Reactome | p-Y690-STAT2 [cytosol]

p-Y690-STAT2 [cytosol]

Stable Identifier

R-HSA-909683

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-STAT2, phospho STAT2 (Y690)

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        Phosphorylation of STAT1 (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
        
        p-STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y690-STAT2 [cytosol] (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
        
        p-STAT2:p-STAT1:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
        
        p-STAT2:p-STAT1 [cytosol] (Homo sapiens)
        
        p-Y690-STAT2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52630 STAT2

Gene Names

STAT2

Chain

chain:1-851

Reference Genes

BioGPS Gene:6773 STAT2

COSMIC (genes):STAT2 STAT2

CTD Gene:6773 STAT2

dbSNP Gene:6773 STAT2

ENSEMBL:ENSG00000170581 STAT2

ENSEMBL_homo_sapiens_GENE:ENSG00000170581.15 STAT2

HGNC:11363 STAT2

KEGG Gene (Homo sapiens):6773 STAT2

Monarch:6773 STAT2

NCBI Gene:6773 STAT2

OMIM:600556 STAT2

UCSC:P52630 STAT2

Reference Transcript

Other Identifiers

11718652_a_at

11752794_a_at

11752795_x_at

11755147_s_at

1244_at

16766093

205170_PM_at

205170_at

217199_3p_s_at

217199_PM_s_at

217199_s_at

225636_PM_at

225636_at

3457753

3457754

3457755

3457756

3457757

3457758

3457759

3457760

3457763

3457765

3457766

3457767

3457770

3457772

3457775

3457777

3457778

3457779

3457781

3457782

3457784

3457785

3457786

3457787

3457788

3457789

3457790

36770_at

52062_f_at

6773

7964119

91777_s_at

A_23_P76090

A_33_P3213064

GE58983

GO:0000785

GO:0000978

GO:0000981

GO:0001932

GO:0002376

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006357

GO:0006952

GO:0007005

GO:0007165

GO:0007166

GO:0007259

GO:0023052

GO:0036211

GO:0042127

GO:0042802

GO:0043226

GO:0043434

GO:0044389

GO:0045944

GO:0048856

GO:0051607

GO:0060337

GO:0060339

GO:0070721

GO:0071310

GO:0090140

GO:0090575

GO:0098542

GO:0140110

HMNXSV003000479

HMNXSV003003633

HMNXSV003007001

Hs.247981.0.S1_3p_s_at

Hs.42491.0.S1_3p_at

ILMN_1690921

PH_hs_0028948

TC12001602.hg

U18671_rna1_at

g4885614_3p_at

Participates

as a component of

Other forms of this molecule

STAT2 [cytosol]

p-Y690-STAT2 [nucleoplasm]

p-Y-STAT2 [cytosol]

Inferred To

Homologues of p-Y690-STAT2 [cytosol] (Caenorhabditis elegans)

Homologues of p-Y690-STAT2 [cytosol] (Dictyostelium discoideum)

phospho-dstD [cytosol] (Dictyostelium discoideum)

phospho-Stat2 [cytosol] (Mus musculus)

phospho-Stat2 [cytosol] (Rattus norvegicus)

phospho-sta-2 [cytosol] (Caenorhabditis elegans)

phospho-STAT2 [cytosol] (Bos taurus)

phospho-STAT2 [cytosol] (Canis familiaris)

phospho-STAT2 [cytosol] (Sus scrofa)

phospho-sta-1 [cytosol] (Caenorhabditis elegans)

phospho-stat2 [cytosol] (Xenopus tropicalis)

phospho-dstB [cytosol] (Dictyostelium discoideum)

phospho-Stat92E [cytosol] (Drosophila melanogaster)

phospho-dstA [cytosol] (Dictyostelium discoideum)

phospho-p-Y690-STAT2 [cytosol] (Caenorhabditis elegans)

phospho-p-Y690-STAT2 [cytosol] (Dictyostelium discoideum)

phospho-p-Y690-STAT2 [cytosol] (Gallus gallus)

phospho-dstC [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O4'-phospho-L-tyrosine at 690

Coordinate

690

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005410.1, NP_938146.1

OpenTargets

ENSG00000170581

GeneCards

P52630

HPA

ENSG00000170581-STAT2

Ensembl

ENST00000557235, ENSG00000170581, ENSP00000450751, ENSP00000315768, ENST00000314128, ENST00000698192, ENSP00000513599

PRO

P52630

Pharos - Targets

P52630

Orphanet

23276

PDB

8T12, 2KA4, 6UX2, 8T13, 6WCZ

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42224 STAT1	8	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.92	19
UniProt:Q00978 IRF9	2	IRF9 [nucleoplasm] (R-HSA-913522) IRF9 [cytosol] (R-HSA-879183)	0.839	10
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.76	7
UniProt:P17181 IFNAR1	2	IFNAR1 [plasma membrane] (R-HSA-877334) p-Y466,Y481-IFNAR1 [plasma membrane] (R-HSA-909675)	0.758	5
UniProt:P48551 IFNAR2			0.688	4
UniProt:P29597 TYK2	5	p-TYK2 [cytosol] (R-HSA-8950424) p-Y-TYK2 [cytosol] (R-HSA-6784366) TYK2 [cytosol] (R-HSA-877348) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) p-Y1054-TYK2 [cytosol] (R-HSA-1112598)	0.641	4
UniProt:P0C774 V			0.576	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.532	3
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.527	2
UniProt:Q6JEL2 KLH10			0.527	2
UniProt:Q9NSE4 IARS2	1	IARS2 [mitochondrial matrix] (R-HSA-379571)	0.527	2
UniProt:O94782 USP1	3	USP1 [nucleoplasm] (R-HSA-419546) USP1(672-785) [nucleoplasm] (R-HSA-5655474) USP1(1-671) [nucleoplasm] (R-HSA-5655484)	0.527	2
UniProt:P0C2W1 FBSP1			0.527	2
UniProt:O15357 INPPL1	1	INPPL1 [cytosol] (R-HSA-913354)	0.527	3
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.527	3
UniProt:Q9BVL4 SELO			0.527	3
UniProt:Q9Y234 LIPT1	1	LIPT1 [mitochondrial matrix] (R-HSA-6792623)	0.527	2
UniProt:Q997F2 V			0.527	2
UniProt:P02724 GYPA	1	GYPA [plasma membrane] (R-HSA-8867204)	0.527	2
UniProt:Q6ZSG2 INSY2			0.527	2
UniProt:Q77PU6 U90			0.524	2
UniProt:P11207 V			0.508	2
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.488	2

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