Reactome | GRK2 [plasma membrane]

GRK2 [plasma membrane]

Stable Identifier

R-HSA-50270

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ADRBK1, Beta-adrenergic receptor kinase 1 , Beta-ARK-1, G- protein coupled receptor kinase 2

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External Reference Information

External Reference

UniProt:P25098 GRK2

Gene Names

GRK2, ADRBK1, BARK, BARK1

Chain

chain:1-689

Reference Genes

BioGPS Gene:156 GRK2

COSMIC (genes):GRK2 GRK2

CTD Gene:156 GRK2

dbSNP Gene:156 GRK2

ENSEMBL:ENSG00000173020 GRK2

ENSEMBL_homo_sapiens_GENE:ENSG00000173020.11 GRK2

HGNC:289 GRK2

KEGG Gene (Homo sapiens):156 GRK2

Monarch:156 GRK2

NCBI Gene:156 GRK2

OMIM:109635 GRK2

UCSC:P25098 GRK2

Reference Transcript

RefSeq:NM_001619.3 GRK2

Other Identifiers

11716022_at

11716023_s_at

156

16727702

201401_PM_s_at

201401_s_at

201402_PM_at

201402_at

3336802

3336803

3336818

3336820

3336822

3336823

3336824

3336825

3336827

3336828

3336829

3336830

3336832

3336833

3336834

3336835

3336837

3336839

3336842

3336845

3336847

3336849

3336850

3336851

3336852

3336853

3336854

3336855

3336856

38447_PM_at

38447_at

7941797

A_23_P202667

A_24_P326635

A_33_P3384392

GE81046

GE87490

GO:0000166

GO:0001664

GO:0002026

GO:0002029

GO:0003012

GO:0003013

GO:0003108

GO:0003824

GO:0004672

GO:0004674

GO:0004703

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005929

GO:0006468

GO:0007165

GO:0007186

GO:0007213

GO:0007217

GO:0007507

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0019079

GO:0023052

GO:0031623

GO:0031694

GO:0031755

GO:0033605

GO:0036211

GO:0042995

GO:0043226

GO:0045202

GO:0045988

GO:0046718

GO:0047696

GO:0048856

GO:0050896

GO:0060048

GO:0098793

GO:0098794

GO:0140096

GO:1901081

HMNXSV003043248

ILMN_1673330

PH_hs_0004771

TC11000682.hg

U08438_at

g179334_3p_s_at

g6138971_3p_at

g6138971_3p_s_at

Participates

as a member of

GRK2, GRK3, GRK5, GRK6 [plasma membrane] (Homo sapiens)

as a component of

as an input of

Other forms of this molecule

p-S29-ADRBK1 [cytosol]

ADRBK1 [cilium]

p-S29-ADRBK1 [plasma membrane]

Inferred To

GRK2 [plasma membrane] (Bos taurus)

GRK2 [plasma membrane] (Caenorhabditis elegans)

GRK2 [plasma membrane] (Canis familiaris)

GRK2 [plasma membrane] (Drosophila melanogaster)

GRK2 [plasma membrane] (Gallus gallus)

GRK2 [plasma membrane] (Mus musculus)

GRK2 [plasma membrane] (Rattus norvegicus)

GRK2 [plasma membrane] (Sus scrofa)

GRK2 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001610.2

Guide to Pharmacology - Targets

1466

OpenTargets

ENSG00000173020

ZINC - Substances

ARBK1_HUMAN

ZINC - Biogenic

ARBK1_HUMAN

ZINC target

P25098

PRO

P25098

PDB

3KRW, 5UVC, 7PWD, 5UKK, 5UKL, 3KRX, 7K7Z, 3CIK, 5WG3, 5WG4, 4MK0, 1BAK, 5WG5, 5UUU, 4PNK, 6U7C, 3V5W, 7K7L, 6C2Y, 5HE1

HPA

ENSG00000173020-GRK2

GeneCards

P25098

Ensembl

ENSG00000173020, ENST00000308595, ENSP00000312262

Pharos - Targets

P25098

ZINC - Predictions - Purchasable

ARBK1_HUMAN

HMDB Protein

HMDBP01262

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35626 GRK3	2	ADRBK2 [cytosol] (R-HSA-8866004) ADRBK2 [plasma membrane] (R-HSA-8852029)	0.688	3
UniProt:P25963 NFKBIA	9	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805)	0.558	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P21860 ERBB3			0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:P13591 NCAM1	2	6xN-linked glycan core-NCAM1 [Golgi membrane] (R-HSA-422430) NCAM1 [plasma membrane] (R-HSA-190987)	0.556	3
UniProt:Q96T49 PP16B			0.527	2
UniProt:Q13085 ACACA	2	ACACA [cytosol] (R-HSA-1660609) Btn-ACACA [cytosol] (R-HSA-2976730)	0.527	2
UniProt:Q9P2M4 TBC1D14	1	TBC1D14 [recycling endosome] (R-HSA-8854764)	0.527	2
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.524	3
UniProt:Q13635 PTCH1	4	PTCH1 [plasma membrane] (R-HSA-445133) ub-PTCH1 [endocytic vesicle membrane] (R-HSA-5632520) ub-PTCH1 [ciliary membrane] (R-HSA-5632517) PTCH1 [ciliary membrane] (R-HSA-5610415)	0.499	2
UniProt:P21462 FPR1	4	FPR1 [azurophil granule membrane] (R-HSA-6799143) FPR1 [ficolin-1-rich granule membrane] (R-HSA-6800878) FPR1 [secretory granule membrane] (R-HSA-6800929) FPR1 [plasma membrane] (R-HSA-375450)	0.499	3
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.463	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.463	3
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.463	5

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