EGFR L747_T751delinsP

Stable Identifier
R-HSA-1228012
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Epidermal Growth Factor Receptor L747_T751delinsP, EGFR Leu747_Thr751delinsPro, EGFR L747_T751>P
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
15329413 EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

Pao, W, Miller, V, Zakowski, M, Doherty, J, Politi, K, Sarkaria, I, Singh, B, Heelan, R, Rusch, V, Fulton, L, Mardis, E, Kupfer, D, Wilson, R, Kris, M, Varmus, H

Proc Natl Acad Sci U S A 2004
External Reference Information
External Reference
Gene Names
EGFR, ERBB, ERBB1, HER1
Chain
signal peptide:1-24, chain:25-1210
Other Identifiers
0000840253
0002940025
0005900148
0006350504
11725102_at
11725103_s_at
11725104_a_at
11733760_a_at
11738815_at
11742247_a_at
11751983_a_at
1200
1537_at
1565483_at
1565484_x_at
17046135
18530
1956
1DNQ
1DNR
1IVO
1M14
1M17
1MOX
1NQL
1XKK
1YY9
1Z9I
201983_s_at
201984_s_at
210984_x_at
211550_at
211607_x_at
224999_at
2EB2
2EB3
2EXP
2EXQ
2GS2
2GS6
2GS7
2ITN
2ITO
2ITP
2ITQ
2ITT
2ITU
2ITV
2ITW
2ITX
2ITY
2ITZ
2J5E
2J5F
2J6M
2JIT
2JIU
2JIV
2KS1
2M0B
2M20
2N5S
2RF9
2RFD
2RFE
2RGP
3002641
3002642
3002729
3002731
3002733
3002738
3002741
3002743
3002747
3002749
3002750
3002751
3002753
3002757
3002760
3002761
3002763
3002767
3002769
3002770
3002771
3002775
3002776
3002778
3002779
3002786
3002798
3002800
3002801
3002802
3002806
3002807
3002808
3002811
3002812
3002813
3002814
3002815
3002816
3002817
3002818
3002819
3002820
35
37327_at
3B2U
3B2V
3BEL
3BUO
3C09
3G5V
3G5Y
3GT8
3IKA
3LZB
3NJP
3OB2
3OP0
3P0Y
3PFV
3POZ
3QWQ
3UG1
3UG2
3VJN
3VJO
3VRP
3VRR
3W2O
3W2P
3W2Q
3W2R
3W2S
3W32
3W33
48285_at
4G5J
4G5P
4HJO
4I1Z
4I20
4I21
4I22
4I23
4I24
4JQ7
4JQ8
4JR3
4JRV
4KRL
4KRM
4KRO
4KRP
4LI5
4LL0
4LQM
4LRM
4R3P
4R3R
4R5S
4RIW
4RIX
4RIY
4RJ4
4RJ5
4RJ6
4RJ7
4RJ8
4TKS
4UIP
4UV7
4WD5
4WKQ
4WRG
4ZAU
4ZJV
4ZSE
5C8K
5C8M
5C8N
5CAL
5CAN
5CAO
5CAP
5CAQ
5CAS
5CAU
5CAV
5CNN
5CNO
5CZH
5CZI
5D41
5EDP
5EDQ
5EDR
5EM5
5EM6
5EM7
5EM8
5FED
5FEE
5FEQ
5GMP
5GNK
5GTY
5GTZ
5HCX
5HCY
5HCZ
5HG5
5HG7
5HG8
5HG9
5HIB
5HIC
5J9Y
5J9Z
5JEB
5LV6
5SX4
5SX5
5U8L
5UG8
5UG9
5UGA
5UGB
5UGC
5UWD
5WB7
5WB8
5XGM
5XGN
65700_at
68186
73534
8132860
A_14_P106592
A_23_P215790
A_33_P3351944
A_33_P3351955
AAA52370
AAA63171
AAB53063
AAC50796
AAC50797
AAC50798
AAC50799
AAC50800
AAC50801
AAC50802
AAC50804
AAG35786
AAG35787
AAG35788
AAG35789
AAG35790
AAG43240
AAG43243
AAK01080
AAS83109
AAT97979
AF125253
AF125538
AF125539
