APP(714-770) [endosome lumen]

Stable Identifier
R-HSA-6783325
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Gamma-secretase C-terminal fragment 57, Amyloid beta A4 protein precursor, ABPP, Alzheimer's disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA4, Soluble APP-alpha, S-APP- alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), Gamma-CTF(59), Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AID(59), Gamma-CTF(57), Gamma- secretase C-terminal fragment 57, Amyloid intracellular domain 57, AID(57), Gamma-CTF(50), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AID(50), C31
APP(714-770) [endosome lumen] icon
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
APP, A4, AD1
Chain
signal peptide:1-17, chain:18-770, chain:18-687, chain:18-671, chain:18-286, chain:672-770, chain:672-713, chain:672-711, chain:688-770, peptide:688-713, peptide:688-711, chain:691-770, chain:712-770, chain:714-770, chain:721-770, chain:740-770
Other Identifiers
0001230601
11738008_s_at
11741216_x_at
11742210_a_at
11742211_x_at
11742215_s_at
11746866_a_at
11750384_a_at
11751350_a_at
11752199_a_at
11752200_x_at
11752481_a_at
11762804_x_at
16924551
200602_at
211277_3p_x_at
211277_x_at
214953_s_at
351
3927225
3927227
3927228
3927229
3927230
3927233
3927234
3927237
3927241
3927242
3927262
3927264
3927271
3927272
3927273
3927274
3927281
3927282
3927289
3927298
3927300
3927301
3927306
3927307
3927320
3927335
3927336
3927337
41136_s_at
64309_f_at
8069644
A_24_P314159
A_33_P3296479
A_33_P3508822
GE57419
GO:0000003
GO:0000278
GO:0000902
GO:0000978
GO:0001774
GO:0001934
GO:0001967
GO:0002265
GO:0002376
GO:0002576
GO:0003674
GO:0003677
GO:0004867
GO:0005102
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005635
GO:0005641
GO:0005737
GO:0005768
GO:0005769
GO:0005783
GO:0005788
GO:0005790
GO:0005791
GO:0005794
GO:0005796
GO:0005798
GO:0005829
GO:0005856
GO:0005886
GO:0005887
GO:0005905
GO:0005911
GO:0005929
GO:0005975
GO:0006091
GO:0006378
GO:0006397
GO:0006412
GO:0006417
GO:0006464
GO:0006468
GO:0006629
GO:0006810
GO:0006878
GO:0006892
GO:0006897
GO:0006915
GO:0006950
GO:0006979
GO:0007049
GO:0007155
GO:0007165
GO:0007176
GO:0007186
GO:0007219
GO:0007267
GO:0007399
GO:0007409
GO:0007568
GO:0007611
GO:0007612
GO:0007617
GO:0007626
GO:0008021
GO:0008088
GO:0008150
GO:0008201
GO:0008203
GO:0008219
GO:0008283
GO:0008285
GO:0008344
GO:0008542
GO:0009056
GO:0009058
GO:0009314
GO:0009986
GO:0009987
