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What is Reactome ?
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Team
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
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Content
Table of Contents
DOIs
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ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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Spike S2' Fragment [plasma membrane]
Stable Identifier
R-COV-9770189
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
plasma membrane
Synonyms
P0DTC2, Spike fusion peptide, FP
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Induction of Cell-Cell Fusion (Homo sapiens)
S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion (Homo sapiens)
Spike S2' Fragment [plasma membrane] (Severe acute respiratory syndrome coronavirus 2)
External Reference Information
External Reference
UniProt:P0DTC2 S
Gene Names
S, 2
Chain
signal peptide:1-13, chain:14-1273, chain:14-685, chain:686-1273, chain:816-1273
Participates
as an output of
S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion (Homo sapiens)
Other forms of this molecule
S(686-815) [plasma membrane]
S1 [plasma membrane]
fully glycosylated Spike [plasma membrane]
nascent Spike [endoplasmic reticulum lumen]
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
fully glycosylated Spike [virion membrane]
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
Modified Residues
Name
palmitoylated-L-cysteine at unknown position
PsiMod Name
palmitoylated-L-cysteine
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1074
Coordinate
1074
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1098
Coordinate
1098
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1134
Coordinate
1134
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1173
Coordinate
1173
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1158
Coordinate
1158
Modification
sialylated complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1194
Coordinate
1194
Modification
sialylated complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
PDB
8ELQ
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7TLB
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7Q9I
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7ENG
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8CBF
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7WHH
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8AAA
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7KKL
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7SY2
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8DF5
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7UB5
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7L09
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7PS0
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7FB4
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8HHY
,
7WRO
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8G71
,
7WSA
,
8DTX
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7MDW
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8CWK
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7EJ4
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8I9H
,
7VXI
,
7YCK
,
7N4L
,
7CZT
,
6YLA
,
7DDN
,
8DM7
,
7SXT
,
7SN0
,
7BEI
,
7NX6
,
8H07
,
7K8X
,
8DI5
,
7V7J
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6XEY
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7N1T
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7BNN
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7M8T
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7UOW
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7Y6L
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7CWU
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7XOE
,
7TP9
,
7WBH
,
7TZ0
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7OAU
,
7X94
,
7R95
,
7L2C
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7ZCE
,
7TLD
,
6XC3
,
7WED
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7KNE
,
7LXW
,
7SY5
,
7RAL
,
7YVO
,
8HN6
,
7Q9K
,
6X45
,
7V24
,
7U2D
,
8DLS
,
7OWX
,
7V88
,
7MZJ
,
8FA2
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7Z9R
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7YHW
,
7FG3
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8H3E
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8VKK
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7XIY
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7E86
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7EK0
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7Y1Z
