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p-STAT1 [nucleoplasm]
Stable Identifier
R-HSA-8987140
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)
2 x p-STAT1 [nucleoplasm] (Homo sapiens)
p-STAT1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42224 STAT1
Gene Names
STAT1
Chain
initiator methionine:, chain:2-750
Reference Genes
ENSEMBL:ENSG00000115415 STAT1
Participates
as a component of
2 x p-STAT1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
STAT1 [cytosol]
p-Y701-STAT1 [cytosol]
p-Y701-STAT1 [nucleoplasm]
p-Y701-STAT1 [cytosol]
p-Y701-STAT1 [nucleoplasm]
p-Y701,S727-STAT1 [cytosol]
p-STAT1 [cytosol]
Inferred To
phospho-sta-2 [nucleoplasm]
(Caenorhabditis elegans)
phospho-stat1a [nucleoplasm]
(Danio rerio)
phospho-sta-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-Stat1 [nucleoplasm]
(Mus musculus)
phospho-Stat1 [nucleoplasm]
(Rattus norvegicus)
phospho-dstD [nucleoplasm]
(Dictyostelium discoideum)
phospho-dstC [nucleoplasm]
(Dictyostelium discoideum)
phospho-Stat92E [nucleoplasm]
(Drosophila melanogaster)
phospho-dstB [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-STAT1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-STAT1 [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-STAT1 [nucleoplasm]
(Gallus gallus)
phospho-dstA [nucleoplasm]
(Dictyostelium discoideum)
phospho-STAT1 [nucleoplasm]
(Bos taurus)
phospho-STAT1 [nucleoplasm]
(Canis familiaris)
phospho-STAT1 [nucleoplasm]
(Sus scrofa)
phospho-stat1 [nucleoplasm]
(Xenopus tropicalis)
Homologues of p-STAT1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of p-STAT1 [nucleoplasm]
(Dictyostelium discoideum)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52630 STAT2
4
p-Y690-STAT2 [cytosol]
(R-HSA-909683)
STAT2 [cytosol]
(R-HSA-882029)
p-Y690-STAT2 [nucleoplasm]
(R-HSA-909673)
p-Y-STAT2 [cytosol]
(R-HSA-8987235)
0.92
19
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.908
10
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.774
7
UniProt:P23458 JAK1
6
p-Y-JAK1 [cytosol]
(R-HSA-451921)
JAK1 [cytosol]
(R-HSA-451898)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
p-JAK1 [cytosol]
(R-HSA-8950711)
JAK1 [endosome]
(R-HSA-8983168)
p-Y1034,Y1035-JAK1 [cytosol]
(R-HSA-9005335)
0.757
6
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.706
6
UniProt:P15260 IFNGR1
2
IFNGR1 [plasma membrane]
(R-HSA-629623)
p-Y457-IFNGR1 [plasma membrane]
(R-HSA-873798)
0.69
4
IntAct:EBI-9984951 IRF1
0.669
3
UniProt:Q8N9N8 EIF1A
0.666
4
UniProt:P42224 STAT1
8
STAT1 [cytosol]
(R-HSA-629622)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
0.643
4
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.623
4
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.576
3
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.571
3
IntAct:EBI-10178797 4005
0.556
3
UniProt:Q01804 OTUD4
0.556
3
UniProt:Q13813 SPTAN1
6
SPTAN1 [cytosol]
(R-HSA-201601)
SPTAN1(1-1185) [cytosol]
(R-HSA-202944)
SPTAN1(1186-2472) [cytosol]
(R-HSA-202964)
SPTAN1 [specific granule lumen]
(R-HSA-6799533)
SPTAN1 [extracellular region]
(R-HSA-6806322)
SPTAN1 [tertiary granule lumen]
(R-HSA-6800874)
0.547
2
UniProt:P07239 DUSP
0.544
2
UniProt:P03255-2
0.544
2
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.536
6
UniProt:Q14765 STAT4
4
p-Y693-STAT4 [nucleoplasm]
(R-HSA-8950636)
p-STAT4 [cytosol]
(R-HSA-8950350)
p-Y693-STAT4 [cytosol]
(R-HSA-8950343)
STAT4 [cytosol]
(R-HSA-8950606)
0.536
2
UniProt:Q05397 PTK2
11
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
PTK2 [cytosol]
(R-HSA-201621)
PTK2(1-772) [cytosol]
(R-HSA-202827)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
0.536
3
UniProt:P10276 RARA
3
RARA [nucleoplasm]
(R-HSA-446164)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
0.532
4
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.527
3
UniProt:Q00978 IRF9
2
IRF9 [nucleoplasm]
(R-HSA-913522)
IRF9 [cytosol]
(R-HSA-879183)
0.527
3
UniProt:P0C1C7 W
0.527
2
UniProt:Q997F2 V
0.527
2
UniProt:Q77M19 Q77M19
0.527
4
UniProt:P26664 POLG
0.524
5
UniProt:Q01094 E2F1
2
E2F1 [nucleoplasm]
(R-HSA-68639)
p-E2F1 [nucleoplasm]
(R-HSA-187911)
0.524
2
UniProt:Q4VW77 Q4VW77
0.524
2
IntAct:EBI-10097350 STAT
0.524
2
UniProt:P03255-1
0.508
2
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.508
2
UniProt:P19793 RXRA
4
RXRA [nucleoplasm]
(R-HSA-381319)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
RXRA [cytosol]
(R-HSA-9619757)
0.508
2
UniProt:P17181 IFNAR1
2
IFNAR1 [plasma membrane]
(R-HSA-877334)
p-Y466,Y481-IFNAR1 [plasma membrane]
(R-HSA-909675)
0.499
2
UniProt:P48551 IFNAR2
0.499
2
IntAct:EBI-9825772 C-FOS PROMOTER REGION
0.499
3
IntAct:EBI-10097414 FOXP3
0.499
2
UniProt:P11277 SPTB
1
SPTB [cytosol]
(R-HSA-391565)
0.488
2
UniProt:P27958-PRO_0000037576
0.463
4
UniProt:Q9UIV1 CNOT7
1
CNOT7 [cytosol]
(R-HSA-429877)
0.463
2
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