AF277897
AF288738
AY588246
AY698024
CAA25240
CAA25282
CAA29668
CAB000035
CAB068186
CAB073534
CCDS47587
CCDS5514
CCDS5515
CCDS5516
EGFR
EGFR-201
EGFR-202
EGFR-203
EGFR-204
ENSG00000146648
ENSP00000275493
ENSP00000342376
ENSP00000345973
ENSP00000413843
ENST00000275493
ENST00000342916
ENST00000344576
ENST00000420316
EntrezGene:1956
g12002211_3p_at
g1628549_3p_s_at
g4885198_3p_a_at
GE59632
GO:0000003
GO:0000139
GO:0000165
GO:0000166
GO:0000186
GO:0000278
GO:0000902
GO:0001503
GO:0001618
GO:0001889
GO:0001892
GO:0001934
GO:0001942
GO:0003013
GO:0003674
GO:0003677
GO:0003682
GO:0003690
GO:0004672
GO:0004709
GO:0004713
GO:0004714
GO:0004716
GO:0004871
GO:0004888
GO:0005006
GO:0005088
GO:0005102
GO:0005178
GO:0005515
GO:0005516
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005737
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005925
GO:0006259
GO:0006357
GO:0006412
GO:0006464
GO:0006468
GO:0006605
GO:0006629
GO:0006810
GO:0006913
GO:0006950
GO:0006970
GO:0006979
GO:0007009
GO:0007049
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0007173
GO:0007202
GO:0007267
GO:0007275
GO:0007435
GO:0007494
GO:0007611
GO:0007623
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008544
GO:0009056
GO:0009058
GO:0009790
GO:0009986
GO:0010008
GO:0010750
GO:0010960
GO:0014066
GO:0014070
GO:0016020
GO:0016021
GO:0016101
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0018108
GO:0019899
GO:0019901
GO:0019903
GO:0021795
GO:0030122
GO:0030139
GO:0030154
GO:0030234
GO:0030235
GO:0030307
GO:0030324
GO:0030335
GO:0030665
GO:0031410
GO:0031625
GO:0031659
GO:0031901
GO:0031965
GO:0032355
GO:0032930
GO:0032991
GO:0033138
GO:0033590
GO:0033594
GO:0033993
GO:0034614
GO:0034641
GO:0035413
GO:0035556
GO:0035690
GO:0038083
GO:0038128
GO:0040007
GO:0040011
GO:0042059
GO:0042060
GO:0042127
GO:0042177
GO:0042327
GO:0042592
GO:0042698
GO:0042743
GO:0042802
GO:0043006
GO:0043066
GO:0043167
GO:0043226
GO:0043234
GO:0043235
GO:0043406
GO:0043586
GO:0044403
GO:0045121
GO:0045202
GO:0045296
GO:0045739
GO:0045740
GO:0045746
GO:0045780
GO:0045893
GO:0045907
GO:0045930
GO:0045944
GO:0046328
GO:0046718
GO:0046777
GO:0046854
GO:0046934
GO:0046982
GO:0048143
GO:0048146
GO:0048408
GO:0048471
GO:0048546
GO:0048661
GO:0048812
GO:0048856
GO:0048870
GO:0050679
GO:0050729
GO:0050730
GO:0050877
GO:0050999
GO:0051015
GO:0051186
GO:0051205
GO:0051592
GO:0051897
GO:0051968
GO:0060571
GO:0061024
GO:0061029
GO:0070141
GO:0070372
