Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
Stable Identifier
R-HSA-210466
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-sculpted glutamate transport vesicle membrane
Synonyms
Rab3A
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
Glutamate synaptic vesicle docking and priming (Homo sapiens)
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
Glutamate loaded synaptic vesicle [cytosol] (Homo sapiens)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (Homo sapiens)
Glutamate loaded synaptic vesicle [cytosol] (Homo sapiens)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (Homo sapiens)
L-Glutamate loading of synaptic vesicle (Homo sapiens)
Empty Glutamate Synaptic Vesicle [cytosol] (Homo sapiens)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (Homo sapiens)
Glutamate loaded synaptic vesicle [cytosol] (Homo sapiens)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (Homo sapiens)
Release of L-Glutamate at the synapse (Homo sapiens)
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
Glutamate loaded synaptic vesicle [cytosol] (Homo sapiens)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
Exocytosis of glutamate from cochlear inner hair cell (Homo sapiens)
Glutamate depleted vesicle:Ca2+:SNAP25:STX1A [plasma membrane] (Homo sapiens)
Glutamate depleted synaptic vesicle (cochlear inner hair cell) [cytosol] (Homo sapiens)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (Homo sapiens)
Glutamate loaded vesicle:BSN:RIBEYE:PICCOLINO [cytosol] (Homo sapiens)
Glutamate loaded synaptic vesicle (cochlear inner hair cell) [cytosol] (Homo sapiens)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (Homo sapiens)
General
Rab3A, located in the synaptic vesicle membrane, interacts with RIM ( Rab3A interacting Molecule) and with Doc2. These interactions are beleived to initiate the process of priming which precedes the fuison of the synaptic vesicle with the plasma membrane.
External Reference Information
External Reference
UniProt:P20336 RAB3A
Gene Names
RAB3A
Chain
chain:1-220
Reference Genes
BioGPS Gene:5864 RAB3A
COSMIC (genes):RAB3A RAB3A
CTD Gene:5864 RAB3A
dbSNP Gene:5864 RAB3A
ENSEMBL:ENSG00000105649 RAB3A
HGNC:9777 RAB3A
KEGG:hsa:5864 RAB3A
Monarch:5864 RAB3A
NCBI Gene:5864 RAB3A
OMIM:179490 RAB3A
UCSC:P20336 RAB3A
Reference Transcript
RefSeq:XM_011528164.1 RAB3A
RefSeq:NM_002866.4 RAB3A
Other Identifiers
11723977_at
11723978_x_at
11748842_a_at
16870329
204974_PM_at
204974_at
3854757
3854758
3854760
3854761
3854762
3854763
3854766
57558_at
5864
620_at
8035398
A_23_P108200
A_33_P3314550
GE57899
GO:0000166
GO:0001669
GO:0001778
GO:0003016
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005737
GO:0005764
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0006886
GO:0006887
GO:0006904
GO:0007005
GO:0007274
GO:0007409
GO:0008021
GO:0008092
GO:0009306
GO:0009791
GO:0015031
GO:0016020
GO:0016079
GO:0016188
GO:0016192
GO:0016787
GO:0017156
GO:0017157
GO:0023052
GO:0030073
GO:0030133
GO:0030324
GO:0030424
GO:0030667
GO:0030672
GO:0030674
GO:0030742
GO:0031410
GO:0031489
GO:0031630
GO:0031982
GO:0032418
GO:0034330
GO:0036465
GO:0042995
GO:0043195
GO:0043226
GO:0045054
GO:0045055
GO:0045202
GO:0045921
GO:0048172
GO:0048471
GO:0048489
GO:0048786
GO:0048790
GO:0048856
GO:0050877
GO:0050975
GO:0051602
GO:0051649
GO:0060090
GO:0060201
GO:0060203
GO:0060478
GO:0061024
GO:0061202
GO:0061670
GO:0070083
