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p-S144,T423-PAK1 [plasma membrane]
Stable Identifier
R-HSA-3928472
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
PAK1 autophosphorylates (Homo sapiens)
RAC1-GTP:p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)
p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)
Ephrin signaling (Homo sapiens)
PAKs autophosphorylate (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
p-PAK1/3, 2 [plasma membrane] (Homo sapiens)
p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)
PAKs phosphorylate MLC (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
p-PAK1/3, 2 [plasma membrane] (Homo sapiens)
p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)
p-PAK1/3, 2 [plasma membrane] (Homo sapiens)
p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13153 PAK1
Gene Names
PAK1
Chain
initiator methionine:, chain:2-545
Reference Genes
BioGPS Gene:5058 PAK1
COSMIC (genes):PAK1 PAK1
CTD Gene:5058 PAK1
dbSNP Gene:5058 PAK1
ENSEMBL:ENSG00000149269 PAK1
ENSEMBL_homo_sapiens_GENE:ENSG00000149269.10 PAK1
HGNC:8590 PAK1
KEGG Gene (Homo sapiens):5058 PAK1
Monarch:5058 PAK1
NCBI Gene:5058 PAK1
OMIM:602590 PAK1
UCSC:Q13153 PAK1
Reference Transcript
RefSeq:NM_002576.4 PAK1
RefSeq:XM_017017847.1 PAK1
RefSeq:XM_017017850.1 PAK1
RefSeq:XM_011545081.2 PAK1
RefSeq:XM_017017849.1 PAK1
RefSeq:NM_001128620.1 PAK1
RefSeq:XM_011545083.2 PAK1
RefSeq:XM_011545080.2 PAK1
RefSeq:XM_011545082.2 PAK1
RefSeq:XM_017017846.1 PAK1
RefSeq:XM_011545084.2 PAK1
RefSeq:XM_017017848.1 PAK1
Other Identifiers
11720103_a_at
11720104_a_at
1557_at
1558_g_at
1565772_PM_at
1565772_at
16742454
209615_PM_s_at
209615_s_at
226507_PM_at
226507_at
230100_PM_x_at
230100_x_at
3382862
3382863
3382864
3382865
3382866
3382867
3382869
3382871
3382873
3382874
3382876
3382878
3382879
3382881
3382884
3382886
3382891
3382893
3382895
3382896
3382900
3382909
43052_at
43053_g_at
47835_at
5058
60859_at
7950578
A_23_P75989
A_33_P3288609
A_33_P3784253
GE59021
GE86276
GO:0000166
GO:0001726
GO:0001934
GO:0002223
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005518
GO:0005524
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005911
GO:0005925
GO:0006325
GO:0006338
GO:0006468
GO:0006887
GO:0006915
GO:0006974
GO:0007010
GO:0008092
GO:0008152
GO:0008284
GO:0012501
GO:0014704
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0023052
GO:0030018
GO:0030027
GO:0030036
GO:0030154
GO:0030335
GO:0030424
GO:0030425
GO:0031116
GO:0031267
GO:0031965
GO:0032587
GO:0032956
GO:0032991
GO:0033138
GO:0033148
GO:0035556
GO:0036211
GO:0038096
GO:0042060
GO:0042802
GO:0042995
GO:0043015
GO:0043226
GO:0043408
GO:0043507
GO:0046777
GO:0048012
GO:0048013
GO:0048754
GO:0048812
GO:0048856
GO:0048870
GO:0050770
GO:0051179
GO:0051496
GO:0060244
GO:0065003
GO:0070161
GO:0090063
GO:0098542
GO:0106310
GO:0140096
GO:1903608
HMNXSV003022832
HMNXSV003030470
Hs.23295.0.A1_3p_at
Hs.329996.0.A1_3p_s_at
ILMN_1767365
PH_hs_0003990
TC11002123.hg
