Reactome | p-T14,Y15,T161-CDK1 [nucleoplasm]

p-T14,Y15,T161-CDK1 [nucleoplasm]

Stable Identifier

R-HSA-170074

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-T14,T161,Y15-CDK1, phosph-Cdc2(Thr 161, Thr 14, Tyr 15)

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P06493 CDK1

Gene Names

CDK1, CDC2, CDC28A, CDKN1, P34CDC2

Chain

chain:1-297

Reference Genes

BioGPS Gene:983 CDK1

COSMIC (genes):CDK1 CDK1

CTD Gene:983 CDK1

dbSNP Gene:983 CDK1

ENSEMBL:ENSG00000170312 CDK1

ENSEMBL_homo_sapiens_GENE:ENSG00000170312.17 CDK1

HGNC:1722 CDK1

KEGG Gene (Homo sapiens):983 CDK1

Monarch:983 CDK1

NCBI Gene:983 CDK1

OMIM:116940 CDK1

UCSC:P06493 CDK1

Reference Transcript

Other Identifiers

11726617_s_at

11745843_a_at

16705159

1803_at

203213_PM_at

203213_at

203214_PM_x_at

203214_x_at

210559_PM_s_at

210559_s_at

3248301

3248302

3248303

3248306

3248307

3248308

3248309

3248310

3248314

3248315

3248316

3248318

3248319

3248320

3248322

33324_s_at

40915_r_at

7927710

91194_at

983

A_23_P138507

GE63002

GO:0000082

GO:0000086

GO:0000166

GO:0000226

GO:0000278

GO:0000307

GO:0000781

GO:0001618

GO:0003682

GO:0003824

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005759

GO:0005783

GO:0005789

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005876

GO:0006091

GO:0006260

GO:0006281

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0006468

GO:0006886

GO:0006913

GO:0006915

GO:0007010

GO:0007049

GO:0007059

GO:0007095

GO:0007098

GO:0007344

GO:0008353

GO:0009410

GO:0009636

GO:0010243

GO:0010628

GO:0010629

GO:0010971

GO:0012501

GO:0014038

GO:0014070

GO:0014075

GO:0014823

GO:0016020

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0018105

GO:0018107

GO:0022414

GO:0023052

GO:0030154

GO:0030261

GO:0030332

GO:0030496

GO:0030544

GO:0030855

GO:0031100

GO:0034501

GO:0035173

GO:0036211

GO:0042307

GO:0042542

GO:0042752

GO:0043066

GO:0043226

GO:0044772

GO:0045471

GO:0045740

GO:0045931

GO:0045995

GO:0046686

GO:0046688

GO:0046718

GO:0048144

GO:0048511

GO:0048678

GO:0048856

GO:0048870

GO:0051301

GO:0055015

GO:0060045

GO:0062033

GO:0065003

GO:0070062

GO:0070301

GO:0070371

GO:0071407

GO:0072686

GO:0090166

GO:0097122

GO:0097125

GO:0097472

GO:0106310

GO:0140014

GO:0140096

GO:1900182

GO:1902850

GO:1905448

HMNXSV003002530

HMNXSV003023507

Hs.184572.0.S2_3p_at

ILMN_1710428

ILMN_1747911

PH_hs_0016443

TC10000373.hg

X05360_at

g3126638_3p_a_at

Participates

as a component of

Other forms of this molecule

CDK1 [endoplasmic reticulum membrane]

p-Y4-CDK1 [cytosol]

p-T14,T161-CDK1 [nucleoplasm]

p-T14-CDK1 [nucleoplasm]

p-T14-CDK1 [cytosol]

CDK1 [nucleoplasm]

CDK1 [cytosol]

p-T14,Y15,T161-CDK1 [cytosol]

p-T161-CDK1 [cytosol]

p-T161-CDK1 [nucleoplasm]