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8GOU
,
7YR1
,
8IFY
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7M3I
,
7S6K
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7VZT
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7N64
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7JV2
,
7U8E
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8F2J
,
7LRS
,
7CHF
,
8IOS
,
8CWV
,
7WON
,
7PS2
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7JX3
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8D48
,
6XM5
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7XS8
,
7TF2
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8EPN
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8HT9
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8EPQ
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8SIQ
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8S9G
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8H5T
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8CXQ
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7KDL
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7VNC
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7N5H
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8EYG
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8G74
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8D56
,
7OLZ
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7WSE
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7JWB
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7XQS
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7F46
,
6LZG
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7R14
,
8GRY
,
8FU7
,
8UUL
,
7F7E
,
8F4P
,
8FDW
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8DV2
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7YCN
,
7CZV
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8BG4
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7VXM
,
7OD3
,
7BZ5
,
7SXV
,
7NX8
,
7BNV
,
7UPX
,
7DMU
,
7UFK
,
7N1V
,
7EDF
,
7V7O
,
7SN3
,
7TP0
,
8SDG
,
7WHZ
,
7TPC
,
7Y71
,
7KML
,
6ZER
,
7ORA
,
8HWT
,
7X96
,
7S0C
,
6W41
,
7X66
,
7JJC
,
7ND3
,
7WBP
,
7B62
,
7XA7
,
8ITU
,
7L2E
,
7LXY
,
7M53
,
7S83
,
7YVU
,
7Q9P
,
7VHJ
,
7KNI
,
7V8A
,
7FH0
,
7CHO
,
8DLU
,
7V27
,
7E9Q
,
7XJ9
,
7U9P
,
8VKM
,
7MZM
,
7EAM
,
7KGK
,
7PS5
,
7Y0C
,
7FCQ
,
7VQ0
,
7YR3
,
8HES
,
8HP9
,
7WTG
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7KE8
,
6XKQ
,
8IOU
,
7ZR2
,
7XSB
,
7JV6
,
7MW2
,
7QNW
,
7N6E
,
7YDY
,
7WP0
,
7TF4
,
6XRA
,
7WSK
,
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,
7WPH
,
7DWZ
,
7SOA
,
8SIS
,
8WGW
,
8CY7
,
8C3V
,
7VNE
,
8H6F
,
7DF3
,
7KE6
,
8G76
,
7QDH
,
8UUN
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7V7E
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7F5G
,
7UR1
,
6ZGE
,
7N1X
,
7CZX
,
8FU9
,
7YD1
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8GS9
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7R16
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7WK0
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7RU3
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7BEM
,
7X7D
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7SD5
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7V7Q
,
7RBU
,
7MSQ
,
8CBE
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8DW3
,
7ZFC
,
7TN0
,
7ZDQ
,
7XB0
,
7Y75
,
8D6Z
,
8BCZ
,
7SBK
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8VYE
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7NEG
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7ND5
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8C8P
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8DM5
,
7RPV
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7LD1
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7W6U
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7N8I
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7LY0
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7KJ4
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7CHS
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8D8R
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7VHL
,
8FXC
,
7V8C
,
7X2H
,
7EKG
,
8HC4
,
7EAZ
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7LJR
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8DAO
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7UAQ
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,
8IV5
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,
6ZOW
,
8I3S
,
7XST
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8TYL
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7EH5
