Reactome | UROD [cytosol]

UROD [cytosol]

Stable Identifier

R-HSA-189427

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Uroporphyrinogen III decarboxylase, DCUP_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P06132 UROD

Gene Names

UROD

Chain

chain:1-367

Reference Genes

BioGPS Gene:7389 UROD

COSMIC (genes):UROD UROD

CTD Gene:7389 UROD

dbSNP Gene:7389 UROD

ENSEMBL:ENSG00000126088 UROD

HGNC:12591 UROD

KEGG Gene (Homo sapiens):7389 UROD

Monarch:7389 UROD

NCBI Gene:7389 UROD

OMIM:613521 UROD

UCSC:P06132 UROD

Reference Transcript

RefSeq:NM_000374.4 UROD

Other Identifiers

11748578_x_at

11756593_a_at

11756594_x_at

11757384_x_at

11760950_x_at

208970_s_at

208971_at

2334283

2334284

2334286

2334288

2334291

2334293

2334294

2334296

2334298

2334301

2334302

2334303

37667_at

7389

7901073

A_14_P200853

GE54801

GO:0003674

GO:0004853

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006779

GO:0006782

GO:0006783

GO:0008150

GO:0009058

GO:0016829

GO:0016831

GO:0034641

GO:0042168

GO:0043226

GO:0051186

M60891_s_at

PH_hs_0004534

TC01004350.hg

g340180_3p_a_at

Participant Of

hasComponent

2xUROD [cytosol]

Inferred To

hemE [cytosol] (Dictyostelium discoideum)

UROD [cytosol] (Canis familiaris)

UROD [cytosol] (Gallus gallus)

UROD [cytosol] (Plasmodium falciparum)

UROD [cytosol] (Sus scrofa)

HEM12 [cytosol] (Saccharomyces cerevisiae)

urod [cytosol] (Danio rerio)

urod [cytosol] (Xenopus tropicalis)

Urod [cytosol] (Drosophila melanogaster)

Urod [cytosol] (Mus musculus)

Urod [cytosol] (Rattus norvegicus)

hem12 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_000365.3

OpenTargets

ENSG00000126088

HPA

ENSG00000126088-UROD

GeneCards

P06132

Ensembl

ENST00000246337, ENSP00000246337, ENSG00000126088

PRO

P06132

Orphanet

15698

HMDB Protein

HMDBP00250

PDB

1R3Q, 1R3V, 2Q6Z, 3GVV, 1JPH, 1R3Y, 1URO, 2Q71, 1R3T, 1JPK, 3GVR, 3GVQ, 1R3S, 3GW3, 1R3R, 1R3W, 3GVW, 3GW0, 1JPI

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2

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