Inferred To

phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (Bos taurus)

phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (Danio rerio)

phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (Drosophila melanogaster)

phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (Mus musculus)

phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (Rattus norvegicus)

phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (Sus scrofa)

phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (Xenopus tropicalis)

phospho-CDK1 [nucleoplasm] (Canis familiaris)

phospho-CDK1 [nucleoplasm] (Gallus gallus)

Modified Residues

Name

O-phospho-L-threonine at 161

Coordinate

161

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 14

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 15

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_005270360.1, NP_001307847.1, NP_203698.1, NP_001777.1

ZINC - World Drugs

CDK1_HUMAN

Guide to Pharmacology - Targets

1961

OpenTargets

ENSG00000170312

ZINC - Substances

CDK1_HUMAN

ZINC - Biogenic

CDK1_HUMAN

ZINC target

P06493

PRO

P06493

PDB

6TWN, 6GU6, 4YC3, 6GU2, 6GU4, 4YC6, 6GU7, 4Y72, 5HQ0, 7NJ0, 5LQF, 6GU3

ZINC - Investigational

CDK1_HUMAN

ZINC - Metabolites

CDK1_HUMAN

HPA

ENSG00000170312-CDK1

GeneCards

P06493

Ensembl

ENSG00000170312, ENST00000316629, ENSP00000325970, ENST00000373809, ENSP00000362915, ENST00000395284, ENSP00000378699

Pharos - Targets

P06493

ZINC - Predictions - Purchasable

CDK1_HUMAN

HMDB Protein

HMDBP01364

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.976	28
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.924	13
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.903	10
UniProt:Q99640 PKMYT1	3	PKMYT1 [cytosol] (R-HSA-157457) p-PKMYT1 [nucleoplasm] (R-HSA-162650) PKMYT1 [nucleoplasm] (R-HSA-74386)	0.893	9
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.886	9
UniProt:O95067 CCNB2	1	CCNB2 [cytosol] (R-HSA-68897)	0.837	10
UniProt:P33552 CKS2			0.837	9
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.837	9
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.725	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.667	3
UniProt:Q12778 FOXO1	5	p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158)	0.645	5
UniProt:P30281 CCND3	2	CCND3 [cytosol] (R-HSA-68333) CCND3 [nucleoplasm] (R-HSA-113835)	0.643	4
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.643	3
UniProt:O95835 LATS1	2	LATS1 [cytosol] (R-HSA-2028562) p-S909,T1079-LATS1 [cytosol] (R-HSA-2028551)	0.632	3
UniProt:P30307 CDC25C	8	p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) CDC25C [nucleoplasm] (R-HSA-69741) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [cytosol] (R-HSA-8981697) p-S198-CDC25C [nucleoplasm] (R-HSA-156668)	0.623	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:O43508 TNFSF12	2	TNFSF12 [plasma membrane] (R-HSA-5667154) sTNFSF12 [extracellular region] (R-HSA-5675974)	0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:Q16667 CDKN3			0.553	2
UniProt:Q00526 CDK3			0.527	3
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.527	2
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	2
UniProt:Q00537 CDK17			0.527	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	2
UniProt:Q9H211 CDT1	1	CDT1 [nucleoplasm] (R-HSA-68536)	0.527	2
UniProt:Q99741 CDC6	4	CDC6 [nucleoplasm] (R-HSA-68542) p-CDC6 [nucleoplasm] (R-HSA-5661317) p-CDC6 [cytosol] (R-HSA-68583) CDC6 [cytosol] (R-HSA-113566)	0.524	2
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581) DLST [mitochondrial matrix] (R-HSA-6792574)	0.499	3
UniProt:O75618-1 DEDD			0.499	2
UniProt:Q86V81 ALYREF	2	ALYREF [nucleoplasm] (R-HSA-156649) ALYREF [cytosol] (R-HSA-158482)	0.499	4
UniProt:P21796 VDAC1	7	PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991)	0.499	3
UniProt:P01732 CD8A	1	CD8A [plasma membrane] (R-HSA-197601)	0.488	2
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.483	3
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.463	5
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.463	6
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.463	2
UniProt:A0A096LP01 SIM26			0.462	2

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