Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
WASL [endocytic vesicle membrane]
Stable Identifier
R-HSA-535012
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endocytic vesicle membrane
Synonyms
N-WASP
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
NOSTRIN mediated eNOS trafficking (Homo sapiens)
NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Homo sapiens)
WASL [endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00401 WASL
Gene Names
WASL
Chain
initiator methionine:, chain:2-505
Reference Genes
BioGPS Gene:8976 WASL
COSMIC (genes):WASL WASL
CTD Gene:8976 WASL
dbSNP Gene:8976 WASL
ENSEMBL:ENSG00000106299 WASL
ENSEMBL_homo_sapiens_GENE:ENSG00000106299.8 WASL
HGNC:12735 WASL
KEGG Gene (Homo sapiens):8976 WASL
Monarch:8976 WASL
NCBI Gene:8976 WASL
OMIM:605056 WASL
UCSC:O00401 WASL
Reference Transcript
RefSeq:NM_003941.3 WASL
Other Identifiers
11717284_a_at
11717285_a_at
11754385_s_at
17062460
205809_PM_s_at
205809_s_at
205810_PM_s_at
205810_s_at
224813_PM_at
224813_at
3070714
3070715
3070716
3070717
3070721
3070722
3070727
3070728
3070729
3070730
3070731
3070732
3070735
3070736
3070737
3070750
3070751
3070752
3070753
3070754
3070755
3070756
321_at
39875_at
44736_at
8142671
8976
A_33_P3405444
D88460_at
GE57430
GO:0002376
GO:0003779
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0005856
GO:0005886
GO:0006351
GO:0006355
GO:0006900
GO:0007010
GO:0007015
GO:0007049
GO:0008017
GO:0008092
GO:0008154
GO:0009617
GO:0015629
GO:0016050
GO:0016192
GO:0030027
GO:0030036
GO:0030041
GO:0030050
GO:0030154
GO:0030478
GO:0030666
GO:0030695
GO:0031410
GO:0031503
GO:0032880
GO:0034330
GO:0043226
GO:0045944
GO:0048856
GO:0048870
GO:0051301
GO:0051491
GO:0051653
GO:0060997
GO:0061024
GO:0065003
GO:0070062
GO:0098772
GO:0098978
GO:0099175
GO:1903526
GO:2000370
GO:2000402
HMNXSV003030896
Hs.170065.0.S1_3p_at
Hs.288830.0.A1_3p_a_at
ILMN_1666004
TC07001823.hg
g4505322_3p_a_at
Participates
as a component of
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
N-WASP [cytosol]
p-Y256-WASL [cytosol]
WASL [plasma membrane]
Inferred To
wasla [endocytic vesicle membrane]
(Danio rerio)
Ghost homologue of WASL [endocytic vesicle membrane]
(Mus musculus)
Ghost homologue of WASL [endocytic vesicle membrane]
(Rattus norvegicus)
WASL [endocytic vesicle membrane]
(Bos taurus)
WASL [endocytic vesicle membrane]
(Canis familiaris)
WASL [endocytic vesicle membrane]
(Gallus gallus)
WASL [endocytic vesicle membrane]
(Sus scrofa)
Cross References
RefSeq
NP_003932.3
OpenTargets
ENSG00000106299
HPA
ENSG00000106299-WASL
GeneCards
O00401
Ensembl
ENSG00000106299
,
ENSP00000223023
,
ENST00000223023
PRO
O00401
Pharos - Targets
O00401
PDB
4CC2
,
2LNH
,
2FF3
,
4CC7
,
2VCP
Interactors (44)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.935
12
UniProt:O43516 WIPF1
1
WIPF1 [cytosol]
(R-HSA-201874)
0.92
10
UniProt:Q8TF74 WIPF2
1
WIPF2 [cytosol]
(R-HSA-2197666)
0.847
8
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.832
9
UniProt:O76064 RNF8
1
RNF8 [nucleoplasm]
(R-HSA-5682539)
0.83
8
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.75
4
UniProt:A6NGB9 WIPF3
1
WIPF3 [cytosol]
(R-HSA-2197670)
0.738
4
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.718
6
UniProt:Q9H4E5 RHOJ
1
RHOJ [plasma membrane]
(R-HSA-3006725)
0.718
6
UniProt:O15145 ARPC3
1
ARPC3 [cytosol]
(R-HSA-200812)
0.718
6
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.704
5
UniProt:P61157 ACTR3
1
ARP3 [cytosol]
(R-BTA-419940)
0.702
3
UniProt:Q8X482 ESPFU
0.691
5
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.669
4
UniProt:Q99828 CIB1
0.633
7
UniProt:P0DJ88 ESFU2
0.623
2
UniProt:O96013 PAK4
1
PAK4 [cytosol]
(R-HSA-428461)
0.619
8
UniProt:O15143 ARPC1B
1
ARPC1B [cytosol]
(R-HSA-6787770)
0.609
2
UniProt:P68135 ACTS
0.609
2
UniProt:O60504-2 SORBS3
0.589
3
UniProt:Q6XZF7-1 DNMBP
0.558
2
UniProt:P59998 ARPC4
1
ARPC4 [cytosol]
(R-HSA-200813)
0.556
3
UniProt:O94875-10 SORBS2
0.556
3
UniProt:Q15642-2 TRIP10
0.556
5
UniProt:P57075-2 UBASH3A
0.556
3
UniProt:Q8IWW6-4 ARHGAP12
0.556
3
IntAct:EBI-22315148 CCSB ORF ID
0.556
3
UniProt:E7ERP6 E7ERP6
0.556
3
UniProt:Q9UNF0 PACSIN2
1
PACSIN2 [cytosol]
(R-HSA-8868267)
0.556
3
IntAct:EBI-22313194 CCSB ORF ID
0.556
3
IntAct:EBI-16429374 CCSB ISOFORM ID
0.556
3
UniProt:Q8TF42 UBS3B
0.556
3
UniProt:A0A0S2Z4D7 A0A0S2Z4D7
0.556
3
UniProt:Q9NYB9-2 ABI2
0.556
5
UniProt:Q9UKS6 PACSIN3
1
PACSIN3 [cytosol]
(R-HSA-8868270)
0.556
3
UniProt:Q13882 PTK6
5
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.547
2
UniProt:Q9ESJ4
1
Nckipsd [cytosol]
(R-MMU-2197671)
0.544
2
UniProt:P06276 BCHE
2
BCHE [extracellular region]
(R-HSA-434469)
BCHE [plasma membrane]
(R-HSA-3640835)
0.527
2
UniProt:Q96DT6 ATG4C
1
ATG4C [cytosol]
(R-HSA-5671863)
0.527
2
UniProt:Q8R511
1
Fnbp1 [cytosol]
(R-RNO-8862261)
0.524
2
UniProt:Q9Y5X1 SNX9
3
SNX9 [cytosol]
(R-HSA-8867737)
SNX9 [Golgi membrane]
(R-HSA-432988)
SNX9 [cytoplasmic vesicle membrane]
(R-HSA-432990)
0.524
2
UniProt:P16333-1 NCK1
0.499
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text