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SNAP25 [tertiary granule membrane]
Stable Identifier
R-HSA-6806142
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
tertiary granule membrane
Synonyms
Synaptosomal-associated protein 25
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)
SNAP25 [tertiary granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60880 SNAP25
Gene Names
SNAP25, SNAP
Chain
chain:1-206
Reference Genes
BioGPS Gene:6616 SNAP25
COSMIC (genes):SNAP25 SNAP25
CTD Gene:6616 SNAP25
dbSNP Gene:6616 SNAP25
ENSEMBL:ENSG00000132639 SNAP25
ENSEMBL:ENSG00000132639.15 SNAP25
HGNC:11132 SNAP25
KEGG Gene (Homo sapiens):6616 SNAP25
Monarch:6616 SNAP25
NCBI Gene:6616 SNAP25
OMIM:600322 SNAP25
UCSC:P60880 SNAP25
Reference Transcript
RefSeq:NM_001322908.1 SNAP25
RefSeq:NM_001322903.1 SNAP25
RefSeq:XM_017028022.1 SNAP25
RefSeq:NM_001322910.1 SNAP25
RefSeq:NM_001322905.1 SNAP25
RefSeq:NM_130811.3 SNAP25
RefSeq:NM_001322907.1 SNAP25
RefSeq:XM_017028021.1 SNAP25
RefSeq:NM_001322909.1 SNAP25
RefSeq:NM_001322902.1 SNAP25
RefSeq:NM_001322904.1 SNAP25
RefSeq:NM_003081.4 SNAP25
RefSeq:XM_005260808.4 SNAP25
RefSeq:NM_001322906.1 SNAP25
Other Identifiers
11733726_a_at
11733727_s_at
11750076_a_at
11750077_x_at
16911418
202507_PM_s_at
202507_s_at
202508_PM_s_at
202508_s_at
38484_at
3876244
3876246
3876247
3876248
3876249
3876252
3876253
3876254
3876258
3876259
3876262
3876265
3876271
3876272
3876279
3876280
3876282
3876283
3876288
3876289
3876310
6616
8060963
A_23_P210756
A_33_P3338693
D21267_at
GE61378
GO:0000149
GO:0001504
GO:0001917
GO:0005215
GO:0005249
GO:0005484
GO:0005515
GO:0005737
GO:0005768
GO:0005794
GO:0005802
GO:0005829
GO:0005856
GO:0005886
GO:0005938
GO:0006887
GO:0007268
GO:0007269
GO:0007409
GO:0007616
GO:0007626
GO:0008021
GO:0008076
GO:0008092
GO:0008289
GO:0008306
GO:0010975
GO:0015629
GO:0016020
GO:0016079
GO:0016081
GO:0016082
GO:0016192
GO:0016197
GO:0017022
GO:0017075
GO:0019904
GO:0023052
GO:0030027
GO:0030154
GO:0030175
GO:0030182
GO:0030424
GO:0030426
GO:0031083
GO:0031201
GO:0031410
GO:0031629
GO:0031982
GO:0032024
GO:0034330
GO:0035493
GO:0035579
GO:0036477
GO:0042734
GO:0043005
GO:0043025
GO:0043226
GO:0044295
GO:0044325
GO:0045202
GO:0046887
GO:0048306
GO:0048471
GO:0048787
GO:0048791
GO:0048856
GO:0050796
GO:0050877
GO:0051179
GO:0051963
GO:0055085
GO:0060090
GO:0060291
GO:0061024
GO:0065003
GO:0070032
GO:0070033
GO:0070044
GO:0070201
GO:0070821
GO:0071805
GO:0097470
GO:0098794
GO:0098888
GO:0098967
GO:0098978
GO:0099525
GO:0099590
HMNXSV003025439
HMNXSV003041197
ILMN_1740555
ILMN_2408080
PH_hs_0023120
TC20000082.hg
g307425_3p_a_at
g4507098_3p_a_at
Participates
as a member of
Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)
Other forms of this molecule
SNAP25(1-197) [plasma membrane]
SNAP25(198-206) [cytosol]
SNAP25(1-198) [plasma membrane]
SNAP25(199-206) [cytosol]
SNAP25 [specific granule membrane]
SNAP25 [plasma membrane]
Inferred To
sec9 [tertiary granule membrane]
(Schizosaccharomyces pombe)
snap25 [tertiary granule membrane]
(Xenopus tropicalis)
