Reactome | SNAP25(198-206) [cytosol]

SNAP25(198-206) [cytosol]

Stable Identifier

R-HSA-5244499

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Synaptosomal-associated protein 25, residues 198-206

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Uptake and actions of bacterial toxins (Homo sapiens)
      - Neurotoxicity of clostridium toxins (Homo sapiens)
        
        Toxicity of botulinum toxin type A (botA) (Homo sapiens)
        
        botA LC cleaves target cell SNAP25 (Homo sapiens)
        
        SNAP25(198-206) [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
9886085	Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage Vaidyanathan, VV, Yoshino, K, Jahnz, M, Dorries, C, Bade, S, Nauenburg, S, Niemann, H, Binz, T	J Neurochem	1999
8294407	Proteolysis of SNAP-25 by types E and A botulinal neurotoxins Binz, T, Blasi, J, Yamasaki, S, Baumeister, A, Link, E, Südhof, TC, Jahn, R, Niemann, H	J Biol Chem	1994

External Reference Information

External Reference

UniProt:P60880 SNAP25

Gene Names

SNAP25, SNAP

Chain

chain:1-206

Reference Genes

BioGPS Gene:6616 SNAP25

COSMIC (genes):SNAP25 SNAP25

CTD Gene:6616 SNAP25

dbSNP Gene:6616 SNAP25

ENSEMBL:ENSG00000132639 SNAP25

HGNC:11132 SNAP25

KEGG:hsa:6616 SNAP25

Monarch:6616 SNAP25

NCBI Gene:6616 SNAP25

OMIM:600322 SNAP25

UCSC:P60880 SNAP25

Reference Transcript

Participates

as an output of

botA LC cleaves target cell SNAP25 (Homo sapiens)

Other forms of this molecule

SNAP25 [plasma membrane]

SNAP25 [specific granule membrane]

SNAP25 [tertiary granule membrane]

SNAP25(199-206) [cytosol]

SNAP25(1-198) [plasma membrane]

SNAP25(1-197) [plasma membrane]

Disease

Name	Identifier	Synonyms
botulism	DOID:11976	Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning

Cross References

RefSeq

NP_570824.1, XP_005260865.1, NP_001309836.1, NP_001309834.1, NP_001309837.1, XP_054179863.1, NP_001309835.1, XP_016883510.1, NP_001309838.1, XP_016883511.1, NP_001309832.1, NP_001309831.1, NP_001309833.1, NP_001309839.1, NP_001411344.1, NP_003072.2, NP_001411345.1

OpenTargets

ENSG00000132639

ENSEMBL

ENSP00000508939, ENSP00000510219, ENST00000687785, ENST00000691665, ENST00000691161, ENSP00000254976, ENSP00000508837, ENST00000690812, ENST00000693325, ENST00000692411, ENSG00000132639, ENSP00000510558, ENSP00000516314, ENST00000254976, ENSP00000509312, ENSP00000508541, ENSP00000509759, ENST00000685131, ENSP00000307341, ENST00000689757, ENST00000691353, ENSP00000510663, ENST00000689858, ENST00000304886, ENSP00000509287, ENST00000706269, ENSP00000510109

Mondo

0005498

GeneCards

SNAP25

HPA

ENSG00000132639-SNAP25

PRO

P60880

Pharos - Targets

P60880

GlyGen

P60880

Orphanet

SNAP25

HMDB Protein

HMDBP02940

PDB

5W7I, 3RK2, 5W7J, 3RK3, 1XTG, 3RL0, 8BAN, 6JLH, 3DDA, 2N1T, 1KIL, 3DDB, 3ZUR, 8BAV

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75558 STX11			0.667	3
UniProt:P0DTD1-PRO_0000449622 REP			0.556	3
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.553	2
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.547	3
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.527	2
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.527	2
UniProt:Q86Y82 STX12			0.527	2
UniProt:P84077 ARF1	2	ARF1 [Golgi membrane] (R-HSA-199971) ARF1 [cytosol] (R-HSA-200826)	0.512	5
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.502	2
UniProt:Q8IUH5 ZDH17			0.489	3
UniProt:Q9Y3C0 WASC3			0.488	2

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