fully glycosylated Spike [virion membrane]

Stable Identifier
R-COV-9698327
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
virion membrane
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
32366695 Site-specific glycan analysis of the SARS-CoV-2 spike

Watanabe, Y, Crispin, M, Allen, JD, McLellan, JS, Wrapp, D

Science 2020
External Reference Information
External Reference
UniProt:P0DTC2 S
Gene Names
S, 2
Chain
signal peptide:1-12, chain:13-1273, chain:13-685, chain:686-1273, chain:816-1273
Reference Genes
BioGPS Gene:43740568 S
KEGG Gene (Hepatitis C Virus):43740568 S
Monarch:43740568 S
NCBI Gene:43740568 S
Reference Transcript
Participates
as a component of
Other forms of this molecule
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
nascent Spike [endoplasmic reticulum lumen]
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
Modified Residues
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1074
Coordinate
1074
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 122
Coordinate
122
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 603
Coordinate
603
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 61
Coordinate
61
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 709
Coordinate
709
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 717
Coordinate
717
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 801
Coordinate
801
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (Man(9) N-glycan group) at 234
Coordinate
234
Modification
Man(9) N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
palmitoylated-L-cysteine at unknown position
PsiMod Name
palmitoylated-L-cysteine
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1098
Coordinate
1098
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1134
Coordinate
1134
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1173
Coordinate
1173
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 149
Coordinate
149
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 165
Coordinate
165
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 17
Coordinate
17
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 282
Coordinate
282
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 331
Coordinate
331
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 343
Coordinate
343
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 616
Coordinate
616
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 657
Coordinate
657
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 74
Coordinate
74
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1158
Coordinate
1158
Modification
sialylated complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1194
Coordinate
1194
Modification
sialylated complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
RefSeq
GlyGen
PDB
