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PDGFRA D842V [plasma membrane]
Stable Identifier
R-HSA-9671549
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha platelet-derived growth factor receptor, PGDS_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by PDGFR in disease (Homo sapiens)
Drug resistance of PDGFR mutants (Homo sapiens)
Imatinib-resistant PDGFR mutants (Homo sapiens)
Imatinib-resistant PDGFR mutants don't bind imatinib (Homo sapiens)
imatinib-resistant PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
Regorafenib-resistant PDGFR mutants (Homo sapiens)
Regorafenib-resistant PDGFR mutants don't bind regorafenib (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
Sorafenib-resistant PDGFR mutants (Homo sapiens)
Sorafenib-resistant PDGFR mutants don't bind sorefenib (Homo sapiens)
sorafenib-resistant PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
Sunitinib-resistant PDGFR mutants (Homo sapiens)
D842V PDGFRA doesn't bind sunitinib (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
PDGFR mutants bind TKIs (Homo sapiens)
PDGFR mutants bind type I TKIs (Homo sapiens)
type I TKI sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
avapritinib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
crenolanib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
midostaurin-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
type I sensitive PDGFR mutants:type I TKIs [plasma membrane] (Homo sapiens)
type I TKI sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
avapritinib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
crenolanib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
midostaurin-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
PDGFR mutants bind type II TKIs (Homo sapiens)
type II TKI sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
ponatinib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
quizartinib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
regorafenib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
ripretinib sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
type II sensitive PDGFR mutants:type II TKIs [plasma membrane] (Homo sapiens)
type II TKI sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
ponatinib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
quizartinib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
regorafenib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
ripretinib sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants (Homo sapiens)
Autophosphorylation of PDGFR mutant dimers (Homo sapiens)
PDGFR mutant dimers [plasma membrane] (Homo sapiens)
kinase domain PDGFRA mutant dimers [plasma membrane] (Homo sapiens)
PDGFRA D842V dimer [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
Ligand-independent dimerization of PDGFR mutants (Homo sapiens)
PDGFR mutant dimers [plasma membrane] (Homo sapiens)
kinase domain PDGFRA mutant dimers [plasma membrane] (Homo sapiens)
PDGFRA D842V dimer [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
PDGFR mutant receptors [plasma membrane] (Homo sapiens)
kinase domain mutants of PDGFRA [plasma membrane] (Homo sapiens)
PDGFRA D842V [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16234 PDGFRA
Gene Names
PDGFRA, PDGFR2, RHEPDGFRA
Chain
signal peptide:1-23, chain:24-1089
Reference Genes
COSMIC (genes):PDGFRA PDGFRA
dbSNP Gene:5156 PDGFRA
ENSEMBL:ENSG00000134853 PDGFRA
Participates
as a candidate of
regorafenib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
quizartinib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
as a member of
ripretinib sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
ponatinib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
avapritinib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
midostaurin-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
crenolanib-sensitive PDGFR mutants [plasma membrane] (Homo sapiens)
imatinib-resistant PDGFR mutants [plasma membrane] (Homo sapiens)
sorafenib-resistant PDGFR mutants [plasma membrane] (Homo sapiens)
kinase domain mutants of PDGFRA [plasma membrane] (Homo sapiens)
as an input of
D842V PDGFRA doesn't bind sunitinib (Homo sapiens)
Regorafenib-resistant PDGFR mutants don't bind regorafenib (Homo sapiens)
as a component of
PDGFRA D842V dimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
PDGFRA L629P [plasma membrane]
PDGFRA N659K [plasma membrane]
PDGFRA T674I [plasma membrane]
PDGFRA S601P [plasma membrane]
PDGFRA Y288C [endoplasmic reticulum membrane]
PDGFRA Y375_K455del [endoplasmic reticulum membrane]
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]
PDGFRA D842_M844del [plasma membrane]
PDGFRA D842Y [plasma membrane]
PDGFRA I843_D846del [plasma membrane]
PDGFRA D842_H845del [plasma membrane]
PDGFRA D842del [plasma membrane]
PDGFRA D842_I843delinsV [plasma membrane]
PDGFRA D846Y [plasma membrane]
PDGFRA D843_845del [plasma membrane]
PDGFRA D842_D846del [plasma membrane]
PDGFRA N848K [plasma membrane]
PDGFRA Y849C [plasma membrane]
PDGFRA D843_844del [plasma membrane]
PDGFRA D846V [plasma membrane]
PDGFRA D842L [plasma membrane]
PDGFRA V561D [plasma membrane]
PDGFRA V561A [plasma membrane]
PDGFRA V536E [plasma membrane]
PDGFRA V536M [plasma membrane]
p-11Y PDGFRA D842V [plasma membrane]
p-11Y PDGFRA D846Y [plasma membrane]
p-11Y-PDGFRA [plasma membrane]
PDGFRA [plasma membrane]
p-11Y PDGFRA V561A [plasma membrane]
p-11Y PDGFRA V561D [plasma membrane]
p-11Y PDGFRA V536M [plasma membrane]
p-11Y PDGFRA V536E [plasma membrane]
p-11Y PDGFRA D846V [plasma membrane]
p-11Y PDGFRA D842L dimer [plasma membrane]
p-11Y PDGFRA N848K [plasma membrane]
p-11Y PDGFRA D843_845del [plasma membrane]
p-10Y PDGFRA Y849C [plasma membrane]
p-11Y PDGFRA D842_D846del [plasma membrane]
p-11Y PDGFRA D842_H845del [plasma membrane]
p-11Y PDGFRA D842Y [plasma membrane]
p-11Y PDGFRA D843_846del [plasma membrane]
p-11Y-PDGFRA D842_I843delinsV [plasma membrane]
p-11Y PDGFRA D843_844del [plasma membrane]
p-11Y PDGFRA D842del [plasma membrane]
Modified Residues
Name
L-aspartic acid 842 replaced with L-valine
Coordinate
842
PsiMod
L-valine residue [MOD:00029]
A protein modification that effectively converts a source amino acid residue to an L-valine.
L-aspartic acid removal [MOD:01634]
A protein modification that effectively removes or replaces an L-aspartic acid.
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
gastrointestinal stromal tumor
DOID:9253
GANT, GIST, Stromal tumor of gastrointestinal tract
Cross References
COSMIC
COSV57264120
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01127 PDGFB
8
PDGFB(82-241) [platelet alpha granule lumen]
(R-HSA-387075)
PDGFB(21-81) [platelet alpha granule lumen]
(R-HSA-184200)
PDGFB(191-241) [Golgi lumen]
(R-HSA-396945)
PDGFB(1-81) [Golgi lumen]
(R-HSA-389058)
PDGFB(1-241) [Golgi membrane]
(R-HSA-380740)
PDGFB(1-241) [endoplasmic reticulum lumen]
(R-HSA-381903)
PDGFB(82-241) [extracellular region]
(R-HSA-381904)
PDGFB (82-190) [extracellular region]
(R-HSA-184201)
0.733
11
UniProt:P09619 PDGFRB
3
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
0.706
5
UniProt:P04085 PDGFA
1
PDGFA [extracellular region]
(R-HSA-2426265)
0.691
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.683
4
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.671
4
UniProt:Q9NRA1 PDGFC
0.656
3
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.569
3
UniProt:Q8N6L0 KASH5
0.556
3
UniProt:P19174 PLCG1
6
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.544
3
UniProt:Q8WVM8 SCFD1
1
SCFD1 [cytosol]
(R-HSA-5688147)
0.483
2
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