p-T308,S473-AKT1 E17K [nucleoplasm]

Stable Identifier
R-HSA-2399994
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
p-T308,S473-AKT1 E17K [nucleoplasm] icon
p-T308,S473-AKT1 E17K [nucleoplasm] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
17611497 A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Carpten, JD, Faber, AL, Horn, C, Donoho, GP, Briggs, SL, Robbins, CM, Hostetter, G, Boguslawski, S, Moses, TY, Savage, S, Uhlik, M, Lin, A, Du, J, Qian, YW, Zeckner, DJ, Tucker-Kellogg, G, Touchman, J, Patel, K, Mousses, S, Bittner, M, Schevitz, R, Lai, MHT, Blanchard, KL, Thomas, JE

Nature 2007
External Reference Information
External Reference
UniProt:P31749 AKT1
Gene Names
AKT1, PKB, RAC
Chain
chain:1-480
Reference Genes
BioGPS Gene:207 AKT1
COSMIC (genes):AKT1 AKT1
CTD Gene:207 AKT1
dbSNP Gene:207 AKT1
ENSEMBL:ENSG00000142208 AKT1
HGNC:391 AKT1
KEGG Gene (Homo sapiens):207 AKT1
Monarch:207 AKT1
NCBI Gene:207 AKT1
OMIM:164730 AKT1
UCSC:P31749 AKT1
Reference Transcript
Other Identifiers
04150+2.7.11.1
04151+2.7.11.1
04714+2.7.11.1
04926+2.7.11.1
05163+2.7.11.1
05165+2.7.11.1
05170+2.7.11.1
11716087_s_at
11722186_a_at
11722187_a_at
1564_at
16797157
1H10
1UNP
1UNQ
1UNR
207
207163_s_at
2891
2UVM
2UZR
2UZS
3581133
3581134
3581135
3581136
3581137
3581138
3581143
3581144
3581145
3581148
3581150
3581152
3581155
3581157
3581159
3581161
3581169
3581174
3581175
3581176
3581177
3581178
3581179
3581180
3765
3CQU
3CQW
3MV5
3MVH
3O96
3OCB
3OW4
3QKK
3QKL
3QKM
4EJN
4EKK
4EKL
4GV1
5KCV
6BUU
6CCY
6HHF
6HHG
6HHH
6HHI
6HHJ
6NPZ
7981494
A0A087WY56
A_23_P2960
A_33_P3275235
AAA36539
AAH00479
AAH84538
AAL55732
AB451242
AB451367
ABY87524
AF283819
AF283820
AF283821
AF283822
AF283823
AF283824
AF283825
AF283826
AF283827
AF283828
AF283829
AF283830
AGC09587
AK299310
AK314256
AKT1
AKT1-201
AKT1-202
AKT1-203
AKT1-208
AKT1-211
AKT1-214
AKT1-220
AL583722
AL590327
ALQ33356
B0LPE5
BAG36922
BAG70056
BAG70181
BAH12997
BC000479
BC084538
CAA43372
CAB003765
CCDS9994
CH471061
EAW81881
EAW81882
EAW81883
ENSG00000142208
ENSP00000270202
ENSP00000384293
ENSP00000385326
ENSP00000450688
ENSP00000451166
ENSP00000451828
ENSP00000497822
ENST00000349310
ENST00000349310.7
ENST00000402615
ENST00000402615.6
ENST00000407796
ENST00000407796.6
ENST00000554581
ENST00000554581.5
ENST00000554848
ENST00000554848.5
ENST00000555528
ENST00000555528.5
ENST00000649815
ENST00000649815.1
EntrezGene:207
EntrezGene:AKT1
EU332835
G3V4I6
g4885060_3p_a_at
GE58023
GO:0000003
GO:0000166
GO:0000278
GO:0001649
GO:0001893
GO:0001934
GO:0001938
GO:0002042
GO:0002376
GO:0003013
GO:0003674
GO:0004672
GO:0004674
GO:0004712
GO:0005080
GO:0005515
GO:0005516
GO:0005524
GO:0005547
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005929
GO:0005975
GO:0005977
GO:0005978
GO:0005979
GO:0006006
GO:0006091
GO:0006259
GO:0006412
GO:0006417
GO:0006464
GO:0006468
GO:0006469
GO:0006606
GO:0006629
GO:0006809
GO:0006810
GO:0006913
GO:0006914
GO:0006915
GO:0006924
GO:0006950
GO:0006954
GO:0006974
GO:0006979
GO:0007005
GO:0007009