TC11003261.hg
U24152_at
g1256421_3p_a_at
p18341
Participates
as a component of
RAC1-GTP:p-S144,T423-PAK1 [plasma membrane] (Homo sapiens)
as a member of
p-PAK1/3, 2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
PAK1 [plasma membrane]
Active PAK1 [cytosol]
PAK1 [cytosol]
p-S144,T423-PAK1 [cytosol]
Inferred To
phospho-p-S144,T423-PAK1 [plasma membrane]
(Bos taurus)
phospho-p-S144,T423-PAK1 [plasma membrane]
(Caenorhabditis elegans)
phospho-p-S144,T423-PAK1 [plasma membrane]
(Dictyostelium discoideum)
phospho-p-S144,T423-PAK1 [plasma membrane]
(Drosophila melanogaster)
phospho-p-S144,T423-PAK1 [plasma membrane]
(Mus musculus)
phospho-p-S144,T423-PAK1 [plasma membrane]
(Rattus norvegicus)
phospho-p-S144,T423-PAK1 [plasma membrane]
(Sus scrofa)
phospho-p-S144,T423-PAK1 [plasma membrane]
(Xenopus tropicalis)
phospho-PAK1 [plasma membrane]
(Canis familiaris)
phospho-PAK1 [plasma membrane]
(Gallus gallus)
Modified Residues
Name
O-phospho-L-serine at 144
Coordinate
144
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 423
Coordinate
423
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_011543386.1
,
XP_016873335.1
,
XP_016873337.1
,
NP_001122092.1
,
XP_011543383.1
,
XP_016873339.1
,
XP_011543385.1
,
NP_002567.3
,
XP_016873336.1
,
XP_011543382.1
,
XP_016873338.1
,
XP_011543384.1
ZINC - World Drugs
PAK1_HUMAN
Guide to Pharmacology - Targets
2133
OpenTargets
ENSG00000149269
ZINC - FDA approved
PAK1_HUMAN
ZINC - Substances
PAK1_HUMAN
ZINC - Biogenic
PAK1_HUMAN
ZINC target
Q13153
PRO
Q13153
PDB
3DVP
,
2QME
,
4O0R
,
4ZJI
,
4P90
,
4ZJJ
,
1YHW
,
5IME
,
6B16
,
3FY0
,
5DEW
,
4EQC
,
5KBQ
,
8X5Z
,
1YHV
,
5DEY
,
7VTO
,
5KBR
,
4O0T
,
3FXZ
,
4ZLO
,
4DAW
,
2HY8
,
4ZY5
,
4ZY6
,
3Q52
,
3Q4Z
,
1ZSG
,
3Q53
,
5DFP
,
4ZY4
,
1F3M
ZINC - Investigational
PAK1_HUMAN
GeneCards
Q13153
HPA
ENSG00000149269-PAK1
Ensembl
ENSP00000348696
,
ENSG00000149269
,
ENST00000356341
,
ENSP00000278568
,
ENST00000278568
Pharos - Targets
Q13153
ZINC - Predictions - Purchasable
PAK1_HUMAN
HMDB Protein
HMDBP08499
Interactors (54)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.977
28
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.953
16
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.944
15
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.939
13
UniProt:Q15052 ARHGEF6
1
ARHGEF6 [cytosol]
(R-HSA-195017)
0.798
7
GTP [ChEBI:15996]
7
GTP [cilium]
(R-ALL-5617813)
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [Golgi membrane]
(R-ALL-1806221)
0.778
4
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.744
5
UniProt:P21127 CDK11B
1
CDK11B [cytosol]
(R-HSA-380451)
0.69
4
UniProt:P63001 Rac1
7
RAC1 [ficolin-1-rich granule membrane]
(R-MMU-6804802)
RAC1 [secretory granule membrane]
(R-MMU-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-MMU-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-MMU-5672076)
Rac1 [plasma membrane]
(R-MMU-2316449)
RAC1 [cytosol]
(R-MMU-442615)
Rac1 [plasma membrane]
(R-MMU-421093)
0.688
3
UniProt:P60766 Cdc42
