Reactome | p-T308,S473-AKT1 E17K [nucleoplasm]

p-T308,S473-AKT1 E17K [nucleoplasm]

Stable Identifier

R-HSA-2399994

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Icon

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
17611497	A transforming mutation in the pleckstrin homology domain of AKT1 in cancer Tucker-Kellogg, G, Lin, A, Blanchard, KL, Carpten, JD, Qian, YW, Moses, TY, Briggs, SL, Zeckner, DJ, Hostetter, G, Bittner, M, Savage, S, Thomas, JE, Uhlik, M, Du, J, Boguslawski, S, Robbins, CM, Schevitz, R, Touchman, J, Patel, K, Mousses, S, Lai, MHT, Faber, AL, Donoho, GP, Horn, C	Nature	2007

External Reference Information

External Reference

UniProt:P31749 AKT1

Gene Names

AKT1, PKB, RAC

Chain

chain:1-480

Reference Genes

BioGPS Gene:207 AKT1

COSMIC (genes):AKT1 AKT1

CTD Gene:207 AKT1

dbSNP Gene:207 AKT1

ENSEMBL:ENSG00000142208 AKT1

HGNC:391 AKT1

KEGG:hsa:207 AKT1

Monarch:207 AKT1

NCBI Gene:207 AKT1

OMIM:164730 AKT1

UCSC:P31749 AKT1

Reference Transcript

Other Identifiers

11716087_s_at

11722186_a_at

11722187_a_at

1564_at

16797157

207

207163_PM_s_at

207163_s_at

3581133

3581134

3581135

3581136

3581137

3581138

3581139

3581140

3581141

3581142

3581143

3581144

3581145

3581146

3581147

3581148

3581150

3581151

3581152

3581153

3581154

3581155

3581156

3581157

3581158

3581159

3581160

3581161

3581162

3581163

3581164

3581165

3581166

3581167

3581168

3581169

3581174

3581175

3581176

3581177

3581178

3581179

3581180

67939_at

7981494

A_23_P2960

A_33_P3275235

GE58023

GO:0001649

GO:0001893

GO:0001938

GO:0002042

GO:0002376

GO:0003376

GO:0003824

GO:0004672

GO:0004674

GO:0004676

GO:0004677

GO:0004679

GO:0004694

GO:0004711

GO:0004712

GO:0005515

GO:0005516

GO:0005524

GO:0005547

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005758

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005929

GO:0005938

GO:0005975

GO:0005977

GO:0005978

GO:0005979

GO:0006006

GO:0006091

GO:0006325

GO:0006338

GO:0006355

GO:0006417

GO:0006468

GO:0006606

GO:0006809

GO:0006886

GO:0006913

GO:0006915

GO:0006924

GO:0006954

GO:0006979

GO:0007005

GO:0007165

GO:0007173

GO:0007186

GO:0007281

GO:0007399

GO:0008283

GO:0008286

GO:0008289

GO:0008637

GO:0009408

GO:0009725

GO:0010467

GO:0010507

GO:0010595

GO:0010628

GO:0010629

GO:0010748

GO:0010761

GO:0010763

GO:0010765

GO:0010907

GO:0010975

GO:0012501

GO:0015630

GO:0016020

GO:0016242

GO:0016301

GO:0016310

GO:0016567

GO:0016740

GO:0018105

GO:0018107

GO:0019221

GO:0019899

GO:0019900

GO:0019901

GO:0022414

GO:0022605

GO:0030027

GO:0030154

GO:0030163

GO:0030235

GO:0030291

GO:0030307

GO:0030334

GO:0030335

GO:0031295

GO:0031397

GO:0031641

GO:0031663

GO:0031929

GO:0031982

GO:0031999

GO:0032079

GO:0032094

GO:0032287

GO:0032436

GO:0032869

GO:0032880

GO:0032991

GO:0033138

GO:0033554

GO:0034405

GO:0035175

GO:0035402

GO:0035403

GO:0035556

GO:0035655

GO:0035924

GO:0035979

GO:0036064

GO:0036294

GO:0042593

GO:0042802

GO:0042803

GO:0042981

GO:0043066

GO:0043161

GO:0043226

GO:0043276

GO:0043325

GO:0043488

GO:0043491

