Reactome | ERCC1 [nucleoplasm]

ERCC1 [nucleoplasm]

Stable Identifier

R-HSA-54427

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ERCC1, DNA excision repair protein, DNA excision repair protein ERCC-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07992 ERCC1

Gene Names

ERCC1

Chain

chain:1-297

Reference Genes

COSMIC (genes):ERCC1 ERCC1

dbSNP Gene:2067 ERCC1

ENSEMBL:ENSG00000012061 ERCC1

Participates

as an input of

Formation of ERCC1:XPF heterodimeric complex (Homo sapiens)

as an output of

USP45 deubiquitinates ERCC1 (Homo sapiens)

as a component of

ERCC1:ERCC4 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Ub-ERCC1 [nucleoplasm]

Inferred To

Ercc1 [nucleoplasm] (Drosophila melanogaster)

Ercc1 [nucleoplasm] (Mus musculus)

Ercc1 [nucleoplasm] (Rattus norvegicus)

ERCC1 [nucleoplasm] (Bos taurus)

ERCC1 [nucleoplasm] (Canis familiaris)

ERCC1 [nucleoplasm] (Plasmodium falciparum)

ERCC1 [nucleoplasm] (Sus scrofa)

Ghost homologue of ERCC1 [nucleoplasm] (Gallus gallus)

Ghost homologue of ERCC1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of ERCC1 [nucleoplasm] (Xenopus tropicalis)

ercc-1 [nucleoplasm] (Caenorhabditis elegans)

ercc1 [nucleoplasm] (Danio rerio)

ercc1 [nucleoplasm] (Dictyostelium discoideum)

swi10 [nucleoplasm] (Schizosaccharomyces pombe)

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.905	9
UniProt:Q92889 ERCC4	1	ERCC4 [nucleoplasm] (R-HSA-67445)	0.878	14
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.666	4
UniProt:Q96S82 UBL7			0.666	4
UniProt:Q8IY92 SLX4	1	SLX4 [nucleoplasm] (R-HSA-5686477)	0.641	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.571	21
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q6NSB6 Q6NSB6			0.556	3
UniProt:Q96GJ1 TRM2B			0.556	3
UniProt:Q9BQ83 SLX1A	1	SLX1A [nucleoplasm] (R-HSA-5686481)	0.527	2

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