Reactome | MAPK8 [cytosol]

MAPK8 [cytosol]

Stable Identifier

R-HSA-168141

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

JNK1, mitogen-activated protein kinase 8

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-38 signaling (Homo sapiens)
        
        MAPK8 phosphorylation (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated MAPK activation (Homo sapiens)
      - Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P45983 MAPK8

Gene Names

MAPK8, JNK1, PRKM8, SAPK1, SAPK1C

Chain

chain:1-427

Reference Genes

BioGPS Gene:5599 MAPK8

COSMIC (genes):MAPK8 MAPK8

CTD Gene:5599 MAPK8

dbSNP Gene:5599 MAPK8

ENSEMBL:ENSG00000107643 MAPK8

ENSEMBL_homo_sapiens_GENE:ENSG00000107643.17 MAPK8

HGNC:6881 MAPK8

KEGG Gene (Homo sapiens):5599 MAPK8

Monarch:5599 MAPK8

NCBI Gene:5599 MAPK8

OMIM:601158 MAPK8

UCSC:P45983 MAPK8

Reference Transcript

Other Identifiers

11736292_a_at

11747477_a_at

11759192_a_at

16704687

2070_i_at

2071_s_at

210477_PM_x_at

210477_x_at

210671_PM_x_at

210671_x_at

226046_PM_at

226046_at

226048_PM_at

226048_at

229664_PM_at

229664_at

3245685

3245686

3245690

3245693

3245701

3245713

3245714

3245715

3245717

3245718

3245720

3245721

3245723

3245724

3245728

3245731

3245732

3245735

3245739

3245740

3245741

3245742

3245743

3245744

34006_s_at

47790_at

49510_at

49512_at

5599

56901_at

7927389

A_14_P128899

A_23_P202540

A_23_P356152

A_24_P286898

A_33_P3250289

GE57700

GO:0000165

GO:0000166

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004705

GO:0004707

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006468

GO:0006914

GO:0006979

GO:0007254

GO:0007258

GO:0009411

GO:0009612

GO:0010628

GO:0012501

GO:0016241

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0019899

GO:0019903

GO:0023052

GO:0030424

GO:0031281

GO:0031343

GO:0032091

GO:0032880

GO:0033554

GO:0034198

GO:0034599

GO:0034614

GO:0035033

GO:0036211

GO:0038095

GO:0042752

GO:0042826

GO:0043065

GO:0043066

GO:0043226

GO:0045202

GO:0048511

GO:0051247

GO:0051403

GO:0065003

GO:0071222

GO:0071260

GO:0071276

GO:0090398

GO:0097441

GO:0098772

GO:0106310

GO:0120283

GO:0140096

GO:1900227

HMNXSV003013434

Hs.267445.0.S1_3p_at

Hs.267445.0.S2_3p_at

Hs.65228.0.A1_3p_at

ILMN_1849941

ILMN_2308806

ILMN_2364574

PH_hs_0026061

PH_hs_0039294

TC10000322.hg

TC10002063.hg

U35005_s_at

g1463136_3p_a_at

g1463136_3p_s_at

Participates

as a member of

as an input of

Other forms of this molecule

p-T,Y-MAPK8 [cytosol]

p-T,Y-MAPK8 [nucleoplasm]

Inferred To

Homologues of MAPK8 [cytosol] (Dictyostelium discoideum)

MAPK8 [cytosol] (Bos taurus)

MAPK8 [cytosol] (Caenorhabditis elegans)

MAPK8 [cytosol] (Canis familiaris)

MAPK8 [cytosol] (Danio rerio)

MAPK8 [cytosol] (Dictyostelium discoideum)

MAPK8 [cytosol] (Drosophila melanogaster)

MAPK8 [cytosol] (Gallus gallus)

MAPK8 [cytosol] (Mus musculus)

MAPK8 [cytosol] (Rattus norvegicus)

MAPK8 [cytosol] (Saccharomyces cerevisiae)

MAPK8 [cytosol] (Schizosaccharomyces pombe)

MAPK8 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001310255.1, NP_001310256.1, NP_001310250.1, NP_001310260.1, NP_001310252.1, NP_001310259.1, NP_620634.1, NP_001310251.1, NP_620637.1, NP_001310253.1, NP_001310258.1, NP_001265477.1, NP_001310231.1, NP_001310254.1, NP_001310257.1, NP_001265476.1

ZINC - World Drugs

MK08_HUMAN

Guide to Pharmacology - Targets

1496

OpenTargets

ENSG00000107643

ZINC - FDA approved

MK08_HUMAN

ZINC - Substances

MK08_HUMAN

ZINC target

P45983

ZINC - Biogenic

MK08_HUMAN

PRO

P45983

PDB

3ELJ, 4G1W, 3VUD, 8X5M, 1UKH, 2G01, 4AWI, 3O17, 6ZR5, 3VUM, 2XRW, 2XS0, 3O2M, 2GMX, 3V3V, 2H96, 3VUL, 6F5E, 2NO3, 4YR8, 3VUK, 4HYU, 4HYS, 4QTD, 4UX9, 3VUI, 4E73, 3VUH, 5LW1, 3PZE, 4L7F, 4IZY, 3VUG, 1UKI

ZINC - Investigational

MK08_HUMAN

HPA

ENSG00000107643-MAPK8

GeneCards

P45983

Ensembl

ENSP00000363291, ENST00000395611, ENSP00000363294, ENSP00000363297, ENST00000374179, ENSP00000378974, ENSP00000353483, ENST00000374189, ENST00000374176, ENST00000360332, ENSP00000363304, ENST00000374182, ENSG00000107643

Pharos - Targets

P45983

ZINC - Predictions - Purchasable

MK08_HUMAN

HMDB Protein

HMDBP01536

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.854	5
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.773	5
UniProt:Q9UQF2 JIP1			0.708	8
UniProt:P45985 MAP2K4	4	MAP2K4 [cytosol] (R-HSA-168107) p-S257,T261-MAP2K4 [cytosol] (R-HSA-168170) MAP2K4(1-?) [cytosol] (R-HSA-5211402) MAP2K4(?-399) [cytosol] (R-HSA-5211396)	0.688	3
UniProt:Q13202 DUSP8	2	DUSP8 [nucleoplasm] (R-HSA-5675349) DUSP8 [cytosol] (R-HSA-5675348)	0.659	3
UniProt:O43379 WDR62			0.643	3
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.623	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:O14733-2 MAP2K7			0.544	3
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.536	2
UniProt:P29401 TKT	1	TKT [cytosol] (R-HSA-71321)	0.527	2
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.524	3
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.516	2
UniProt:Q8N122 RPTOR	3	RPTOR [nucleoplasm] (R-HSA-5083664) RPTOR [cytosol] (R-HSA-3006727) p-S722,S792-RPTOR [cytosol] (R-HSA-3132767)	0.499	6
UniProt:Q9WVI9-1 MAPK8IP1			0.499	2
UniProt:P56747 CLDN6	2	CLDN6 [plasma membrane] (R-HSA-419992) CLDN6 [cell junction] (R-HSA-421250)	0.488	3
UniProt:O14733 MAP2K7	4	MAP2K7(?-419) [cytosol] (R-HSA-5211401) MAP2K7(2-?) [cytosol] (R-HSA-5211389) MAP2K7 [cytosol] (R-HSA-450276) p-S271,T275-MAP2K7 [cytosol] (R-HSA-450353)	0.483	4
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.483	2