GO:0072659
GO:0097091
GO:0098793
GO:0098794
GO:0099161
GO:1903307
GO:1903561
GO:1905684
HMNXSV003006200
HMNXSV003030499
Hs.27744.0.S2_3p_at
Hs.27744.0.S2_3p_x_at
ILMN_1755369
M28210_at
TC19001282.hg
Participates
as a component of
Glutamate depleted synaptic vesicle (cochlear inner hair cell) [cytosol] (Homo sapiens)
Glutamate loaded synaptic vesicle (cochlear inner hair cell) [cytosol] (Homo sapiens)
Empty Glutamate Synaptic Vesicle [cytosol] (Homo sapiens)
Glutamate loaded synaptic vesicle [cytosol] (Homo sapiens)
Other forms of this molecule
RAB3A [clathrin-sculpted monoamine transport vesicle membrane]
RAB3A [plasma membrane]
RAB3A [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
RAB3A [secretory granule membrane]
RAB3A [clathrin-sculpted acetylcholine transport vesicle membrane]
RAB3A [cytosol]
GGC-RAB3A [cytosol]
GGC-RAB3A [secretory granule membrane]
Inferred To
RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
(Bos taurus)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
(Caenorhabditis elegans)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
(Canis familiaris)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
(Dictyostelium discoideum)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
(Drosophila melanogaster)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
(Gallus gallus)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
(Rattus norvegicus)
RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
(Sus scrofa)
Rab3a [clathrin-sculpted glutamate transport vesicle membrane]
(Mus musculus)
Homologues of RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
(Dictyostelium discoideum)
Homologues of RAB3A [clathrin-sculpted glutamate transport vesicle membrane]
(Sus scrofa)
rab3ab [clathrin-sculpted glutamate transport vesicle membrane]
(Danio rerio)
rab3a [clathrin-sculpted glutamate transport vesicle membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002857.1
,
XP_011526466.1
OpenTargets
ENSG00000105649
ENSEMBL
ENSP00000222256
,
ENST00000222256
HPA
ENSG00000105649-RAB3A
PRO
P20336
Pharos - Targets
P20336
GlyGen
P20336
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P47224 MSS4
0.782
11
UniProt:P50395 GDI2
4
GDI2 [cytosol]
(R-HSA-195089)
GDI2 [azurophil granule lumen]
(R-HSA-6799337)
GDI2 [extracellular region]
(R-HSA-6806176)
GDI2 [secretory granule lumen]
(R-HSA-6800904)
0.643
3
UniProt:P31150 GDI1
1
GDI1 [cytosol]
(R-HSA-195106)
0.643
3
UniProt:Q96QF0 RAB3IP
1
RAB3IP [cytosol]
(R-HSA-5617610)
0.556
3
UniProt:Q8TBN0 RAB3IL1
1
RAB3IL1 [cytosol]
(R-HSA-8875296)
0.556
3
UniProt:Q96QF0-7 RAB3IP
0.556
3
UniProt:Q9H8Y1 VRTN
0.556
5
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P24386 CHM
1
CHM [cytosol]
(R-HSA-6801097)
0.527
3
UniProt:Q9HD47 RANGRF
1
RANGRF [cytosol]
(R-HSA-5216063)
0.527
3
UniProt:P20337 RAB3B
2
GGC-RAB3B [cytosol]
(R-HSA-8874009)
RAB3B [cytosol]
(R-HSA-8873715)
0.527
2
UniProt:Q9H082 RAB33B
4
GGC-RAB33B [Golgi membrane]
(R-HSA-6810968)
RAB33B [Golgi membrane]
(R-HSA-8854609)
GGC-RAB33B [cytosol]
(R-HSA-8874107)
RAB33B [cytosol]
(R-HSA-8873702)
0.527
3
UniProt:Q9UHK0 NUFP1
0.527
2
UniProt:Q96C24 SYTL4
2
SYTL4 [plasma membrane]
(R-HSA-8862971)
SYTL4 [platelet alpha granule membrane]
(R-HSA-8862959)
0.527
3
UniProt:P26374 CHML
1
CHML [cytosol]
(R-HSA-8870443)
0.527
3
UniProt:Q8N398 VW5B2
0.527
3
UniProt:Q9NVT9 ARMC1
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text