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7ZR8
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7TF5
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7WP2
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7VX4
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7KEA
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7V78
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7QNY
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7MW6
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7T01
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8HPQ
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7JVB
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7YE9
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8HPV
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7L7K
,
7URS
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7V76
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7SOC
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6ZP5
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7E3C
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7TOV
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7N3I
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7QF0
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8G78
,
6ZGI
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7WK3
,
8CYA
,
7RKV
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7XBY
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7CZZ
,
7UZ5
,
7KQE
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7ZF4
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7X7N
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7R18
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,
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,
7EFP
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8SK5
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7Y7J
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7V7S
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7T7B
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,
7MJK
,
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7RBY
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6M17
,
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,
7W9E
,
8DWA
,
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,
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7VRW
,
7M6E
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7C8D
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8VYG
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7VHN
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7LY3
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7FEM
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8SMT
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7B18
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7X2L
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7RZQ
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7YH6
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7K43
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8DXT
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7E8F
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8HC8
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6XM4
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7MY8
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7DK4
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7Y0W
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7WWM
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7UB0
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8DLY
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7EJL
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7XU0
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8WMF
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8IVA
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7JW0
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7QO9
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7WUH
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7R40
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7DET
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7YBI
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7F6Z
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7TBF
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7KS9
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7WP6
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8I4E
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7KEC
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8JJE
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7XNR
