complex N-glycan-PALM-Spike S1 Fragment [virion membrane]

Stable Identifier
R-COV-9694638
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
Synonyms
P0DTC2
Locations in the PathwayBrowser
General

SARS-CoV-2 mRNA2 has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).

Literature References
PubMed ID Title Journal Year
16122388 The SARS coronavirus S glycoprotein receptor binding domain: fine mapping and functional characterization

Chakraborti, S, Prabakaran, P, Xiao, X, Dimitrov, DS

Virol. J. 2005
12775768 Mass spectrometric characterization of proteins from the SARS virus: a preliminary report

Krokhin, O, Li, Y, Andonov, A, Feldmann, H, Flick, R, Jones, S, Stroeher, U, Bastien, N, Dasuri, KV, Cheng, K, Simonsen, JN, Perreault, H, Wilkins, J, Ens, W, Plummer, F, Standing, KG

Mol. Cell Proteomics 2003
20129637 Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoprotein

Ritchie, G, Harvey, DJ, Feldmann, F, Stroeher, U, Feldmann, H, Royle, L, Dwek, RA, Rudd, PM

Virology 2010
15253436 Proteomic analysis of SARS associated coronavirus using two-dimensional liquid chromatography mass spectrometry and one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by mass spectroemtric analysis

Zeng, R, Ruan, HQ, Jiang, XS, Zhou, H, Shi, L, Zhang, L, Sheng, QH, Tu, Q, Xia, QC, Wu, JR

J. Proteome Res. 2004
14760722 Proteomic analysis on structural proteins of Severe Acute Respiratory Syndrome coronavirus

Ying, W, Hao, Y, Zhang, Y, Peng, W, Qin, E, Cai, Y, Wei, K, Wang, J, Chang, G, Sun, W, Dai, S, Li, X, Zhu, Y, Li, J, Wu, S, Guo, L, Dai, J, Wang, J, Wan, P, Chen, T, Du, C, Li, D, Wan, J, Kuai, X, Li, W, Shi, R, Wei, H, Cao, C, Yu, M, Liu, H, Dong, F, Wang, D, Zhang, X, Qian, X, Zhu, Q, He, F

Proteomics 2004
17715238 Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry

Han, DP, Lohani, M, Cho, MW

J. Virol. 2007
External Reference Information
External Reference
Gene Names
S, 2
Chain
signal peptide:1-12, chain:13-1273, chain:13-685, chain:686-1273, chain:816-1273
Reference Transcript
Participant Of
Other forms of this molecule
Inferred From
Modified Residues
Name
palmitoylated-L-cysteine at unknown position
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 122
Coordinate
122
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 603
Coordinate
603
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 61
Coordinate
61
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 709
Coordinate
709
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 717
Coordinate
717
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (Man(9) N-glycan group) at 234
Coordinate
234
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 149
Coordinate
149
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 165
Coordinate
165
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 17
Coordinate
17
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 282
Coordinate
282
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 331
Coordinate
331
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 343
Coordinate
343
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 616
Coordinate
616
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 657
Coordinate
657
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 74
Coordinate
74
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Disease
Name Identifier Synonyms
COVID-19 0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Interactors (14)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9BYF1 ACE2  5 0.991 84
 UniProt:P0DTC2 S  16 0.937 13
 UniProt:P09958 FURIN  4 0.801 4
 UniProt:Q9H2X3 CLC4M      0.71 5
 UniProt:Q9NNX6 CD209  1 0.683 4
 UniProt:Q7Z5G4 GOLGA7  3 0.643 3
 UniProt:Q9C0B5 ZDHC5      0.643 3
 UniProt:P35613 BSG  2 0.618 5
 UniProt:Q8IUN9-2 CLEC10A      0.558 3
 UniProt:Q61830 Mrc1  4 0.558 2
 lipopolysaccharide [ChEBI:16412]  5 0.558 3
 cholesterol [ChEBI:16113]  20 0.558 3
 UniProt:Q96D42 HAVR1      0.524 5
 linoleic acid [ChEBI:17351]  6 0.522 2
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