Reactome | ERCC1 [nucleoplasm]

ERCC1 [nucleoplasm]

Stable Identifier

R-HSA-54427

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ERCC1, DNA excision repair protein, DNA excision repair protein ERCC-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07992 ERCC1

Gene Names

ERCC1

Chain

chain:1-297

Reference Genes

BioGPS Gene:2067 ERCC1

COSMIC (genes):ERCC1 ERCC1

CTD Gene:2067 ERCC1

dbSNP Gene:2067 ERCC1

ENSEMBL:ENSG00000012061 ERCC1

HGNC:3433 ERCC1

KEGG Gene (Homo sapiens):2067 ERCC1

Monarch:2067 ERCC1

NCBI Gene:2067 ERCC1

OMIM:126380 ERCC1

UCSC:P07992 ERCC1

Reference Transcript

Other Identifiers

0001570280

0004010575

11719830_a_at

11728311_x_at

16873313

1878_g_at

1902_at

1Z00

203719_at

203720_s_at

2067

228131_at

29773

2A1I

2A1J

2JNW

2JPD

2MUT

36519_at

3865377

3865379

3865380

3865381

3865386

3865387

3865388

3865389

3865391

3865394

3865397

3865399

3865401

3865402

3865404

3865405

3865406

3865407

3865408

3865409

3865410

3865419

4390

50182

64167_f_at

64168_r_at

72859

72860

8037579

A0A024R0Q6

A_23_P107701

A_33_P3228128

A_33_P3365037

AAA35810

AAA52394

AAA52395

AAC16253

AAH08930

AAH52813

AAM34796

AAV38609

AB069681

AC092309

AC138128

AC138534

AC139353

AF001925

AF512555

AK092039

AK314884

BAB62810

BAG37398

BAG52472

BC008930

BC052813

BT019806

CAB004390

CAB072859

CAB072860

CCDS12662

CCDS12663

CCDS54279

CH471126

EAW57348

EAW57349

EAW57350

ENSG00000012061

ENSP00000013807

ENSP00000300853

ENSP00000345203

ENSP00000394875

ENSP00000468035

ENST00000013807

ENST00000013807.9

ENST00000300853

ENST00000300853.7

ENST00000340192

ENST00000340192.11

ENST00000423698

ENST00000423698.6

ENST00000589165

ENST00000589165.5

EntrezGene:2067

EntrezGene:ERCC1

ERCC1

ERCC1-201

ERCC1-202

ERCC1-203

ERCC1-204

ERCC1-208

g4503598_3p_a_at

GE57817

GE61630

GO:0000003

GO:0000014

GO:0000109

GO:0000110

GO:0000228

GO:0000710

GO:0000720

GO:0000784

GO:0001094

GO:0001302

GO:0002376

GO:0003674

GO:0003677

GO:0003684

GO:0003697

GO:0004518

GO:0004519

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005669

GO:0005694

GO:0005737

GO:0005829

GO:0006259

GO:0006281

GO:0006283

GO:0006289

GO:0006293

GO:0006295

GO:0006296

GO:0006302

GO:0006303

GO:0006310

GO:0006312

GO:0006949

GO:0006950

GO:0006974

GO:0006979

GO:0007049

GO:0007281

GO:0007283

GO:0007568

GO:0007584

GO:0008022

GO:0008134

GO:0008150

GO:0008283

GO:0008584

GO:0009058

GO:0009650

GO:0009744

GO:0009790

GO:0010165

GO:0010259

GO:0016787

GO:0019904

GO:0022607

GO:0030154

GO:0032205

GO:0032991

GO:0033683

GO:0034641

GO:0035166

GO:0035264

GO:0035902

GO:0036297

GO:0040007

GO:0042592

GO:0043226

GO:0045190

GO:0046686

GO:0048468

GO:0048477

GO:0048568

GO:0048646

GO:0048856

GO:0051276

GO:0060261

GO:0061819

GO:0065003

GO:0070522

GO:0070911

GO:0070914

GO:0090305

GO:0090656

