Reactome | p-T308,S473-AKT1 E17K [nucleoplasm]

p-T308,S473-AKT1 E17K [nucleoplasm]

Stable Identifier

R-HSA-2399994

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Icon

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
17611497	A transforming mutation in the pleckstrin homology domain of AKT1 in cancer Tucker-Kellogg, G, Lin, A, Blanchard, KL, Carpten, JD, Qian, YW, Moses, TY, Briggs, SL, Zeckner, DJ, Hostetter, G, Bittner, M, Savage, S, Thomas, JE, Uhlik, M, Du, J, Boguslawski, S, Robbins, CM, Schevitz, R, Touchman, J, Patel, K, Mousses, S, Lai, MHT, Faber, AL, Donoho, GP, Horn, C	Nature	2007

External Reference Information

External Reference

UniProt:P31749 AKT1

Gene Names

AKT1, PKB, RAC

Chain

chain:1-480

Reference Genes

BioGPS Gene:207 AKT1

COSMIC (genes):AKT1 AKT1

CTD Gene:207 AKT1

dbSNP Gene:207 AKT1

ENSEMBL:ENSG00000142208 AKT1

HGNC:391 AKT1

KEGG Gene (Homo sapiens):207 AKT1

Monarch:207 AKT1

NCBI Gene:207 AKT1

OMIM:164730 AKT1

UCSC:P31749 AKT1

Reference Transcript

Other Identifiers

11716087_s_at

11722186_a_at

11722187_a_at

1564_at

16797157

207

207163_PM_s_at

207163_s_at

3581133

3581134

3581135

3581136

3581137

3581138

3581143

3581144

3581145

3581148

3581150

3581152

3581155

3581157

3581159

3581161

3581169

3581174

3581175

3581176

3581177

3581178

3581179

3581180

7981494

A_23_P2960

A_33_P3275235

GE58023

GO:0000003

GO:0000166

GO:0000278

GO:0001649

GO:0001893

GO:0001934

GO:0001938

GO:0002042

GO:0002376

GO:0003376

GO:0003674

GO:0004672

GO:0004674

GO:0004712

GO:0005515

GO:0005516

GO:0005524

GO:0005547

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005929

GO:0005975

GO:0005977

GO:0005978

GO:0005979

GO:0006006

GO:0006091

GO:0006259

GO:0006412

GO:0006417

GO:0006464

GO:0006468

GO:0006469

GO:0006606

GO:0006629

GO:0006809

GO:0006810

GO:0006913

GO:0006914

GO:0006915

GO:0006924

GO:0006950

GO:0006954

GO:0006979

GO:0007005

GO:0007009

GO:0007049

GO:0007155

GO:0007165

GO:0007173

GO:0007186

GO:0007249

GO:0007267

GO:0007281

GO:0007399

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008286

GO:0008289

GO:0008637

GO:0008643

GO:0009056

GO:0009058

GO:0009408

GO:0009725

GO:0009790

GO:0010033

GO:0010467

GO:0010507

GO:0010595

GO:0010628

GO:0010629

GO:0010748

GO:0010761

GO:0010763

GO:0010765

GO:0010907

GO:0010918

GO:0010951

GO:0010975

GO:0014065

GO:0015031

GO:0015630

GO:0016020

GO:0016242

GO:0016301

GO:0016310

GO:0016567

GO:0016740

GO:0018105

GO:0018107

GO:0019221

GO:0019899

GO:0019901

GO:0030027

GO:0030154

GO:0030163

GO:0030234

GO:0030235

GO:0030307

GO:0030334

GO:0031234

GO:0031295

GO:0031397

GO:0031641

GO:0031663

GO:0031929

GO:0031982

GO:0031999

GO:0032079

GO:0032091

GO:0032094

GO:0032270

GO:0032287

GO:0032436

GO:0032869

GO:0032880

GO:0032991

GO:0033138

GO:0034405

GO:0034614

GO:0034641

GO:0034655

GO:0035556

GO:0035655

GO:0035924

GO:0036064

GO:0036294

GO:0038061

GO:0040007

GO:0040011

GO:0042592

GO:0042593

GO:0042802

GO:0042803

GO:0042981

GO:0043066

GO:0043154

GO:0043167

GO:0043226

GO:0043276

GO:0043325

