Reactome | Polyglutamyl-TUBA1A [cytosol]

Polyglutamyl-TUBA1A [cytosol]

Stable Identifier

R-HSA-8867408

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBA1A, alpha tubulin 3

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA1A [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA1A [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA1A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q71U36 TUBA1A

Gene Names

TUBA1A, TUBA3

Chain

chain:1-451, chain:1-450

Reference Genes

BioGPS Gene:7846 TUBA1A

COSMIC (genes):TUBA1A TUBA1A

CTD Gene:7846 TUBA1A

dbSNP Gene:7846 TUBA1A

ENSEMBL:ENSG00000167552 TUBA1A

ENSEMBL_homo_sapiens_GENE:ENSG00000167552.15 TUBA1A

HGNC:20766 TUBA1A

KEGG Gene (Homo sapiens):7846 TUBA1A

Monarch:7846 TUBA1A

NCBI Gene:7846 TUBA1A

OMIM:602529 TUBA1A

UCSC:Q71U36 TUBA1A

Reference Transcript

Other Identifiers

11727362_x_at

11757913_x_at

201090_x_at

209118_PM_s_at

209118_s_at

209251_PM_x_at

211058_x_at

211750_PM_x_at

212639_PM_x_at

212639_x_at

213646_PM_x_at

213646_x_at

2872626

3344241

3413815

3413819

3413822

3453739

3453741

3453742

3453746

3453748

3453749

3453838

3453839

3453840

3453841

3453842

3453844

3453845

3453846

3453849

3453850

3453851

3453852

3453853

3453855

3453856

3453857

3453858

3453859

3453860

3640627

40567_at

59760_f_at

7846

7963054

A_23_P139547

GE541560

GO:0000166

GO:0000226

GO:0000278

GO:0000793

GO:0001764

GO:0001964

GO:0003824

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0005737

GO:0005768

GO:0005829

GO:0005856

GO:0005874

GO:0005879

GO:0005881

GO:0005886

GO:0005929

GO:0006886

GO:0007010

GO:0007017

GO:0007018

GO:0007098

GO:0007224

GO:0007613

GO:0007626

GO:0008344

GO:0008542

GO:0009612

GO:0010001

GO:0010467

GO:0012501

GO:0015630

GO:0016787

GO:0021542

GO:0021696

GO:0021766

GO:0021859

GO:0021987

GO:0022008

GO:0023052

GO:0030154

GO:0030182

GO:0030534

GO:0030705

GO:0031410

GO:0031594

GO:0034330

GO:0034612

GO:0035641

GO:0036464

GO:0042802

GO:0043226

GO:0044877

GO:0045202

GO:0046785

GO:0046872

GO:0046982

GO:0048853

GO:0048856

GO:0048870

GO:0048873

GO:0050807

GO:0050808

GO:0050877

GO:0051301

GO:0051402

GO:0055037

GO:0061744

GO:0065003

GO:0070062

GO:0071277

GO:0072384

GO:0140058

GO:1902065

HMNXSV003015261

ILMN_1742981

ILMN_2148819

TC12000363.hg

TC12001472.hg

TC12002866.hg

X01703_at

g4929133_3p_s_at

Participates

as a candidate of

Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

AcK-TUBA1A [cytosol]

Ac K40 TUBA1A [axonemal microtubule]

TUBA1A folding intermediate [cytosol]

TUBA1A unfolded [cytosol]

L-isoglutamyl polyglycyl-TUBA1A [cytosol]

TUBA1A(1-450) [cytosol]

TUBA1A [cytosol]

TUBA1A [axonemal microtubule]

Inferred To

TUBA1A [cytosol] (Sus scrofa)

Polyglutamyl-TUBA1A [cytosol] (Dictyostelium discoideum)

Polyglutamyl-TUBA1A [cytosol] (Mus musculus)

Polyglutamyl-TUBA1A [cytosol] (Plasmodium falciparum)

Polyglutamyl-TUBA1A [cytosol] (Rattus norvegicus)

Homologues of Polyglutamyl-TUBA1A [cytosol] (Dictyostelium discoideum)

Homologues of Polyglutamyl-TUBA1A [cytosol] (Plasmodium falciparum)

Homologues of Polyglutamyl-TUBA1A [cytosol] (Xenopus tropicalis)

tuba1cl.3 [cytosol] (Xenopus tropicalis)

TUBA1C [cytosol] (Bos taurus)

tuba1cl [cytosol] (Xenopus tropicalis)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_001257328.1, NP_006000.2, NP_001257329.1

Guide to Pharmacology - Targets

2638

OpenTargets

ENSG00000167552

HPA

ENSG00000167552-TUBA1A

GeneCards

Q71U36

Ensembl

ENST00000550767, ENST00000547939, ENSP00000446637, ENSP00000450268, ENST00000301071, ENSP00000439020, ENSP00000448725, ENST00000552924, ENSP00000301071, ENSG00000167552, ENST00000295766

PRO

Q71U36

Pharos - Targets

Q71U36

Orphanet

17324

PDB

8J07, 6WSL, 7UN1, 7C1M, 6J8F, 7UNG, 5JCO

HMDB Protein

HMDBP08593

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.745	4
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.725	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.687	7
UniProt:P31689 DNAJA1	2	SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072) DNAJA1 [cytosol] (R-HSA-3371544)	0.671	6
UniProt:Q8N0Z6 TTC5	3	TTC5 [nucleoplasm] (R-HSA-6804264) p-S203-TTC5 [nucleoplasm] (R-HSA-6804261) p-S203,S221-TTC5 [nucleoplasm] (R-HSA-6804259)	0.615	3
UniProt:Q9NQC7 CYLD	3	K48polyUb-K338, K530-CYLD [cytosol] (R-HSA-9818664) p-S418-CYLD [cytosol] (R-HSA-5212667) CYLD [cytosol] (R-HSA-741420)	0.576	6
UniProt:Q9UBX3 SLC25A10	1	SLC25A10 [mitochondrial inner membrane] (R-HSA-372848)	0.569	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	4
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.564	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.547	5
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.534	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	2
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	3
UniProt:P42677 RPS27	2	RPS27 [nucleoplasm] (R-HSA-6791190) RPS27 [cytosol] (R-HSA-72361)	0.527	2
UniProt:A6NED2 RCCD1	2	3OHR141-RCCD1 [cytosol] (R-HSA-9629871) RCCD1 [cytosol] (R-HSA-9629873)	0.527	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	4
UniProt:Q07954 LRP1	2	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981)	0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	3
UniProt:Q9HC77 CENPJ	2	CENPJ [cytosol] (R-HSA-380291) p-S589,S595-CENPJ [cytosol] (R-HSA-6801670)	0.483	2
UniProt:Q9H0U3 MAGT1	2	MAGT1 [azurophil granule membrane] (R-HSA-6799208) MAGT1 [plasma membrane] (R-HSA-4836523)	0.483	3

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