Reactome | PPP5C [nucleoplasm]

PPP5C [nucleoplasm]

Stable Identifier

R-HSA-5683410

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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External Reference Information

External Reference

UniProt:P53041 PPP5C

Gene Names

PPP5C, PPP5

Chain

initiator methionine:, chain:2-499

Reference Genes

BioGPS Gene:5536 PPP5C

COSMIC (genes):PPP5C PPP5C

CTD Gene:5536 PPP5C

dbSNP Gene:5536 PPP5C

ENSEMBL:ENSG00000011485 PPP5C

HGNC:9322 PPP5C

KEGG:hsa:5536 PPP5C

Monarch:5536 PPP5C

NCBI Gene:5536 PPP5C

OMIM:600658 PPP5C

UCSC:P53041 PPP5C

Reference Transcript

RefSeq:NM_006247.3 PPP5C

Other Identifiers

11718622_x_at

11745533_x_at

11762182_a_at

16863460

201979_PM_s_at

201979_s_at

215705_PM_at

215705_at

3836761

3836762

3836763

3836764

3836771

3836772

3836774

3836777

3836778

3836779

3836780

3836781

3836782

3836783

3836784

3836785

3836786

3836787

3836788

3836789

3836790

3836791

3836792

3836793

3836794

3836795

3836796

3836797

3836798

3836799

3836800

3866044

391_at

392_g_at

5536

8029814

A_14_P136374

A_23_P153583

GE60120

GO:0000165

GO:0000278

GO:0003723

GO:0003824

GO:0004721

GO:0004722

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006281

GO:0006302

GO:0006351

GO:0006470

GO:0008092

GO:0008289

GO:0010288

GO:0016787

GO:0016791

GO:0017018

GO:0032991

GO:0035970

GO:0042802

GO:0043123

GO:0043226

GO:0043231

GO:0043278

GO:0043531

GO:0046872

GO:0048156

GO:0051879

GO:0070262

GO:0101031

GO:0140096

GO:1904550

HMNXSV003006202

Hs.75180.1.S1_3p_at

ILMN_1745332

PH_hs_0025229

TC19000663.hg

X89416_at

g5453957_3p_at

g5453957_3p_x_at

Participates

as a candidate of

TPR-containing co-chaperones [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PPP5C [cytosol]

Inferred To

PpD3 [nucleoplasm] (Drosophila melanogaster)

ppp5c [nucleoplasm] (Xenopus tropicalis)

PPP5C [nucleoplasm] (Bos taurus)

PPP5C [nucleoplasm] (Canis familiaris)

PPP5C [nucleoplasm] (Dictyostelium discoideum)

PPP5C [nucleoplasm] (Mus musculus)

PPP5C [nucleoplasm] (Rattus norvegicus)

PPP5C [nucleoplasm] (Saccharomyces cerevisiae)

PPP5C [nucleoplasm] (Schizosaccharomyces pombe)

PPP5C [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_006238.1

OpenTargets

ENSG00000011485

ENSEMBL

ENST00000012443, ENSP00000012443

IntEnz

3.1.3.16

HPA

ENSG00000011485-PPP5C

ZINC - Substances

PPP5_HUMAN

ZINC target

P53041

PRO

P53041

Pharos - Targets

P53041

GlyGen

P53041

HMDB Protein

HMDBP08687

PDB

5UI1, 1WAO, 1A17, 3H69, 5HPE, 3H62, 4ZX2, 3H61, 2BUG, 8GFT, 3H64, 3H66, 3H63, 7ZR6, 5WG8, 7ZR5, 8GAE, 4ZVZ, 3H67, 3H60, 3H68, 1S95

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.901	9
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.873	13
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.725	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.708	5
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.625	4
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.623	4
UniProt:O14654 IRS4	2	p-Y-IRS4 [plasma membrane] (R-HSA-2424302) IRS4 [plasma membrane] (R-HSA-2424297)	0.569	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q9UHD1 CHRD1			0.547	2
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.539	3
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.527	6
UniProt:P49005 POLD2	1	POLD2 [nucleoplasm] (R-HSA-68443)	0.527	3
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.524	3
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.508	4
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.499	2
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.499	3
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.499	2
UniProt:Q9H9G7 AGO3	1	EIF2C3 [cytosol] (R-HSA-210615)	0.499	2
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.499	2
UniProt:Q5JT25 RAB41	3	RAB41 [Golgi membrane] (R-HSA-8849603) GGC-RAB41 [cytosol] (R-HSA-8874030) RAB41 [cytosol] (R-HSA-8873689)	0.499	2
UniProt:Q9Y4P8 WIPI2	1	WIPI2 [cytosol] (R-HSA-5678305)	0.483	2

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