GO:0043488

GO:0043491

GO:0043536

GO:0044281

GO:0045429

GO:0045600

GO:0045725

GO:0045737

GO:0045746

GO:0045861

GO:0045893

GO:0045944

GO:0046326

GO:0046622

GO:0046777

GO:0046889

GO:0048009

GO:0048266

GO:0048646

GO:0048661

GO:0048856

GO:0048870

GO:0050877

GO:0051000

GO:0051091

GO:0051146

GO:0055085

GO:0060079

GO:0060416

GO:0060644

GO:0060709

GO:0060716

GO:0061024

GO:0070141

GO:0070848

GO:0071276

GO:0071356

GO:0071363

GO:0071364

GO:0071380

GO:0071889

GO:0071901

GO:0072655

GO:0072656

GO:0090201

GO:0097011

GO:0097194

GO:0098794

GO:0099104

GO:0100002

GO:0106310

GO:0140052

GO:1900087

GO:1900182

GO:1901215

GO:1901653

GO:1901796

GO:1902176

GO:1903038

GO:1903078

GO:1903721

GO:1990090

GO:1990418

GO:2000010

GO:2000074

GO:2000402

GO:2001240

GO:2001243

HMNXSV003045285

ILMN_1748661

ILMN_1784157

ILMN_2388507

ILMN_2410909

M63167_at

PH_hs_0024085

TC14001560.hg

g4885060_3p_a_at

Participates

as an output of

AKT1 E17K mutant translocates to the nucleus (Homo sapiens)

Other forms of this molecule

p-T308,S473-AKT1 E17K [cytosol]

AKT1 E17K [cytosol]

p-S473-AKT1 E17K [plasma membrane]

AKT1 E17K [plasma membrane]

p-Y315,Y326-AKT1 [cytosol]

p-T308,S473-AKT1 [plasma membrane]

p-T308-AKT1 [cytosol]

AKT1 [cytosol]

AKT1 [plasma membrane]

p-S473-AKT1 [plasma membrane]

p-T308,S473-AKT1 [cytosol]

p-T308,S473-AKT1 [nucleoplasm]

Modified Residues

Name

L-glutamic acid 17 replaced with L-lysine

Coordinate

PsiMod

L-lysine residue [MOD:00021]

A protein modification that effectively converts a source amino acid residue to L-lysine.

L-glutamic acid removal [MOD:01636]

A protein modification that effectively removes or replaces an L-glutamic acid.

Name

O-phospho-L-serine at 473

Coordinate

473

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 308

Coordinate

308

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Disease

Name	Identifier	Synonyms
ovarian cancer	DOID:2394	ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
breast cancer	DOID:1612	malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
large intestine cancer	DOID:5672	malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS

Cross References

RefSeq

NP_001014432.1, NP_005154.2, NP_001014431.1, XP_005267458.1

ZINC - World Drugs

AKT1_HUMAN

Guide to Pharmacology - Targets

1479

OpenTargets

ENSG00000142208

ZINC - FDA approved

AKT1_HUMAN

ZINC - Substances

AKT1_HUMAN

ZINC target

P31749

ZINC - Biogenic

AKT1_HUMAN

PRO

P31749

PDB

3MVH, 2UZR, 6HHH, 6BUU, 3O96, 3QKM, 4EJN, 7APJ, 2UVM, 4GV1, 6HHF, 6S9W, 3CQU, 1UNQ, 5KCV, 6S9X, 3OCB, 2UZS, 1UNP, 6HHG, 1H10, 3QKK, 3CQW, 4EKL, 1UNR, 6NPZ, 3OW4, 6HHI, 7NH4, 3QKL, 7NH5, 6HHJ, 3MV5, 4EKK, 6CCY

ZINC - Investigational

AKT1_HUMAN

ZINC - Metabolites

AKT1_HUMAN

COSMIC

COSM34142, COSV62571334

GeneCards

P31749

HPA

ENSG00000142208-AKT1

Ensembl

ENSP00000270202, ENST00000649815, ENSG00000142208, ENSP00000450688, ENST00000349310, ENST00000554848, ENST00000402615, ENSP00000385326, ENSP00000451166, ENST00000555528, ENSP00000451828, ENSP00000497822, ENST00000407796, ENSP00000384293, ENST00000554581

