K63polyUb-PIK3R1

Stable Identifier
R-HSA-3080572
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
K63polyUb-PI3K p85 alpha, K63polyUb-Phosphatidylinositol 3-kinase regulatory alpha subunit, K63polyUb-PI3-kinase p85-alpha subunit, K63polyUb-PtdIns-3-kinase p85-alpha
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
11087752 Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells

Fang, D, Wang, HY, Fang, N, Altman, Y, Elly, C, Liu, YC

J Biol Chem 2001
11526404 Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells

Fang, D, Liu, YC

Nat Immunol 2001
External Reference Information
External Reference
Gene Names
PIK3R1, GRB1
Chain
initiator methionine:1, chain:2-724
Other Identifiers
0000770592
0001190184
0004610204
0005050156
11733017_a_at
11733018_s_at
11733019_a_at
11739539_a_at
11739540_a_at
11739541_a_at
11748670_a_at
11754631_x_at
1216
1269_at
16985518
1A0N
1AZG
1H9O
1PBW
1PHT
1PIC
1PKS
1PKT
212239_at
212240_s_at
212249_at
2813092
2813101
2813102
2813103
2813125
2813127
2813132
2813134
2813135
2813137
2813140
2813142
2813143
2813145
2813146
2813148
2813150
2813152
2813153
2813154
2813155
2813156
2813157
2813158
2813159
2IUG
2IUH
2IUI
2RD0
2V1Y
35373_at
3HHM
3HIZ
3I5R
3I5S
4268
44015_at
4A55
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4WAF
4YKN
4ZOP
5295
55623_at
5AUL
5FI4
5GJI
5ITD
5M6U
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBT
5UK8
5UKJ
5UL1
5VLR
73148_at
73150_g_at
77475_at
8105778
A_14_P105607
A_23_P144980
A_24_P29401
AAB04140
AAH30815
AAH94795
AAO15359
AC016564
AC104120
AF279367
AK094785
AK223613
BAD97333
BAG52931
BC030815
BC094795
CAB004268
CCDS3993
CCDS3994
CCDS3995
CCDS56374
CH471137
EAW51312
EAW51313
ENSG00000145675
ENSP00000323512
ENSP00000338554
ENSP00000428056
ENSP00000429277
ENSP00000430098
ENST00000320694
ENST00000336483
ENST00000521381
ENST00000521657
ENST00000523872
EntrezGene:5295
GE58013
GE85962
GO:0000902
GO:0001678
GO:0001784
GO:0001953
GO:0002376
GO:0003674
GO:0004871
GO:0005068
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005783
GO:0005801
GO:0005829
GO:0005886
GO:0005911
GO:0005942
GO:0005943
GO:0006464
GO:0006468
GO:0006605
GO:0006629
GO:0006661
GO:0006810
GO:0006913
GO:0006950
GO:0007009
GO:0007010
GO:0007155
GO:0007162
GO:0007165
GO:0007173
GO:0007186
GO:0007411
GO:0008134
GO:0008150
GO:0008219
GO:0008286
GO:0008625
GO:0008630
GO:0009058
GO:0014065
GO:0015031
GO:0016020
GO:0016032
GO:0016192
GO:0016301
GO:0016303
GO:0019221
GO:0019899
GO:0019903
GO:0022607
GO:0030154
GO:0030168
GO:0030183
GO:0030234
GO:0030335
GO:0030674
GO:0031295
GO:0032760
GO:0032869
GO:0033120
GO:0034641
GO:0034644
GO:0034976
GO:0035014
GO:0036092
GO:0036312
GO:0038095
GO:0038096
GO:0038128
GO:0040011
GO:0042592
GO:0042993
GO:0043066
GO:0043125
GO:0043226
GO:0043548
GO:0043551
GO:0043559
GO:0043560
GO:0044403
GO:0045671
GO:0045944
GO:0046326
GO:0046626
GO:0046854
GO:0046934
GO:0046935
GO:0046982
GO:0048009
GO:0048010
GO:0048015
GO:0048856
GO:0048870
GO:0050821
GO:0050852
GO:0050900
GO:0051492
GO:0051531
GO:0051897
GO:0060396
GO:0061024
GO:1900103
GO:1903076
GO:1903078
GO:1990578
GO:2001275
HGNC:8979
HPA001216
Hs.6241.0.S1_3p_a_at
Hs.6241.0.S2_3p_at
Hs.6241.0.S3_3p_at
ILMN_1689057
ILMN_1691433
ILMN_1760303
ILMN_2289433