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7T9L
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8HQT
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7MJN
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7LO4
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7L56
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8G7A
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8CYC
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7UZ7
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7SBR
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7WGB
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7V7U
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7F63
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7ENF
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7M6G
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8A95
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7P40
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7N9B
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8GTQ
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7F12
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8GB5
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8DM9
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8PQ2
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7YOW
,
7JMO
,
7D03
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7DK7
,
8DYA
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7ZSD
,
6XKL
,
7TGX
,
7WS1
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7XU2
,
7KFX
,
8DM0
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8U1G
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7R4Q
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7FCD
,
7WNB
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7FAT
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7K8S
,
7VXB
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7TCA
,
7LQW
,
6ZP0
,
8HN4
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7CYV
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7K9H
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7YBK
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8CMC
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7UHB
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8T22
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7L7D
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7MLZ
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7P77
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8ASY
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8HEC
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7CWM
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7X8Z
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7XDA
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7N1A
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8I4G
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7X8W
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7MKL
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7RTR
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7EY4
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7BEJ
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7E7X
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6YZ7
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8DLL
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7CAH
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7QUR
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7K8Z
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7XO7
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8I5I
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7N0G
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7P5Q
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8BG5
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7SBT
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7L58
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7CN4
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7YVF
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7W98
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7WCU
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8G7C
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8CYJ
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7V7Z
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8AQV
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8HRD
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7X63
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6YOR
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7M6I
