AKT1 E17K [cytosol]

Stable Identifier
R-HSA-2219526
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
AKT1 Glu17Lys
AKT1 E17K [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
17611497 A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Tucker-Kellogg, G, Lin, A, Blanchard, KL, Carpten, JD, Qian, YW, Moses, TY, Briggs, SL, Zeckner, DJ, Hostetter, G, Bittner, M, Savage, S, Thomas, JE, Uhlik, M, Du, J, Boguslawski, S, Robbins, CM, Schevitz, R, Touchman, J, Patel, K, Mousses, S, Lai, MHT, Faber, AL, Donoho, GP, Horn, C

Nature 2007
External Reference Information
External Reference
Gene Names
AKT1, PKB, RAC
Chain
chain:1-480
Other Identifiers
11716087_s_at
11722186_a_at
11722187_a_at
1564_at
16797157
207
207163_PM_s_at
207163_s_at
3581133
3581134
3581135
3581136
3581137
3581138
3581139
3581140
3581141
3581142
3581143
3581144
3581145
3581146
3581147
3581148
3581150
3581151
3581152
3581153
3581154
3581155
3581156
3581157
3581158
3581159
3581160
3581161
3581162
3581163
3581164
3581165
3581166
3581167
3581168
3581169
3581174
3581175
3581176
3581177
3581178
3581179
3581180
67939_at
7981494
A_23_P2960
A_33_P3275235
GE58023
GO:0001649
GO:0001893
GO:0001934
GO:0001938
GO:0002042
GO:0002376
GO:0003376
GO:0003824
GO:0004672
GO:0004674
GO:0004712
GO:0005515
GO:0005516
GO:0005524
GO:0005547
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005758
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005938
GO:0005975
GO:0005977
GO:0005978
GO:0005979
GO:0006006
GO:0006091
GO:0006355
GO:0006417
GO:0006468
GO:0006469
GO:0006606
GO:0006809
GO:0006886
GO:0006913
GO:0006915
GO:0006924
GO:0006954
GO:0006979
GO:0007005
GO:0007165
GO:0007173
GO:0007186
GO:0007249
GO:0007281
GO:0007399
GO:0008283
GO:0008286
GO:0008289
GO:0008637
GO:0009408
GO:0009725
GO:0010467
GO:0010507
GO:0010595
GO:0010628
GO:0010629
GO:0010748
GO:0010761
GO:0010763
GO:0010765
GO:0010907
GO:0010951
GO:0010975
GO:0012501
GO:0015630
GO:0016020
GO:0016242
GO:0016301
GO:0016310
GO:0016567
GO:0016740
GO:0018105
GO:0018107
GO:0019049
GO:0019221
GO:0019899
GO:0019901
GO:0022414
GO:0022605
GO:0030027
GO:0030154
GO:0030163
GO:0030235
GO:0030291
GO:0030307
GO:0030334
GO:0030335
GO:0031295
GO:0031397
GO:0031641
GO:0031663
GO:0031929
GO:0031982
GO:0031999
GO:0032079
GO:0032091
GO:0032094
GO:0032287
GO:0032436
GO:0032869
GO:0032880
GO:0032991
GO:0033138
GO:0034405
GO:0034614
GO:0035556
GO:0035655
GO:0035924
GO:0036064
GO:0036294
GO:0038061
GO:0042593
GO:0042802
GO:0042803
GO:0042981
GO:0043066
GO:0043154
GO:0043161
GO:0043226
GO:0043276
GO:0043325
GO:0043488
GO:0043491
GO:0043536
GO:0045429
GO:0045600
GO:0045725
GO:0045737
GO:0045746
GO:0045861
GO:0045893
GO:0045944
GO:0046326
GO:0046622
GO:0046777
GO:0046889
GO:0048009
GO:0048266
GO:0048661
GO:0048856
GO:0048870
GO:0051000
GO:0051091
GO:0051146
GO:0051247
GO:0060079
GO:0060416
GO:0060644
GO:0060709
GO:0060716
GO:0061024
GO:0070141
GO:0070848
GO:0071276
GO:0071356
GO:0071363
GO:0071364
GO:0071380
GO:0071889
GO:0071901
GO:0072655
GO:0072656
GO:0072752
GO:0090201
GO:0097011
GO:0097194
GO:0098772
GO:0098794
GO:0098978
GO:0099104
GO:0099175
GO:0106310
GO:0110002
GO:0140052
GO:0140096
GO:0150033
GO:0160049
GO:1900087
GO:1900182
GO:1901653
GO:1901796
GO:1902018
GO:1902176
GO:1903038
GO:1903078
GO:1903318
GO:1903721
GO:1904263
GO:1905552
GO:1990090
GO:1990418
GO:2000010
GO:2000074
GO:2000402
GO:2001240
GO:2001243
HMNXSV003045285
ILMN_1748661
ILMN_2388507
ILMN_2410909
M63167_at
PH_hs_0024085
PH_hs_0035844
TC14001560.hg
g4885060_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
L-glutamic acid 17 replaced with L-lysine
Coordinate
17
PsiMod
A protein modification that effectively converts a source amino acid residue to L-lysine.
