657
3881661
3881663
3881664
3881665
3881666
3881670
3881671
3881672
3881673
3881676
3881679
3881681
3881682
40742_at
8061668
GO:0000166
GO:0000902
GO:0001784
GO:0002376
GO:0002522
GO:0002758
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005794
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005901
GO:0005925
GO:0006464
GO:0006468
GO:0006810
GO:0006887
GO:0006909
GO:0006950
GO:0006954
GO:0007010
GO:0007155
GO:0007165
GO:0007169
GO:0007229
GO:0007498
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008360
GO:0009058
GO:0016020
GO:0016032
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019221
GO:0022607
GO:0030054
GO:0030133
GO:0030154
GO:0030838
GO:0031234
GO:0031410
GO:0031663
GO:0034641
GO:0038083
GO:0038096
GO:0040011
GO:0042127
GO:0042995
GO:0043066
GO:0043167
GO:0043226
GO:0043231
GO:0043299
GO:0044403
GO:0045087
GO:0045728
GO:0046777
GO:0048856
GO:0048870
GO:0050690
GO:0050727
GO:0050764
GO:0051090
GO:0060333
GO:0065003
GO:0071801
GO:2000251
HMNXSV003043088
ILMN_1791771
M16591_s_at
PH_hs_0004996
TC20000206.hg
g4504356_3p_a_at
Participates
as an input of
Active FLT3 binds HCK (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
Nef Binds and activates the Src-family tyrosine kinase Hck (Homo sapiens)
as a component of
Active FLT3:HCK [plasma membrane] (Homo sapiens)
Hck-1:Nef [cytosol] (Homo sapiens)
as a candidate of
FYN-like kinases [cytosol] (Homo sapiens)
as a member of
Src family kinases (SFKs) [cytosol] (Homo sapiens)
Other forms of this molecule
p-HCK [cytosol]
Inferred To
Hck [cytosol]
(Mus musculus)
Hck [cytosol]
(Rattus norvegicus)
Src64B [cytosol]
(Drosophila melanogaster)
hck [cytosol]
(Danio rerio)
HCK [cytosol]
(Bos taurus)
HCK [cytosol]
(Caenorhabditis elegans)
HCK [cytosol]
(Canis familiaris)
HCK [cytosol]
(Gallus gallus)
HCK [cytosol]
(Sus scrofa)
src-1 [cytosol]
(Caenorhabditis elegans)
Homologues of HCK [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001165600.1
,
NP_001165604.1
,
NP_001165602.1
,
NP_002101.2
,
NP_001165601.1
ZINC - World Drugs
HCK_HUMAN
OpenTargets
ENSG00000101336
ZINC - FDA approved
HCK_HUMAN
ZINC - Substances
HCK_HUMAN
ZINC - Biogenic
HCK_HUMAN
ZINC target
P08631
PRO
P08631
PDB
2HCK
,
1BU1
,
5H0G
,
3HCK
,
3VRZ
,
5H0E
,
3VS5
,
3VS0
,
1QCF
,
3RBB
,
3VS4
,
3NHN
,
3REB
,
2OI3
,
2C0T
,
5HCK
,
4U5W
,
5NUH
,
5H0B
,
3VRY
,
2OJ2
,
3VS3
,
2HK5
,
2C0O
,
3REA
,
4ORZ
,
4LUE
,
1AD5
,
5ZJ6
,
4HCK
,
5H09
,
3VS2
,
3VS7
,
5H0H
,
3VS6
,
2C0I
,
3VS1
,
4LUD
ZINC - Investigational
HCK_HUMAN
HPA
ENSG00000101336-HCK
GeneCards
P08631
Ensembl
ENST00000518730
,
ENSP00000486627
,
ENST00000629881
,
ENSP00000427757
,
ENST00000520553
,
ENSP00000429848
,
ENSG00000101336
ZINC - Predictions - Purchasable
HCK_HUMAN
HMDB Protein
HMDBP01256
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.78
4
UniProt:P27958 Genome polyprotein
1
POLG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HCV-8854138)
0.729
5
UniProt:P42768 WAS
2
p-Y291-WAS [cytosol]
(R-HSA-2197668)
WAS [cytosol]
(R-HSA-201879)
0.718
9
UniProt:Q13444 ADAM15
1
ADAM15 [plasma membrane]
(R-HSA-708329)
0.713
4
UniProt:Q8WUM4 PDCD6IP
1
PDCD6IP [cytosol]
(R-HSA-917717)
0.709
4
UniProt:Q07889 SOS1
3
SOS1 [plasma membrane]
(R-HSA-983559)
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [cytosol]
(R-HSA-64847)
0.692
4
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.653
3
UniProt:P03407 NEF
0.646
4
UniProt:Q9ULH1 ASAP1
1
ASAP1 [cytosol]
(R-HSA-5620905)
0.609
2
UniProt:O92972 POLG
0.589
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
3
IntAct:EBI-7149158 PD1
0.558
2
UniProt:O43184 ADAM12
1
ADAM12 [plasma membrane]
(R-HSA-179792)
0.558
2
UniProt:P04324 NEF
0.558
2
UniProt:Q9HD26 GOPC
3
GOPC [plasma membrane]
(R-HSA-5626572)
GOPC [lysosomal membrane]
(R-HSA-5627281)
GOPC [Golgi-associated vesicle membrane]
(R-HSA-5627067)
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
UniProt:Q7Z3S9 NT2NA
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:P03406 NEF
0.542
2
UniProt:P12504 VIF
0.524
3
IntAct:EBI-7355238 Q85737
0.524
3
UniProt:Q9QPN3 NEF
0.524
3
UniProt:Q90VU7 Q90VU7
0.524
2
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
0.524
2
UniProt:Q92556 ELMO1
1
ELMO1 [cytosol]
(R-HSA-200932)
0.524
4
UniProt:P59046 NAL12
0.508
4
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text