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7Z1B
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8G73
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7NDC
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6XF5
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7MFU
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7CT5
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7E9N
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8WRL
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7K4N
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7A4N
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8GB7
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7KGJ
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7CZQ
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7Y21
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7EKC
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8BSE
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7PQY
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7DZW
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7THE
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8I9C
,
7R0Z
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7E3L
,
7S3N
,
7PHG
,
7WO4
,
7XU4
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7JMW
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8XEA
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7DHX
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7LS9
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7LAB
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8DM2
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7FB0
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7WS3
,
8DNN
,
7Q3Q
,
7N1E
,
7K8U
,
6ZWV
,
7MMO
,
7TCQ
,
7VXD
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7P79
,
7DX1
,
7QEZ
,
6ZP2
,
8EL2
,
8DZI
,
7YBM
,
8CMH
,
7SWX
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7XDL
,
7OAO
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7K9J
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7V7G
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7Z3Z
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8T25
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7XOB
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6VSB
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7UZC
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7RU2
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7TP2
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7XO9
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7E23
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8DLN
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7NXA
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8K3K
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8BG8
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7M7B
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7A25
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8J1V
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7YVH
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7TPF
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7RAQ
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7Q0I
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7EDH
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7V81
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7KMZ
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7WI0
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7KLW
,
8HFZ
,
8HRL
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7Z1D
,
7SIS
,
7WD0
,
7NKT
,
7JZM
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7D0C
,
6XC7
,
7R6W
,
7LWQ
,
7YQU
,
8DT3
,
8Q94
,
6ZB4
,
7RZU
,
6WPS
,
7LYN
,
8WRO
,
7UKL
,
7U0D
,
7SY8
,
7FG7
,
8DTK
,
7FB3
,
7D6I
,
7WRL
,
7WO7
,
8I9E
,
7PR0
,
7EKF
,
8GJM
,
8CWI
,
7WTH
,
7WS7
,
8P99
,
7XU6
,
7R11
,
8WTJ
,
7N4J
,
8KHC
,
7MW5
,
8H00
,
7CZS
,
7T9K
,
7FJS
,
7K9Z
,
7XEI
,
7SXS
,
7DX3
,
8KA8
,
7BEH
,
7YC5
,
7VXF
,
7K8W
,
7V7I
,
6ZDG
,
7P7B
,
8GDR
,
7TYZ
,
7OAQ
,
7L4Z
,
7CWT
,
7XOD
,
7TP8
,
8ELJ
,
7Y6K
,
7X93
,
8BH5
,
8IDN
,
7X91
,
7RBV
,
7LWI
,
8AQS
,
7TP4
,
6ZBP
,
7KMB
,
7TPI
,
8GNH
,
7SXZ
,
7NXC
,
7M8J
,
8D0Z
,
7MTE
,
8DLP
,
7WH8
,
7MJJ
,
8F0G
,
8DCE
,
7YVJ
,
6Z43
,
7SJS
,
8CSA
,
7KN4
,
7AKD
,
8K47
,
7WD2
,
7ND7
,
7EDJ
,
7D2Z
,
6VXX
,
7V83
,
7CH4
,
7Y42
,
8HGL
,
7KJ3
,
7NT9
,
7R7N
,
7YQW
,
7LWT
,
7A5S
,
7B14
,
7FDH
,
8HSO
,
6XCN
,
7A96
,
7U0Q
,
6X29
,
7THT
,
7TEW
,
7Z7X
,
7DK0
,
7UL0
,
7LYP
,
7WWK
,
7S5P
,
7WOB
,
7KDK
,
8CWU
,
8DTT
,
7WSC
,
6LXT
,
7VNB
,
7ME7
,
7FBJ
,
7R13
,
8I9G
,
6YM0
,
7YCL
,
8DGU
,
7V79
,
7N4M
,
