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About
What is Reactome ?
News
Team
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Our Logo
License Agreement
Privacy Notice
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Content
Table of Contents
DOIs
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LRIG1 [plasma membrane]
Stable Identifier
R-HSA-197745
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor, LIG1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR binds EGF ligand (Homo sapiens)
LRIG1 [plasma membrane] (Homo sapiens)
Signaling by MET (Homo sapiens)
Negative regulation of MET activity (Homo sapiens)
LRIG1 undergoes ubiquitination (Homo sapiens)
MET:LRIG1 [plasma membrane] (Homo sapiens)
LRIG1 [plasma membrane] (Homo sapiens)
MET binds LRIG1 (Homo sapiens)
LRIG1 [plasma membrane] (Homo sapiens)
MET:LRIG1 [plasma membrane] (Homo sapiens)
LRIG1 [plasma membrane] (Homo sapiens)
USP8 deubiquitinates LRIG1 (Homo sapiens)
MET:LRIG1 [plasma membrane] (Homo sapiens)
LRIG1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96JA1 LRIG1
Gene Names
LRIG1, LIG1
Chain
signal peptide:1-34, chain:35-1093
Reference Genes
BioGPS Gene:26018 LRIG1
COSMIC (genes):LRIG1 LRIG1
CTD Gene:26018 LRIG1
dbSNP Gene:26018 LRIG1
ENSEMBL:ENSG00000144749 LRIG1
HGNC:17360 LRIG1
KEGG Gene (Homo sapiens):26018 LRIG1
Monarch:26018 LRIG1
NCBI Gene:26018 LRIG1
OMIM:608868 LRIG1
UCSC:Q96JA1 LRIG1
Reference Transcript
RefSeq:NM_015541.2 LRIG1
Other Identifiers
0006900148
11750405_a_at
11755110_a_at
16955939
211596_s_at
238339_x_at
240140_s_at
26018
2680602
2680603
2680604
2680605
2680606
2680607
2680610
2680612
2680613
2680614
2680617
2680620
2680621
2680622
2680625
2680631
2680634
2680637
2680641
2680642
2680644
2680645
2680661
2680669
2680683
2680684
2680685
34800_at
63691_at
70503_at
8088642
A_23_P109636
GE56536
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005886
GO:0007605
GO:0008150
GO:0009790
GO:0016020
GO:0016021
GO:0022405
GO:0031012
GO:0032474
GO:0048856
GO:0050877
GO:0060384
Hs.121706.1.S1_3p_s_at
Hs.207432.0.A1_3p_s_at
ILMN_1707342
ILMN_2128795
PH_hs_0022789
PH_hs_0034614
TC03001532.hg
g13537354_3p_s_at
Participant Of
input
MET binds LRIG1
hasComponent
MET:LRIG1 [plasma membrane]
This entity regulates
Negatively
EGFR binds EGF ligand
Other forms of this molecule
Ub-LRIG1 [plasma membrane]
Inferred To
Homologues of LRIG1 [plasma membrane] (Drosophila melanogaster)
trn [plasma membrane] (Drosophila melanogaster)
ltl [plasma membrane] (Drosophila melanogaster)
Lrig1 [plasma membrane] (Mus musculus)
Lrig1 [plasma membrane] (Rattus norvegicus)
Dmel\CG7509 [plasma membrane] (Drosophila melanogaster)
lrig1 [plasma membrane] (Xenopus tropicalis)
lbk [plasma membrane] (Drosophila melanogaster)
LRIG1 [plasma membrane] (Bos taurus)
LRIG1 [plasma membrane] (Canis familiaris)
LRIG1 [plasma membrane] (Gallus gallus)
LRIG1 [plasma membrane] (Sus scrofa)
Cross References
RefSeq
NP_056356.2
OpenTargets
ENSG00000144749
GeneCards
Q96JA1
HPA
ENSG00000144749-LRIG1
Ensembl
ENSP00000273261
,
ENST00000273261
,
ENSP00000373208
,
ENST00000383703
,
ENSG00000144749
PRO
Q96JA1
PDB
4U7M
,
4U7L
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04626 ERBB2
117
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665656)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
p-Y-ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 L755W [plasma membrane]
(R-HSA-9654193)
p-Y-ERBB2 T733I [plasma membrane]
(R-HSA-9654610)
p-Y-ERBB2 H878R [plasma membrane]
(R-HSA-9654835)
p-Y-ERBB2 L869R [plasma membrane]
(R-HSA-9654730)
p-Y-ERBB2 G776S [plasma membrane]
(R-HSA-9664608)
p-Y-ERBB2 L869Q [plasma membrane]
(R-HSA-9654732)
p-Y-ERBB2 G776L [plasma membrane]
(R-HSA-9664600)
p-Y-ERBB2 G776V [plasma membrane]
(R-HSA-9664602)
p-Y-ERBB2 G776C [plasma membrane]
(R-HSA-9664611)
ERBB2 D769Y [plasma membrane]
(R-HSA-9646620)
ERBB2 L755P [plasma membrane]
(R-HSA-9646494)
ERBB2 V842I [plasma membrane]
(R-HSA-9646703)