7FDI, 7DX5, 7E86, 6YLA, 7OAO, 6ZXN, 7KNI, 7CAB, 6VW1, 7V7N, 7L7K, 7D4G, 7KQB, 7L02, 7KML, 7M7B, 6M0J, 7BEM, 7MZG, 7MJN, 7LS9, 7LAB, 7V7J, 7K8X, 7CWN, 7KDK, 6YZ7, 7E23, 7DD8, 7KFV, 7V89, 7N1U, 7CHC, 6XEY, 7R6W, 7LC8, 7JVB, 7NXC, 7V80, 7LXZ, 7V78, 7DDD, 7CZR, 6YM0, 7EB5, 7LCN, 7NDA, 7MKB, 7M7W, 6VXX, 7FDK, 6ZGG, 7E88, 7N8I, 7MZH, 7KL9, 6ZP5, 7L06, 7E39, 7K8Y, 6WPT, 7LYP, 7DK3, 7LWS, 7C8V, 7N1V, 6XF5, 6XE1, 7V7Z, 7JMW, 7M71, 7MJJ, 7KDJ, 7L7F, 7KKK, 7ND8, 7E7Y, 7CZP, 7LRS, 7MZF, 6VSB, 7C8D, 7MJM, 7CHB, 7CZZ, 7LAA, 7D2Z, 7V7I, 7K8W, 6ZP1, 6WPS, 7JV4, 7C53, 7N1T, 7DD2, 7B3O, 7V87, 7B62, 7JVA, 7A98, 7FDH, 7NXB, 7DX4, 7LXY, 7KEC, 7KNH, 7OAN, 7V77, 7LWQ, 7A5S, 7DK0, 7D30, 7N6E, 7KKL, 7ND9, 6ZGE, 7EB4, 7N8H, 7CZQ, 6ZP2, 7BEL, 7LRT, 6ZWV, 7KMK, 7C8J, 7CWM, 7LYO, 7JV6, 7MJK, 6ZFO, 7CN9, 7V88, 7A91, 6YZ5, 7K4N, 7K8M, 6XC2, 7M53, 7NDC, 7DWX, 7KFY, 7JW0, 7K90, 7FG3, 7NT9, 7CZT, 6M1V, 7DX8, 7L2D, 7LWK, 7V7P, 6ZB4, 7KE4, 7EDG, 7N1X, 7CWS, 7S0C, 7DK5, 7BWJ, 6VYB, 7KMZ, 7N9B, 7KLH, 7LDJ, 7E3J, 7KRR, 7OAQ, 7R8L, 7L4Z, 7V7A, 7KLW, 7BNN, 7LY2, 7EAM, 6ZLR, 7MKM, 7V82, 7M8K, 7FG7, 7S0D, 7CAI, 7L2E, 7M6D, 7V7Q, 7LWL, 6ZH9, 7N0H, 7DK6, 7BYR, 7CZU, 7E8C, 6ZOW, 7V8B, 7MZJ, 7CHH, 7BH9, 7A92, 7OAU, 7E3K, 7KN3, 7MDW, 6XKQ, 7DEO, 7L56, 7LWU, 7V7D, 6X2A, 7LQ7, 7BEP, 7ORB, 7JWB, 7LSS, 7V79, 7OAP, 7OR9, 7F63, 7CAC, 7OLZ, 7V7O, 7LYQ, 7R7N, 7LWI, 7FG2, 7LD1, 7DX6, 7JVC, 6XKL, 7E3B, 7CWO, 7BEN, 7EDF, 7KQE, 7DK4, 6M17, 7KDL, 7KFW, 7F62, 6YOR, 7KLG, 6ZP7, 7R6X, 7LJR, 7KMS, 7K43, 7CHE, 7BNM, 7V81, 7LY0, 7L0N, 7NDB, 7MKL, 7CAH, 7C8W, 7M8J, 7KFX, 6ZGI, 7L3N, 7LOP, 7L2C, 7CZS, 7LWJ, 7DX7, 7DDN, 7V8A, 6XKP, 7K8Z, 7M42, 7MZI, 7L09, 7S0B, 7N9A, 7KRQ, 7LWT, 6X29, 7MJL, 7LO4, 7K45, 7BEO, 7LM8, 7E3C, 6XF6, 7CHF, 7N1W, 7N0G, 7ORA, 7JJC, 7RTD, 7LWN, 7A94, 7E5R, 7V84, 7RNJ, 7CHP, 7MZL, 7RKV, 7JZL, 7KJ2, 7MF1, 7KMB, 7K8T, 7V7S, 7KDG, 7NTC, 7M6F, 7L2F, 7LYK, 7ND4, 7E8M, 7V7F, 7MEJ, 7NX6, 7KSG, 7MM0, 7KN5, 7P78, 7N9E, 7M8T, 7DZX, 7LWW, 7D03, 7L57, 6ZBP, 7CWU, 7AKD, 7N1E, 7LQV, 7M6G, 6XC7, 7KZB, 7D0B, 7DX0, 7MMO, 7EJ4, 7KN6, 7JZM, 6X79, 7KJ3, 7EH5, 7N4J, 7CAN, 7M0J, 7EAZ, 7NX7, 7MZM, 7RAL, 6XM3, 7B14, 6ZOY, 7RR0, 7BEH, 7N9T, 6ZCZ, 7CYH, 7CZW, 7NEH, 7KXK, 7DEU, 7K9J, 7DZY, 7EY4, 6LXT, 7KE8, 7EDJ, 7RA8, 6LVN, 7MTD, 7R8O, 7L58, 7LWM, 7NDD, 7KM5, 7DWY, 7JWY, 7DMU, 6Z97, 7P77, 7E3O, 7CHO, 6XC3, 7RKU, 6ZB5, 7DPM, 7MZK, 7MLZ, 7S0E, 7N1A, 7M6E, 7K8S, 7BNO, 7V7R, 7DX9, 7S4S, 7KGJ, 6XLU, 7NTA, 7BZ5, 7N1Y, 7ND3, 7V8C, 7R8M, 7E3L, 6Z2M, 7K9H, 7KRS, 7OAY, 7D00, 7CWT, 7M8S, 7LWV, 7EDH, 7N9C, 7KE6, 6XC4, 7DWZ, 6X2C, 7LY3, 7EAN, 7JX3, 6X6P, 7V83, 7E5O, 7KXJ, 7N4I, 7NKT, 6XM0, 7KGK, 7CAK, 7N1B, 7DK7, 6ZOX, 7EY0, 7CZV, 6Z43, 7E8F, 7NEG, 7DET, 7R8N, 7K9I, 7KN4, 7ME7, 7A93, 7N3I, 6X2B, 7MTC, 7DZW, 7V7E, 7P3D, 7KE7, 7EDI, 6ZHD, 7KS9, 7LXW, 7M6I, 7LWO, 6XDG, 7MJI, 7DX2, 7FDG, 7DF4, 7A96, 7NX9, 7K8V, 7A29, 7AD1, 7A5R, 7CZY, 6XCN, 7V26, 7V7H, 7JZU, 7LYM, 7KMH, 6ZP0, 7MY3, 7BEJ, 7N1Q, 7CYV, 7V86, 7JMO, 7CJF, 7JV2, 7A4N, 6ZDH, 7A97, 7V76, 7V7V, 7E7X, 7LXX, 