GO:0043536

GO:0044022

GO:0044023

GO:0044024

GO:0044025

GO:0045429

GO:0045600

GO:0045725

GO:0045746

GO:0045861

GO:0045944

GO:0046209

GO:0046326

GO:0046622

GO:0046777

GO:0046889

GO:0048009

GO:0048266

GO:0048661

GO:0048856

GO:0048870

GO:0051146

GO:0051247

GO:0060079

GO:0060416

GO:0060644

GO:0060716

GO:0061024

GO:0070141

GO:0070848

GO:0071356

GO:0071363

GO:0071364

GO:0071380

GO:0071889

GO:0072354

GO:0072371

GO:0072518

GO:0072655

GO:0072656

GO:0072752

GO:0090201

GO:0097011

GO:0097194

GO:0097700

GO:0098772

GO:0098794

GO:0098978

GO:0099104

GO:0099175

GO:0106310

GO:0110002

GO:0140052

GO:0140096

GO:0140823

GO:0140855

GO:0140857

GO:0150033

GO:0160049

GO:1900087

GO:1900182

GO:1901653

GO:1901796

GO:1902018

GO:1902176

GO:1903038

GO:1903078

GO:1903318

GO:1903384

GO:1903898

GO:1904263

GO:1904515

GO:1904841

GO:1905552

GO:1990090

GO:1990244

GO:1990418

GO:2000010

GO:2000074

GO:2000402

GO:2001240

GO:2001243

HMNXSV003045285

ILMN_1748661

ILMN_2388507

ILMN_2410909

M63167_at

PH_hs_0024085

PH_hs_0035844

TC14001560.hg

g4885060_3p_a_at

Participates

as an output of

AKT1 E17K mutant translocates to the nucleus (Homo sapiens)

Other forms of this molecule

p-T308,S473-AKT1 [nucleoplasm]

p-T308,S473-AKT1 [cytosol]

p-S473-AKT1 [plasma membrane]

AKT1 [plasma membrane]

AKT1 [cytosol]

p-T308-AKT1 [cytosol]

p-Y315,Y326-AKT1 [cytosol]

p-T308,S473-AKT1 [plasma membrane]

p-S473-AKT1 [cytosol]

AKT1 E17K [plasma membrane]

p-S473-AKT1 E17K [plasma membrane]

AKT1 E17K [cytosol]

p-T308,S473-AKT1 E17K [cytosol]

Modified Residues

Name

L-glutamic acid 17 replaced with L-lysine

Coordinate

PsiMod

L-lysine residue [MOD:00021]

A protein modification that effectively converts a source amino acid residue to L-lysine.

L-glutamic acid removal [MOD:01636]

A protein modification that effectively removes or replaces an L-glutamic acid.

Name

O-phospho-L-serine at 473

Coordinate

473

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 308

Coordinate

308

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Disease

Name	Identifier	Synonyms
ovarian cancer	DOID:2394	ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
breast cancer	DOID:1612	malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
large intestine cancer	DOID:5672	malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS

Cross References

RefSeq

XP_054231528.1, XP_054231530.1, XP_054231532.1, XP_054231531.1, NP_001369362.1, XP_047287026.1, XP_047287031.1, NP_001369360.1, NP_001369361.1, XP_005267458.1, XP_047287028.1, NP_001014432.1, XP_047287029.1, XP_054231533.1, XP_047287030.1, NP_005154.2, XP_047287027.1, XP_047287025.1, NP_001369359.1, XP_054231529.1, NP_001014431.1

ZINC - World Drugs

AKT1_HUMAN

Guide to Pharmacology - Targets

1479

OpenTargets

ENSG00000142208

ENSEMBL

ENSP00000451166, ENST00000683722, ENST00000554848, ENST00000402615, ENSP00000384293, ENST00000555528, ENSP00000507879, ENST00000649815, ENSP00000385326, ENSP00000270202, ENSP00000451828, ENST00000349310, ENST00000554581, ENSP00000497822, ENST00000407796, ENSG00000142208, ENSP00000450688

