Reactome | AP2M1 [plasma membrane]

AP2M1 [plasma membrane]

Stable Identifier

R-HSA-167585

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

AP-2 clathrin coat assembly protein, Clathrin -coated Pit Adapter Protein

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Retrograde neurotrophin signalling (Homo sapiens)
        
        Axonal transport of NGF:Trk complexes (Homo sapiens)
        
        Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
        
        Activated TrkA receptor complex:Clathrin-coated vesicle:dynein:dynactin complex [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
        
        Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)
        
        Activated TrkA receptor complex:Clathrin-coated vesicle [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
        
        Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
        
        Formation of clathrin-coated vesicle (Homo sapiens)
        
        Activated TrkA receptor complex:Clathrin-coated vesicle [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - Epsin family proteins bind ubiquitinated cargo (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
  - Gap junction trafficking and regulation (Homo sapiens)
    - Gap junction trafficking (Homo sapiens)
      - Gap junction degradation (Homo sapiens)
        
        Formation of annular gap junctions (Homo sapiens)
        
        Dab2 is recruited to the junctional plaques (Homo sapiens)
        
        planar gap junction plaques [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
        
        Dynamin is recruited to the gap junction plaque (Homo sapiens)
        
        Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)
        
        Internalization of gap junction plaques (Homo sapiens)
        
        Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques [plasma membrane] (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96CW1 AP2M1

Gene Names

AP2M1, CLAPM1, KIAA0109

Chain

chain:1-435

Reference Genes

BioGPS Gene:1173 AP2M1

COSMIC (genes):AP2M1 AP2M1

CTD Gene:1173 AP2M1

dbSNP Gene:1173 AP2M1

ENSEMBL:ENSG00000161203.14 AP2M1

HGNC:564 AP2M1

KEGG Gene (Homo sapiens):1173 AP2M1

Monarch:1173 AP2M1

NCBI Gene:1173 AP2M1

OMIM:601024 AP2M1

UCSC:Q96CW1 AP2M1

Reference Transcript

Other Identifiers

0000870341

11724231_s_at

1173

11746645_x_at

11747195_x_at

11749846_x_at

16948738

200613_PM_at

200613_at

2655477

2655479

2655480

2655481

2655484

2655486

2655490

2655491

2655493

2655494

2655495

2655497

2655498

2655501

2655504

2655505

2655506

2655507

2655508

2655509

2655510

39795_at

8084345

A_33_P3378800

D63475_at

GE57272

GO:0002092

GO:0005048

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005829

GO:0005886

GO:0005905

GO:0006886

GO:0006897

GO:0006900

GO:0008289

GO:0009898

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0030119

GO:0030122

GO:0030131

GO:0030666

GO:0030669

GO:0031410

GO:0031623

GO:0032991

GO:0035615

GO:0036020

GO:0043226

GO:0044325

GO:0045334

GO:0048488

GO:0050750

GO:0051649

GO:0060090

GO:0061024

GO:0065003

GO:0070062

GO:0072583

GO:0072659

GO:0097494

GO:0097718

GO:0098793

GO:0098794

GO:0098884

GO:0098978

GO:1900244

GO:1903077

HMNXSV003025018

ILMN_1699598

ILMN_2402798

PH_hs_0025297

g4757993_3p_x_at

Participates

as a component of

as an input of

Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex (Homo sapiens)

Other forms of this molecule

AP2M1 [lysosomal membrane]

AP2M1 [cytosol]

AP2M1 [clathrin-coated endocytic vesicle membrane]

AP2M1 [endolysosome membrane]

p-T156 AP2M1 [cytosol]

Inferred To

APM4 [plasma membrane] (Saccharomyces cerevisiae)

AP2M1 [plasma membrane] (Bos taurus)

AP2M1 [plasma membrane] (Canis familiaris)

AP2M1 [plasma membrane] (Danio rerio)

AP2M1 [plasma membrane] (Drosophila melanogaster)

AP2M1 [plasma membrane] (Gallus gallus)

AP2M1 [plasma membrane] (Mus musculus)

AP2M1 [plasma membrane] (Plasmodium falciparum)

AP2M1 [plasma membrane] (Rattus norvegicus)

AP2M1 [plasma membrane] (Sus scrofa)

AP2M1 [plasma membrane] (Xenopus tropicalis)

apm4 [plasma membrane] (Schizosaccharomyces pombe)

dpy-23 [plasma membrane] (Caenorhabditis elegans)

Homologues of AP2M1 [plasma membrane] (Danio rerio)

apm2 [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001298127.1, NP_004059.2, NP_001020376.1

