Reactome | AP2A2(1-939) [secretory granule membrane]

AP2A2(1-939) [secretory granule membrane]

Stable Identifier

R-HSA-6800412

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

Synonyms

Adaptor protein AP2A2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O94973 AP2A2

Gene Names

AP2A2, ADTAB, CLAPA2, HIP9, HYPJ, KIAA0899

Chain

chain:1-939

Reference Genes

BioGPS Gene:161 AP2A2

COSMIC (genes):AP2A2 AP2A2

CTD Gene:161 AP2A2

dbSNP Gene:161 AP2A2

ENSEMBL:ENSG00000183020 AP2A2

ENSEMBL:ENSG00000183020.15 AP2A2

HGNC:562 AP2A2

KEGG Gene (Homo sapiens):161 AP2A2

Monarch:161 AP2A2

NCBI Gene:161 AP2A2

OMIM:607242 AP2A2

UCSC:O94973 AP2A2

Reference Transcript

Other Identifiers

11741016_a_at

11741017_s_at

11755014_a_at

161

16720440

211779_PM_x_at

211779_x_at

212159_PM_x_at

212159_x_at

212161_3p_at

212161_PM_at

212161_at

215764_3p_x_at

215764_PM_x_at

215764_x_at

32228_at

3316451

3316452

3316453

3316454

3316455

3316471

3316477

3316481

3316484

3316488

3316492

3316493

3316494

3316502

3316508

3316512

3316514

3316515

3316516

3316520

3316528

3316532

3316540

3316542

3316543

3316544

3316546

3316547

3316548

3316549

3316550

3316551

3316552

3316553

3316554

3316555

3316556

3316557

3316558

3316559

3316560

3316562

7937533

A_14_P126629

A_23_P21853

A_24_P339974

A_24_P932418

A_33_P3311863

GE53571

GO:0003674

GO:0005515

GO:0005764

GO:0005768

GO:0005773

GO:0005829

GO:0005886

GO:0005905

GO:0006886

GO:0006897

GO:0008289

GO:0009898

GO:0015031

GO:0016020

GO:0016192

GO:0019900

GO:0019901

GO:0019904

GO:0030117

GO:0030122

GO:0030131

GO:0030666

GO:0030667

GO:0030669

GO:0031410

GO:0035615

GO:0036020

GO:0043226

GO:0045334

GO:0060090

GO:0072583

GO:0097718

GO:0098794

GO:0098884

GO:0101003

HMNXSV003023222

HMNXSV003045833

Hs.19121.0.S2_3p_a_at

Hs.19121.0.S2_3p_at

Hs.19121.0.S2_3p_x_at

Hs.19121.1.S1_3p_a_at

Hs.19121.1.S1_3p_at

ILMN_1803779

PH_hs_0001684

TC11000036.hg

g13544040_3p_s_at

Participates

as a member of

Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)

Other forms of this molecule

AP2A2(1-939) [endolysosome membrane]

AP2A2(1-939) [ficolin-1-rich granule membrane]

AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]

AP2A2(1-939) [cytosol]

AP2A2(1-939) [plasma membrane]

Inferred To

AP-2alpha [secretory granule membrane] (Drosophila melanogaster)

ap2a2 [secretory granule membrane] (Xenopus tropicalis)

apl3 [secretory granule membrane] (Schizosaccharomyces pombe)

ap2a1-2 [secretory granule membrane] (Dictyostelium discoideum)

AP2A2(1-939) [secretory granule membrane] (Bos taurus)

AP2A2(1-939) [secretory granule membrane] (Caenorhabditis elegans)

AP2A2(1-939) [secretory granule membrane] (Canis familiaris)

AP2A2(1-939) [secretory granule membrane] (Mus musculus)

AP2A2(1-939) [secretory granule membrane] (Plasmodium falciparum)

AP2A2(1-939) [secretory granule membrane] (Rattus norvegicus)

AP2A2 [secretory granule membrane] (Gallus gallus)

AP2A2 [secretory granule membrane] (Sus scrofa)

APL3 [secretory granule membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_036437.1, NP_001229766.1

OpenTargets

ENSG00000183020

GeneCards

O94973

HPA

ENSG00000183020-AP2A2

Ensembl

ENST00000332231, ENSP00000327694, ENST00000528815, ENST00000448903, ENSP00000413234, ENSG00000183020, ENSP00000431630

PRO

O94973

Pharos - Targets

O94973

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29353 SHC1	5	SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.643	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.569	4
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.527	2
UniProt:P98078	3	Dab2 [cytosol] (R-MMU-8862456) Dab2 [lysosomal membrane] (R-MMU-2980807) Dab2 [plasma membrane] (R-MMU-2980808)	0.499	2

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