GO:0010288
GO:0010466
GO:0010468
GO:0010628
GO:0010629
GO:0010800
GO:0010951
GO:0010952
GO:0010971
GO:0014005
GO:0016020
GO:0016021
GO:0016192
GO:0016199
GO:0016322
GO:0016358
GO:0016504
GO:0019899
GO:0021700
GO:0022607
GO:0030111
GO:0030134
GO:0030154
GO:0030198
GO:0030234
GO:0030414
GO:0030424
GO:0030426
GO:0030546
GO:0030705
GO:0030900
GO:0031093
GO:0031175
GO:0031410
GO:0031594
GO:0031904
GO:0032092
GO:0032588
GO:0032722
GO:0032731
GO:0032755
GO:0032760
GO:0032991
GO:0033138
GO:0034330
GO:0034641
GO:0035235
GO:0035253
GO:0035590
GO:0040007
GO:0040011
GO:0040014
GO:0042327
GO:0042592
GO:0042802
GO:0042995
GO:0043005
GO:0043167
GO:0043197
GO:0043198
GO:0043204
GO:0043226
GO:0043235
GO:0043393
GO:0043687
GO:0044267
GO:0044281
GO:0044304
GO:0045048
GO:0045087
GO:0045121
GO:0045177
GO:0045202
GO:0045665
GO:0045821
GO:0045931
GO:0045944
GO:0046330
GO:0046872
GO:0046914
GO:0048143
GO:0048169
GO:0048471
GO:0048669
GO:0048786
GO:0048856
GO:0048870
GO:0050729
GO:0050730
GO:0050803
GO:0050808
GO:0050877
GO:0050885
GO:0050890
GO:0051091
GO:0051092
GO:0051124
GO:0051233
GO:0051247
GO:0051402
GO:0051425
GO:0051563
GO:0055037
GO:0055085
GO:0061024
GO:0070062
GO:0070374
GO:0070555
GO:0070851
GO:0071280
GO:0071287
GO:0071320
GO:0071874
GO:0090647
GO:0097449
GO:0098815
GO:0150003
GO:1900272
GO:1900273
GO:1901224
GO:1904646
GO:1905606
GO:1905908
GO:1990000
GO:1990090
GO:1990535
GO:1990761
GO:1990812
GO:2000310
GO:2000406
HMNXSV003024560
Hs.177486.2.A1_3p_a_at
ILMN_1653283
ILMN_1678152
ILMN_2404063
ILMN_2404065
PH_hs_0010546
TC21000340.hg
TC21000887.hg
Y00264_at
g4502166_3p_at
Participates
Other forms of this molecule
Cross References
OpenTargets
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
GlyGen
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (389)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P05067 APP  20 0.993 107
 UniProt:P56817 BACE1  8 0.865 11
 UniProt:O00213 APBB1  1 0.839 7
 UniProt:P04156 PRNP  2 0.775 6
 UniProt:P10636 MAPT  3 0.749 8
 UniProt:Q99714 HSD17B10  1 0.747 7
 UniProt:P02647 APOA1  11 0.747 8
 UniProt:O95704 APBB3      0.742 5
 UniProt:P27797 CALR  6 0.737 5
 UniProt:Q9UQF2 JIP1      0.72 5
 UniProt:P61812 TGFB2  3 0.705 7
 UniProt:P09936 UCHL1  1 0.703 5
 UniProt:P30101 PDIA3  3 0.703 6
 UniProt:Q92673 SORL1  2 0.69 5
 UniProt:Q92876 KLK6      0.683 4
 UniProt:P05412 JUN  4 0.675 5
 UniProt:Q92529 SHC3  2 0.675 5
 UniProt:Q9Y287 ITM2B  1 0.675 4
