Reactome | fully glycosylated Spike [virion membrane]

fully glycosylated Spike [virion membrane]

Stable Identifier

R-COV-9698327

Type

Protein [EntityWithAccessionedSequence]

Species

Severe acute respiratory syndrome coronavirus 2

Compartment

virion membrane

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - SARS-CoV Infections (Homo sapiens)
    - SARS-CoV-2 Infection (Homo sapiens)
      - Attachment and Entry (Homo sapiens)
        
        Cleavage of S protein into S1:S2 (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [endocytic vesicle lumen] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M lattice:E protein [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike trimer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M lattice:E protein [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike trimer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Endocytosis of SARS-CoV-2 Virion (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M lattice:E protein [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike trimer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [endocytic vesicle lumen] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M lattice:E protein [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike trimer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M lattice:E protein [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike trimer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M lattice:E protein [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike trimer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M lattice:E protein [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike trimer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M lattice:E protein [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike trimer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
      - Virion Assembly and Release (Homo sapiens)
        
        SARS virus buds into ERGIC lumen (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M lattice:E protein [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike trimer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Viral release (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M lattice:E protein [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike trimer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        fully glycosylated Spike [virion membrane] (Severe acute respiratory syndrome coronavirus 2)

Literature References

PubMed ID	Title	Journal	Year
32366695	Site-specific glycan analysis of the SARS-CoV-2 spike Watanabe, Y, Allen, JD, Wrapp, D, McLellan, JS, Crispin, M	Science	2020

External Reference Information

External Reference

UniProt:P0DTC2 S

Gene Names

S, 2

Chain

signal peptide:1-12, chain:13-1273, chain:13-685, chain:686-1273, chain:816-1273

Reference Genes

BioGPS Gene:43740568 S

Monarch:43740568 S

NCBI Gene:43740568 S

Reference Transcript

RefSeq:NC_045512.2 S

Participant Of

hasComponent

fully glycosylated Spike trimer [virion membrane]

Other forms of this molecule

fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]

tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]

di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]

high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]

nascent Spike [endoplasmic reticulum lumen]

14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]

Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]

high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]

high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]

high-mannose N-glycan-PALM-Spike [endoplasmic reticulum lumen]

complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]

complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]

complex N-glycan-PALM-Spike S1 Fragment [virion membrane]

complex N-glycan-PALM-Spike S2 Fragment [virion membrane]

fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1074

Coordinate

1074

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 122

Coordinate

122

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 603

Coordinate

603

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 61

Coordinate

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 709

Coordinate

709

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 717

Coordinate

717

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 801

Coordinate

801

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (Man(9) N-glycan group) at 234

Coordinate

234

Modification

Man(9) N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

palmitoylated-L-cysteine at unknown position

PsiMod Name

palmitoylated-L-cysteine

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1098

Coordinate

1098

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1134

Coordinate

1134

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1173

Coordinate

1173

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 149

Coordinate

149

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 165

Coordinate

165

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 17

Coordinate

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 282

Coordinate

282

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 331

Coordinate

331

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 343

Coordinate

343

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 616

Coordinate

616

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 657

Coordinate

657

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 74

Coordinate

Modification

tri-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1158

Coordinate

1158

Modification

sialylated complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1194

Coordinate

1194

Modification

sialylated complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Disease

Name	Identifier	Synonyms
COVID-19	0080600	2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection

Cross References

RefSeq

YP_009724390.1

PDB

6VSB, 6ZP1, 7BZ5, 6ZER, 6ZOX, 6X2A, 7C2L, 6ZOZ, 6X2C, 6XS6, 6XC2, 6M17, 7C8V, 6W41, 6ZGG, 6XEY, 6WPT, 6VYB, 6ZFO, 6XKL, 6YZ7, 7C01, 6XR8, 6XCN, 6M1V, 6LZG, 6XC3, 6XC7, 6LVN, 6X6P, 6LXT, 7BYR, 6YLA, 6ZP2, 6X29, 6ZOY, 6XDG, 7C8W, 6X2B, 6ZCZ, 6YOR, 6VXX, 6ZGE, 6WPS, 6XRA, 6ZP0, 6M0J, 7BWJ, 6ZGI, 6YZ5, 6Z2M, 6VW1, 6XCM, 6XE1, 6XC4, 6Z43, 6YM0, 6ZDH, 7CAN