GO:0070374
GO:0070435
GO:0071230
GO:0071260
GO:0071276
GO:0071363
GO:0071364
GO:0071392
GO:0071549
GO:0097421
GO:0097489
GO:0097755
GO:0098609
GO:1900020
GO:1901185
GO:1901224
GO:1902722
GO:1903078
GO:1903800
GO:1905208
GO:2000145
HGNC:3236
HPA001200
HPA018530
Hs.279898.0.S1_3p_at
Hs.77432.0.S1_3p_a_at
Hs2.367845.1.S1_3p_at
Hs2.367845.1.S1_3p_x_at
ILMN_1728858
ILMN_1755535
ILMN_1798975
IPR000494
IPR000719
IPR001245
IPR006211
IPR006212
IPR008266
IPR009030
IPR011009
IPR016245
IPR017441
IPR020635
IPR021157
IPR032675
IPR032778
IPR036941
LRG_304
LRG_304t1
M11234
M38425
MIM:131550
MIM:211980
MIM:616069
NM_005228
NM_201282
NM_201283
NM_201284
NP_005219
NP_958439
NP_958440
NP_958441
PF00757
PF01030
PF07714
PF14843
PH_hs_0004462
PH_hs_0014421
PR00109
Q504U8
SM00219
SM00261
TC07000328.hg
TC07002321.hg
U48722
U48723
U48724
U48725
U48726
U48727
U48728
U48729
U95089
uc003tqh.4
uc003tqi.3
uc003tqj.4
uc003tqk.4
UPI000002A8C9
UPI000002A8CA
UPI000002A8CB
UPI000003E750
X00588
X00588_at
X00663
X06370
Participant Of
Other forms of this molecule
Modified Residues
Name
L-leucine removal at 747
Coordinate
747
PsiMod Name
PsiMod Definition
A protein modification that effectively removes or replaces an L-leucine.
Name
L-arginine removal at 748
Coordinate
748
PsiMod Name
PsiMod Definition
A protein modification that effectively removes or replaces an L-arginine.
Name
L-glutamic acid removal at 749
Coordinate
749
PsiMod Name
PsiMod Definition
A protein modification that effectively removes or replaces an L-glutamic acid.
Name
L-alanine removal at 750
Coordinate
750
PsiMod Name
PsiMod Definition
A protein modification that effectively removes or replaces an L-alanine.
Name
L-threonine 751 replaced with L-proline
Coordinate
751
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to L-proline.
A protein modification that effectively removes or replaces an L-threonine.
Disease
Name Identifier Synonyms
non-small cell lung carcinoma 3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
lung cancer 1324
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
ZINC - World Drugs
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Metabolites
COSMIC
GeneCards
BRENDA (Homo sapiens)
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (150)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P62993 GRB2  1 0.978 47
 UniProt:P00533 EGFR  58 0.978 26
 UniProt:P29353 SHC1  5 0.968 35
 UniProt:P22681 CBL  7 0.964 26