ZINC - FDA approved

AKT1_HUMAN

ZINC - Substances

AKT1_HUMAN

ZINC - Biogenic

AKT1_HUMAN

ZINC target

P31749

PRO

P31749

GlyGen

P31749

PDB

6NPZ, 8UVY, 6CCY, 3QKM, 5KCV, 7APJ, 3QKK, 7NH4, 7NH5, 3MVH, 4EKL, 4GV1, 3CQW, 3CQU, 3MV5, 3OW4, 8JOW, 1H10, 3O96, 1UNP, 1UNQ, 6HHF, 2UVM, 6HHG, 6S9W, 8UW2, 1UNR, 2UZR, 6HHH, 6HHI, 3OCB, 4EJN, 2UZS, 6HHJ, 6S9X, 4EKK, 7MYX, 3QKL, 8UW7, 6BUU, 8UW9

ZINC - Investigational

AKT1_HUMAN

ZINC - Metabolites

AKT1_HUMAN

COSMIC

COSM34142, COSV62571334

GeneCards

AKT1

HPA

ENSG00000142208-AKT1

Pharos - Targets

P31749

Orphanet

AKT1

ZINC - Predictions - Purchasable

AKT1_HUMAN

HMDB Protein

HMDBP01385

Interactors (151)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P56279 TCL1A			0.83	8
UniProt:P49841 GSK3B	4	GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.825	5
UniProt:O15530 PDPK1	3	PDPK1 [plasma membrane] (R-HSA-61459) PDPK1 [cytosol] (R-HSA-202210) p-S241-PDPK1 [cytosol] (R-HSA-9860799)	0.815	5
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.807	6
UniProt:P42345 MTOR	2	MTOR [cytosol] (R-HSA-165662) MTOR [nucleoplasm] (R-HSA-5083674)	0.805	6
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.756	4
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.753	4
UniProt:Q5T1C6 THEM4	3	THEM4 [mitochondrial matrix] (R-HSA-162408) THEM4 [cytosol] (R-HSA-6809345) THEM4 [plasma membrane] (R-HSA-199437)	0.734	4
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.724	5
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.72	10
UniProt:P46527 CDKN1B	8	p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.712	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.708	5
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.706	29
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.701	5
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.692	4
UniProt:O95999 BCL10	3	K48polyUb-BCL10 [cytosol] (R-HSA-8939329) BCL10 [cytosol] (R-HSA-202447) p-BCL10 [cytosol] (R-HSA-202488)	0.69	5
UniProt:Q6GPH4 XAF1	1	XAF1 [cytosol] (R-HSA-1015680)	0.666	4
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.659	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.653	4
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.646	3
UniProt:P31751 AKT2	7	p-T309,S474-AKT2 [nucleoplasm] (R-HSA-202087) p-T309,S474-AKT2 [cytosol] (R-HSA-202062) p-S474-AKT2 [plasma membrane] (R-HSA-2317312) AKT2 [plasma membrane] (R-HSA-202053) AKT2 [cytosol] (R-HSA-49859) p-T309-AKT2 [cytosol] (R-HSA-202066) p-T309,S474-AKT2 [plasma membrane] (R-HSA-202056)	0.641	3
UniProt:P23443 RPS6KB1	2	p-T412-RPS6KB1 [cytosol] (R-HSA-165714) RPS6KB1 [cytosol] (R-HSA-165716)	0.64	3
UniProt:P53804 TTC3			0.639	4
UniProt:Q86V81 ALYREF	2	ALYREF [nucleoplasm] (R-HSA-156649) ALYREF [cytosol] (R-HSA-158482)	0.639	5
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.636	5
UniProt:Q9BPZ7 MAPKAP1	1	MAPKAP1 [cytosol] (R-HSA-3006620)	0.628	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.623	3
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682)	0.619	13
UniProt:Q8IXJ9 ASXL1	1	ASXL1 [nucleoplasm] (R-HSA-5689645)	0.618	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [secretory granule lumen] (R-HSA-6801515)	0.615	4
UniProt:P04150 NR3C1	3	NR3C1 [nucleoplasm] (R-HSA-879837) NR3C1 [cytosol] (R-HSA-5618118) SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106)	0.611	5
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.611	6
