Reactome | LRP1 [endocytic vesicle membrane]

LRP1 [endocytic vesicle membrane]

Stable Identifier

R-HSA-2230981

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle membrane

Synonyms

Prolow-density lipoprotein receptor-related protein 1, LRP1_HUMAN

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External Reference Information

External Reference

UniProt:Q07954 LRP1

Gene Names

LRP1, A2MR, APR

Chain

signal peptide:1-19, chain:20-4544, chain:20-3943, chain:3944-4544, chain:4441-4544

Reference Genes

BioGPS Gene:4035 LRP1

COSMIC (genes):LRP1 LRP1

CTD Gene:4035 LRP1

dbSNP Gene:4035 LRP1

ENSEMBL:ENSG00000123384 LRP1

ENSEMBL_homo_sapiens_GENE:ENSG00000123384.14 LRP1

HGNC:6692 LRP1

KEGG Gene (Homo sapiens):4035 LRP1

Monarch:4035 LRP1

NCBI Gene:4035 LRP1

OMIM:107770 LRP1

UCSC:Q07954 LRP1

Reference Transcript

RefSeq:NM_002332.2 LRP1

Other Identifiers

11715533_a_at

11715534_a_at

11760039_a_at

1555353_PM_at

1555353_at

16752715

200784_PM_s_at

200784_s_at

200785_PM_s_at

200785_s_at

3417843

3417844

3417849

3417850

3417852

3417853

3417854

3417855

3417857

3417858

3417859

3417860

3417862

3417863

3417866

3417867

3417868

3417869

3417870

3417871

3417872

3417877

3417878

3417881

3417882

3417884

3417886

3417887

3417888

3417889

3417891

3417892

3417894

3417896

3417897

3417898

3417900

3417901

3417902

3417903

3417905

3417909

3417910

3417911

3417912

3417915

3417916

3417917

3417918

3417920

3417921

3417922

3417923

3417924

3417925

3417927

3417928

3417929

3417931

3417932

3417933

3417935

3417936

3417937

3417938

3417939

3417940

3417941

3417942

3417943

3417944

3417945

3417946

3417947

3417948

3417949

3417950

3417951

3417952

3417955

3417956

3417959

3417960

3417962

3417963

3417964

3417965

3417967

3417968

3417970

3417972

3417973

3417974

3417975

3417977

3417978

3417979

3417981

3417982

3417983

3417984

3417985

3417986

3417987

38775_at

4035

7956301

A_14_P111898

A_23_P124837

A_33_P3391105

GE59712

GO:0001523

GO:0001540

GO:0002265

GO:0002376

GO:0003013

GO:0003723

GO:0005041

GO:0005044

GO:0005509

GO:0005515

GO:0005634

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005794

GO:0005815

GO:0005856

GO:0005886

GO:0005905

GO:0005925

GO:0006629

GO:0006897

GO:0006898

GO:0006909

GO:0006954

GO:0007010

GO:0007041

GO:0007167

GO:0010629

GO:0010715

GO:0010875

GO:0014912

GO:0016020

GO:0016192

GO:0016323

GO:0016964

GO:0023052

GO:0030154

GO:0030163

GO:0030178

GO:0030198

GO:0030226

GO:0030666

GO:0031410

GO:0031623

GO:0032050

GO:0032092

GO:0032370

GO:0032374

GO:0032429

GO:0032956

GO:0034185

GO:0035909

GO:0038023

GO:0038024

GO:0042953

GO:0043226

GO:0043235

GO:0043277

GO:0043395

GO:0044877

GO:0045056

GO:0045807

GO:0046872

GO:0048856

GO:0048870

GO:0060089

GO:0060392

GO:0070325

GO:0072659

GO:0097242

GO:0098797

GO:0150093

GO:0150094

GO:0150104

GO:1900223

GO:1903078

GO:1904300

GO:1904646

GO:1905049

GO:1905167

GO:2000587

HMNXSV003000066

Hs.89137.0.A1_3p_a_at

Hs2Affx.1.232.S1_3p_s_at

ILMN_1669772

PH_hs_0022761

TC12000521.hg

TC12002395.hg

TC12002396.hg

X13916_at

g4758685_3p_s_at

Participates

as a component of

LRP1:Hemopexin:heme [endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

LRP1 [plasma membrane]