A protein modification that effectively removes or replaces an L-glutamic acid.
Disease
Name Identifier Synonyms
ovarian cancer DOID:2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
ZINC - Investigational
ZINC - Metabolites
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (74)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P56279 TCL1A      0.83 8
 UniProt:Q00987 MDM2  11 0.807 6
 UniProt:P49841 GSK3B  4 0.779 4
 UniProt:O15530 PDPK1  3 0.767 4
 UniProt:P67775 PPP2CA  4 0.756 4
 UniProt:Q5T1C6 THEM4  3 0.734 4
 UniProt:P42345 MTOR  2 0.731 4
 ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE      0.724 5
 UniProt:Q16543 CDC37  1 0.708 5
 UniProt:P08670 VIM  11 0.706 29
 UniProt:O43524 FOXO3  11 0.692 3
 UniProt:O95999 BCL10  3 0.69 5
 UniProt:Q6GPH4 XAF1  1 0.666 4
 UniProt:P31751 AKT2  7 0.641 3
 UniProt:P23443 RPS6KB1  2 0.64 3
 UniProt:Q86V81 ALYREF  2 0.639 5
 UniProt:P53804 TTC3      0.639 4
 UniProt:Q15047 SETDB1  1 0.639 9
 UniProt:P46527 CDKN1B  8 0.63 3
 UniProt:Q13043 STK4  4 0.619 13
 UniProt:P26358 DNMT1  2 0.611 6
 UniProt:P04150 NR3C1  3 0.611 5
 UniProt:P31749 AKT1  14 0.609 3
 UniProt:P19174 PLCG1  6 0.602 9
 UniProt:Q96EB6 SIRT1  1 0.602 5
 UniProt:O60437 PPL  2 0.573 2
 UniProt:P62136 PPP1CA  1 0.571 4
 UniProt:Q12778 FOXO1  5 0.571 2
 UniProt:P08238 HSP90AB1  6 0.564 3
 UniProt:Q5S007 LRRK2  1 0.558 6
 UniProt:Q99683 MAP3K5  1 0.558 2
 UniProt:Q9UNE7-1 STUB1      0.558 5
 UniProt:P17612 PRKACA  4 0.556 3
 UniProt:P06241 FYN  6 0.556 3
 UniProt:Q96D03 DDT4L      0.556 3
 UniProt:Q9H0C5 BTBD1  1 0.556 3
 UniProt:Q15438 CYTH1  2 0.556 3
 UniProt:P42858 HTT  1 0.556 3
 UniProt:Q8WUY3 PRUN2      0.556 3
 UniProt:Q96LI6-3 Q96LI63      0.556 3
 UniProt:Q6UY14-3 ADAMTSL4      0.556 3
 UniProt:Q8TAP6 CEP76  1 0.556 3
 UniProt:P22466 GAL  1 0.556 3
 UniProt:P54253 ATX1      0.556 6
 IntAct:EBI-25830852 RZPDO839G03145      0.556 3
 UniProt:P17028 ZNF24      0.556 3
 UniProt:Q9UQM7 CAMK2A  6 0.556 3
 UniProt:P10599 TXN  4 0.556 3
 UniProt:Q14696 MESD      0.556 3
 UniProt:P00533 EGFR  20 0.553 2
 UniProt:P49327 FASN  3 0.547 2
 UniProt:P05771 PRKCB  5 0.547 2
 UniProt:P30153 PPP2R1A  2 0.544 2
 UniProt:Q05513 PRKCZ  5 0.544 2
 UniProt:Q9BZQ8 NIBA1      0.544 2
 UniProt:Q92547 TOPBP1  1 0.544 2
 UniProt:Q14643 ITPR1  2 0.536 2
 UniProt:P04049 RAF1  20 0.536 2
 UniProt:P24468 NR2F2  1 0.527 2
 UniProt:P38646 HSPA9  6 0.527 3
 UniProt:P07900 HSP90AA1  8 0.527 3
 UniProt:Q96S96 PEBP4      0.524 2
 UniProt:P29067  3 0.524 2
 UniProt:P20248 CCNA2  3 0.524 2
 UniProt:Q83730 MT5      0.524 3
 UniProt:Q9UKG1 APPL1  1 0.519 2
 UniProt:Q9NYB0 TERF2IP  1 0.508 2
 UniProt:Q8IXJ9 ASXL1  1 0.508 2
 IntAct:EBI-4399559 UBIQ      0.499 2
 UniProt:Q92793 CREBBP  4 0.499 3
 UniProt:P10636 MAPT  3 0.499 2
 UniProt:P04792 HSBP1  3 0.483 3
 UniProt:P11021 HSPA5  6 0.471 2
 UniProt:P10276 RARA  3 0.463 2
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