 UniProt:P49810 PSEN2  2 0.675 4
 UniProt:P02511 CRYAB  1 0.666 7
 UniProt:P11142 HSPA8  10 0.666 8
 UniProt:P61764 STXBP1  2 0.666 7
 UniProt:P18669 PGAM1  4 0.666 4
 UniProt:P07437 TUBB  3 0.666 5
 UniProt:P07900 HSP90AA1  8 0.666 5
 UniProt:P62937 PPIA  5 0.666 4
 UniProt:P60709 ACTB  5 0.666 8
 UniProt:P42574 CASP3  5 0.659 4
 UniProt:O14672 ADAM10  6 0.659 7
 UniProt:P37840 SNCA  4 0.659 6
 UniProt:P36544 CHRNA7  1 0.646 4
 UniProt:Q02410 APBA1  1 0.646 4
 UniProt:Q13526 PIN1  2 0.646 4
 UniProt:Q92870 APBB2      0.635 3
 UniProt:P49768 PSEN1  6 0.632 6
 UniProt:O35431 Apba2  1 0.618 5
 UniProt:P01137 TGFB1  6 0.604 3
 UniProt:Q99767 APBA2  1 0.592 2
 UniProt:Q9NP59 SLC40A1  7 0.589 5
 UniProt:P29353 SHC1  5 0.589 6
 UniProt:P42704 LRPPRC  1 0.584 8
 UniProt:Q13625 TP53BP2  1 0.581 3
 UniProt:O75955 FLOT1  1 0.581 5
 UniProt:P08138 NGFR  7 0.558 2
 UniProt:Q16650 TBR1      0.556 3
 UniProt:P62942 FKBP1A  1 0.556 3
 UniProt:Q9NY61 AATF  1 0.556 3
 UniProt:P68366 TUBA4A  9 0.556 3
 UniProt:P14625 HSP90B1  4 0.556 3
 UniProt:P68363 TUBA1B  9 0.556 3
 UniProt:Q8IU99 CAHM1      0.556 3
 UniProt:O75888-3 TNFSF13      0.556 3
 UniProt:Q05BL1 Q05BL1      0.556 3
 UniProt:Q99719 SEPT5      0.556 3
 IntAct:EBI-25936029 EBI11820565      0.556 3
 UniProt:Q13393 PLD1  4 0.556 3
 UniProt:Q8WW43 APH1B  2 0.556 3
 UniProt:Q6IPE9 Q6IPE9      0.556 3
 UniProt:P0DP24 CALM      0.556 3
 UniProt:P14735 IDE  4 0.556 3
 UniProt:P43405-2 P434052      0.556 3
 UniProt:P02766 TTR  2 0.556 3
 UniProt:Q13148 TADBP      0.556 6
 IntAct:EBI-25936019 CCSB      0.556 3
 UniProt:P19544-6 WT1      0.556 3
 UniProt:Q6ZNA4-2 Q6ZNA42      0.556 3
 UniProt:P48730 CSNK1D  3 0.556 3
 UniProt:O43236 SEPTIN4      0.556 3
 UniProt:O60260-5 PRKN      0.556 5
 UniProt:Q96FW1 OTUB1  2 0.556 3
 IntAct:EBI-25880053 IOH23180      0.556 3
 UniProt:Q13113 PDZ1I      0.556 3
 UniProt:P48736 PIK3CG  1 0.556 3
 UniProt:Q16740 CLPP      0.556 3
 IntAct:EBI-25936001 CCSB      0.556 3
 UniProt:Q6AZY7-2 Q6AZY72      0.556 3
 UniProt:Q9BYZ2 LDHAL6B  1 0.556 3
 UniProt:P00491 PNP  4 0.556 9
 UniProt:Q9UJC3 HOOK1      0.556 3
 UniProt:Q9BX74 TM2D1      0.556 3
 UniProt:P49711 CTCF  1 0.556 3
 UniProt:P16234-2 PDGFRA      0.556 3
 UniProt:Q16512 PKN1  3 0.556 3
 UniProt:O14939 PLD2  2 0.556 3
 UniProt:P11277 SPTB  1 0.556 6
 UniProt:Q96S59 RANBP9  1 0.556 3
 UniProt:Q14790 CASP8  8 0.556 3
 UniProt:Q00266 MAT1A  4 0.556 3
 UniProt:Q06481-5 APLP2      0.556 3