Inferred To

LRP1 [endocytic vesicle membrane] (Bos taurus)

LRP1 [endocytic vesicle membrane] (Mus musculus)

LRP1 [endocytic vesicle membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_002323.2

OpenTargets

ENSG00000123384

HPA

ENSG00000123384-LRP1

GeneCards

Q07954

Ensembl

ENSP00000243077, ENSP00000341264, ENST00000338962, ENSG00000123384, ENST00000243077

PRO

Q07954

Pharos - Targets

Q07954

Orphanet

23577

HMDB Protein

HMDBP07785

PDB

1J8E, 2KNY, 2FYL, 1CR8, 2KNX, 2FYJ, 1D2L

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30533 AMRP			0.806	5
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE-4 [extracellular region] (R-HSA-9711070) APOE [endocytic vesicle lumen] (R-HSA-3221641) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908) APOE [extracellular region] (R-HSA-174646)	0.784	23
UniProt:O00213 APBB1	1	APBB1 [nucleoplasm] (R-HSA-5683987)	0.704	4
calcium(2+) [ChEBI:29108]	20	Ca2+ [platelet dense granule lumen] (R-ALL-114582) Ca2+ [endosome membrane] (R-ALL-5210949) Ca2+ [sarcoplasmic reticulum lumen] (R-ALL-2855229) Ca2+ [mitochondrial intermembrane space] (R-ALL-8949232) Ca2+ [lysosomal lumen] (R-ALL-1606834) Ca2+ [endocytic vesicle lumen] (R-ALL-8851519) Ca2+ [endoplasmic reticulum-Golgi intermediate compartment] (R-ALL-9706979) Ca2+ [Golgi lumen] (R-ALL-167012) Ca2+ [platelet dense tubular network lumen] (R-ALL-139827) Ca2+ [platelet dense tubular network membrane] (R-ALL-141090) Ca2+ [plasma membrane] (R-ALL-140648) Ca2+ [secretory granule lumen] (R-ALL-216801) Ca2+ [nuclear envelope] (R-ALL-2318767) Ca2+ [nucleoplasm] (R-ALL-29496) Ca2+ [mitochondrial matrix] (R-ALL-8949220) Ca2+ [mitochondrial inner membrane] (R-ALL-1524102) Ca2+ [endoplasmic reticulum membrane] (R-ALL-1500625) Ca2+ [cytosol] (R-ALL-74016) Ca2+ [extracellular region] (R-ALL-74112) Ca2+ [endoplasmic reticulum lumen] (R-ALL-111875)	0.609	4
UniProt:P11226 MBL2	1	MBL2 [extracellular region] (R-HSA-166674)	0.558	5
UniProt:Q15485 FCN2	1	FCN2 [extracellular region] (R-HSA-2530438)	0.558	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P49590 HARS2	1	HARS2 [mitochondrial matrix] (R-HSA-379581)	0.527	2
UniProt:Q5SVS4 KMCP1			0.527	2
UniProt:Q02742 GCNT1	1	GCNT1 [Golgi membrane] (R-HSA-914020)	0.527	2
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.527	2
UniProt:P68371 TUBB4B	8	TUBB4B [cytosol] (R-HSA-191702) TUBB4B [azurophil granule lumen] (R-HSA-6799347) TUBB4B [extracellular region] (R-HSA-6806178) TUBB4B [axonemal microtubule] (R-HSA-5610441) Polyglutamyl-TUBB4B [cytosol] (R-HSA-8867427) Polyglycyl-TUBB4B [cytosol] (R-HSA-8867452) TUBB4B unfolded [cytosol] (R-HSA-392779) TUBB4B folding intermediate [cytosol] (R-HSA-392788)	0.527	2
UniProt:Q9BV35 SCMC3			0.527	2
UniProt:O75879 GATB			0.527	2
UniProt:Q12947 FOXF2			0.527	2
UniProt:Q8TF76 HASP			0.527	2
UniProt:Q9H4K7 MTG2			0.527	2
