Reactome | ERCC1 [nucleoplasm]

ERCC1

Stable Identifier

R-HSA-54427

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ERCC1, DNA excision repair protein, DNA excision repair protein ERCC-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07992 ERCC1

Gene Names

ERCC1

Chain

chain:1-297

Reference Genes

BioGPS Gene:2067 ERCC1

COSMIC (genes):ERCC1 ERCC1

CTD Gene:2067 ERCC1

dbSNP Gene:2067 ERCC1

ENSEMBL:ENSG00000012061 ERCC1

HGNC:3433 ERCC1

KEGG Gene (Homo sapiens):hsa:2067 ERCC1

Monarch:2067 ERCC1

NCBI Gene:2067 ERCC1

OMIM:126380 ERCC1

UCSC:P07992 ERCC1

Reference Transcript

Other Identifiers

0001570280

0004010575

11719830_a_at

11728311_x_at

16873313

1878_g_at

1902_at

1Z00

203719_at

203720_s_at

2067

228131_at

29773

2A1I

2A1J

2JNW

2JPD

2MUT

36519_at

3865379

3865380

3865381

3865386

3865387

3865388

3865389

3865391

3865394

3865397

3865399

3865401

3865402

3865404

3865405

3865406

3865407

3865409

3865410

3865419

4390

50182

64167_f_at

64168_r_at

72859

72860

8037579

A0A024R0Q6

A_23_P107701

A_33_P3228128

A_33_P3365037

CAB004390

CAB072859

CAB072860

CCDS12662

CCDS12663

CCDS54279

ENSG00000012061

ENSP00000013807

ENSP00000300853

ENSP00000345203

ENSP00000394875

ENSP00000468035

ENST00000013807

ENST00000300853

ENST00000340192

ENST00000423698

ENST00000589165

EntrezGene:2067

ERCC1

ERCC1-201

ERCC1-202

ERCC1-203

ERCC1-204

ERCC1-208

g4503598_3p_a_at

GE57817

GE61630

GO:0000014

GO:0000109

GO:0000110

GO:0000710

GO:0000720

GO:0000784

GO:0001094

GO:0001302

GO:0003677

GO:0003684

GO:0003697

GO:0004518

GO:0004519

GO:0005515

GO:0005634

GO:0005654

GO:0005669

GO:0005737

GO:0005829

GO:0006281

GO:0006283

GO:0006289

GO:0006293

GO:0006295

GO:0006296

GO:0006302

GO:0006303

GO:0006310

GO:0006312

GO:0006949

GO:0006974

GO:0006979

GO:0007281

GO:0007283

GO:0007584

GO:0008022

GO:0008283

GO:0008584

GO:0009650

GO:0009744

GO:0010165

GO:0010259

GO:0016787

GO:0019904

GO:0032205

GO:0033683

GO:0035166

GO:0035264

GO:0035902

GO:0036297

GO:0045190

GO:0046686

GO:0048468

GO:0048477

GO:0048568

GO:0051276

GO:0061819

GO:0070522

GO:0070911

GO:0070914

GO:0090305

GO:0090656

GO:1904431

GO:1905765

GO:1990599

HGNC:3433

HPA029773

HPA050182

Hs.25523.0.A1_3p_at

Hs.25523.0.A1_3p_x_at

ILMN_1652369

ILMN_1676748

ILMN_1726562

ILMN_1797172

ILMN_2277676

ILMN_2377496

M13194_at

MIM:126380

MIM:610758

NM_001166049

NM_001983

NM_202001

NP_001159521

NP_001974

NP_973730

PF00633

PF03834

PF14520

PH_hs_0025459

TC19001620.hg

TC19002520.hg

uc002pbs.3

uc002pbt.3

uc002pbu.3

uc002pbv.4

uc060zyi.1

UPI0000071CF0

UPI000012A11A

UPI000013F4D6

UPI000019C835

XM_005258634

XM_005258635

XM_005258636

XM_005258637

XM_011526610

XM_017026459

XM_017026460

XM_017026461

XM_017026462

XM_017026463

XM_017026464

XM_017026465

XM_017026466

XP_005258691

XP_005258692

XP_005258693

XP_005258694

XP_011524912

XP_016881948

XP_016881949

XP_016881950

XP_016881951

XP_016881952

XP_016881953

XP_016881954

XP_016881955

XR_001753631

XR_001753632

Participant Of

input

Formation of ERCC1:XPF heterodimeric complex

hasComponent

ERCC1:ERCC4 [nucleoplasm]

output

USP45 deubiquitinates ERCC1

Other forms of this molecule

Ub-ERCC1 [nucleoplasm]

Inferred To

Homologues of ERCC1 [nucleoplasm] (Drosophila melanogaster)

Homologues of ERCC1 [nucleoplasm] (Oryza sativa)

Homologues of ERCC1 [nucleoplasm] (Sus scrofa)

ERCC1 [nucleoplasm] (Arabidopsis thaliana)

ERCC1 [nucleoplasm] (Bos taurus)

ERCC1 [nucleoplasm] (Caenorhabditis elegans)

ERCC1 [nucleoplasm] (Canis familiaris)

ERCC1 [nucleoplasm] (Danio rerio)

ERCC1 [nucleoplasm] (Dictyostelium discoideum)

ERCC1 [nucleoplasm] (Drosophila melanogaster)

ERCC1 [nucleoplasm] (Mus musculus)

ERCC1 [nucleoplasm] (Oryza sativa)

ERCC1 [nucleoplasm] (Plasmodium falciparum)

ERCC1 [nucleoplasm] (Rattus norvegicus)

ERCC1 [nucleoplasm] (Saccharomyces cerevisiae)

ERCC1 [nucleoplasm] (Schizosaccharomyces pombe)

ERCC1 [nucleoplasm] (Sus scrofa)

ERCC1 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of ERCC1 [nucleoplasm] (Gallus gallus)

Ghost homologue of ERCC1 [nucleoplasm] (Taeniopygia guttata)

Cross References

RefSeq

XP_016881955.1, XP_005258693.1, XP_016881954.1, XP_005258692.1, XP_016881953.1, XP_005258691.1, NP_973730.1, XP_016881951.1, XP_016881952.1, NP_001974.1, XP_016881950.1, NP_001159521.1, XP_016881949.1, XP_016881948.1, XP_011524912.1

Brenda

3.1

GeneCards

P07992

DOCK Blaster

2A1I, 2A1J

PRO

P07992

Orphanet

16865

PDB

2A1I, 1Z00, 2MUT, 2JPD, 2JNW, 2A1J

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92889 ERCC4	1	ERCC4 [nucleoplasm] (R-HSA-67445)	0.793	12
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.692	3
UniProt:Q96S82 UBL7			0.666	4
UniProt:Q8IY92 SLX4	1	SLX4 [nucleoplasm] (R-HSA-5686477)	0.641	6
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.599	21
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q6NSB6 Q6NSB6			0.556	3
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.556	3
UniProt:Q96GJ1 TRM2			0.556	3