Reactome | K63polyUb-BECN1 [cytosol]

K63polyUb-BECN1 [cytosol]

Stable Identifier

R-HSA-6782989

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BECN1, Beclin-1, BECN1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP13 deubiquitinates BECN1,USP10 (Homo sapiens)
        
        USP13:K63polyUb-BECN1,K63polyUb-USP10 [cytosol] (Homo sapiens)
        
        K63polyUb-BECN1,K63polyUb-USP10 [cytosol] (Homo sapiens)
        
        K63polyUb-BECN1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14457 BECN1

Gene Names

BECN1, GT197

Chain

chain:1-450, chain:134-450, chain:150-450

Reference Genes

BioGPS Gene:8678 BECN1

COSMIC (genes):BECN1 BECN1

CTD Gene:8678 BECN1

dbSNP Gene:8678 BECN1

ENSEMBL:ENSG00000126581 BECN1

ENSEMBL:ENSG00000126581.13 BECN1

HGNC:1034 BECN1

KEGG Gene (Homo sapiens):8678 BECN1

Monarch:8678 BECN1

NCBI Gene:8678 BECN1

OMIM:604378 BECN1

UCSC:Q14457 BECN1

Reference Transcript

Other Identifiers

11743587_a_at

11743588_x_at

11745483_s_at

11746790_a_at

11746791_s_at

11746792_x_at

16845263

208945_PM_s_at

208945_s_at

208946_PM_s_at

208946_s_at

3758158

3758159

3758160

3758161

3758164

3758169

3758172

3758175

3758176

3758177

3758180

3758185

3758188

3758190

3758191

39378_at

8015715

8678

A_23_P433071

A_23_P89410

A_24_P313597

GE79828

GO:0000045

GO:0000278

GO:0000407

GO:0000422

GO:0000423

GO:0000910

GO:0001666

GO:0003012

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005768

GO:0005773

GO:0005776

GO:0005783

GO:0005789

GO:0005794

GO:0005802

GO:0005829

GO:0006468

GO:0006622

GO:0006629

GO:0006886

GO:0006897

GO:0006914

GO:0006915

GO:0006968

GO:0006995

GO:0007005

GO:0007040

GO:0007049

GO:0007059

GO:0007080

GO:0008285

GO:0009410

GO:0010008

GO:0010040

GO:0010288

GO:0010506

GO:0010507

GO:0010508

GO:0010613

GO:0012501

GO:0014068

GO:0016020

GO:0016192

GO:0016236

GO:0016241

GO:0016604

GO:0019901

GO:0023052

GO:0030154

GO:0030425

GO:0030674

GO:0031410

GO:0031625

GO:0031667

GO:0031966

GO:0032465

GO:0032473

GO:0032801

GO:0032991

GO:0033197

GO:0034198

GO:0034271

GO:0034272

GO:0035032

GO:0036092

GO:0036211

GO:0039521

GO:0042149

GO:0042802

GO:0043066

GO:0043069

GO:0043226

GO:0043548

GO:0043652

GO:0045022

GO:0045324

GO:0045335

GO:0048666

GO:0048856

GO:0050435

GO:0050790

GO:0051020

GO:0051301

GO:0051607

GO:0051707

GO:0060090

GO:0061024

GO:0061912

GO:0065003

GO:0070301

GO:0071275

GO:0071280

GO:0071364

GO:0097352

GO:0098542

GO:0098780

GO:0140014

GO:1902425

GO:1902902

GO:1905672

GO:2000378

GO:2000786

GO:2001244

HMNXSV003004505

Hs.12272.0.S1_3p_a_at

ILMN_1744822

L38932_at

PH_hs_0001156

TC17001545.hg

g4680380_3p_a_at

Participates

as a member of

K63polyUb-BECN1,K63polyUb-USP10 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S15-BECN1 [cytosol]

BECN1 [cytosol]

Inferred To

K63polyUb-BECN1 [cytosol] (Canis familiaris)

K63polyUb-BECN1 [cytosol] (Gallus gallus)

K63polyUb-BECN1 [cytosol] (Sus scrofa)

atg6 [cytosol] (Schizosaccharomyces pombe)

Becn1 [cytosol] (Mus musculus)

Becn1 [cytosol] (Rattus norvegicus)

Atg6 [cytosol] (Drosophila melanogaster)

BECN1 [cytosol] (Bos taurus)

bec-1 [cytosol] (Caenorhabditis elegans)

atg6B [cytosol] (Dictyostelium discoideum)

VPS30 [cytosol] (Saccharomyces cerevisiae)

becn1 [cytosol] (Danio rerio)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001300927.1, NP_001300928.1, NP_001300929.1, NP_003757.1

OpenTargets

ENSG00000126581

GeneCards

Q14457

HPA

ENSG00000126581-BECN1

Ensembl

ENST00000361523, ENSG00000126581, ENSP00000355231, ENSP00000465364, ENST00000590099

PRO

Q14457

Pharos - Targets

Q14457

PDB

5VAY, 2P1L, 5EFM, 4DDP, 7BL1, 5VAX, 6HOK, 5VAU, 2PON, 6DCO, 3DVU, 6HOJ, 5HHE, 4MI8, 6DCN, 6HOI

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P2Y5 UVRAG	2	UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510) UVRAG [cytosol] (R-HSA-5668884)	0.97	45
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.951	18
UniProt:Q9C0C7 AMBRA1	2	p-AMBRA1 [cytosol] (R-HSA-1632854) AMBRA1 [cytosol] (R-HSA-1632831)	0.868	9
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.703	14
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.628	7
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.599	4
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P42261 GRIA1	6	GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689811) GRIA1 [ER to Golgi transport vesicle membrane] (R-HSA-5689810) GRIA1 [endoplasmic reticulum membrane] (R-HSA-5689460) p-S849-GRIA1 [plasma membrane] (R-HSA-9620488) GRIA1 [endocytic vesicle membrane] (R-HSA-3004479) GRIA1 [plasma membrane] (R-HSA-3004495)	0.556	3
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.556	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.556	3
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:P12931 SRC	6	SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [nucleoplasm] (R-HSA-5625721) p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613)	0.556	3
UniProt:P17752 TPH1	1	TPH1 [cytosol] (R-HSA-976250)	0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.524	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.499	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.488	2
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.463	2
UniProt:O54921	2	Exoc2 [cytosol] (R-RNO-5623376) Exoc2 [plasma membrane] (R-RNO-264887)	0.463	2

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