GO:1904431

GO:1905765

GO:1990599

GO:1990841

HGNC:3433

HPA029773

HPA050182

Hs.25523.0.A1_3p_at

Hs.25523.0.A1_3p_x_at

ILMN_1652369

ILMN_1676748

ILMN_1726562

ILMN_1797172

ILMN_2277676

ILMN_2377496

IPR000445

IPR004579

IPR010994

IPR011335

K7EJL2

K7EK97

K7EP14

K7ER60

K7ER89

K7ES46

M13194

M13194_at

M26163

M28650

MIM:126380

MIM:610758

NM_001166049

NM_001369408

NM_001369409

NM_001369410

NM_001369411

NM_001369412

NM_001369413

NM_001369414

NM_001369415

NM_001369416

NM_001369417

NM_001369418

NM_001369419

NM_001983

NM_202001

NP_001159521

NP_001356337

NP_001356338

NP_001356339

NP_001356340

NP_001356341

NP_001356342

NP_001356343

NP_001356344

NP_001356345

NP_001356346

NP_001356347

NP_001356348

NP_001974

NP_973730

PF00633

PF03834

PF14520

PH_hs_0025459

TC19001620.hg

TC19002520.hg

UPI0000071CF0

UPI000012A11A

UPI000013F4D6

UPI000019C835

XP_005258693

XP_011524912

XP_016881948

XP_016881953

Participant Of

output

USP45 deubiquitinates ERCC1

input

Formation of ERCC1:XPF heterodimeric complex

hasComponent

ERCC1:ERCC4 [nucleoplasm]

Other forms of this molecule

Ub-ERCC1 [nucleoplasm]

Inferred To

Ercc1 [nucleoplasm] (Drosophila melanogaster)

Ercc1 [nucleoplasm] (Mus musculus)

Ercc1 [nucleoplasm] (Rattus norvegicus)

RAD10 [nucleoplasm] (Saccharomyces cerevisiae)

ERCC1 [nucleoplasm] (Bos taurus)

ERCC1 [nucleoplasm] (Canis familiaris)

ERCC1 [nucleoplasm] (Plasmodium falciparum)

ERCC1 [nucleoplasm] (Sus scrofa)

Ghost homologue of ERCC1 [nucleoplasm] (Gallus gallus)

ercc-1 [nucleoplasm] (Caenorhabditis elegans)

ercc1 [nucleoplasm] (Danio rerio)

ercc1 [nucleoplasm] (Dictyostelium discoideum)

ercc1 [nucleoplasm] (Xenopus tropicalis)

swi10 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_005258692.1, NP_973730.1, XP_011524912.1, XP_016881952.1, XP_005258691.1, XP_016881955.1, XP_016881951.1, NP_001159521.1, XP_016881949.1, XP_016881950.1, XP_016881954.1, XP_016881948.1, XP_005258693.1, NP_001974.1, XP_016881953.1

OpenTargets

ENSG00000012061

GeneCards

P07992

HPA

ENSG00000012061-ERCC1

Ensembl

ENSG00000012061, ENSP00000013807, ENSP00000345203, ENSP00000394875, ENST00000013807, ENSP00000300853, ENST00000423698, ENST00000589165, ENSP00000468035, ENST00000300853, ENST00000340192

PRO

P07992

Orphanet

16865

PDB

2JPD, 2JNW, 1Z00, 2A1J, 2A1I, 2MUT

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92889 ERCC4	1	ERCC4 [nucleoplasm] (R-HSA-67445)	0.84	13
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.763	4
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.666	4
UniProt:Q96S82 UBL7			0.666	4
UniProt:Q8IY92 SLX4	1	SLX4 [nucleoplasm] (R-HSA-5686477)	0.641	6
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.599	21
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q6NSB6 Q6NSB6			0.556	3
UniProt:Q96GJ1 TRM2			0.556	3
UniProt:Q9BQ83 SLX1A	1	SLX1A [nucleoplasm] (R-HSA-5686481)	0.527	2