SEC9 [tertiary granule membrane]
(Saccharomyces cerevisiae)
aex-4 [tertiary granule membrane]
(Caenorhabditis elegans)
SNAP25 [tertiary granule membrane]
(Bos taurus)
SNAP25 [tertiary granule membrane]
(Canis familiaris)
SNAP25 [tertiary granule membrane]
(Dictyostelium discoideum)
SNAP25 [tertiary granule membrane]
(Gallus gallus)
SNAP25 [tertiary granule membrane]
(Plasmodium falciparum)
SNAP25 [tertiary granule membrane]
(Sus scrofa)
ric-4 [tertiary granule membrane]
(Caenorhabditis elegans)
Snap25 [tertiary granule membrane]
(Drosophila melanogaster)
Snap25 [tertiary granule membrane]
(Mus musculus)
Snap25 [tertiary granule membrane]
(Rattus norvegicus)
cspA [tertiary granule membrane]
(Dictyostelium discoideum)
SPO20 [tertiary granule membrane]
(Saccharomyces cerevisiae)
Homologues of SNAP25 [tertiary granule membrane]
(Caenorhabditis elegans)
Homologues of SNAP25 [tertiary granule membrane]
(Dictyostelium discoideum)
Homologues of SNAP25 [tertiary granule membrane]
(Drosophila melanogaster)
Homologues of SNAP25 [tertiary granule membrane]
(Saccharomyces cerevisiae)
Snap24 [tertiary granule membrane]
(Drosophila melanogaster)
snap25a [tertiary granule membrane]
(Danio rerio)
Modified Residues
Name
S-palmitoyl-L-cysteine at 85
Coordinate
85
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-palmitoyl-L-cysteine at 88
Coordinate
88
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-palmitoyl-L-cysteine at 90
Coordinate
90
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-palmitoyl-L-cysteine at 92
Coordinate
92
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Cross References
RefSeq
NP_001309836.1
,
XP_016883510.1
,
XP_016883511.1
,
NP_001309833.1
,
NP_001309832.1
,
NP_001309837.1
,
NP_001309834.1
,
NP_570824.1
,
NP_001309838.1
,
NP_003072.2
,
NP_001309831.1
,
NP_001309835.1
,
XP_005260865.1
,
NP_001309839.1
OpenTargets
ENSG00000132639
HPA
ENSG00000132639-SNAP25
GeneCards
P60880
Ensembl
ENSP00000254976
,
ENSP00000510663
,
ENST00000689757
,
ENSP00000508939
,
ENST00000254976
,
ENSP00000508837
,
ENST00000685131
,
ENSP00000510219
,
ENSP00000510558
,
ENSG00000132639
,
ENSP00000509759
,
ENST00000687785
,
ENSP00000509312
,
ENSP00000307341
,
ENST00000691161
,
ENST00000691665
,
ENST00000693325
,
ENST00000690812
,
ENSP00000508541
,
ENST00000692411
,
ENSP00000510109
,
ENST00000304886
,
ENST00000689858
,
ENSP00000509287
,
ENST00000691353
PRO
P60880
Pharos - Targets
P60880
Orphanet
23214
HMDB Protein
HMDBP02940
PDB
3DDB
,
2N1T
,
3RK2
,
5W7J
,
1KIL
,
3ZUR
,
3DDA
,
5W7I
,
3RK3
,
1XTG
,
6JLH
,
3RL0
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449622 REP
0.556
3
UniProt:O75558 STX11
0.553
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.547
3
UniProt:P61764 STXBP1
2
STXBP1 [cytosol]
(R-HSA-6794256)
STXBP1 [plasma membrane]
(R-HSA-2980862)
0.527
2
UniProt:P84077 ARF1
2
ARF1 [cytosol]
(R-HSA-200826)
ARF1 [Golgi membrane]
(R-HSA-199971)
0.512
5
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.502
2
UniProt:Q8IUH5 ZDH17
0.489
3
UniProt:Q9Y3C0 WASC3
0.488
2
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