UniProt:Q9HB96 FANCE	2	FANCE [cytosol] (R-HSA-420786) FANCE [nucleoplasm] (R-HSA-419543)	0.609	4
UniProt:Q00597 FANCC	2	FANCC [nucleoplasm] (R-HSA-419530) FANCC [cytosol] (R-HSA-420801)	0.609	4
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.602	5
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.602	9
UniProt:O15264 MAPK13	2	p-T180,Y182-MAPK13 [cytosol] (R-HSA-171022) MAPK13 [cytosol] (R-HSA-171012)	0.596	4
UniProt:P62324 BTG1	1	BTG1 [nucleoplasm] (R-HSA-9620886)	0.596	4
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.596	4
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.583	3
UniProt:Q6R327 RICTOR	1	RICTOR [cytosol] (R-HSA-198632)	0.577	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.577	6
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.577	4
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.573	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.571	4
UniProt:Q12778 FOXO1	5	FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651)	0.571	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.564	3
UniProt:Q9UNE7-1 STUB1			0.558	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.558	6
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.558	2
UniProt:Q15438 CYTH1	2	CYTH1 [Golgi membrane] (R-HSA-8847825) CYTH1 [cytosol] (R-HSA-8847826)	0.556	3
UniProt:Q8WUY3 PRUN2			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
IntAct:EBI-25830852 RZPDO839G03145			0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q9H0C5 BTBD1	1	BTBD1 [cytosol] (R-HSA-8851650)	0.556	3
UniProt:Q96LI6-3 Q96LI63			0.556	3
UniProt:P54253 ATX1			0.556	6
UniProt:P17028 ZNF24			0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [cytosol] (R-HSA-445368) CAMK2A [cytosol] (R-HSA-4332329) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [plasma membrane] (R-HSA-432796)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.556	3
UniProt:P22466 GAL	1	GAL [extracellular region] (R-HSA-389038)	0.556	3
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.556	3
UniProt:Q6W2J9 BCOR			0.553	3
UniProt:Q9NS23 RASF1			0.553	3
UniProt:Q03181 PPARD	1	PPARD [nucleoplasm] (R-HSA-446176)	0.553	3
UniProt:P08476 INHBA	1	INHBA [extracellular region] (R-HSA-205926)	0.553	3
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.553	3
UniProt:Q9UJM3 ERRFI			0.553	3
UniProt:Q8WZ60 KLHL6			0.553	3
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.553	4
UniProt:Q8TD08 MK15			0.553	3
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.553	3
UniProt:Q99728 BARD1	13	K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) BARD1 [nucleoplasm] (R-HSA-5659775) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) BARD1 C83G [nucleoplasm] (R-HSA-9699139) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 H68Y [nucleoplasm] (R-HSA-9699151) BARD1 W34R [nucleoplasm] (R-HSA-9699166) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 G623E [nucleoplasm] (R-HSA-9699135)	0.553	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.553	3
UniProt:P04198 MYCN	1	MYCN [nucleoplasm] (R-HSA-452357)	0.553	3
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.553	3
UniProt:P30281 CCND3	2	CCND3 [nucleoplasm] (R-HSA-113835) CCND3 [cytosol] (R-HSA-68333)	0.553	3
UniProt:P49327 FASN	3	FASN [cytosol] (R-HSA-54659) decanoyl-FASN [cytosol] (R-HSA-5655935) FASN [cytosol] (R-HSA-199233)	0.547	2
UniProt:P05771 PRKCB	5	PRKCB [cytosol] (R-HSA-58198) p-T500-PRKCB [cytosol] (R-HSA-5218728) p-T500,T642,S661-PRKCB [cytosol] (R-HSA-5218706) p-T500,T642,S661-PRKCB [nucleoplasm] (R-HSA-5223294) PRKCB [plasma membrane] (R-HSA-156467)	0.547	2