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BYF1 ACE2	5	ACE2 [endocytic vesicle membrane] (R-HSA-9698958) ACE2(18-805) [plasma membrane] (R-HSA-2022344) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474)	0.991	84
UniProt:P0DTC2 S	16	tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum lumen] (R-COV-9696917) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327)	0.937	13
UniProt:P09958 FURIN	4	FURIN [Golgi lumen] (R-HSA-448351) FURIN [plasma membrane] (R-HSA-2159856) FURIN [extracellular region] (R-HSA-1181103) FURIN [Golgi membrane] (R-HSA-157049)	0.801	4
UniProt:Q9H2X3 CLC4M			0.71	5
UniProt:Q9NNX6 CD209	1	CD209 [plasma membrane] (R-HSA-2079928)	0.683	4
UniProt:Q7Z5G4 GOLGA7	3	GOLGA7 [tertiary granule lumen] (R-HSA-6800164) GOLGA7 [extracellular region] (R-HSA-6800449) GOLGA7 [Golgi membrane] (R-HSA-9647777)	0.643	3
UniProt:Q9C0B5 ZDHC5			0.643	3
UniProt:P35613 BSG	2	BSG [Golgi membrane] (R-HSA-204478) BSG [plasma membrane] (R-HSA-197673)	0.618	5
UniProt:Q8IUN9-2 CLEC10A			0.558	3
UniProt:Q61830 Mrc1	4	Mrc1 [plasma membrane] (R-MMU-1216515) Mrc1 [plasma membrane] (R-MMU-1236776) Mrc1 [clathrin-coated endocytic vesicle membrane] (R-MMU-1236818) Mrc1 [early endosome membrane] (R-MMU-1236785)	0.558	2
lipopolysaccharide [ChEBI:16412]	5	LPS [cell wall] (R-ALL-6803081) LPS [endocytic vesicle lumen] (R-ALL-2239413) LPS [endosome lumen] (R-ALL-2201311) LPS [plasma membrane] (R-ALL-433850) LPS [extracellular region] (R-ALL-166005)	0.558	3
cholesterol [ChEBI:16113]	20	CHOL [lipid droplet] (R-ALL-163586) cholesterol [endocytic vesicle lumen] (R-ALL-2239405) CHOL [lysosomal membrane] (R-ALL-8876478) cholesterol [endosome lumen] (R-ALL-171083) cholesterol [endosome membrane] (R-ALL-171135) cholesterol [clathrin-coated endocytic vesicle membrane] (R-ALL-171069) CHOL [smooth endoplasmic reticulum] (R-ALL-8866305) CHOL [lysosomal lumen] (R-ALL-8848047) CHOL [mitochondrial matrix] (R-ALL-193840) CHOL [transport vesicle membrane] (R-ALL-216762) CHOL [early endosome] (R-ALL-2429660) CHOL [endoplasmic reticulum lumen] (R-ALL-174672) CHOL [cornified envelope] (R-ALL-8847704) CHOL [mitochondrial outer membrane] (R-ALL-8951853) CHOL [cytosol] (R-ALL-176478) cholesterol [mitochondrial intermembrane space] (R-ALL-196084) CHOL [mitochondrial inner membrane] (R-ALL-193156) CHOL [plasma membrane] (R-ALL-171095) CHOL [endoplasmic reticulum membrane] (R-ALL-193384) CHOL [extracellular region] (R-ALL-171149)	0.558	3
UniProt:Q96D42 HAVR1			0.524	5
linoleic acid [ChEBI:17351]	6	LINA [cytosol] (R-ALL-1132021) LINA [endoplasmic reticulum lumen] (R-ALL-2046044) LINA [extracellular region] (R-ALL-879520) LINA [early endosome] (R-ALL-879655) LINA [lipid droplet] (R-ALL-2864095) LINA [nucleoplasm] (R-ALL-400158)	0.522	2

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