Pharos - Targets

P31749

Orphanet

20544

ZINC - Predictions - Purchasable

AKT1_HUMAN

HMDB Protein

HMDBP01385

Interactors (72)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P56279 TCL1A			0.83	8
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.807	6
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.779	4
UniProt:O15530 PDPK1	2	PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.767	4
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939)	0.756	4
UniProt:Q5T1C6 THEM4	3	THEM4 [mitochondrial matrix] (R-HSA-162408) THEM4 [cytosol] (R-HSA-6809345) THEM4 [plasma membrane] (R-HSA-199437)	0.734	4
UniProt:P42345 MTOR	2	MTOR [nucleoplasm] (R-HSA-5083674) MTOR [cytosol] (R-HSA-165662)	0.731	4
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.724	5
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.706	29
UniProt:O43524 FOXO3	9	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413)	0.692	3
UniProt:O95999 BCL10	3	K48polyUb-BCL10 [cytosol] (R-HSA-8939329) BCL10 [cytosol] (R-HSA-202447) p-BCL10 [cytosol] (R-HSA-202488)	0.69	5
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.639	9
UniProt:P53804 TTC3			0.639	4
UniProt:Q86V81 ALYREF	2	ALYREF [nucleoplasm] (R-HSA-156649) ALYREF [cytosol] (R-HSA-158482)	0.639	5
UniProt:P46527 CDKN1B	8	p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.63	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.623	4
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682)	0.619	13
UniProt:P04150 NR3C1	3	SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [cytosol] (R-HSA-5618118) NR3C1 [nucleoplasm] (R-HSA-879837)	0.611	5
UniProt:P26358 DNMT1	2	monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353) DNMT1 [nucleoplasm] (R-HSA-212181)	0.611	6
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.609	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.602	5
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.602	9
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.573	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.571	4
UniProt:Q12778 FOXO1	5	p-S215 FOXO1 [nucleoplasm] (R-HSA-5692651) FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942)	0.571	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.558	6
UniProt:Q9UNE7-1 STUB1			0.558	5
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.558	2
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q9H0C5 BTBD1	1	BTBD1 [cytosol] (R-HSA-8851650)	0.556	3
UniProt:Q15438 CYTH1	2	CYTH1 [cytosol] (R-HSA-8847826) CYTH1 [Golgi membrane] (R-HSA-8847825)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q96LI6-3 Q96LI63			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q6GPH4 XAF1	1	XAF1 [cytosol] (R-HSA-1015680)	0.556	3
UniProt:A0A024RC47 A0A024RC47			0.556	3
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:P54253 ATX1			0.556	6
IntAct:EBI-25830852 RZPDO839G03145			0.556	3
UniProt:A0A0C4DFM3 A0A0C4DFM3			0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [plasma membrane] (R-HSA-432796) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [cytosol] (R-HSA-445368)	0.556	3
UniProt:P10599 TXN	4	2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:P17612 PRKACA	3	PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3
UniProt:P22466 GAL	1	GAL [extracellular region] (R-HSA-389038)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P49327 FASN	3	decanoyl-FASN [cytosol] (R-HSA-5655935) FASN [cytosol] (R-HSA-54659) FASN [cytosol] (R-HSA-199233)	0.547	2
UniProt:P05771 PRKCB	5	PRKCB [plasma membrane] (R-HSA-156467) PRKCB [cytosol] (R-HSA-58198) p-T500-PRKCB [cytosol] (R-HSA-5218728) p-T500,T642,S661-PRKCB [cytosol] (R-HSA-5218706) p-T500,T642,S661-PRKCB [nucleoplasm] (R-HSA-5223294)	0.547	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.544	2
UniProt:Q05513 PRKCZ	5	pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cell junction] (R-HSA-2134483) PRKCZ [cytosol] (R-HSA-58218) p-T410-PRKCZ [cytosol] (R-HSA-437181) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698)	0.544	2
UniProt:Q9BZQ8 NIBA1			0.544	2
UniProt:Q92547 TOPBP1	1	TOPBP1 [nucleoplasm] (R-HSA-5684878)	0.544	2
UniProt:Q14643 ITPR1	2	ITPR1 [platelet dense tubular network membrane] (R-HSA-3325593) ITPR1 [endoplasmic reticulum membrane] (R-HSA-3006433)	0.536	2
UniProt:P04049 RAF1	20	p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094)	0.536	2
UniProt:P38646 HSPA9	6	HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.527	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	3
UniProt:Q96S96 PEBP4			0.524	2
UniProt:P29067	2	Arrb2 [cytosol] (R-RNO-6783000) Arrb2 [cytosol] (R-RNO-416464)	0.524	2
UniProt:Q83730 MT5			0.524	3
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.524	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.519	2
UniProt:P23443 RPS6KB1	2	RPS6KB1 [cytosol] (R-HSA-165716) p-S371,T389-RPS6KB1 [cytosol] (R-HSA-165714)	0.519	2
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
UniProt:Q8IXJ9 ASXL1	1	ASXL1 [nucleoplasm] (R-HSA-5689645)	0.508	2
IntAct:EBI-4399559 UBIQ			0.499	2
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.499	3
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.499	2
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.483	3
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.471	2
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.463	2

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