7BYR
,
7CZU
,
7VXK
,
8BG3
,
7NX7
,
7P5G
,
8H06
,
7SN2
,
7UPW
,
7TOZ
,
6ZDH
,
7N1U
,
7EPX
,
7V7N
,
7F3Q
,
7BNO
,
7M8U
,
7OR9
,
7Y6N
,
7S0B
,
7WBL
,
7WHJ
,
7XOG
,
8ELP
,
7TPA
,
7OAY
,
8AQU
,
7X95
,
7LWL
,
7SL5
,
7KKK
,
7Q9G
,
7WHD
,
6XE1
,
7E5Y
,
7W9I
,
7KMH
,
7TPL
,
7M8S
,
6X2B
,
7SY1
,
7YVL
,
7TLA
,
7WB5
,
8DLR
,
7SY7
,
7LWV
,
8F0I
,
8FA1
,
8IF2
,
7KN6
,
8H3D
,
7R8M
,
7XXL
,
7A92
,
7WD8
,
7V85
,
7V20
,
7UM2
,
8GON
,
7YQY
,
7XIL
,
8EOO
,
7NTC
,
7EJ5
,
7FDK
,
7EB3
,
7A98
,
7CHB
,
7L06
,
8D47
,
8HT1
,
7PRZ
,
7S5R
,
7Z86
,
7MY3
,
8HHX
,
7TEZ
,
7WRY
,
8EPP
,
7ODL
,
7XRP
,
6ZFO
,
7VYR
,
7M0J
,
7WOG
,
8CXN
,
6X6P
,
7DWY
,
8D55
,
6XR8
,
7KE4
,
7WSH
,
7DEU
,
7VND
,
7QDG
,
7YCO
,
8DV1
,
7CZW
,
7F7H
,
7DPM
,
7SO9
,
7R15
,
7V7P
,
7UPY
,
7S0D
,
7EDG
,
8CBD
,
7XAZ
,
7UFL
,
7F4W
,
7N1W
,
8C1V
,
7Y72
,
7X6A
,
7X9E
,
8SDF
,
7SC1
,
7KMS
,
7SY6
,
8HWS
,
7ORB
,
7WEF
,
7TLT
,
7WBQ
,
7ND4
,
7JJJ
,
7DX7
,
7WCZ
,
7KNB
,
7TLC
,
7RA8
,
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,
7R8O
,
8HXJ
,
8A99
,
6XC2
,
7ZBU
,
7WDF
,
7KL9
,
7KMK
,
8HN7
,
7YVN
,
6X2C
,
7V23
,
7XY4
,
7LX5
,
7E7D
,
7V87
,
8DLT
,
7WZ2
,
7N9C
,
7MZH
,
8VKL
,
7U1R
,
7FG2
,
7Z9Q
,
7A94
,
7XIX
,
7B3O
,
8JYP
,
8FAH
,
7EJZ
,
8IFZ
,
8SGU
,
7L0N
,
7YR0
,
7S6J
,
7EB5
,
7CHE
,
8IOT
,
8GPY
,
7KFW
,
7DK6
,
7N62
,
8H5C
,
7WS0
,
7PS1
,
7JWY
,
7TF1
,
8F2X
,
7UB6
,
7URQ
,
8H5U
,
7SOB
,
8WGV
,
7DX0
,
7YDI
,
8SIR
,
8CY6
,
8G75
,
7TOU
,
7E3B
,
8EQF
,
7A29
,
8D5A
,
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,
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,
8GS6
,
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,
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,
7F5H
,
7N1Y
,
7KQB
,
6ZGG
,
7CZY
,
8UUM
,
8FU8
,
7XMX
,
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,
6XS6
,
7ZF3
,
7WK2
,
7R17
,
7L7F
,
7WG7
,
8BE1
,
7V7R
,
7X7E
,
7C01
,
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,
7ZFD
,
8DW2
,
8FEZ
,
7Y76
,
7SBL
,
7MTD
,
7E5O
,
7RU4
,
7XB1
,
7DCX
,
7ND6
,
6M0J
,
7DX9
,
7BEN
,
7M6D
,
7T72
,
7ZCF
,
7JZL
,
8BBN
,
7KNH
,
6XC4
,
7L2D
,
7LXX
,
7YVP
,
8FXB
,
8D8Q
,
7SA2
,
7VHH
,
8C89
,
7T67
,
7Q9M
,
8DAD
,
7V89
,
7V26
,
7SI2
,
7U2E
,
8IV4
,
8DLV
,
7M42
,
7T3M
,
7E9P
,
7XIZ
,
8FI9
,
8VKN
,
7MZL
,
8WLO
,
7CZP
,
7EK6
,
7FCP
,
7YR2
,
7UAP
,
7U9O
,
7S6L
,
7KE7
,
7CHH
,
7JV4
,
7LRT
,
8IOV
,
7N6D
,
8HPF
,
7WT9
,
7PS4
,
7XSA
,
7TF3
,
7VOA
,
7WOP
,
7TOW
,
7D4G
,
7SOD
,
7YE5
,
8HPU
,
7V77
,
6ZP7
,
7E3J
,
7QF1
,
7W1S
,
7XCI
,
7BNM
,
8G77
,
8CY9
,
8BEV
,
7XNQ
,
7TAS
,
7DD8
,
8SIT
,
7KRQ
,
8UUO
,
7YA1
,
7CDJ
,
7UZ6
,
7ZF5
,
7WK8
,
7X7O
,
7F62
,
7R19
,
8GSB
,
7EFR
,
7LWK
,
7F0X
,
8H7L
,
7E7Y
,
7A91
,
7M6F
,
7WCK
,
7Y7K
,
7ND9
,
7W8S
,
7WG9
,
7T5O
,
7V7T
,
7P3E
,
7SBQ
,
7YUE
,
7RU8
,
7MJM
,
8A94
,
8DW9
,
7LM8
,
7Z0X
,
8CII
,
7C8J
,
7BEP
,
8VYF
,
6ZLR
,
8DM4
,
8DM6
,
8QZR
,
8SMI
,
7N8H
,
7VRV
,
7L2F
,
7JZU
,
7LXZ
,
7CHP
,
8DXS
,
7V8B
,
7V2A
,
7VHK
,
7FDG
,
7E9T
,
8HC5
,
7MZN
,
7P19
,
8IV8
,
8DLX
,
7EAN
,
7E88
,
7Y0N
,
7UKM
,
7LCN
,
6XLU
,
8WMD
,
7KDH
,
7X1M
,
7THK
,
7ZJL
,
7YR4
,
8VKP
,
7PS6
,
8TYO
,
6ZH9
,
7DZY
,
8I3U
,
7ZR7
,
7XSC
,
7MW4
,
7C53
,
7KE9
,
7VX1
,
8JYK
,
7QNX
,
7RNJ
,
7JVA
,
7WP1
,
7R1B
,
7DX5
,
7LOP
,
7SXU
,
7EY0
,
7TOY
,
7BWJ
,
8DLI
,
6YZ5
,
8HQ7
,
7CM4
,
7WKA
,
7UZ9
,
7K8Y
,
7XNS
,
7XCP
,
7TB8
,
8WOX
,
7CAC
,
7SOF
,
7L57
,
7DEO
,
7QTI
,
8G79
,
8CYB
,
7SBS
,
7ZF8
,
7X7U
,
7V7V
,
7MKB
,
7W94
,
7RTD
,
7YVE
,
7WGC
,
7F15
,
7NDB
,
8G70
,
7LWN
,
7WCR
,
7M6H
,
7Q0A
,
8A96
,
7Z1A
,
7SY3
,
7E8M
,
8TMA
,
7K45
,
8CIN
,
7C8W
,
7MZG
,
8H91
,
8GTP
,
7LYK
,
7RQ6
,
8DM8
,
7LY2
,
7N9A
,
7KJ5
,
7VHM
,
7LDJ
,
7CJF
,
8DXU
,
7EKH
,
7X2K
,
7E8C
,
7MY2
,
7EB0
,
7TGE
,
7DK3
,
7Y0V
,
7XTZ
,
7UAR
,
8DLZ
,
6XM3
,
7WUE
,
7WOA
,
7RXD
,
7KDJ
,
8GX9
,
7VX5
,
6ZOX
,
7ZR9
,
7WP5
,
7VMU
,
7F6Y
,
7R12
,
7KRS
,
7YBH
,
7YEG
,
8I4F
,
8IX3
,
7KEB
,
7QO7
,
8JYN
,
8T20
,
8HEB
,
7JVC
,
8TAZ
,
8BG2
,
7BEK
,
7TP1
,
7MKM
,
7NX9
,
7X8Y
,
7RU1
,
7XD2
,
7XO8
,
8DLK
,
7EY5
,
7K90
,
7CAI
,
7QUS
,
7P5S
,
7WGX
,
7SWO
,
7MJG
,
7N0H
,
8I5H
,
7ZFA
,
6XF6
,
7UZB
,
7SXW
,
8HR2
,
8BG6
,
7TPE
,
7SBU
,
7CN9
,
7Q0H
,
7YVG
,
7KLH
,
8CYD
,
8G7B
,
7L5B
,
7V80
,
8AQW
,
8GZZ
,
7JJI
,
7W99
,
7Z1C
,
8G72
,
7M71
,
7D0B
,
7LWP
,
7YJ3
,
7YQT
,
7NDD
,
7KXK
,
8WRH
,
7LYM
,
7MZK
,
7N9T
,
7E9O
,
8GB0
,
8GB6
,
7Y1Y
,
7EJY
,
8I9B
,
8XE9
,
8DMA
,
7FET
,
7X2M
,
7RZR
,
7YH7
,
7D00
,
7WVL
,
7TGW
,
7FC5
,
7FAF
,
8DM1
,
7R4I
,
7XU1
,
7MF1
,
7ZRV
,
7VXA
,
8EKD
,
6ZOZ
,
7LQV
,
7DWX
,
7WN2
,
7WOC
,
8DZH
,
8U28
,
8PSD
,
7V7D
,
7YBJ
,
7CYP
,
7WP8
,
8CMB
,
7TC9
,
8T23
,
7SPP
,
7K8M
,
8HED
,
7KSG
,
7CWL
,
7X90
,
6Z2M
,
7XOA
,
7TP3
,
7UZD
,
7S0E
,
8BON
,
7CAN
,
8BGG
,
8DPZ
,
7MJI
,
7Q1Z
,
7NXB
,
8DLM
,
8J1T
,
7SXY
,
7MTC
,
8XI6
,
7WGZ
,
7E39
,
7YVI
,
7TPH
