Reactome | CD81 [plasma membrane]

CD81 [plasma membrane]

Stable Identifier

R-HSA-197933

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CD81 antigen, CD81_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60033 CD81

Gene Names

CD81, TAPA1, TSPAN28

Chain

chain:1-236

Reference Genes

BioGPS Gene:975 CD81

COSMIC (genes):CD81 CD81

CTD Gene:975 CD81

dbSNP Gene:975 CD81

ENSEMBL:ENSG00000110651 CD81

HGNC:1701 CD81

KEGG:hsa:975 CD81

Monarch:975 CD81

NCBI Gene:975 CD81

OMIM:186845 CD81

UCSC:P60033 CD81

Reference Transcript

Other Identifiers

11715394_s_at

200675_PM_at

200675_at

3317310

3317311

3317312

3317313

3317314

3317316

3317317

3317318

3317319

3317320

3317321

3317322

3317323

3317324

3317325

3317326

3317327

3317328

3317329

3317330

3317331

3317332

3317333

3317334

3317335

3317337

35282_r_at

7937802

89843_at

975

A_14_P108804

A_21_P0007425

A_23_P13425

A_33_P3373375

GE57936

GO:0001618

GO:0001771

GO:0001772

GO:0002250

GO:0002376

GO:0002455

GO:0002863

GO:0005178

GO:0005515

GO:0005886

GO:0005925

GO:0006355

GO:0008289

GO:0009925

GO:0014905

GO:0015485

GO:0016020

GO:0016192

GO:0016323

GO:0016328

GO:0023026

GO:0030890

GO:0031623

GO:0031647

GO:0031982

GO:0034238

GO:0035783

GO:0042289

GO:0043226

GO:0043410

GO:0045944

GO:0046718

GO:0050861

GO:0050862

GO:0050871

GO:0061462

GO:0070062

GO:0070863

GO:0071404

GO:0072659

GO:0072675

GO:0097197

GO:1903911

GO:1904352

GO:1905521

GO:1905676

GO:1990459

GO:2000145

GO:2000553

GO:2000563

GO:2001190

HMNXSV003032636

HMNXSV003044211

ILMN_1689953

M33680_at

PH_hs_0003564

TC11000063.hg

TC11002519.hg

g4757943_3p_at

p18405

p18406

Participates

as a component of

Inferred To

CD81 [plasma membrane] (Bos taurus)

CD81 [plasma membrane] (Canis familiaris)

CD81 [plasma membrane] (Mus musculus)

CD81 [plasma membrane] (Rattus norvegicus)

CD81 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_004347.1, NP_001284578.1

OpenTargets

ENSG00000110651

ENSEMBL

ENST00000263645, ENSP00000263645

HPA

ENSG00000110651-CD81

ZINC - Substances

CD81_HUMAN

ZINC target

P60033

PRO

P60033

Pharos - Targets

P60033

Orphanet

CD81

GlyGen

P60033

ZINC - Predictions - Purchasable

CD81_HUMAN

PDB

5M3D, 5M2C, 5DFW, 5DFV, 6EK2, 3X0E, 5M4R, 1G8Q, 5TCX, 6U9S, 5M3T, 7JIC, 5M33, 1IV5, 6EJG, 6EJM

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.758	7
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [specific granule membrane] (R-HSA-6799566) ADAM10 [tertiary granule membrane] (R-HSA-6800992)	0.744	9
UniProt:P05556 ITGB1	2	ITGB1 [plasma membrane] (R-HSA-57596) ITGB1 [endosome membrane] (R-HSA-9611157)	0.597	8
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.597	6
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q96PE7 MCEE	1	MCEE [mitochondrial matrix] (R-HSA-71012)	0.556	3
UniProt:Q5VUM1 SDHAF4	1	SDHAF4 [mitochondrial matrix] (R-HSA-9854972)	0.556	3
UniProt:Q10589 BST2	2	BST2 [azurophil granule membrane] (R-HSA-6799130) BST2 [plasma membrane] (R-HSA-5624196)	0.556	3
UniProt:Q14739 LBR	4	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) LBR [endosome membrane] (R-HSA-9715094)	0.556	3
UniProt:P02647 APOA1	11	APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-266) [secretory granule lumen] (R-HSA-350761)	0.527	7
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.527	4
UniProt:P02649 APOE	10	APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [extracellular region] (R-HSA-174646) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.527	7
UniProt:P08648 ITGA5	3	ITGA5 [plasma membrane] (R-HSA-9857636) p-S-ITGA5 [plasma membrane] (R-HSA-9857662) ITGA5(42-894) [plasma membrane] (R-HSA-202735)	0.527	5
UniProt:Q9Y624 F11R	2	F11R [cell junction] (R-HSA-2134498) F11R [plasma membrane] (R-HSA-197845)	0.527	6
UniProt:P02787 TF	6	TF [endoplasmic reticulum lumen] (R-HSA-8956763) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) apoTF [endosome membrane] (R-HSA-917974) apoTF [extracellular region] (R-HSA-350754) TF [secretory granule lumen] (R-HSA-350704) apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140)	0.527	6
UniProt:P48509 CD151	2	CD151 [cytosol] (R-HSA-446072) CD151 [plasma membrane] (R-HSA-913947)	0.527	4

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