Reactome | SUMO1-K277,K293-NR3C1 [nucleoplasm]

SUMO1-K277,K293-NR3C1 [nucleoplasm]

Stable Identifier

R-HSA-4341106

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Glucocorticoid receptor, GCR_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        SUMOylation of NR3C1 (GR) with SUMO1 (Homo sapiens)
        
        2SUMO1:NR3C1:Glucocorticoid ligand dimer [nucleoplasm] (Homo sapiens)
        
        2SUMO1:NR3C1:Glucocorticoid ligand [nucleoplasm] (Homo sapiens)
        
        SUMO1-K277,K293-NR3C1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04150 NR3C1

Gene Names

NR3C1, GRL

Chain

chain:1-777

Reference Genes

BioGPS Gene:2908 NR3C1

COSMIC (genes):NR3C1 NR3C1

CTD Gene:2908 NR3C1

dbSNP Gene:2908 NR3C1

ENSEMBL:ENSG00000113580 NR3C1

HGNC:7978 NR3C1

KEGG:hsa:2908 NR3C1

Monarch:2908 NR3C1

NCBI Gene:2908 NR3C1

OMIM:138040 NR3C1

UCSC:P04150 NR3C1

Reference Transcript

Participates

as a component of

2SUMO1:NR3C1:Glucocorticoid ligand [nucleoplasm] (Homo sapiens)

Other forms of this molecule

NR3C1 [nucleoplasm]

NR3C1 [cytosol]

Inferred To

nr3c1 [nucleoplasm] (Danio rerio)

nr3c1 [nucleoplasm] (Xenopus tropicalis)

SUMO1-K277,K293-NR3C1 [nucleoplasm] (Gallus gallus)

Nr3c1 [nucleoplasm] (Mus musculus)

Nr3c1 [nucleoplasm] (Rattus norvegicus)

NR3C1 [nucleoplasm] (Bos taurus)

NR3C1 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 277

Coordinate

277

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 293

Coordinate

293

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

XP_005268480.1, NP_001191193.1, NP_001191192.1, XP_016864886.1, NP_001019265.1, NP_000167.1, NP_001191189.1, NP_001191190.1, NP_001191191.1, NP_001018086.1, NP_001191188.1, XP_016864887.1, XP_005268477.1, NP_001018084.1, NP_001018085.1, XP_005268479.1, XP_005268476.1, NP_001018661.1, NP_001018087.1, NP_001191187.1

Guide to Pharmacology - Targets

625

OpenTargets

ENSG00000113580

ENSEMBL

ENSP00000231509, ENSP00000422518, ENSG00000113580, ENST00000231509, ENST00000503201, ENSP00000405282, ENST00000415690, ENSP00000377977, ENST00000504572, ENST00000394466, ENST00000343796, ENSP00000377979, ENST00000394464, ENSP00000387672, ENSP00000427672, ENSP00000343205, ENST00000424646

ZINC - FDA approved

GCR_HUMAN

ZINC - Substances

GCR_HUMAN

ZINC - Biogenic

GCR_HUMAN

ZINC target

P04150

PRO

P04150

GlyGen

P04150

PDB

6X6D, 4MDD, 1P93, 7KRJ, 4CSJ, 4P6X, 3K22, 3K23, 5EMQ, 5EMP, 8FFW, 6EL6, 5VA7, 5EMC, 4P6W, 1NHZ, 5E6D, 3CLD, 4UDC, 5CC1, 6DXK, 5UC3, 5G3J, 5NFP, 5E6A, 6YO8, 5E69, 8VKZ, 8A9G, 5CBX, 7PRX, 4HN6, 8FFV, 6X6E, 3H52, 6YMO, 5G5W, 6CFN, 6EL7, 6EL9, 3E7C, 3BQD, 7KW7, 5UC1, 5E6B, 5VA0, 5E6C, 4UDD, 5CBZ, 5CBY, 4LSJ, 5NFT, 7PRV, 7PRW, 6BQU, 6YOS, 4HN5, 1M2Z

ZINC - Investigational

GCR_HUMAN

ZINC - Metabolites

GCR_HUMAN

GeneCards

NR3C1

HPA

ENSG00000113580-NR3C1

Pharos - Targets

P04150

Orphanet

NR3C1

ZINC - Predictions - Purchasable

GCR_HUMAN

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.775	8
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.643	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.611	5
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.61	5
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:P25491	3	SOH-C149,C150-DNAJA1 [cytosol] (R-SCE-9857072) DNAJA4 [cytosol] (R-SCE-3371578) DNAJA2 [cytosol] (R-SCE-3371555)	0.499	5
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.463	3

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