,
7W9C
,
7KN3
,
7EDI
,
8HFY
,
7NEH
,
7DCC
,
7WD1
,
7V82
,
7M7W
,
7KM5
,
7PKI
,
6Z97
,
8HRK
,
7D0D
,
8R1D
,
7SJ0
,
7R6X
,
7Z1E
,
7JZN
,
7KJ2
,
6VW1
,
7NLL
,
7Y3O
,
8CZI
,
8EYH
,
7YQV
,
7LWS
,
7E3O
,
6ZB5
,
7PBE
,
7U0P
,
7NS6
,
7LC8
,
8Q93
,
7RZV
,
8WRM
,
7DJZ
,
7LYO
,
7A95
,
6WPT
,
6XCM
,
8GB8
,
7TGY
,
7RZT
,
7WVO
,
7Y20
,
8I9D
,
7ZSS
,
7WNM
,
6XKP
,
7JMP
,
7E3K
,
7WQV
,
7LAA
,
7KFY
,
7R4R
,
7XU3
,
8WTD
,
7WS2
,
7FAU
,
7FCE
,
7VXC
,
7TCC
,
7K8T
,
7P78
,
7EZV
,
7DF4
,
6ZP1
,
7YBL
,
8CMD
,
7K9I
,
7V7F
,
7OAN
,
7MM0
,
7UHC
,
8ELH
,
7CWN
,
8FHY
,
7N1B
,
7L7E
,
8GF2
,
7WHB
,
8AQT
,
7X92
,
7TP7
,
7Q9F
,
8KC2
,
7KMG
,
7SBP
,
7M8K
,
6XDG
,
7TPK
,
7E5S
,
7MJL
,
8DLO
,
8CSJ
,
7SY0
,
7SKZ
,
7YVK
,
8J26
,
8DCC
,
7W9F
,
7R8L
,
7WA1
,
8K46
,
8HG0
,
7KN5
,
7ND8
,
6VYB
,
7WD7
,
7D30
,
7V84
,
7CH5
,
7XIK
,
7YQX
,
7U0X
,
7B17
,
7NTA
,
7LWU
,
7XWA
,
6X2A
,
7FDI
,
8Q95
,
7TIK
,
7L02
,
7MXP
,
8HSM
,
7A97
,
8DT8
,
7PRY
,
7WWL
,
7DK2
,
7Z85
,
7TEY
,
7S5Q
,
7UL1
,
7LYQ
,
7WRJ
,
7CZR
,
7KDG
,
7LSS
,
8DTR
,
7PQZ
,
7WVQ
,
7WO5
,
8BSF
,
7DZX
,
7S4S
,
7Z6V
,
7EKE
,
8GJN
,
8E1G
,
7A5R
,
8I9F
,
7WS6
,
7XU5
,
7R10
,
7B0B
,
7MW3
,
7TE1
,
8H01
,
7N4I
,
8KHD
,
7FB1
,
7X08
,
8P9Y
,
7T9J
,
7P7A
,
7VXE
,
7K8V
,
7DX2
,
7N1F
,
7SXR
,
7YBN
,
7XEG
,
7Q3R
,
6ZCZ
,
7AD1
,
8CMI
,
7OAP
,
7V7H
,
7CWS
,
7K9K
,
6ZXN
,
7FJO
,
7XOC
,
8ELO
,
7Y6D
Interactors (63)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BYF1 ACE2
5
ACE2(18-805) [plasma membrane]
(R-HSA-2022344)
ACE2 [endoplasmic reticulum lumen]
(R-HSA-9683474)
glycosylated-ACE2 [endocytic vesicle membrane]
(R-HSA-9686721)
ACE2 [endocytic vesicle membrane]
(R-HSA-9698958)
glycosylated-ACE2 [plasma membrane]
(R-HSA-9683480)
0.997
242
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.986
60
UniProt:Q9C0B5 ZDHHC5
1
ZDHHC5 [Golgi membrane]
(R-HSA-9766353)
0.864
8
UniProt:Q9H2X3 CLEC4M
1
CLEC4M [plasma membrane]
(R-HSA-1472862)
0.857
12
UniProt:P09958 FURIN
6
FURIN [macropinosome membrane]
(R-HSA-9837714)
FURIN [trans-Golgi network membrane]
(R-HSA-9832627)
FURIN [Golgi lumen]
(R-HSA-448351)
FURIN [plasma membrane]
(R-HSA-2159856)
FURIN [extracellular region]
(R-HSA-1181103)
FURIN [Golgi membrane]
(R-HSA-157049)
0.854
5
UniProt:Q9NNX6 CD209
1
CD209 [plasma membrane]
(R-HSA-2079928)
0.848
11
UniProt:Q7Z5G4 GOLGA7
3
GOLGA7 [extracellular region]
(R-HSA-6800449)
GOLGA7 [tertiary granule lumen]
(R-HSA-6800164)
GOLGA7 [Golgi membrane]
(R-HSA-9647777)
0.817
7
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.746
8
UniProt:Q8R0I0
1
ACE2(18-805) [plasma membrane]
(R-MMU-2022344)
0.688
4
UniProt:Q8IUN9-2 CLEC10A
0.683
4
UniProt:P35247-PRO_0000017465 SFTPD
0.683
11
UniProt:Q96D42 HAVCR1
1
HAVCR1 [plasma membrane]
(R-HSA-5660386)
0.667
7
UniProt:Q96L92 SNX27
0.664
16
UniProt:P30530 AXL
2
p-Y779,Y821-AXL [plasma membrane]
(R-HSA-5357460)
AXL [plasma membrane]
(R-HSA-197705)
0.655
9
UniProt:P35613 BSG
2
BSG [Golgi membrane]
(R-HSA-204478)
BSG [plasma membrane]
(R-HSA-197673)
0.652
7
IntAct:EBI-26657218 PEPTIDE
0.645
7
ChEBI:17033 BILIVERDIN
0.642
9
UniProt:Q58DD0 ACE2
0.641
3
UniProt:O14786 NRP1
1
NRP1 [plasma membrane]
(R-HSA-3008773)
0.639
9
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.636
8
UniProt:P11226-PRO_0000017401 MBL2
0.632
11
ChEBI:28304 HEPARIN
0.623
5
UniProt:P07711 CTSL
8
CTSL(114-288) [extracellular region]
(R-HSA-449861)
CTSL(292-333) [extracellular region]
(R-HSA-449863)
CTSL1(114-288) [lysosomal lumen]
(R-HSA-1181225)
CTSL1(114-288) [early endosome lumen]
(R-HSA-4127474)
CTSL(292-333) [endolysosome lumen]
(R-HSA-1679026)
CTSL(114-288) [endolysosome lumen]
(R-HSA-1679050)
CTSL(114-288) [endocytic vesicle lumen]
(R-HSA-9686686)
CTSL(292-333) [endocytic vesicle lumen]
(R-HSA-9686680)
0.623
3
maltose [ChEBI:17306]
2
Mal [cytosol]
(R-ALL-868706)
Mal [extracellular region]
(R-ALL-188986)
0.623
3
UniProt:P59665-PRO_0000006773 DEFA1
0.618
3
UniProt:A5CKE2 A5CKE2
0.618
3
UniProt:P31431 SDC4
20
SDC4 [lysosomal lumen]
(R-HSA-2090041)
HS(6)-SDC4 [lysosomal lumen]
(R-HSA-2090058)
HS(1)-SDC4 [Golgi lumen]
(R-HSA-2076434)
HS(2)-SDC4 [Golgi lumen]
(R-HSA-2076411)
HS(3)-SDC4 [Golgi lumen]
(R-HSA-2076418)
HS(4)-SDC4 [Golgi lumen]
(R-HSA-2076407)
HS(6)-SDC4 [Golgi lumen]
(R-HSA-2076330)
HS(5)-SDC4 [Golgi lumen]
(R-HSA-2076510)
Heparan-SDC4 [Golgi lumen]
(R-HSA-2076374)
Heparan(1)-SDC4 [Golgi lumen]
(R-HSA-2076394)
Heparan(2)-SDC4 [Golgi lumen]
(R-HSA-2076446)
Heparan(4)-SDC4 [Golgi lumen]
(R-HSA-2076613)
Heparan(3)-SDC4 [Golgi lumen]
(R-HSA-2076460)
SDC4 [Golgi lumen]
(R-HSA-2054111)
XylS-SDC4 [Golgi lumen]
(R-HSA-2064195)
HS(4)-SDC4 [plasma membrane]
(R-HSA-2076670)
HS(6)-SDC4 [plasma membrane]
(R-HSA-2076633)