GO:0007049
GO:0007155
GO:0007165
GO:0007173
GO:0007186
GO:0007249
GO:0007267
GO:0007275
GO:0007281
GO:0007399
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008286
GO:0008289
GO:0008637
GO:0008643
GO:0009056
GO:0009058
GO:0009408
GO:0009725
GO:0009790
GO:0010033
GO:0010507
GO:0010628
GO:0010629
GO:0010748
GO:0010763
GO:0010765
GO:0010907
GO:0010918
GO:0010951
GO:0010975
GO:0014065
GO:0015031
GO:0015630
GO:0016020
GO:0016242
GO:0016301
GO:0016310
GO:0016567
GO:0016740
GO:0018105
GO:0018107
GO:0019221
GO:0019899
GO:0019901
GO:0021510
GO:0030030
GO:0030154
GO:0030163
GO:0030212
GO:0030234
GO:0030235
GO:0030307
GO:0030334
GO:0031018
GO:0031295
GO:0031397
GO:0031641
GO:0031663
GO:0031929
GO:0031982
GO:0031999
GO:0032079
GO:0032091
GO:0032094
GO:0032148
GO:0032270
GO:0032287
GO:0032436
GO:0032794
GO:0032869
GO:0032880
GO:0032991
GO:0033138
GO:0034405
GO:0034614
GO:0034641
GO:0034655
GO:0035556
GO:0035655
GO:0035924
GO:0036064
GO:0036294
GO:0038061
GO:0040007
GO:0040011
GO:0042592
GO:0042593
GO:0042802
GO:0042803
GO:0042981
GO:0043065
GO:0043066
GO:0043154
GO:0043167
GO:0043226
GO:0043276
GO:0043325
GO:0043488
GO:0043491
GO:0043536
GO:0044281
GO:0045429
GO:0045600
GO:0045725
GO:0045737
GO:0045742
GO:0045746
GO:0045792
GO:0045861
GO:0045893
GO:0045907
GO:0045944
GO:0046326
GO:0046329
GO:0046622
GO:0046777
GO:0046889
GO:0048009
GO:0048646
GO:0048661
GO:0048856
GO:0048870
GO:0050877
GO:0050999
GO:0051000
GO:0051091
GO:0051146
GO:0051186
GO:0051721
GO:0051898
GO:0055085
GO:0060079
GO:0060416
GO:0060644
GO:0060709
GO:0060716
GO:0061024
GO:0070141
GO:0071260
GO:0071276
GO:0071356
GO:0071363
GO:0071364
GO:0071380
GO:0071407
GO:0071456
GO:0071889
GO:0071901
GO:0072655
GO:0072656
GO:0090201
GO:0097011
GO:0097194
GO:0098794
GO:0100002
GO:0140052
GO:1900087
GO:1900182
GO:1901215
GO:1901653
GO:1901796
GO:1902176
GO:1903038
GO:1903078
GO:1903721
GO:1990090
GO:1990418
GO:2000010
GO:2000402
GO:2001240
GO:2001243
HGNC:391
HPA002891
ILMN_1748661
ILMN_1784157
ILMN_2388507
ILMN_2410909
IPR000719
IPR000961
IPR001849
IPR008271
IPR011009
IPR011993
IPR017441
IPR017892
IPR034676
IPR039026
IPR039027
JX512440
KU177898
LRG_721
LRG_721t1
LRG_721t2
M63167
M63167_at
MIM:114480
MIM:114500
MIM:164730
MIM:167000
MIM:176920
MIM:181500
MIM:615109
NM_001014431
NM_001014432
NM_005163
NP_001014431
NP_001014432
NP_005154
PF00069
PF00169
PF00433
PH_hs_0024085
SM00133
SM00220
SM00233
TC14001560.hg
UPI0000070813
X61037
XR_002957536
Participant Of
output
Other forms of this molecule
p-T308,S473-AKT1 E17K [cytosol]
AKT1 E17K [cytosol]
p-S473-AKT1 E17K [plasma membrane]
AKT1 E17K [plasma membrane]
p-T308,S473-AKT1 [plasma membrane]
p-Y315,Y326-AKT1 [cytosol]
p-T308-AKT1 [cytosol]
p-T308,S473-AKT1 [nucleoplasm]
AKT1 [cytosol]
AKT1 [plasma membrane]
p-S473-AKT1 [plasma membrane]
p-T308,S473-AKT1 [cytosol]
Modified Residues
Name
L-glutamic acid 17 replaced with L-lysine
Coordinate
17
PsiMod
L-glutamic acid removal [MOD:01636]
A protein modification that effectively removes or replaces an L-glutamic acid.