OpenTargets

ENSG00000161203

HPA

ENSG00000161203-AP2M1

GeneCards

Q96CW1

Ensembl

ENST00000439647, ENSP00000371894, ENST00000292807, ENSP00000292807, ENSG00000161203, ENST00000382456, ENSP00000409081

PRO

Q96CW1

Pharos - Targets

Q96CW1

Orphanet

28614

HMDB Protein

HMDBP14128

PDB

6BNT, 1H6E, 6URI

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.767	7
UniProt:Q7Z3C6 ATG9A	1	ATG9A [phagophore assembly site membrane] (R-HSA-5671732)	0.75	8
UniProt:Q92609 TBCD5			0.737	4
UniProt:P63010 AP2B1	4	AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166)	0.678	3
UniProt:Q9UHP6 RSP14			0.666	6
UniProt:P29353 SHC1	5	SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.643	5
UniProt:Q2M2I8 AAK1	1	AAK1 [cytosol] (R-HSA-8854795)	0.643	3
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.593	3
UniProt:Q96MH2 HEXI2			0.556	3
UniProt:P35268 RPL22	1	RPL22 [cytosol] (R-HSA-72428)	0.556	3
UniProt:Q9BSU3 NAA11			0.556	3
UniProt:Q9NZ81 PRR13			0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:Q9P0T4 ZN581			0.556	3
UniProt:Q6ZUT1 NKAP1			0.556	3
UniProt:Q8N9N8 EIF1A			0.556	3
IntAct:EBI-16429620 CCSB ORF ID			0.556	3
UniProt:Q96EY4 TMA16			0.556	3
UniProt:Q8N8X9 MB213			0.556	5
UniProt:P62807 H2BC4	9	HIST1H2BC [extracellular region] (R-HSA-977564) Ub-HIST1H2BC [nucleoplasm] (R-HSA-6782552) AcK-HIST1H2BC [nucleoplasm] (R-HSA-4549246) AcK16-HIST1H2BC [nucleoplasm] (R-HSA-4568634) AcK6-HIST1H2BC [nucleoplasm] (R-HSA-4568623) AcK13-HIST1H2BC [nucleoplasm] (R-HSA-4568620) AcK21-HIST1H2BC [nucleoplasm] (R-HSA-4568626) Ub-121-HIST1H2BC [nucleoplasm] (R-HSA-3364029) HIST1H2BC [nucleoplasm] (R-HSA-181906)	0.556	5
UniProt:Q86YD7 F90A1			0.556	5
UniProt:Q1ED39 KNOP1			0.556	3
UniProt:Q99880 H2BC13	9	HIST1H2BL [extracellular region] (R-HSA-977579) Ub-HIST1H2BL [nucleoplasm] (R-HSA-6782543) AcK-HIST1H2BL [nucleoplasm] (R-HSA-4549254) AcK13-HIST1H2BL [nucleoplasm] (R-HSA-4568650) AcK16-HIST1H2BL [nucleoplasm] (R-HSA-4568697) AcK6-HIST1H2BL [nucleoplasm] (R-HSA-4568719) AcK21-HIST1H2BL [nucleoplasm] (R-HSA-4568674) Ub-121-HIST1H2BL [nucleoplasm] (R-HSA-3364013) HIST1H2BL [nucleoplasm] (R-HSA-181920)	0.556	3
UniProt:Q00013 MPP1	1	MPP1 [plasma membrane] (R-HSA-420423)	0.556	5
UniProt:Q9BU76 MMTAG2	3	MMTAG2 [secretory granule lumen] (R-HSA-6801073) MMTAG2 [extracellular region] (R-HSA-6806452) MMTAG2 [ficolin-1-rich granule lumen] (R-HSA-6801074)	0.556	3
UniProt:Q03393 PTS	2	PTS [cytosol] (R-HSA-1475061) p-S19-PTS [cytosol] (R-HSA-1475426)	0.556	3
UniProt:Q68CQ4 UTP25	1	DIEXF [nucleoplasm] (R-HSA-6790689)	0.556	5
UniProt:Q16778 H2BC21	9	HIST2H2BE [extracellular region] (R-HSA-977571) Ub-HIST2H2BE [nucleoplasm] (R-HSA-6782539) Ack-HIST2H2BE [nucleoplasm] (R-HSA-4549257) AcK13-HIST2H2BE [nucleoplasm] (R-HSA-4568651) AcK21-HIST2H2BE [nucleoplasm] (R-HSA-4568716) AcK6-HIST2H2BE [nucleoplasm] (R-HSA-4568679) AcK16-HIST2H2BE [nucleoplasm] (R-HSA-4568660) Ub-121-HIST2H2BE [nucleoplasm] (R-HSA-3364018) HIST2H2BE [nucleoplasm] (R-HSA-181908)	0.556	3
UniProt:P0DPH9 CX05B			0.556	3
UniProt:Q8NAV1 PRPF38A	1	PRPF38A [nucleoplasm] (R-HSA-8867897)	0.556	5
UniProt:Q99633 PRPF18	1	PRPF18 [nucleoplasm] (R-HSA-5688093)	0.556	3
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	5
UniProt:P51116 FXR2			0.553	2
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.553	2
UniProt:P27958-PRO_0000037566			0.543	4
UniProt:O94973 AP2A2	6	AP2A2(1-939) [endolysosome membrane] (R-HSA-6784819) AP2A2(1-939) [secretory granule membrane] (R-HSA-6800412) AP2A2(1-939) [ficolin-1-rich granule membrane] (R-HSA-6800414) AP2A2(1-939) [plasma membrane] (R-HSA-177502) AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138448) AP2A2(1-939) [cytosol] (R-HSA-182155)	0.527	2
UniProt:P0DTD1-PRO_0000449628 REP			0.527	2
UniProt:P42566 EPS15	2	EPS15 [cytosol] (R-HSA-182920) p-Y850 EPS15 [cytosol] (R-HSA-8867028)	0.527	3
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.527	4
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q01968 OCRL	4	OCRL [Golgi membrane] (R-HSA-434339) OCRL [cytoplasmic vesicle membrane] (R-HSA-434214) OCRL [plasma membrane] (R-HSA-3769049) OCRL [cytosol] (R-HSA-1806196)	0.508	3
UniProt:P51114 FXR1	2	FXR1(2-784)-BRAF(381-766) fusion [cytosol] (R-HSA-6802326) FXR1(2-784)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802530)	0.508	2
UniProt:A9UF07 A9UF07			0.462	2

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