HS(2)-SDC4 [plasma membrane]
(R-HSA-2076694)
HS(1)-SDC4 [plasma membrane]
(R-HSA-2076653)
HS(3)-SDC4 [plasma membrane]
(R-HSA-2076674)
0.599
17
hemin [ChEBI:50385]
1
hemin [cytosol]
(R-ALL-421489)
0.59
2
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.59
2
IntAct:EBI-27090397 RC-101
0.558
2
lipopolysaccharide [ChEBI:16412]
5
LPS [peptidoglycan-based cell wall]
(R-ALL-6803081)
LPS [endocytic vesicle lumen]
(R-ALL-2239413)
LPS [endosome lumen]
(R-ALL-2201311)
LPS [plasma membrane]
(R-ALL-433850)
LPS [extracellular region]
(R-ALL-166005)
0.558
3
UniProt:Q07021-PRO_0000018590 C1QBP
0.558
2
UniProt:Q61830 Mrc1
4
Mrc1 [plasma membrane]
(R-MMU-1236776)
Mrc1 [plasma membrane]
(R-MMU-1216515)
Mrc1 [clathrin-coated endocytic vesicle membrane]
(R-MMU-1236818)
Mrc1 [early endosome membrane]
(R-MMU-1236785)
0.558
2
cholesterol [ChEBI:16113]
20
CHOL [lipid droplet]
(R-ALL-163586)
CHOL [early endosome]
(R-ALL-2429660)
CHOL [mitochondrial matrix]
(R-ALL-193840)
CHOL [cornified envelope]
(R-ALL-8847704)
cholesterol [mitochondrial intermembrane space]
(R-ALL-196084)
CHOL [mitochondrial outer membrane]
(R-ALL-8951853)
CHOL [mitochondrial inner membrane]
(R-ALL-193156)
CHOL [lysosomal membrane]
(R-ALL-8876478)
cholesterol [endosome lumen]
(R-ALL-171083)
cholesterol [endosome membrane]
(R-ALL-171135)
cholesterol [clathrin-coated endocytic vesicle membrane]
(R-ALL-171069)
CHOL [endoplasmic reticulum lumen]
(R-ALL-174672)
CHOL [smooth endoplasmic reticulum]
(R-ALL-8866305)
CHOL [transport vesicle membrane]
(R-ALL-216762)
CHOL [lysosomal lumen]
(R-ALL-8848047)
CHOL [cytosol]
(R-ALL-176478)
cholesterol [endocytic vesicle lumen]
(R-ALL-2239405)
CHOL [plasma membrane]
(R-ALL-171095)
CHOL [endoplasmic reticulum membrane]
(R-ALL-193384)
CHOL [extracellular region]
(R-ALL-171149)
0.558
5
N-acetylneuraminic acid [ChEBI:17012]
1
Neu5Ac [Golgi lumen]
(R-ALL-975925)
0.558
2
UniProt:P35247 SFTPD
3
SFTPD [endoplasmic reticulum membrane]
(R-HSA-5685278)
SFTPD [clathrin-coated endocytic vesicle]
(R-HSA-5686343)
SFTPD [extracellular region]
(R-HSA-391099)
0.544
3
UniProt:P01130 LDLR
4
LDLR [endolysosome membrane]
(R-HSA-6784818)
LDLR [endosome membrane]
(R-HSA-171127)
LDLR [clathrin-coated endocytic vesicle membrane]
(R-HSA-171105)
LDLR [plasma membrane]
(R-HSA-171053)
0.537
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.537
4
UniProt:P60660 MYL6
2
p-S20-MYL6 [cytosol]
(R-HSA-445778)
MYL6 [cytosol]
(R-HSA-419186)
0.527
2
UniProt:Q9ULV4 COR1C
0.527
2
UniProt:Q9NYL9 TMOD3
1
TMOD3 [cytosol]
(R-HSA-217354)
0.527
2
IntAct:EBI-26657222 PEPTIDE
0.525
2
IntAct:EBI-26657225 PEPTIDE
0.525
2
IntAct:EBI-26997889 ACE2
0.524
2
UniProt:A0A1S3APE5 A0A1S3APE5
0.524
2
UniProt:Q5EGZ1
1
ACE2(18-805) [plasma membrane]
(R-RNO-2022344)
0.524
2
UniProt:E2DHI3 E2DHI3
0.524
2
UniProt:Q14416 GRM2
1
GRM2 [plasma membrane]
(R-HSA-420468)
0.524
4
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.524
4
linoleic acid [ChEBI:17351]
6
LINA [endoplasmic reticulum lumen]
(R-ALL-2046044)
LINA [early endosome]
(R-ALL-879655)
LINA [cytosol]
(R-ALL-1132021)
LINA [extracellular region]
(R-ALL-879520)
LINA [lipid droplet]
(R-ALL-2864095)
LINA [nucleoplasm]
(R-ALL-400158)
0.522
2
UniProt:P35606 COPB2
4
COPB2 [endoplasmic reticulum membrane]
(R-HSA-6810957)
COPB2 [Golgi membrane]
(R-HSA-6808739)
COPB2 [transport vesicle]
(R-HSA-6808741)
COPB2 [cytosol]
(R-HSA-199972)
0.499
3
UniProt:Q9Y5S1 TRPV2
1
TRPV2 [plasma membrane]
(R-HSA-2671909)
0.499
2
UniProt:Q5EA32
1
TRPV2 [plasma membrane]
(R-BTA-2671909)
0.499
3
UniProt:Q5MNZ6 WDR45B
1
WDR45B [cytosol]
(R-HSA-5678303)
0.499
4
UniProt:Q15005 SPCS2
1
SPCS2 [endoplasmic reticulum membrane]
(R-HSA-264996)
0.499
2
UniProt:P26038 MSN
4
MSN [cytosol]
(R-HSA-437350)
MSN(2-448)-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711966)
MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711971)
p-T558-MSN [cytosol]
(R-HSA-9663005)
0.499
20
UniProt:Q15436 SEC23A
4
p-S738,T744 SEC23A [cytosol]
(R-HSA-5685740)
SEC23A [ER to Golgi transport vesicle membrane]
(R-HSA-204024)
SEC23A [cytosol]
(R-HSA-203972)
SEC23A [endoplasmic reticulum membrane]
(R-HSA-203976)
0.499
20
UniProt:P0DTD1-PRO_0000449625 REP
0.488
2
UniProt:P0DTD1-PRO_0000449627 REP
0.488
2
UniProt:P0DTD1-PRO_0000449628 REP
0.488
2
UniProt:P15311 EZR
3
p-Y146,Y354-EZR [cytosol]
(R-HSA-374572)
p-T567-EZR [cytosol]
(R-HSA-374559)
EZR [cytosol]
(R-HSA-9020826)
0.483
10
UniProt:P14649 MYL6B
2
MYL6B [cytosol]
(R-HSA-445776)
p-S20-MYL6B [cytosol]
(R-HSA-445763)
0.482
2
UniProt:Q8WXE9 STON2
2
NEDD8-STON2 [cytosol]
(R-HSA-8863733)
STON2 [cytosol]
(R-HSA-8862856)
0.482
2
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