Reactome | WASF3 [cytosol]

WASF3 [cytosol]

Stable Identifier

R-HSA-200975

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Wave3

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RAC1 GTPase cycle (Homo sapiens)
        
        RAC1 binds effectors at the plasma membrane (Homo sapiens)
        
        RAC1 effectors [cytosol] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
        
        RAC1 effectors [cytosol] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPY6 WASF3

Gene Names

WASF3, KIAA0900, SCAR3, WAVE3

Chain

chain:1-502

Reference Genes

BioGPS Gene:10810 WASF3

COSMIC (genes):WASF3 WASF3

CTD Gene:10810 WASF3

dbSNP Gene:10810 WASF3

ENSEMBL:ENSG00000132970 WASF3

HGNC:12734 WASF3

KEGG:hsa:10810 WASF3

Monarch:10810 WASF3

NCBI Gene:10810 WASF3

OMIM:605068 WASF3

UCSC:Q9UPY6 WASF3

Reference Transcript

Participates

as a candidate of

WAVEs [cytosol] (Homo sapiens)

Other forms of this molecule

p-Y151,S,T-WASF3 [cytosol]

p-Y151-WASF3 [cytosol]

Inferred To

SCAR [cytosol] (Drosophila melanogaster)

WASF3 [cytosol] (Bos taurus)

WASF3 [cytosol] (Canis familiaris)

WASF3 [cytosol] (Gallus gallus)

WASF3 [cytosol] (Sus scrofa)

wve-1 [cytosol] (Caenorhabditis elegans)

Wasf3 [cytosol] (Mus musculus)

Wasf3 [cytosol] (Rattus norvegicus)

Homologues of WASF3 [cytosol] (Drosophila melanogaster)

gukh [cytosol] (Drosophila melanogaster)

wasf3 [cytosol] (Xenopus tropicalis)

scrA [cytosol] (Dictyostelium discoideum)

Cross References

ENSEMBL

ENSG00000132970, ENST00000335327, ENST00000361042, ENSP00000335055, ENSP00000354325

OpenTargets

ENSG00000132970

GeneCards

WASF3

HPA

ENSG00000132970-WASF3

PRO

Q9UPY6

Pharos - Targets

Q9UPY6

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.527	2