UniProt:Q9BZQ8 NIBA1			0.544	2
UniProt:Q05513 PRKCZ	5	PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cytosol] (R-HSA-58218) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698)	0.544	2
UniProt:Q92547 TOPBP1	1	TOPBP1 [nucleoplasm] (R-HSA-5684878)	0.544	2
UniProt:Q14849 STARD3	1	STARD3 [cytosol] (R-HSA-5216089)	0.539	3
UniProt:Q8N3U4 STAG2	8	STAG2 [nucleoplasm] (R-HSA-163046) STAG2 [chromosome, centromeric region] (R-HSA-2466018) STAG2 [chromosome] (R-HSA-1638777) STAG2 [cytosol] (R-HSA-2484897) p-STAG2 [chromosome] (R-HSA-1638793) p-STAG2 [cytosol] (R-HSA-2484806) p-STAG2 [chromosome, centromeric region] (R-HSA-2466013) monoSUMO1-K-STAG2 [nucleoplasm] (R-HSA-3108187)	0.539	3
UniProt:Q14643 ITPR1	2	ITPR1 [platelet dense tubular network membrane] (R-HSA-3325593) ITPR1 [endoplasmic reticulum membrane] (R-HSA-3006433)	0.536	2
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.529	3
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.527	3
UniProt:Q96S96 PEBP4			0.524	2
UniProt:P20248 CCNA2	5	p-S154-CCNA2 [nucleoplasm] (R-HSA-9929512) p-S154-CCNA2 [cytosol] (R-HSA-9929551) CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.524	2
UniProt:Q83730 MT5			0.524	3
UniProt:P29067	3	Arrb2 [endocytic vesicle membrane] (R-RNO-9910881) Arrb2 [cytosol] (R-RNO-6783000) Arrb2 [cytosol] (R-RNO-416464)	0.524	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.519	2
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.519	5
UniProt:P01111 NRAS	20	S-Farn-Me PalmS NRAS [plasma membrane] (R-HSA-9647910) S-Farn NRAS [endoplasmic reticulum membrane] (R-HSA-9647782) S-Farn-Me NRAS [endoplasmic reticulum membrane] (R-HSA-9647891) S-Farn-proNRAS [endoplasmic reticulum membrane] (R-HSA-9647928) proNRAS [cytosol] (R-HSA-9647758) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906) NRAS [plasma membrane] (R-HSA-62725) NRAS Q60E [plasma membrane] (R-HSA-9656589) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12V [plasma membrane] (R-HSA-9649666)	0.519	2
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) Ub,p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-9773843) SMAD2 [nucleoplasm] (R-HSA-3006352) p-S250-SMAD2 [cytosol] (R-HSA-9731121) SMAD2 Q429* [cytosol] (R-HSA-9668727) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 S296* [cytosol] (R-HSA-9668729)	0.519	2
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.519	2
UniProt:P54278 PMS2	3	PMS2 [nucleoplasm] (R-HSA-5357527) PMS2 R628* [nucleoplasm] (R-HSA-5632980) PMS2 R134* [nucleoplasm] (R-HSA-5632982)	0.519	2
UniProt:P43246 MSH2	3	MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243) MSH2 R406* [nucleoplasm] (R-HSA-5575594)	0.519	2
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.519	2
UniProt:P29474 NOS3	9	2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) MyrG-NOS3 [cytosol] (R-HSA-203687) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) NOS3 [cytosol] (R-HSA-202114) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) 2xPalmC-MyrG-p-S633-NOS3 [plasma membrane] (R-HSA-9861341) 2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane] (R-HSA-9860783)	0.509	3
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
IntAct:EBI-4399559 UBIQ			0.499	2
UniProt:P10636 MAPT	3	MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642)	0.499	2