3
CDC42 [endoplasmic reticulum membrane]
(R-MMU-5672086)
CDC42 [cytosol]
(R-MMU-442630)
Cdc42 [plasma membrane]
(R-MMU-448841)
0.688
3
UniProt:Q14161 GIT2
1
GIT2 [cytosol]
(R-HSA-446034)
0.669
4
UniProt:Q9H4E5 RHOJ
1
RHOJ [plasma membrane]
(R-HSA-3006725)
0.666
4
UniProt:P63167 DYNLL1
6
DYNLL1 [ciliary tip]
(R-HSA-5625335)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [cytosol]
(R-HSA-387105)
0.666
4
UniProt:B3KX85 B3KX85
0.645
6
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.643
4
UniProt:P63000-1 RAC1
0.641
3
UniProt:Q92963 RIT1
1
RIT1 [plasma membrane]
(R-HSA-187703)
0.619
4
UniProt:P53667 LIMK1
3
p-S,T508-LIMK1 [cytosol]
(R-HSA-419610)
p-T508-LIMK1 [cytosol]
(R-HSA-399816)
LIMK1 [cytosol]
(R-HSA-397785)
0.619
5
UniProt:P62999
6
RAC1 [ficolin-1-rich granule membrane]
(R-CFA-6804802-2)
RAC1 [secretory granule membrane]
(R-CFA-6804770-2)
GGC-PalmC-RAC1 [plasma membrane]
(R-CFA-2316446-2)
RAC1 [endoplasmic reticulum membrane]
(R-CFA-5672076-2)
RAC1 [cytosol]
(R-CFA-442615-2)
RAC1 [plasma membrane]
(R-CFA-351141-2)
0.617
3
UniProt:Q7L0Q8 RHOU
4
p-Y254-RHOU [endosome membrane]
(R-HSA-9726860)
p-Y254-RHOU [plasma membrane]
(R-HSA-9726857)
RHOU [plasma membrane]
(R-HSA-194914)
RHOU [cytosol]
(R-HSA-194901)
0.589
3
UniProt:Q5PP90 Q5PP90
0.558
2
UniProt:Q96EF9 ZHX1R
0.556
3
UniProt:Q96BD6 SPSB1
1
SPSB1 [cytosol]
(R-HSA-976024)
0.556
3
UniProt:Q9H892-2 TTC12
0.556
3
IntAct:EBI-25839738 CCSB
0.556
3
UniProt:P11117 PPAL
0.556
3
UniProt:Q9BXU0 TEX12
1
TEX12 [nucleoplasm]
(R-HSA-912441)
0.556
3
UniProt:O15273 TCAP
1
TCAP [cytosol]
(R-HSA-390571)
0.556
3
UniProt:Q9Y2M5 KLHL20
1
KLHL20 [cytosol]
(R-HSA-976032)
0.556
3
UniProt:Q15759 MAPK11
4
p-T180,Y182-MAPK11 [nucleoplasm]
(R-HSA-198741)
MAPK11 [nucleoplasm]
(R-HSA-203790)
MAPK11 [cytosol]
(R-HSA-170989)
p-T180,Y182-MAPK11 [cytosol]
(R-HSA-171009)
0.556
3
UniProt:O60830 TIMM17B
2
TIMM17B [mitochondrial intermembrane space]
(R-HSA-1955371)
TIMM17B [mitochondrial inner membrane]
(R-HSA-1252138)
0.556
3
UniProt:P32243-2 OTX2
0.556
3
UniProt:Q8WZ73-3 Q8WZ733
0.556
3
UniProt:Q9NTN9-3 SEMA4G
0.556
3
IntAct:EBI-25839688 CCSB
0.556
3
UniProt:Q8N0Y2-2 ZNF444
0.556
3
UniProt:Q6NZ36-4 FAAP20
0.556
3
UniProt:Q9H0W9-3 C11ORF54
0.556
3
UniProt:O75558 STX11
0.556
3
UniProt:Q14847-2 LASP1
0.556
3
IntAct:EBI-25835277 CCSB
0.556
3
UniProt:Q8TDR4 TCP1L
0.556
3
UniProt:Q96A04 TSACC
0.556
3
UniProt:O60506-4 SYNCRIP
0.556
3
UniProt:Q13322-4 GRB10
0.556
3
UniProt:Q8N490-3 PNKD
0.556
3
UniProt:P35611 ADD1
3
ADD1(634-737) [cytosol]
(R-HSA-202890)
ADD1(1-633) [cytosol]
(R-HSA-202891)
ADD1 [cytosol]
(R-HSA-201623)
0.556
3
UniProt:Q9Y239 NOD1
1
NOD1 [cytosol]
(R-HSA-168407)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P60953-2 CDC42
0.547
2
UniProt:Q9NVF7 FBX28
0.527
4
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.527
3
UniProt:Q15365 PCBP1
1
PCBP1 [nucleoplasm]
(R-HSA-71919)
0.524
2
UniProt:Q05513-1 PRKCZ
0.499
5
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