 UniProt:P04626 ERBB2  12 0.96 25
 UniProt:P01133 EGF  5 0.957 21
 UniProt:P21860 ERBB3      0.916 13
 UniProt:P40763 STAT3  10 0.893 14
 UniProt:P19174 PLCG1  5 0.85 6
 UniProt:P08238 HSP90AB1  5 0.839 8
 UniProt:Q9UJM3 ERRFI      0.826 13
 UniProt:P18031 PTPN1  1 0.822 7
 UniProt:P12931 SRC  4 0.818 7
 UniProt:P08107 HSP71      0.809 6
 UniProt:P27348 YWHAQ  1 0.809 6
 UniProt:P20417  1 0.802 11
 UniProt:P08581 MET  7 0.8 8
 UniProt:P31947 SFN  1 0.779 8
 UniProt:P27986 PIK3R1  15 0.779 6
 UniProt:P15941 MUC1  19 0.766 5
 UniProt:P07948 LYN  5 0.763 6
 UniProt:P62158 CALM      0.756 4
 UniProt:O00750 PIK3C2B  1 0.755 9
 UniProt:Q9UBN7 HDAC6  2 0.753 11
 UniProt:Q03135 CAV1  5 0.752 6
 UniProt:P16885 PLCG2  9 0.744 5
 UniProt:P04406 GAPDH  1 0.721 6
 UniProt:P10599 TXN  2 0.721 4
 UniProt:P11142 HSPA8  8 0.716 5
 UniProt:P42224 STAT1  7 0.706 6
 UniProt:Q92569 PIK3R3  2 0.704 6
 UniProt:P16333 NCK1  2 0.704 4
 UniProt:P04083 ANXA1  2 0.701 4
 UniProt:P63104 YWHAZ  2 0.701 5
 UniProt:P46109 CRKL  2 0.692 4
 UniProt:Q9UKV8 AGO2  2 0.679 11
 UniProt:P12830 CDH1  10 0.678 3
 UniProt:P35221 CTNNA1  2 0.669 4
 UniProt:P04792 HSPB1  3 0.669 3
 UniProt:Q05209 PTPN12  2 0.668 3
 UniProt:P07900 HSP90AA1  7 0.667 5
 UniProt:Q71U36 TUBA1A  9 0.659 3
 UniProt:P38646 HSPA9  6 0.659 4
 UniProt:O60716 CTNND1  1 0.659 4
 UniProt:Q92625 ANS1A      0.658 5
 UniProt:Q92870 APBB2      0.658 6
 UniProt:Q9NSE2 CISH  1 0.658 3
 UniProt:Q13322 GRB10  1 0.646 3
 UniProt:Q8NBJ4 GOLM1  2 0.644 13
 UniProt:P08195 SLC3A2  1 0.643 5
 UniProt:Q9UNE7 STUB1  1 0.635 3
 UniProt:Q14457 BECN1  3 0.628 7
 UniProt:P46940 IQGAP1  3 0.626 4
 UniProt:Q96B97 SH3KBP1  3 0.623 3
 UniProt:Q16543 CDC37  1 0.623 9
 UniProt:Q06124 PTPN11  4 0.609 4
 UniProt:O14965 AURKA  6 0.602 4
 UniProt:Q9UJ41 RABGEF1  2 0.599 4
 UniProt:Q86VI4 LAP4B      0.599 10
 UniProt:P07992 ERCC1  2 0.599 21
 UniProt:O00459 PIK3R2  2 0.592 3
 UniProt:Q13387 JIP2      0.592 4
 UniProt:Q13239 SLAP1      0.592 2
 UniProt:Q9NRF2 SH2B1  1 0.592 2
 UniProt:P43403 ZAP70  3 0.592 2
 UniProt:P42684 ABL2  1 0.592 8
 UniProt:P01135 TGFA  3 0.592 2
 UniProt:P00519 ABL1  5 0.592 2
 UniProt:P46108 CRK  1 0.592 3
 UniProt:P51451 BLK  2 0.592 2
 UniProt:P14174 MIF  3 0.591 3
 UniProt:P16234 PDGFRA  2 0.581 3
 UniProt:P29353-7 SHC1      0.581 4
 UniProt:Q68CZ2 TNS3  1 0.581 4
 UniProt:Q14318 FKBP8  2 0.581 3
 UniProt:Q01973 ROR1  2 0.576 8
 UniProt:P17936 IGFBP3  15 0.576 3