 UniProt:P41586-2 ADCYAP1R1      0.556 3
 UniProt:Q9GZS3 WDR61  2 0.556 3
 UniProt:Q9BS26 ERP44  2 0.556 3
 IntAct:EBI-25934154 EBI16882364      0.556 3
 UniProt:O75116 ROCK2  2 0.556 6
 UniProt:P21333-2 FLNA      0.556 3
 UniProt:Q00005 2ABB      0.556 3
 UniProt:Q92599-3 SEPTIN8      0.556 3
 UniProt:Q9Y5Q9 GTF3C3  1 0.556 3
 IntAct:EBI-25857140 ORF      0.556 3
 UniProt:Q16828 DUSP6  2 0.556 3
 UniProt:O14662-5 STX16      0.556 3
 UniProt:P60891 PRPS1  1 0.556 3
 UniProt:Q8WV41 SNX33      0.556 3
 UniProt:O00744 WNT10B  9 0.556 3
 UniProt:Q8NHT4 Q8NHT4      0.556 3
 UniProt:Q9UGJ0-3 Q9UGJ03      0.556 3
 UniProt:P04406 GAPDH  1 0.556 3
 UniProt:P01011 SERPINA3  4 0.556 3
 UniProt:P01375 TNF  5 0.556 3
 IntAct:EBI-25834291 CCSB      0.556 3
 UniProt:P49755 TMED10  5 0.556 3
 UniProt:O43680 TCF21      0.556 3
 UniProt:P62837 UBE2D2  4 0.556 3
 UniProt:Q13564 NAE1  1 0.556 3
 UniProt:O14901 KLF11      0.556 3
 UniProt:Q13561 DCTN2  1 0.556 3
 UniProt:P23142-4 FBLN1      0.556 3
 UniProt:Q92870-2 Q928702      0.556 3
 UniProt:P41271-2 NBL1      0.556 3
 UniProt:P22694-8 PRKACB      0.556 3
 UniProt:Q8WTV0 SCARB1      0.556 3
 UniProt:Q92993-2 KAT5      0.556 3
 UniProt:P26441 CNTF  1 0.556 3
 UniProt:P17980 PSMC3  5 0.556 6
 UniProt:Q8N895 ZN366      0.556 3
 UniProt:P29466-3 CASP1      0.556 3
 UniProt:O60749 SNX2  2 0.556 3
 UniProt:P12036 NFH      0.556 3
 UniProt:Q96AX1 VP33A      0.556 3
 UniProt:P61204 ARF3  2 0.556 3
 UniProt:Q3B7T1 EDRF1      0.556 3
 UniProt:P28062-2 PSMB8      0.556 3
 UniProt:P01034 CST3  6 0.556 3
 UniProt:P46379-2 BAG6      0.556 5
 UniProt:Q15583-2 TGIF1      0.556 3
 UniProt:Q13303 KCNAB2  3 0.556 3
 UniProt:Q8NE08 Q8NE08      0.556 3
 UniProt:Q01658 DR1  1 0.556 3
 IntAct:EBI-25911596 CCSB      0.556 3
 IntAct:EBI-25939806 RZPDO834E0519D      0.556 3
 UniProt:Q8WUB8-2 PHF10      0.556 3
 UniProt:P07948 LYN  7 0.556 3
 UniProt:P48454 PPP3CC  1 0.556 3
 UniProt:P63010-2 AP2B1      0.556 3
 UniProt:P16671 CD36  5 0.556 3
 IntAct:EBI-25830852 RZPDO839G03145      0.556 3
 UniProt:Q99547 MPHOSPH6  1 0.556 3
 UniProt:O75604-3 USP2      0.556 3
 UniProt:Q13765 NACA      0.556 3
 UniProt:Q92915 FGF14  1 0.556 3
 UniProt:P21917 DRD4  1 0.556 6
 UniProt:P17535 JUND  1 0.556 3
 UniProt:P11171-2 EPB41      0.556 3
 UniProt:Q9P0L2 MARK1      0.556 3
 UniProt:P11171-7 EPB41      0.556 3
 UniProt:Q9C026 TRIM9  1 0.556 3
 UniProt:O94851 MICA2      0.556 3
