Reactome | NCK1 [plasma membrane]

NCK1 [plasma membrane]

Stable Identifier

R-HSA-202992

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

NCK1_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P16333 NCK1

Gene Names

NCK1, NCK

Chain

initiator methionine:1, chain:2-377

Reference Genes

BioGPS Gene:4690 NCK1

COSMIC (genes):NCK1 NCK1

CTD Gene:4690 NCK1

dbSNP Gene:4690 NCK1

ENSEMBL:ENSG00000158092.7 NCK1

HGNC:7664 NCK1

KEGG Gene (Homo sapiens):4690 NCK1

Monarch:4690 NCK1

NCBI Gene:4690 NCK1

OMIM:600508 NCK1

UCSC:P16333 NCK1

Reference Transcript

Other Identifiers

11729219_at

16946063

204725_PM_s_at

204725_s_at

211063_PM_s_at

211063_s_at

236922_PM_at

236922_at

244487_PM_at

244487_at

2644156

2644157

2644165

2644168

2644170

2644171

2644172

2644175

2644176

2644177

2644178

2644179

2644195

2644197

2644199

41795_at

4690

77058_at

8082911

81605_at

989_at

A_14_P126342

A_23_P255785

GE59747

GE598177

GO:0000164

GO:0002181

GO:0002376

GO:0004860

GO:0005102

GO:0005515

GO:0005634

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0005886

GO:0005911

GO:0006351

GO:0006355

GO:0006417

GO:0006930

GO:0007010

GO:0007015

GO:0007155

GO:0007165

GO:0007172

GO:0008093

GO:0010976

GO:0012501

GO:0012506

GO:0016477

GO:0019904

GO:0023052

GO:0030032

GO:0030154

GO:0030159

GO:0030334

GO:0030674

GO:0030838

GO:0030971

GO:0033137

GO:0035591

GO:0036211

GO:0036493

GO:0042102

GO:0042110

GO:0043226

GO:0045296

GO:0045944

GO:0046627

GO:0046875

GO:0048013

GO:0048856

GO:0048870

GO:0051707

GO:0060090

GO:0060548

GO:0065003

GO:0070262

GO:0071074

GO:0098772

GO:0140693

GO:1902237

GO:1903676

GO:1903679

GO:1903898

GO:1903912

GO:1990441

HMNXSV003048711

Hs.121645.0.A1_3p_at

Hs.126889.0.A1_3p_at

Hs.126889.0.A1_3p_x_at

ILMN_1698001

ILMN_1821397

PH_hs_0007246

PH_hs_0027654

TC03003323.hg

X17576_at

g13623576_3p_s_at

g5453753_3p_s_at

Participates

as a component of

BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)

Other forms of this molecule

NCK1 [cytosol]

Inferred To

Ghost homologue of NCK1 [plasma membrane] (Xenopus tropicalis)

Homologues of NCK1 [plasma membrane] (Gallus gallus)

Nck1 [plasma membrane] (Mus musculus)

Nck1 [plasma membrane] (Rattus norvegicus)

NCK1 [plasma membrane] (Bos taurus)

NCK1 [plasma membrane] (Canis familiaris)

NCK1 [plasma membrane] (Gallus gallus)

NCK1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_006144.1, NP_001278928.1, NP_001177725.1

OpenTargets

ENSG00000158092

HPA

ENSG00000158092-NCK1

GeneCards

P16333

ZINC target

P16333

Ensembl

ENSP00000419631, ENST00000288986, ENSG00000158092, ENST00000481752, ENST00000469404, ENSP00000288986, ENSP00000417273

PRO

P16333

Pharos - Targets

P16333

PDB

2JW4, 5QU4, 5QU8, 2JS2, 5QU3, 5QUA, 5QU7, 5QU1, 2CUB, 5QU5, 2JS0, 2CI9, 5QU6, 5QU2, 2CI8

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.881	21
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.823	6
UniProt:P07766 CD3E	2	CD3E [plasma membrane] (R-HSA-197906) p-Y188,Y199-CD3E [plasma membrane] (R-HSA-202228)	0.737	6
UniProt:Q13177 PAK2	11	PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) PAK2(213-524) [cytosol] (R-HSA-211653) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) p-5S-PAK2 [cytosol] (R-HSA-211609)	0.709	5
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.672	6
UniProt:Q92918 M4K1			0.646	4
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.611	3
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.609	6
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.597	10
UniProt:Q07912 ACK1			0.59	2
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.589	5
UniProt:Q5WMC9 Q5WMC9			0.584	4
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.573	4
UniProt:P42768 WAS	2	WAS [cytosol] (R-HSA-201879) p-Y291-WAS [cytosol] (R-HSA-2197668)	0.571	3
UniProt:O15117 FYB1	1	FYB [cytosol] (R-HSA-390925)	0.564	3
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.564	2
UniProt:Q5HYW2 NHSL2			0.556	3
UniProt:P52757 CHN2	1	CHN2 [cytosol] (R-HSA-2980572)	0.556	3
UniProt:Q9Y2H0-1 DLGAP4			0.556	3
UniProt:Q6ZUJ8-3 PIK3AP1			0.556	3
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.536	4
UniProt:P10912 GHR	7	p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226) GHR(257-638) [plasma membrane] (R-HSA-1168803) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(19-638) [endosome lumen] (R-HSA-1169263) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR activated [plasma membrane] (R-HSA-1168385)	0.536	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.527	3
UniProt:O60500 NPHS1	2	p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (R-HSA-373636) NPHS1 [plasma membrane] (R-HSA-8981500)	0.524	3
UniProt:Q05193 DNM1	3	DNM1 [cytosol] (R-HSA-2213182) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [plasma membrane] (R-HSA-177488)	0.524	2
UniProt:Q15208 STK38	1	STK38 [cytosol] (R-HSA-9715143)	0.499	3
UniProt:P35968 KDR	4	p-11Y VEGFR2(20-674)-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636) VEGFR2(20-674)-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) VEGFR2 [plasma membrane] (R-HSA-195382) p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103)	0.499	3
UniProt:Q8TAK6 OLIG1			0.488	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.488	2
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.488	2

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