 UniProt:P08631 HCK  1 0.573 2
 UniProt:Q8WUM4 PDCD6IP  1 0.573 3
 UniProt:O60603 TLR2  2 0.573 2
 UniProt:O75368 SH3L1      0.573 2
 UniProt:P41240 CSK  2 0.573 2
 UniProt:Q99962 SH3GL2  4 0.573 3
 UniProt:Q92622 RUBIC      0.564 3
 UniProt:P07947 YES1  2 0.564 3
 UniProt:O75674 TM1L1      0.556 6
 UniProt:Q8IZV2 CKLF8      0.556 3
 UniProt:P97313  3 0.556 4
 UniProt:P23528 CFL1  3 0.553 2
 UniProt:P34932 HSPA4  2 0.553 2
 UniProt:Q09666 AHNK      0.547 3
 UniProt:P51636 CAV2      0.547 2
 UniProt:P06493 CDK1  10 0.547 2
 UniProt:Q05397 PTK2  10 0.547 3
 UniProt:Q13480 GAB1  3 0.547 3
 UniProt:Q9UQB8 BAIAP2  1 0.547 2
 UniProt:Q96CW1 AP2M1  6 0.547 4
 UniProt:Q14956-1 GPNMB      0.544 2
 UniProt:Q38SD2 LRRK1      0.544 2
 UniProt:P07948-1 LYN      0.544 2
 UniProt:P68366 TUBA4A  9 0.527 2
 UniProt:Q00325 MPCP      0.527 3
 UniProt:O60884 DNAJA2  1 0.527 2
 UniProt:O95782 AP2A1  5 0.527 4
 UniProt:Q9H0D6 XRN2  2 0.527 5
 UniProt:P16615 ATP2A2  2 0.527 2
 UniProt:P11021 HSPA5  6 0.527 5
 UniProt:Q9UQC2 GAB2  4 0.527 2
 UniProt:P31943 HNRNPH1  1 0.527 2
 UniProt:P30530 AXL  2 0.524 4
 UniProt:P62161 CALM      0.524 6
 UniProt:P03372-4 ESR1  1 0.524 4
 UniProt:Q15109 AGER  1 0.524 2
 UniProt:P13866 SLC5A1  8 0.524 3
 UniProt:Q14956 GPNMB  2 0.524 3
 UniProt:P60520 GABARAPL2  3 0.508 2
 UniProt:Q6S5L8 SHC4      0.508 2
 UniProt:P04150 NR3C1  3 0.508 2
 UniProt:P46108-1 CRK      0.508 3
 UniProt:Q9Y2R2 PTPN22  1 0.508 2
 UniProt:Q8WUI4 HDAC7  1 0.508 2
 UniProt:O75791 GRAP2  1 0.508 2
 UniProt:Q13094 LCP2  2 0.508 2
 UniProt:Q9Y2H9 MAST1      0.508 2
 UniProt:Q12929 EPS8      0.508 2
 UniProt:Q9P0L0 VAPA  3 0.508 2
 UniProt:P42229 STAT5A  5 0.508 3
 UniProt:P17252 PRKCA  8 0.508 2
 UniProt:P49069 CAMLG      0.508 2
 UniProt:Q14247 CTTN  2 0.508 3
 UniProt:Q02952 AKA12      0.508 2
 UniProt:Q9BRG2 SH23A      0.508 2
 UniProt:P09936 UCHL1  1 0.508 2
 UniProt:Q12933 TRAF2  5 0.508 3
 UniProt:O43561 LAT  3 0.508 2
 UniProt:P31948 STIP1  1 0.508 2
 UniProt:P09769 FGR  3 0.508 2
 IntAct:EBI-4399559 UBIQ      0.499 3
 UniProt:P22682  7 0.499 2
 UniProt:Q80U62 RUBIC      0.499 2
 UniProt:Q96A65 EXOC4  2 0.499 2
 UniProt:Q12852 M3K12      0.482 2
 UniProt:P25098 GRK2  3 0.463 3
 UniProt:P07355 ANXA2  4 0.463 3
 UniProt:Q13671 RIN1  1 0.463 3
 UniProt:P0A0I7 AGRA      0.463 2
 UniProt:O75886 STAM2  2 0.463 2
 UniProt:Q9UPT5 EXOC7  2 0.463 2
 UniProt:P46934 NEDD4  1 0.463 3
 UniProt:Q8TF42 UBS3B      0.462 5