 UniProt:P10909 CLU  4 0.556 3
 UniProt:A4FUJ8 A4FUJ8      0.556 3
 UniProt:O43852-3 CALU      0.556 3
 UniProt:P30519 HMOX2  3 0.556 3
 UniProt:D3DTS7 D3DTS7      0.556 3
 UniProt:P48730-2 CSNK1D      0.556 3
 UniProt:O14656 TOR1A  1 0.556 3
 UniProt:P07602 PSAP  7 0.556 3
 UniProt:P04216 THY1  2 0.556 3
 UniProt:P42858 HTT  1 0.556 6
 UniProt:Q9UMX0 UBQLN1  1 0.556 3
 UniProt:Q13867 BLMH  1 0.556 3
 UniProt:P43250-2 GRK6      0.556 3
 UniProt:O14645 IDLC      0.556 3
 IntAct:EBI-25891095 CCSB      0.556 3
 UniProt:P05556 ITGB1  2 0.556 3
 UniProt:Q14203-5 DCTN1      0.556 5
 UniProt:Q9Y5Z0 BACE2      0.556 3
 UniProt:O76041 NEBL      0.556 3
 UniProt:P01116-2 KRAS  8 0.556 3
 UniProt:Q6PK61 Q6PK61      0.556 3
 UniProt:P10809 HSPD1  6 0.556 6
 UniProt:P62328 TMSB4X  2 0.556 3
 UniProt:Q15714-2 TSC22D1      0.556 3
 UniProt:Q8TDB4 HUMMR      0.556 3
 UniProt:Q00535 CDK5  4 0.556 3
 UniProt:P13051-2 UNG      0.556 3
 UniProt:P27824-2 P278242      0.556 3
 UniProt:A0AVL1 A0AVL1      0.556 3
 UniProt:Q8TBC4 UBA3  2 0.556 3
 UniProt:P42773 CDKN2C  1 0.556 3
 UniProt:O94985-2 CLSTN1      0.556 3
 UniProt:P20340-2 RAB6A      0.556 3
 UniProt:Q08722-3 CD47      0.556 3
 UniProt:P04271 S100B  1 0.556 3
 UniProt:Q02818 NUCB1  2 0.556 3
 IntAct:EBI-25935974 CCSB      0.556 3
 UniProt:P16112 ACAN  32 0.556 3
 UniProt:Q16363-3 Q163633      0.556 3
 UniProt:P32745 SSTR3  2 0.556 3
 UniProt:Q8N0S8 Q8N0S8      0.556 3
 UniProt:Q8N2W9 PIAS4  2 0.556 3
 UniProt:Q6P4J0 Q6P4J0      0.556 3
 UniProt:P61278 SST  2 0.556 3
 UniProt:Q9Y272 RASD1      0.556 3
 UniProt:Q8N594 MPND      0.556 3
 IntAct:EBI-25935964 CCSB      0.556 3
 UniProt:P61158 ACTR3  1 0.556 3
 UniProt:Q99497 PARK7  7 0.556 3
 UniProt:P30533 AMRP      0.556 3
 UniProt:P0CG47 UBB  109 0.556 3
 UniProt:Q9Y2W7 KCNIP3  1 0.556 3
 UniProt:Q92624 APBP2      0.556 3
 UniProt:P29400-2 COL4A5      0.556 3
 UniProt:P40227 CCT6A  1 0.556 3
 UniProt:Q6DN90-2 Q6DN902      0.556 3
 UniProt:Q8IWL8 STH      0.556 3
 UniProt:Q9ULX5 RN112      0.556 3
 UniProt:Q92993 KAT5  1 0.556 3
 UniProt:P23560-2 BDNF      0.556 3
 IntAct:EBI-25935954 CCSB      0.556 3
 UniProt:P49841-2 GSK3B      0.556 3
 UniProt:P19404 NDUFV2  1 0.556 3
 UniProt:Q16082 HSPB2      0.556 3
 UniProt:P28482 MAPK1  18 0.556 3
 UniProt:P09619 PDGFRB  3 0.556 3
 UniProt:P53778 MAPK12  3 0.556 3
 UniProt:Q92997 DVL3  4 0.556 3
 UniProt:Q99932-2 SPAG8      0.556 3
 UniProt:P04181 OAT  1 0.556 3