UniProt:Q9Y4K0 LOXL2	3	LOXL2(26-?) [extracellular region] (R-HSA-2022106) LOXL2 [extracellular region] (R-HSA-2022142) LOXL2(?-774) [extracellular region] (R-HSA-2022136)	0.527	2
UniProt:P21953 BCKDHB	2	p-S342-BCKDHB [mitochondrial matrix] (R-HSA-5693124) BCKDHB [mitochondrial matrix] (R-HSA-70015)	0.527	2
UniProt:Q12980 NPRL3	1	NPRL3 [lysosomal membrane] (R-HSA-5490304)	0.527	2
UniProt:P62829 RPL23	1	RPL23 [cytosol] (R-HSA-72430)	0.527	2
UniProt:Q4G0M1 ERFE			0.527	2
UniProt:Q71U36 TUBA1A	9	AcK-TUBA1A [cytosol] (R-HSA-5618312) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) TUBA1A(1-450) [cytosol] (R-HSA-8955577) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433)	0.527	2
UniProt:P12236 SLC25A6	2	SLC25A6 [mitochondrial inner membrane] (R-HSA-49745) SLC25A6 [mitochondrial intermembrane space] (R-HSA-1955374)	0.527	2
UniProt:P04350 TUBB4A	6	TUBB4A [cytosol] (R-HSA-190588) TUBB4A [axonemal microtubule] (R-HSA-5610435) Polyglutamyl-TUBB4A [cytosol] (R-HSA-8867425) Polyglycyl-TUBB4A [cytosol] (R-HSA-8867397) TUBB4A unfolded [cytosol] (R-HSA-392778) TUBB4A folding intermediate [cytosol] (R-HSA-392789)	0.527	2
UniProt:O95271 TNKS	1	TNKS [cytosol] (R-HSA-3640825)	0.527	2
UniProt:Q9H2K2 TNKS2	1	TNKS2 [cytosol] (R-HSA-3640824)	0.527	2
UniProt:Q6PI47 KCD18			0.527	2
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.527	2
UniProt:Q3ZCM7 TUBB8	3	Polyglycyl-TUBB8 [cytosol] (R-HSA-8867423) Polyglutamyl-TUBB8 [cytosol] (R-HSA-8867387) TUBB8 [cytosol] (R-HSA-6805243)	0.527	2
UniProt:Q13509 TUBB3	6	TUBB3 folding intermediate [cytosol] (R-HSA-392806) TUBB3 unfolded [cytosol] (R-HSA-392770) Polyglycyl-TUBB3 [cytosol] (R-HSA-8867372) Polyglutamyl-TUBB3 [cytosol] (R-HSA-8867464) TUBB3 [axonemal microtubule] (R-HSA-5610436) TUBB3 [cytosol] (R-HSA-190532)	0.527	2
UniProt:Q8N8Y5 ZFP41			0.527	2
UniProt:O94808 GFPT2	1	GFPT2 [cytosol] (R-HSA-532208)	0.527	2
UniProt:Q9UK39 NOCT	1	CCRN4L [nucleoplasm] (R-HSA-508391)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.527	2
UniProt:Q6SPF0 SAMD1			0.527	2
UniProt:Q13885 TUBB2A	6	TUBB2A [cytosol] (R-HSA-191699) TUBB2A [axonemal microtubule] (R-HSA-5610431) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) TUBB2A unfolded [cytosol] (R-HSA-392776) TUBB2A folding intermediate [cytosol] (R-HSA-392802)	0.527	2
UniProt:Q92685 ALG3	5	ALG3 [endoplasmic reticulum membrane] (R-HSA-449287) ALG3 W71R [endoplasmic reticulum membrane] (R-HSA-4720466) ALG3 G118D [endoplasmic reticulum membrane] (R-HSA-4720468) ALG3 M157K [endoplasmic reticulum membrane] (R-HSA-4720484) ALG3 R171Q [endoplasmic reticulum membrane] (R-HSA-4720470)	0.508	2
UniProt:Q63722	2	Jag1 [plasma membrane] (R-RNO-9013079) Jag1 [plasma membrane] (R-RNO-157098)	0.499	4
UniProt:Q03350	4	Thbs2 [endoplasmic reticulum lumen] (R-MMU-5173187) Thbs2 [endoplasmic reticulum lumen] (R-MMU-5173234) Thbs2 [endoplasmic reticulum lumen] (R-MMU-5173111) Thbs2 [extracellular region] (R-MMU-66520)	0.499	2

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