ILMN_2398235
IPR000198
IPR000980
IPR001452
IPR001720
IPR008936
IPR032498
IPR035020
IPR035022
IPR035591
IPR036028
IPR036860
M61906
M61906_at
MIM:171833
MIM:269880
MIM:615214
MIM:616005
NM_001242466
NM_181504
NM_181523
NM_181524
NP_001229395
NP_852556
NP_852664
NP_852665
PF00017
PF00620
PF16454
PH_hs_0021977
PIK3R1
PIK3R1-201
PIK3R1-202
PIK3R1-211
PIK3R1-213
PIK3R1-216
PR00401
PR00678
SM00252
SM00324
SM00326
TC05000291.hg
U49349
uc003jva.4
uc003jvc.4
uc003jvd.4
uc021xzn.2
uc063edr.1
UPI00000743EC
UPI000013D9FF
UPI000014094F
UPI0000E5AC63
XM_005248542
XM_011543493
XM_017009585
XM_017009586
XP_005248599
XP_011541795
XP_016865074
XP_016865075
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ZINC - World Drugs
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Metabolites
GeneCards
BRENDA (Homo sapiens)
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (70)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P42336 PIK3CA  25 0.957 22
 UniProt:P09619 PDGFRB  3 0.948 19
 UniProt:P22681 CBL  7 0.94 16
 UniProt:P21860 ERBB3      0.921 41
 UniProt:P35568 IRS1  4 0.921 13
 UniProt:P10747 CD28  3 0.892 8
 UniProt:P62993 GRB2  1 0.863 6
 UniProt:P29353 SHC1  5 0.829 6
 UniProt:P12931 SRC  4 0.822 7
 UniProt:Q13480 GAB1  3 0.796 33
 UniProt:P60953 CDC42  3 0.794 10
 UniProt:P00533 EGFR  58 0.779 6
 UniProt:P10721 KIT  4 0.77 19
 UniProt:P08069 IGF1R  3 0.752 4
 UniProt:O00329 PIK3CD  2 0.744 6
 UniProt:P62999 RAC1      0.717 5
 UniProt:P42338 PIK3CB  1 0.688 3
 UniProt:P04626 ERBB2  12 0.688 11
 UniProt:P06213 INSR  6 0.688 3
 UniProt:Q9Y4H2 IRS2  4 0.688 3
 UniProt:P03496 NS  2 0.659 6
 UniProt:P16410 CTLA4  2 0.643 3
 UniProt:P30874 SSTR2  1 0.639 5
 UniProt:P45983 MAPK8  3 0.623 6
 UniProt:P11362 FGFR1  8 0.623 5
 UniProt:P10398 ARAF  4 0.611 3
 UniProt:P48023 FASLG  1 0.609 2
 UniProt:Q99152 VP3      0.591 3
 UniProt:P16885 PLCG2  9 0.589 2
 UniProt:P49023 PXN  4 0.589 2
 UniProt:P46109 CRKL  2 0.589 2
 UniProt:P61981 YWHAG  1 0.589 2
 UniProt:P62994 Grb2  3 0.589 2
 UniProt:Q07889 SOS1  3 0.589 3
 UniProt:P43405 SYK  6 0.581 5
 UniProt:P41970 ELK3      0.573 2
 UniProt:O43493 TGOLN2  8 0.564 2
 UniProt:P35570 Irs1  2 0.564 2
 UniProt:Q9UQC2 GAB2  4 0.564 2
 UniProt:Q13111 CAF1A      0.564 2
 UniProt:P17948 FLT1  1 0.564 2
 UniProt:P46108 CRK  1 0.564 2
 UniProt:P03372 ESR1  4 0.564 7
 UniProt:P19793 RXRA  3 0.556 8
 UniProt:P42858 HD      0.553 7
 UniProt:Q13746 Q13746      0.544 3
 UniProt:Q86VI4-3 LAPTM4B      0.524 2
 UniProt:O15455 TLR3  6 0.524 2
 UniProt:Q8BM65-4 NYAP2      0.524 3
 UniProt:Q8IY22 CMIP      0.524 2
 UniProt:P48025 Syk  6 0.524 2
 UniProt:Q6PFX7 NYAP1      0.524 4
 UniProt:Q9Y6W8 ICOS      0.499 3
 UniProt:P43626 KIR2DL1  1 0.488 2
 UniProt:P58753 TIRAP  2 0.463 3
 UniProt:P21145 MAL      0.463 3
 UniProt:O00329-2 PIK3CD      0.463 2
 UniProt:P30875  1 0.462 2
 UniProt:O14733 MAP2K7  4 0.462 3
 UniProt:Q16584 MAP3K11  1 0.462 3
 UniProt:P04629 NTRK1  4 0.462 2
 UniProt:Q8TDQ0 HAVCR2  1 0.462 2
 UniProt:P06127 CD5      0.462 2
 UniProt:P30530 AXL  2 0.462 2
 UniProt:P45984 MAPK9  3 0.462 3
 UniProt:P63000 RAC1  6 0.462 5
 UniProt:P25963 NFKBIA  12 0.462 2
 UniProt:P32927 CSF2RB  6 0.462 4
 UniProt:O43561 LAT  3 0.462 4
 UniProt:P29350 PTPN6  5 0.462 2