p-S621-RAF1 T260R [cytosol]

Stable Identifier
R-HSA-9656139
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
RAF proto-oncogene serine/threonine-protein kinase , Raf-1, C-RAF, cRaf
p-S621-RAF1 T260R [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
17603483 Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

Pandit, B, Sarkozy, A, Pennacchio, LA, Carta, C, Oishi, K, Martinelli, S, Pogna, EA, Schackwitz, W, Ustaszewska, A, Landstrom, A, Bos, JM, Ommen, SR, Esposito, G, Lepri, F, Faul, C, Mundel, P, López Siguero, JP, Tenconi, R, Selicorni, A, Rossi, C, Mazzanti, L, Torrente, I, Marino, B, Digilio, MC, Zampino, G, Ackerman, MJ, Dallapiccola, B, Tartaglia, M, Gelb, BD

Nat Genet 2007
External Reference Information
External Reference
Gene Names
RAF1, RAF
Chain
chain:1-648
Other Identifiers
11716472_a_at
11748273_a_at
16950848
1917_at
201244_s_at
2663243
2663245
2663246
2663247
2663248
2663251
2663253
2663258
2663261
2663263
2663270
2663271
2663272
2663273
2663274
2663275
2663278
2663279
2663280
2663281
2663282
2663283
2663284
2663292
38742_s_at
38743_f_at
5894
8085374
A_23_P40952
GE59649
GO:0000165
GO:0000166
GO:0000186
GO:0001666
GO:0001678
GO:0001934
GO:0002223
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005794
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006810
GO:0006915
GO:0006950
GO:0007010
GO:0007165
GO:0007190
GO:0007267
GO:0007507
GO:0008150
GO:0008179
GO:0008219
GO:0008283
GO:0008285
GO:0009058
GO:0010856
GO:0015031
GO:0016020
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0017016
GO:0019899
GO:0022607
GO:0030154
GO:0030168
GO:0030234
GO:0030878
GO:0031143
GO:0031333
GO:0031434
GO:0033138
GO:0034220
GO:0034641
GO:0035019
GO:0035023
GO:0035556
GO:0035773
GO:0035994
GO:0040011
GO:0042060
GO:0042592
GO:0042802
GO:0042981
GO:0043066
GO:0043085
GO:0043154
GO:0043167
GO:0043226
GO:0044877
GO:0045104
GO:0045595
GO:0045944
GO:0046872
GO:0048011
GO:0048538
GO:0048856
GO:0048870
GO:0055085
GO:0060324
GO:0065003
GO:0071550
GO:1902042
GO:2000145
ILMN_1813489
PH_hs_0039978
TC03001174.hg
X03484_at
g4506400_3p_a_at
Participant Of
Other forms of this molecule
Modified Residues
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
L-threonine 260 replaced with L-arginine
Coordinate
260
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-arginine.
A protein modification that effectively removes or replaces an L-threonine.
Disease
Name Identifier Synonyms
hypertrophic cardiomyopathy 11984 familial hypertrophic cardiomyopathy, hypertrophic obstructive cardiomyopathy
Noonan syndrome 3490 Turner's phenotype, karyotype normal (disorder)
Cross References
ZINC - World Drugs
ClinGen
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
IntEnz
GeneCards
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (48)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01112 HRAS  23 0.975 25
 UniProt:P15056 BRAF  68 0.959 57
 UniProt:P63104 YWHAZ  2 0.957 18
 UniProt:Q02750 MAP2K1  27 0.955 37
 UniProt:P31946 YWHAB  1 0.934 20
 UniProt:Q04917 YWHAH  1 0.864 9
 UniProt:P01111 NRAS  25 0.861 8
 UniProt:P27348 YWHAQ  1 0.848 7
 UniProt:P04049 RAF1  54 0.811 6
 UniProt:P61981 YWHAG  1 0.802 6
 UniProt:Q16543 CDC37  1 0.773 6
 UniProt:P08238 HSP90AB1  6 0.758 5
 UniProt:P30086 PEBP1  1 0.758 10
 UniProt:P36507 MAP2K2  12 0.745 5
 UniProt:P31947 SFN  1 0.744 5
 UniProt:P62258 YWHAE  1 0.738 5
 UniProt:P01116-2 KRAS  8 0.676 3
 UniProt:Q3ZCQ8 TIMM50  1 0.659 6
 UniProt:Q13188 STK3  4 0.645 6
 UniProt:O43852 CALU  3 0.643 4
 UniProt:Q13418 ILK  1 0.643 3
 UniProt:P62834 RAP1A  4 0.623 2
 UniProt:P01116 KRAS  47 0.623 5
 UniProt:Q96S96 PEBP4      0.597 4
 UniProt:Q92934 BAD  4 0.589 2
 UniProt:P31749 AKT1  13 0.589 2
 UniProt:Q6TCH7 PAQR3  1 0.576 3
 UniProt:P11021 HSPA5  6 0.576 5
 UniProt:P32883 Kras  12 0.573 2
 UniProt:P07900 HSP90AA1  8 0.564 3
 UniProt:O95816 BAG2  1 0.564 3
 UniProt:Q13526 PIN1  2 0.564 2
 UniProt:Q13177 PAK2  11 0.558 2
 UniProt:O39474 O39474      0.556 4
 UniProt:P00533 EGFR  59 0.553 2
 UniProt:P49368 CCT3  1 0.547 5
 UniProt:Q13362 PPP2R5C  3 0.544 2
 UniProt:P67775 PPP2CA  4 0.544 2
 UniProt:P50990 CCT8  5 0.527 3
 UniProt:P10398 ARAF  4 0.527 3
 UniProt:P50402 EMD  3 0.527 2
 UniProt:Q99933 BAG1  1 0.508 2
 UniProt:P43246 MSH2  3 0.508 2
 UniProt:P03495 NS1      0.508 2
 UniProt:P01120  3 0.499 2
 UniProt:P28301  3 0.499 2
 UniProt:Q9ESN9-2 MAPK8IP3      0.499 2
 UniProt:P05783 KRT18  1 0.488 5
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