Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ROR1 [plasma membrane]
Stable Identifier
R-HSA-197814
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tyrosine-protein kinase transmembrane receptor ROR1 precursor, ROR1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Homo sapiens)
FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Homo sapiens)
WNT5A:FZDs/ROR [plasma membrane] (Homo sapiens)
FZD2/FZD5/ROR2 [plasma membrane] (Homo sapiens)
ROR1 [plasma membrane] (Homo sapiens)
WNT5A binds FZD and ROR receptors (Homo sapiens)
FZD2/FZD5/ROR2 [plasma membrane] (Homo sapiens)
ROR1 [plasma membrane] (Homo sapiens)
WNT5A:FZDs/ROR [plasma membrane] (Homo sapiens)
FZD2/FZD5/ROR2 [plasma membrane] (Homo sapiens)
ROR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01973 ROR1
Gene Names
ROR1, NTRKR1
Chain
signal peptide:1-29, chain:30-937
Reference Genes
BioGPS Gene:4919 ROR1
COSMIC (genes):ROR1 ROR1
CTD Gene:4919 ROR1
dbSNP Gene:4919 ROR1
ENSEMBL:ENSG00000185483 ROR1
HGNC:10256 ROR1
KEGG Gene (Homo sapiens):4919 ROR1
Monarch:4919 ROR1
NCBI Gene:4919 ROR1
OMIM:602336 ROR1
UCSC:Q01973 ROR1
Reference Transcript
RefSeq:NM_005012.3 ROR1
RefSeq:NM_001083592.1 ROR1
Other Identifiers
0001410156
0106370402
11738115_at
11752290_s_at
16665588
205805_PM_s_at
205805_s_at
211057_PM_at
211057_at
213_at
232060_PM_at
232060_at
2339873
2339874
2339875
2339876
2339932
2339942
2339945
2339966
2339967
2339968
2339969
2339976
2339983
2339984
2339985
2339986
2339987
2339988
2339996
2339998
4919
74338_at
7901969
85417_r_at
A_14_P114455
A_14_P122305
A_14_P136179
A_23_P12363
A_32_P4018
GE55619
GE62401
GO:0000166
GO:0001725
GO:0003674
GO:0004672
GO:0004714
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005856
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0007165
GO:0007169
GO:0007267
GO:0007605
GO:0008150
GO:0009058
GO:0009986
GO:0010976
GO:0014002
GO:0014068
GO:0016020
GO:0016021
GO:0016055
GO:0016301
GO:0016310
GO:0016740
GO:0017147
GO:0018108
GO:0030154
GO:0030424
GO:0032991
GO:0033674
GO:0034641
GO:0042813
GO:0042995
GO:0043123
GO:0043167
GO:0043226
GO:0043235
GO:0043679
GO:0048839
GO:0048856
GO:0050877
GO:0051092
GO:0060071
GO:1904929
HMNXSV003003405
Hs.128753.0.S1_3p_at
ILMN_1655904
ILMN_1899404
M97675_at
PH_hs_0007467
PH_hs_0014128
TC01000723.hg
TC01004449.hg
g13623530_3p_at
g4826867_3p_a_at
Participates
as a candidate of
FZD2/FZD5/ROR2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
ROR1 [clathrin-coated endocytic vesicle membrane]
Inferred To
Ror [plasma membrane]
(Drosophila melanogaster)
Ror1 [plasma membrane]
(Mus musculus)
Ror1 [plasma membrane]
(Rattus norvegicus)
ROR1 [plasma membrane]
(Bos taurus)
ROR1 [plasma membrane]
(Canis familiaris)
ROR1 [plasma membrane]
(Gallus gallus)
ROR1 [plasma membrane]
(Sus scrofa)
ror1 [plasma membrane]
(Danio rerio)
ror1 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001077061.1
,
NP_005003.2
Guide to Pharmacology - Targets
1845
OpenTargets
ENSG00000185483
HPA
ENSG00000185483-ROR1
GeneCards
Q01973
Ensembl
ENSG00000185483
,
ENSP00000360121
,
ENSP00000360120
,
ENST00000371079
,
ENST00000371080
PRO
Q01973
Pharos - Targets
Q01973
Orphanet
25518
PDB
6BAN
,
6BA5
,
5Z55
,
6TU9
HMDB Protein
HMDBP09450
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P12931 SRC
6
SRC [cytosol]
(R-HSA-9628701)
p-Y416-SRC [cytosol]
(R-HSA-8964276)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.682
9
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.576
8
UniProt:P05480 Src
13
Src [cytosol]
(R-MMU-9628701)
Src [cytosol]
(R-MMU-191648)
phospho-Src [plasma membrane]
(R-MMU-1810408)
phospho-Src [plasma membrane]
(R-MMU-377598)
phospho-Src [cytosol]
(R-MMU-377592)
Src [plasma membrane]
(R-MMU-65043)
Src [cytosol]
(R-MMU-418782)
phospho-Src [plasma membrane]
(R-MMU-112331)
Src [plasma membrane]
(R-MMU-8876922)
MyrG-p-Y424-Src [plasma membrane]
(R-MMU-9011258)
Activated Src [nucleoplasm]
(R-MMU-8937700)
p-Y416-Src [cytosol]
(R-MMU-8964306)
phospho-Src [cytosol]
(R-MMU-8964276)
0.544
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text