 UniProt:Q15084 PDIA6  3 0.556 3
 UniProt:P42338 PIK3CB  1 0.556 3
 UniProt:P06241 FYN  6 0.556 3
 IntAct:EBI-25935944 CCSB      0.556 3
 UniProt:P63151 PPP2R2A  2 0.556 3
 UniProt:O14494 PLPP1  1 0.556 3
 UniProt:P23443-4 RPS6KB1      0.556 3
 UniProt:P02686-2 MBP      0.556 3
 UniProt:Q0P5N6 ARL16      0.556 3
 UniProt:P05026 ATP1B1  1 0.556 3
 UniProt:P15086 CPB1  1 0.556 3
 UniProt:Q9BTD3 TM121      0.556 3
 UniProt:P06493 CDK1  10 0.556 3
 IntAct:EBI-25935934 CCSB      0.556 3
 UniProt:P11940 PABPC1  1 0.556 3
 UniProt:P84022 SMAD3  21 0.556 3
 UniProt:Q6ZW49 PAXIP1  1 0.556 3
 UniProt:Q9BXM7 PINK1  4 0.556 3
 UniProt:P41227 NAA10      0.556 3
 UniProt:Q07954-2 LRP1      0.556 3
 IntAct:EBI-25853226 CCSB      0.556 3
 UniProt:P43405 SYK  7 0.556 3
 UniProt:P17028 ZNF24      0.556 3
 UniProt:P41236 IPP2      0.556 3
 UniProt:Q96GM8 TOE1      0.556 3
 IntAct:EBI-25935916 CCSB      0.556 3
 UniProt:P22612 PRKACG  3 0.556 3
 UniProt:P20674 COX5A  1 0.556 3
 UniProt:P68400 CSNK2A1  2 0.556 3
 UniProt:Q9Y3C5 RNF11      0.556 3
 UniProt:O15392 BIRC5  3 0.556 3
 UniProt:P21673 SAT1  1 0.556 3
 UniProt:O00213-2 APBB1      0.556 6
 UniProt:Q15036 SNX17      0.556 3
 UniProt:P00734 F2  11 0.556 3
 UniProt:Q71U36 TUBA1A  9 0.556 3
 UniProt:P08473 MME  2 0.556 3
 UniProt:Q15172 PPP2R5A  1 0.556 3
 UniProt:Q16143 SNCB  1 0.556 3
 UniProt:Q8WVK1 Q8WVK1      0.556 3
 UniProt:P07384 CAPN1  4 0.556 3
 UniProt:O43508 TNFSF12  2 0.556 3
 UniProt:Q96BI3 APH1A  2 0.556 3
 UniProt:Q9NZR2 LRP1B      0.556 3
 UniProt:Q8IUQ4-2 SIAH1      0.556 3
 UniProt:O14576-5 O145765      0.556 3
 UniProt:P27986-2 PIK3R1      0.556 3
 UniProt:O14576-2 O145762      0.556 3
 UniProt:P43354 NR4A2  2 0.556 3
 UniProt:P00748 F12  11 0.556 3
 UniProt:Q9BTI6 Q9BTI6      0.556 3
 UniProt:P00749 PLAU  6 0.556 3
 UniProt:O96013-2 PAK4      0.556 3
 UniProt:Q16352 AINX      0.556 3
 UniProt:P67775 PPP2CA  4 0.556 3
 UniProt:O96018 APBA3  1 0.556 3
 UniProt:P43681 CHRNA4  1 0.556 3
 UniProt:O60333-2 KIF1B      0.556 3
 UniProt:Q9BVJ6 UTP14A  1 0.556 3
 UniProt:P08253 MMP2  5 0.556 3
 UniProt:Q99714-2 HSD17B10      0.556 3
 UniProt:I6L9F6 I6L9F6      0.556 6
 UniProt:Q07866-2 KLC1      0.556 3
 UniProt:P08247 SYP  1 0.556 3
 UniProt:O14656-2 TOR1A      0.556 3
 UniProt:Q15019-3 SEPTIN2      0.556 3
 UniProt:Q14031 COL4A6  51 0.556 3
 UniProt:P40763-2 STAT3      0.556 3
 UniProt:Q9UNH7 SNX6      0.556 3
 UniProt:Q03013 GSTM4  1