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.499	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.483	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.483	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.483	3
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.471	2
UniProt:P10827 THRA	1	THRA [nucleoplasm] (R-HSA-446180)	0.471	2
UniProt:Q14344 GNA13	1	GNA13 [plasma membrane] (R-HSA-167451)	0.471	2
UniProt:Q9UKW6 ELF5			0.471	2
UniProt:Q14512 FGFBP1	1	FGFBP1 [extracellular region] (R-HSA-5656040)	0.471	2
UniProt:P15976 GATA1	1	GATA1 [nucleoplasm] (R-HSA-996772)	0.471	2
UniProt:Q14209 E2F2	1	E2F2 [nucleoplasm] (R-HSA-68649)	0.471	2
UniProt:P52797 EFNA3	3	EFNA3 (23-?) N-ter [extracellular region] (R-HSA-3928480) EFNA3 (?-214) C-ter [plasma membrane] (R-HSA-3928391) EFNA3 [plasma membrane] (R-HSA-2682324)	0.471	2
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.471	2
UniProt:Q16633 OBF1			0.471	2
UniProt:P42338 PIK3CB	1	PIK3CB [cytosol] (R-HSA-74788)	0.471	2
UniProt:Q9Y6E7 SIRT4	1	SIRT4 [mitochondrial matrix] (R-HSA-5687775)	0.471	2
UniProt:Q9UIF7 MUTYH			0.471	2
UniProt:O95389 CCN6			0.471	2
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.471	2
UniProt:P36222 CHI3L1	2	CHI3L1 [extracellular region] (R-HSA-6806319) CHI3L1 [specific granule lumen] (R-HSA-6799507)	0.471	2
UniProt:Q15375 EPHA7	2	p-Y608,Y614-EPHA7 [plasma membrane] (R-HSA-3928358) EPHA7 [plasma membrane] (R-HSA-2682337)	0.471	2
UniProt:P29992 GNA11	1	GNA11 [plasma membrane] (R-HSA-167446)	0.471	2
UniProt:Q8WWW0 RASF5			0.471	2
UniProt:Q15116 PDCD1	2	PDCD1 [plasma membrane] (R-HSA-197604) p-Y223,Y248-PDCD1 [plasma membrane] (R-HSA-389736)	0.471	2
UniProt:O95750 FGF19	1	FGF19 [extracellular region] (R-HSA-189888)	0.471	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.471	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.471	2
UniProt:Q86WJ1 CHD1L	1	CHD1L [nucleoplasm] (R-HSA-5688916)	0.471	2
UniProt:P49815 TSC2	4	p-S1387-TSC2 [cytosol] (R-HSA-3132769) TSC2 [cytosol] (R-HSA-2980548) p-S939,T1462-TSC2 [cytosol] (R-HSA-199484) p-S939,S1130,T1462-TSC2 [cytosol] (R-HSA-165164)	0.471	2
UniProt:Q9HCE7 SMURF1	2	SMURF1 [cytosol] (R-HSA-975972) SMURF1 [nucleoplasm] (R-HSA-3004548)	0.471	2
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.471	2
UniProt:Q9GZV9 FGF23	6	p-FGF23 [endoplasmic reticulum lumen] (R-HSA-8957077) FGF23 [endoplasmic reticulum lumen] (R-HSA-8956697) FGF23(25-251) [Golgi lumen] (R-HSA-8851630) GalNAc-T178-FGF23(25-251) [Golgi lumen] (R-HSA-8851624) FGF23(25-251) [extracellular region] (R-HSA-189891) GalNAc-T178-FGF23(25-251) [extracellular region] (R-HSA-8851633)	0.471	2
UniProt:P31040 SDHA	2	FAD-SDHA [mitochondrial matrix] (R-HSA-70983) SDHA [mitochondrial matrix] (R-HSA-9854690)	0.471	2
UniProt:Q92956 TNFRSF14	1	TNFRSF14 [plasma membrane] (R-HSA-198101)	0.471	2
UniProt:A6NLC5 CC070			0.454	2
UniProt:O15522 NKX28			0.454	2
UniProt:P55771 PAX9			0.454	2
UniProt:P23276 KEL	1	KEL [plasma membrane] (R-HSA-5694121)	0.454	2
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.454	2
UniProt:P27540 ARNT	1	ARNT [nucleoplasm] (R-HSA-1234098)	0.454	2
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.454	3
UniProt:Q01196 RUNX1	5	RUNX1 [nucleoplasm] (R-HSA-8865295) MeR206,MeR210-RUNX1 [nucleoplasm] (R-HSA-8934750) p-7Y-RUNX1 [nucleoplasm] (R-HSA-8937712) p-S249,T273,S276-RUNX1 [nucleoplasm] (R-HSA-8878063) RUNX1 [plasma membrane] (R-HSA-5667138)	0.454	2
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.454	2

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