Reactome | SNAP25 [tertiary granule membrane]

SNAP25 [tertiary granule membrane]

Stable Identifier

R-HSA-6806142

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

tertiary granule membrane

Synonyms

Synaptosomal-associated protein 25

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External Reference Information

External Reference

UniProt:P60880 SNAP25

Gene Names

SNAP25, SNAP

Chain

chain:1-206

Reference Genes

BioGPS Gene:6616 SNAP25

COSMIC (genes):SNAP25 SNAP25

CTD Gene:6616 SNAP25

dbSNP Gene:6616 SNAP25

ENSEMBL:ENSG00000132639 SNAP25

HGNC:11132 SNAP25

KEGG Gene (Homo sapiens):6616 SNAP25

Monarch:6616 SNAP25

NCBI Gene:6616 SNAP25

OMIM:600322 SNAP25

UCSC:P60880 SNAP25

Reference Transcript

Other Identifiers

0001580102

11733726_a_at

11733727_s_at

11750076_a_at

11750077_x_at

16911418

202507_PM_s_at

202507_s_at

202508_PM_s_at

202508_s_at

38484_at

3876244

3876246

3876247

3876258

3876259

3876262

3876265

3876271

3876272

3876279

3876280

3876282

3876283

3876288

3876289

6616

8060963

A_23_P210756

A_33_P3338693

D21267_at

GE61378

GO:0000149

GO:0001504

GO:0001917

GO:0003674

GO:0005249

GO:0005484

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005794

GO:0005802

GO:0005829

GO:0005856

GO:0005886

GO:0006810

GO:0006887

GO:0006906

GO:0007267

GO:0007268

GO:0007269

GO:0007626

GO:0008021

GO:0008076

GO:0008150

GO:0008306

GO:0010975

GO:0015031

GO:0016020

GO:0016079

GO:0016081

GO:0016082

GO:0016192

GO:0017075

GO:0019905

GO:0022607

GO:0022857

GO:0030054

GO:0030154

GO:0030424

GO:0030426

GO:0030674

GO:0031083

GO:0031201

GO:0031234

GO:0031410

GO:0031629

GO:0031982

GO:0032991

GO:0035579

GO:0036477

GO:0042734

GO:0043005

GO:0043226

GO:0045202

GO:0048306

GO:0048471

GO:0048856

GO:0050796

GO:0050877

GO:0055085

GO:0060291

GO:0061024

GO:0065003

GO:0070032

GO:0070201

GO:0070821

GO:0071805

GO:0098794

GO:0098967

GO:0098978

GO:0099590

HMNXSV003025439

HMNXSV003041197

ILMN_1740555

ILMN_2408080

PH_hs_0023120

TC20000082.hg

g307425_3p_a_at

g4507098_3p_a_at

Participates

as a member of

Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)

Other forms of this molecule

SNAP25(1-197) [plasma membrane]

SNAP25(198-206) [cytosol]

SNAP25(1-198) [plasma membrane]

SNAP25(199-206) [cytosol]

SNAP25 [specific granule membrane]

SNAP25 [plasma membrane]

Inferred To

sec9 [tertiary granule membrane] (Schizosaccharomyces pombe)

snap25 [tertiary granule membrane] (Xenopus tropicalis)

SEC9 [tertiary granule membrane] (Saccharomyces cerevisiae)

aex-4 [tertiary granule membrane] (Caenorhabditis elegans)

culC [tertiary granule membrane] (Dictyostelium discoideum)

SNAP25 [tertiary granule membrane] (Bos taurus)

SNAP25 [tertiary granule membrane] (Canis familiaris)

SNAP25 [tertiary granule membrane] (Dictyostelium discoideum)

SNAP25 [tertiary granule membrane] (Gallus gallus)

SNAP25 [tertiary granule membrane] (Plasmodium falciparum)

SNAP25 [tertiary granule membrane] (Sus scrofa)

ric-4 [tertiary granule membrane] (Caenorhabditis elegans)

Snap25 [tertiary granule membrane] (Drosophila melanogaster)

Snap25 [tertiary granule membrane] (Mus musculus)

Snap25 [tertiary granule membrane] (Rattus norvegicus)

SPO20 [tertiary granule membrane] (Saccharomyces cerevisiae)

Homologues of SNAP25 [tertiary granule membrane] (Caenorhabditis elegans)

Homologues of SNAP25 [tertiary granule membrane] (Dictyostelium discoideum)

Homologues of SNAP25 [tertiary granule membrane] (Drosophila melanogaster)

Homologues of SNAP25 [tertiary granule membrane] (Saccharomyces cerevisiae)

Snap24 [tertiary granule membrane] (Drosophila melanogaster)

snap25a [tertiary granule membrane] (Danio rerio)

Modified Residues

Name

S-palmitoyl-L-cysteine at 85

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 88

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 90

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 92

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Cross References

RefSeq

XP_016883511.1, NP_001309831.1, NP_570824.1, NP_001309832.1, NP_001309836.1, NP_001309839.1, NP_001309835.1, XP_005260865.1, NP_003072.2, XP_016883510.1, NP_001309834.1, NP_001309838.1, NP_001309837.1, NP_001309833.1

OpenTargets

ENSG00000132639

HPA

ENSG00000132639-SNAP25

GeneCards

P60880

Ensembl

ENSP00000254976, ENST00000304886, ENST00000254976, ENSG00000132639, ENSP00000307341

PRO

P60880

Pharos - Targets

P60880

Orphanet

23214

HMDB Protein

HMDBP02940

PDB

3RL0, 6JLH, 3ZUR, 1KIL, 3RK2, 1XTG, 5W7J, 3RK3, 5W7I, 2N1T, 3DDA, 3DDB

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449622 REP			0.556	3
UniProt:O75558 STX11			0.553	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.547	3
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.527	2
UniProt:P84077 ARF1	2	ARF1 [cytosol] (R-HSA-200826) ARF1 [Golgi membrane] (R-HSA-199971)	0.512	5
UniProt:Q8IUH5 ZDH17			0.489	3
UniProt:Q9Y3C0 WASC3			0.488	2

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