Reactome | PIM1 [cytosol]

PIM1 [cytosol]

Stable Identifier

R-HSA-9954209

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Antimicrobial mechanism of IFN-stimulated genes (Homo sapiens)
      - GBP-mediated host defense (Homo sapiens)
        
        Regulation of GBP-mediated host defense (Homo sapiens)
        
        PIM1 phosphorylates GBP1 (Homo sapiens)
        
        PIM1 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
15657054	Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002 Jacobs, MD, Black, J, Futer, O, Swenson, L, Hare, B, Fleming, M, Saxena, K	J Biol Chem	2005

External Reference Information

External Reference

UniProt:P11309 PIM1

Gene Names

PIM1

Chain

chain:1-313

Reference Genes

COSMIC - genes:PIM1 PIM1

ENSEMBL:ENSG00000137193 PIM1

HGNC:8986 PIM1

UCSC:P11309 PIM1

Other forms of this molecule

PIM1 [nucleoplasm]

Inferred To

LOC119881670 [cytosol] (Canis familiaris)

PIM1 [cytosol] (Bos taurus)

PIM1 [cytosol] (Danio rerio)

PIM1 [cytosol] (Gallus gallus)

PIM1 [cytosol] (Rattus norvegicus)

PIM1 [cytosol] (Sus scrofa)

Cross References

ZINC - World Drugs

PIM1_HUMAN

Guide to Pharmacology - Targets

2158

ENSEMBL

ENSP00000362608, ENSG00000137193, ENST00000373509

OpenTargets

ENSG00000137193

ZINC - FDA approved

PIM1_HUMAN

ZINC - Substances

PIM1_HUMAN

ZINC - Biogenic

PIM1_HUMAN

ZINC target

P11309

PRO

P11309

GlyGen

P11309

ZINC - Investigational

PIM1_HUMAN

ZINC - Metabolites

PIM1_HUMAN

HPA

ENSG00000137193-PIM1

Pharos - Targets

P11309

ZINC - Predictions - Purchasable

PIM1_HUMAN

HMDB Protein

HMDBP01271

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.643	4
UniProt:P39019 RPS19	2	RPS19 [cytosol] (R-HSA-72343) RPS19 [nucleoplasm] (R-HSA-6798710)	0.633	7
UniProt:Q8N7W2-2 BEND7			0.556	3
UniProt:Q96MH2 HEXI2			0.556	3
UniProt:Q5T203 Q5T203			0.556	3
UniProt:P51116 FXR2			0.556	3
UniProt:P0C1Z6-2 TFPT			0.556	3
UniProt:Q9Y2K1 ZBTB1			0.556	3
UniProt:P07954 FH	1	FH [mitochondrial matrix] (R-HSA-70980)	0.556	3
UniProt:Q8N9N5 BANP	2	BANP [cytosol] (R-HSA-9934681) BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.553	2
UniProt:Q8IZD4 DCP1B	1	DCP1B [cytosol] (R-HSA-429834)	0.527	2
UniProt:P27448 MARK3	1	MARK3 [cytosol] (R-HSA-5672591)	0.527	2
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.527	3

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