Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
AP2A1 [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-HSA-5138449
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
Synonyms
Adaptor protein AP2A1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
WNT5A-dependent internalization of FZD4 (Homo sapiens)
WNT5A:FZD4 is endocytosed (Homo sapiens)
WNT5A:FZD4:p-DVL2:AP-2:clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
clathrin:AP-2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 complex large subunits [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP2A1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95782 AP2A1
Gene Names
AP2A1, ADTAA, CLAPA1
Chain
chain:1-977
Reference Genes
BioGPS Gene:160 AP2A1
COSMIC (genes):AP2A1 AP2A1
CTD Gene:160 AP2A1
dbSNP Gene:160 AP2A1
ENSEMBL:ENSG00000196961.13 AP2A1
HGNC:561 AP2A1
KEGG Gene (Homo sapiens):160 AP2A1
Monarch:160 AP2A1
NCBI Gene:160 AP2A1
OMIM:601026 AP2A1
UCSC:O95782 AP2A1
Reference Transcript
RefSeq:NM_130787.2 AP2A1
RefSeq:NM_014203.2 AP2A1
Other Identifiers
11728299_x_at
11748811_a_at
11752077_a_at
11752078_x_at
160
16864304
223237_3p_x_at
223237_PM_x_at
223237_x_at
229617_3p_x_at
229617_PM_x_at
229617_x_at
234068_PM_s_at
234068_s_at
3838887
3838888
3838891
3838892
3838893
3838894
3838895
3838896
3838897
3838902
3838904
3838905
3838906
3838907
3838908
3838909
3838911
3838912
3838914
3838916
3838918
3838920
3838921
3838922
3838925
3838926
3838927
3838928
3838929
3838931
3838932
3838933
49206_at
8030470
A_14_P132495
A_14_P200554
A_23_P4885
GE54012
GO:0005515
GO:0005764
GO:0005768
GO:0005773
GO:0005794
GO:0005829
GO:0005886
GO:0005905
GO:0005975
GO:0006886
GO:0006895
GO:0006897
GO:0009898
GO:0015031
GO:0016020
GO:0016192
GO:0019901
GO:0030117
GO:0030122
GO:0030130
GO:0030131
GO:0030666
GO:0030669
GO:0031410
GO:0032433
GO:0035615
GO:0036020
GO:0043226
GO:0045334
GO:0050750
GO:0060090
GO:0072583
GO:0098794
GO:0098884
GO:0140312
GO:1900126
GO:1901135
HMNXSV003018745
Hs.296426.1.S1_3p_a_at
Hs.296426.1.S1_3p_s_at
ILMN_1673108
ILMN_1815306
ILMN_2359211
PH_hs_0015334
TC19000747.hg
g12053344_3p_s_at
Participates
as a member of
AP-2 complex large subunits [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
AP2A1 [endolysosome membrane]
AP2A1 [plasma membrane]
AP2A1 [endocytic vesicle membrane]
AP2A1 [cytosol]
Inferred To
AP2A1 [clathrin-coated endocytic vesicle membrane]
(Bos taurus)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(Caenorhabditis elegans)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(Canis familiaris)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(Danio rerio)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(Rattus norvegicus)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(Sus scrofa)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(Xenopus tropicalis)
AP-2alpha [clathrin-coated endocytic vesicle membrane]
(Drosophila melanogaster)
Ap2a1 [clathrin-coated endocytic vesicle membrane]
(Mus musculus)
Cross References
RefSeq
NP_570603.2
,
NP_055018.2
OpenTargets
ENSG00000196961
HPA
ENSG00000196961-AP2A1
GeneCards
O95782
Ensembl
ENST00000359032
,
ENSG00000196961
,
ENSP00000351926
,
ENST00000354293
,
ENSP00000346246
PRO
O95782
Pharos - Targets
O95782
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.671
6
UniProt:P29353 SHC1
5
SHC1 [cytosol]
(R-HSA-74680)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
0.643
5
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text