Reactome | p-Y694-STAT5A [cytosol]

p-Y694-STAT5A [cytosol]

Stable Identifier

R-HSA-507936

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p(Y694)-STAT5A, Signal transducer and activator of transcription 5A, STA5A_HUMAN

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External Reference Information

External Reference

UniProt:P42229 STAT5A

Gene Names

STAT5A, STAT5

Chain

chain:1-794

Reference Genes

BioGPS Gene:6776 STAT5A

COSMIC (genes):STAT5A STAT5A

CTD Gene:6776 STAT5A

dbSNP Gene:6776 STAT5A

ENSEMBL:ENSG00000126561 STAT5A

ENSEMBL_homo_sapiens_GENE:ENSG00000126561.18 STAT5A

HGNC:11366 STAT5A

KEGG Gene (Homo sapiens):6776 STAT5A

Monarch:6776 STAT5A

NCBI Gene:6776 STAT5A

OMIM:601511 STAT5A

UCSC:P42229 STAT5A

Reference Transcript

Other Identifiers

11717178_a_at

11745364_a_at

16834273

203010_PM_at

203010_at

3721659

3721660

3721661

3721662

3721663

3721664

3721667

3721669

3721670

3721671

3721672

3721673

3721674

3721676

3721678

3721680

3721681

3721683

3721684

3721685

3721687

3721688

3721689

3721690

3721691

3757791

3757799

3757800

3757801

3757807

40458_at

506_s_at

6776

75183_at

8007212

A_14_P103776

A_14_P118146

A_23_P207367

A_24_P173088

GE81241

GO:0000785

GO:0000978

GO:0000981

GO:0001938

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006790

GO:0006952

GO:0007165

GO:0007166

GO:0007259

GO:0007595

GO:0019221

GO:0019530

GO:0023052

GO:0030154

GO:0030222

GO:0035723

GO:0035771

GO:0038026

GO:0038043

GO:0038110

GO:0038113

GO:0038156

GO:0040014

GO:0042127

GO:0043226

GO:0043434

GO:0043536

GO:0045944

GO:0048856

GO:0048870

GO:0060397

GO:0071310

GO:0090575

GO:0140110

GO:0140297

HMNXSV003024861

HMNXSV003050095

ILMN_1753547

PH_hs_0025570

TC17000523.hg

U43185_s_at

g4507256_3p_at

Participates

as a member of

as a component of

p-Y694-STAT5A homodimer [cytosol] (Homo sapiens)

as a candidate of

Other forms of this molecule

STAT5A [nucleoplasm]

p-Y694-STAT5A [nucleoplasm]

STAT5A [cytosol]

Inferred To

phospho-dstD [cytosol] (Dictyostelium discoideum)

phospho-sta-2 [cytosol] (Caenorhabditis elegans)

phospho-sta-1 [cytosol] (Caenorhabditis elegans)

phospho-stat5b [cytosol] (Danio rerio)

phospho-stat5b [cytosol] (Xenopus tropicalis)

phospho-dstB [cytosol] (Dictyostelium discoideum)

phospho-dstC [cytosol] (Dictyostelium discoideum)

phospho-STAT5A [cytosol] (Bos taurus)

phospho-STAT5A [cytosol] (Canis familiaris)

phospho-STAT5A [cytosol] (Sus scrofa)

phospho-stat6 [cytosol] (Danio rerio)

phospho-Stat5a [cytosol] (Mus musculus)

phospho-Stat5a [cytosol] (Rattus norvegicus)

phospho-p-Y694-STAT5A [cytosol] (Caenorhabditis elegans)

phospho-p-Y694-STAT5A [cytosol] (Dictyostelium discoideum)

phospho-p-Y694-STAT5A [cytosol] (Gallus gallus)

phospho-stat5a [cytosol] (Danio rerio)

Homologues of p-Y694-STAT5A [cytosol] (Caenorhabditis elegans)

Homologues of p-Y694-STAT5A [cytosol] (Danio rerio)

Homologues of p-Y694-STAT5A [cytosol] (Dictyostelium discoideum)

phospho-Stat92E [cytosol] (Drosophila melanogaster)

phospho-dstA [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O4'-phospho-L-tyrosine at 694

Coordinate

694

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001275647.1, NP_003143.2, NP_001275649.1, NP_001275648.1

Guide to Pharmacology - Targets

3221

OpenTargets

ENSG00000126561

ZINC - Substances

STA5A_HUMAN

ZINC target

P42229

PRO

P42229

PDB

7UC7, 7UBT, 7UC6, 7TVA, 7TVB

ZINC - Investigational

STA5A_HUMAN

GeneCards

P42229

HPA

ENSG00000126561-STAT5A

Ensembl

ENSP00000468749, ENSP00000503262, ENST00000676585, ENSP00000504449, ENSG00000126561, ENST00000590949, ENST00000345506, ENST00000546010, ENSP00000341208, ENSP00000443107, ENST00000677301

Pharos - Targets

P42229

ZINC - Predictions - Purchasable

STA5A_HUMAN

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08559 PDHA1	1	PDHA1 [mitochondrial matrix] (R-HSA-69966)	0.643	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	4
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.558	2
UniProt:Q99490-2 AGAP2			0.556	3
UniProt:Q9UGK3 STAP2	2	p-Y250-STAP2 [plasma membrane] (R-HSA-8848079) STAP2 [cytosol] (R-HSA-8848028)	0.556	11
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.556	3
UniProt:P11177 PDHB	1	PDHB [mitochondrial matrix] (R-HSA-69967)	0.527	3
UniProt:O00330 PDHX	1	PDHX [mitochondrial matrix] (R-HSA-70059)	0.527	2
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.527	3
UniProt:Q8IXQ5 KLHL7			0.527	2
UniProt:P51692 STAT5B	4	STAT5B [cytosol] (R-HSA-380737) p-Y699-STAT5B [cytosol] (R-HSA-507939) p-Y699-STAT5B [nucleoplasm] (R-HSA-508016) p-STAT5B [cytosol] (R-HSA-8983127)	0.527	3
UniProt:O60603 TLR2	3	TLR2 [plasma membrane] (R-HSA-9637646) TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-167992)	0.527	2
UniProt:P10515 DLAT	4	Lipo-K259-DLAT [mitochondrial matrix] (R-HSA-69969) LipoH2-K259-DLAT [mitochondrial matrix] (R-HSA-9861664) AcetyllipoH2-K132,K259-DLAT [mitochondrial matrix] (R-HSA-9861594) DLAT [mitochondrial matrix] (R-HSA-6792585)	0.527	2
UniProt:Q15119 PDK2	1	PDK2(?-407) [mitochondrial matrix] (R-HSA-203943)	0.527	2
IntAct:EBI-1566868 IL2RA			0.525	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.524	2
UniProt:Q8TAK6 OLIG1			0.488	2
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.488	2
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.462	2