7KNE, 7DX3, 7LQW, 7D0D, 7LWP, 7KEB, 7C01, 7V2A, 7KDI, 6ZER, 7B18, 7N6D, 7MY8, 7EB3, 7NXA, 7CT5, 7P7B, 7N64, 7CN4, 7KMI, 7DHX, 7DJZ, 7CH5, 7ND7, 7LYN, 7CWL, 7KJ5, 7BEK, 7L7E, 7JMP, 7EZV, 7E7D, 7C2L, 7DCX, 7M6H, 7E5Y, 7V7T, 7MJG, 7CHS, 6XRA, 7A95, 7K9K, 7DX1, 7KN7, 7K8U, 7NX8, 7JJI, 6XM4, 7LYL, 7V7G, 6ZOZ, 6ZDG, 6W41, 7BEI, 6XCM, 7ND5, 7KMG, 7JZN, 6XR8, 7P79, 7DF3, 6LZG, 7RTR, 7MFU, 7M3I, 7KE9, 7CDI, 7EY5, 7M8U, 7CM4, 7D0C, 7EB0, 7V7U, 7RXD, 7N1F, 7EYA, 7RW2, 7MJH, 7EK6, 7KEA, 6XM5, 7A25, 7B17, 7KDH, 7CH4, 7JJJ, 7MZN, 7K9Z, 7KNB, 6XS6, 7CZX, 7MTE, 7R95, 7MY2, 7DCC, 7L5B, 7L7D, 7EJ5, 7KJ4, 7ND6, 7V85, 7E7B, 7CYP, 7N62, 7P7A, 7LX5, 7CDJ
Interactors (58)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9BYF1 ACE2  5 0.997 224
 UniProt:P0DTC2 S  16 0.985 54
 UniProt:Q9NNX6 CD209  1 0.888 12
 UniProt:Q9H2X3 CLC4M      0.857 12
 UniProt:P09958 FURIN  4 0.854 5
 UniProt:P11021 HSPA5  6 0.746 8
 UniProt:Q9C0B5 ZDHHC5  1 0.725 5
 UniProt:Q7Z5G4 GOLGA7  3 0.725 5
 UniProt:Q8R0I0  1 0.688 4
 UniProt:Q8IUN9-2 CLEC10A      0.683 4
 UniProt:P35247-PRO_0000017465 SFTPD      0.683 11
 UniProt:Q96D42 HAVR1      0.667 7
 UniProt:Q96L92 SNX27      0.664 16
 UniProt:P30530 AXL  2 0.655 9
 UniProt:P35613 BSG  2 0.652 7
 IntAct:EBI-26657218 PEPTIDE      0.645 7
 ChEBI:17033 BILIVERDIN      0.642 9
 UniProt:Q58DD0 ACE2      0.641 3
 UniProt:O14786 NRP1  1 0.639 9
 maltose [ChEBI:17306]  2 0.623 3
 UniProt:Q8IUN9 CLEC10A  1 0.623 4
 ChEBI:28304 HEPARIN      0.623 5
 UniProt:Q96LC7 SIGLEC10  1 0.623 2
 UniProt:P07711 CTSL  8 0.623 3
 UniProt:P59665-PRO_0000006773 DEFA1      0.618 3
 UniProt:A5CKE2 A5CKE2      0.618 3
 UniProt:P31431 SDC4  20 0.599 17
 hemin [ChEBI:50385]  1 0.59 2
 UniProt:P14635 CCNB1  4 0.59 2
 IntAct:EBI-27090397 RC-101      0.558 2
 cholesterol [ChEBI:16113]  20 0.558 5
 N-acetylneuraminic acid [ChEBI:17012]  4 0.558 2
 UniProt:Q07021-PRO_0000018590 C1QBP      0.558 2
 UniProt:Q61830 Mrc1  4 0.558 2
 lipopolysaccharide [ChEBI:16412]  5 0.558 3
 UniProt:P35247 SFTPD  3 0.544 3
 UniProt:P01130 LDLR  4 0.537 4
 UniProt:P00533 EGFR  20 0.537 4
 IntAct:EBI-26657222 PEPTIDE      0.525 2
 IntAct:EBI-26657225 PEPTIDE      0.525 2
 IntAct:EBI-26997889 ACE2      0.524 2
 UniProt:A0A1S3APE5 A0A1S3APE5      0.524 2
 UniProt:Q5EGZ1  1 0.524 2
 UniProt:E2DHI3 E2DHI3      0.524 2
 UniProt:Q14416 GRM2  1 0.524 4
 linoleic acid [ChEBI:17351]  6 0.522 2
 UniProt:P35579 MYH9  3 0.518 7
 UniProt:P35606 COPB2  4 0.499 3
 UniProt:Q5EA32  1 0.499 3
 UniProt:Q9Y5S1 TRPV2  1 0.499 2
 UniProt:Q5MNZ6 WDR45B  1 0.499 4
 UniProt:Q15436 SEC23A  4 0.499 20
 UniProt:Q15005 SPCS2  1 0.499 2
 UniProt:P26038 MSN  4 0.499 20
 UniProt:P0DTD1-PRO_0000449625 REP      0.488 2
 UniProt:P0DTD1-PRO_0000449627 REP      0.488 2
 UniProt:P0DTD1-PRO_0000449628 REP      0.488 2
 UniProt:P15311 EZR  3 0.483 10
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