L-lysine residue [MOD:00021]
A protein modification that effectively converts a source amino acid residue to L-lysine.
Name
O-phospho-L-serine at 473
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 308
Coordinate
308
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
ovarian cancer 2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
breast cancer 1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
large intestine cancer 5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
Target Pathogen
ZINC - Metabolites
COSMIC
IntEnz
HPA
GeneCards
Ensembl
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (58)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P56279 TCL1A      0.834 8
 UniProt:Q00987 MDM2  11 0.828 6
 UniProt:O15530 PDPK1  2 0.78 4
 UniProt:P49841 GSK3B  4 0.779 4
 UniProt:P67775 PPP2CA  4 0.756 4
 UniProt:P42345 MTOR  2 0.744 4
 UniProt:Q5T1C6 THEM4  3 0.734 4
 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]  6 0.724 5
 UniProt:O43524 FOXO3  9 0.713 3
 UniProt:P08670 VIM  11 0.706 29
 UniProt:O95999 BCL10  3 0.69 5
 UniProt:P46527 CDKN1B  8 0.646 3
 UniProt:P53804 TTC3      0.639 4
 UniProt:Q86V81 ALYREF  2 0.639 5
 UniProt:Q15047 SETDB1  1 0.639 9
 UniProt:Q16543 CDC37  1 0.623 4
 UniProt:Q13043 STK4  4 0.619 13
 UniProt:P04150 NR3C1  3 0.611 5
 UniProt:P26358 DNMT1  2 0.611 6
 UniProt:P31749 AKT1  13 0.609 3
 UniProt:Q12778 FOXO1  5 0.609 2
 UniProt:P19174 PLCG1  6 0.602 9
 UniProt:Q96EB6 SIRT1  1 0.602 5
 UniProt:Q14643 ITPR1  2 0.589 2
 UniProt:P29474 NOS3  7 0.589 2
 UniProt:P04049 RAF1  10 0.589 2
 UniProt:P23443 RPS6KB1  2 0.573 2
 UniProt:Q9UKG1 APPL1  1 0.573 2
 UniProt:O60437 PPL  2 0.573 2
 UniProt:P62136 PPP1CA  1 0.571 4
 UniProt:P04792 HSPB1  3 0.564 3
 UniProt:P08238 HSP90AB1  6 0.564 3
 UniProt:Q5S007 LRRK2  1 0.558 6
 UniProt:Q9UNE7-1 STUB1      0.558 5
 UniProt:Q99683 MAP3K5  1 0.558 2
 UniProt:Q96D03 DDT4L      0.556 3
 UniProt:Q8TAP6 CEP76  1 0.556 3
 UniProt:Q14696 MESD      0.556 3
 UniProt:Q6GPH4 XAF1  1 0.556 3
 UniProt:P00533 EGFR  59 0.553 2
 UniProt:P49327 FASN  3 0.547 2
 UniProt:P05771 PRKCB  5 0.547 2
 UniProt:P30153 PPP2R1A  2 0.544 2
 UniProt:Q9BZQ8 NIBA1      0.544 2
 UniProt:Q05513 PRKCZ  5 0.544 2
 UniProt:Q92547 TOPBP1  1 0.544 2
 UniProt:P38646 HSPA9  6 0.527 3
 UniProt:Q96S96 PEBP4      0.524 2
 UniProt:P11021 HSPA5  6 0.524 2
 UniProt:P29067  2 0.524 2
 UniProt:Q83730 MT5      0.524 3
 UniProt:P20248 CCNA2  3 0.524 2
 UniProt:Q9NYB0 TERF2IP  1 0.508 2
 UniProt:Q8IXJ9 ASXL1  1 0.508 2
 IntAct:EBI-4399559 UBIQ      0.499 2
 UniProt:Q92793 CREBBP  3 0.499 3
 UniProt:P10636 MAPT  3 0.499 2
 UniProt:P10276 RARA  3 0.463 2
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