ERBB2 H878Y [plasma membrane]
(R-HSA-9646824)
ERBB2 T798M [plasma membrane]
(R-HSA-9646825)
ERBB2 D769H [plasma membrane]
(R-HSA-9646617)
ERBB2 T862A [plasma membrane]
(R-HSA-9649434)
ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665621)
ERBB2 L755S [plasma membrane]
(R-HSA-9646423)
ERBB2 I767M [plasma membrane]
(R-HSA-9646737)
ERBB2 V777L [plasma membrane]
(R-HSA-9646579)
ERBB2 D769N [plasma membrane]
(R-HSA-9646636)
ERBB2 T733I [plasma membrane]
(R-HSA-9646765)
ERBB2 V777M [plasma membrane]
(R-HSA-9646591)
ERBB2 V777E [plasma membrane]
(R-HSA-9646586)
ERBB2 L755W [plasma membrane]
(R-HSA-9646516)
ERBB2 L755M [plasma membrane]
(R-HSA-9646517)
ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665622)
ERBB2 H878R [plasma membrane]
(R-HSA-9646822)
ERBB2 V842E [plasma membrane]
(R-HSA-9646710)
ERBB2 T798I [plasma membrane]
(R-HSA-9646823)
ERBB2 R896C [plasma membrane]
(R-HSA-9646714)
ERBB2 P780_Y781insGSP [plasma membrane]
(R-HSA-9646667)
ERBB2 R896H [plasma membrane]
(R-HSA-9646728)
ERBB2 G778_P780insGSP [plasma membrane]
(R-HSA-9665625)
ERBB2 G776S [plasma membrane]
(R-HSA-9664463)
ERBB2 L869R [plasma membrane]
(R-HSA-9646827)
ERBB2 L869Q [plasma membrane]
(R-HSA-9646828)
ERBB2 G776C [plasma membrane]
(R-HSA-9664457)
ERBB2 G776L [plasma membrane]
(R-HSA-9664454)
ERBB2 G776V [plasma membrane]
(R-HSA-9664450)
p-6Y-ERBB2 V777L [plasma membrane]
(R-HSA-9647214)
p-6Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9647215)
ERBB2 L755_T759del [plasma membrane]
(R-HSA-9663599)
p-6Y-ERBB2 R896C [plasma membrane]
(R-HSA-9647208)
p-6Y-ERBB2 V842I [plasma membrane]
(R-HSA-9647209)
p-6Y-ERBB2 I767M [plasma membrane]
(R-HSA-9647211)
p-6Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654692)
p-6Y-ERBB2 D769H [plasma membrane]
(R-HSA-9647200)
p-6Y-ERBB2 T798I [plasma membrane]
(R-HSA-9647202)
p-6Y-ERBB2 L755P [plasma membrane]
(R-HSA-9647196)
p-6Y-ERBB2 P780_Y781insGSP [plasma membrane]
(R-HSA-9647198)
p-6Y-ERBB2 L755S [plasma membrane]
(R-HSA-9647216)
p-6Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665650)
p-6Y-ERBB2 T798M [plasma membrane]
(R-HSA-9647218)
p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665644)
p-6Y-ERBB2 D769Y [plasma membrane]
(R-HSA-9647199)
p-6Y-ERBB2 V777E [plasma membrane]
(R-HSA-9647210)
p-6Y-ERBB2 T733I [plasma membrane]
(R-HSA-9647195)
p-6Y-ERBB2 L755M [plasma membrane]
(R-HSA-9647204)
p-6Y-ERBB2 V777M [plasma membrane]
(R-HSA-9647205)
p-6Y-ERBB2 V842E [plasma membrane]
(R-HSA-9647206)
p-6Y-ERBB2 D769N [plasma membrane]
(R-HSA-9647207)
p-6Y-ERBB2 R896H [plasma membrane]
(R-HSA-9647217)
p-6Y-ERBB2 L755W [plasma membrane]
(R-HSA-9647201)
p-6Y-ERBB2 G778_P780insGSP [plasma membrane]
(R-HSA-9665634)
p-6Y-ERBB2 H878R [plasma membrane]
(R-HSA-9647203)
p-6Y-ERBB2 E693K [plasma membrane]
(R-HSA-9665871)
p-6Y-ERBB2 R677L [plasma membrane]
(R-HSA-9665864)
p-6Y-ERBB2 Q709L [plasma membrane]
(R-HSA-9665865)
p-6Y-ERBB2 G660D [plasma membrane]
(R-HSA-9665866)
p-6Y-ERBB2 G660R [plasma membrane]
(R-HSA-9665878)
p-6Y-ERBB2 V659K [plasma membrane]
(R-HSA-9665863)
p-6Y-ERBB2 V659E [plasma membrane]
(R-HSA-9665874)
ERBB2 R678Q [plasma membrane]
(R-HSA-9665756)
ERBB2 S653C [plasma membrane]
(R-HSA-9665754)
ERBB2 R677L [plasma membrane]
(R-HSA-9665759)
ERBB2 G660R [plasma membrane]
(R-HSA-9665768)
ERBB2 V659E [plasma membrane]
(R-HSA-9665752)
ERBB2 G660D [plasma membrane]
(R-HSA-9665753)
ERBB2 V659K [plasma membrane]
(R-HSA-9665769)
ERBB2 Q709L [plasma membrane]
(R-HSA-9665770)
ERBB2 E693K [plasma membrane]
(R-HSA-9665761)
p-6Y-ERBB2 R678Q [plasma membrane]
(R-HSA-9665876)
p-6Y-ERBB2 S653C [plasma membrane]
(R-HSA-9665875)
p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863841)
p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863836)
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864084)
p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864090)
p-Y877-ERBB2 [plasma membrane]
(R-HSA-1810438)
ERBB2 [plasma membrane]
(R-HSA-372889)
p-6Y-ERBB2 [plasma membrane]
(R-HSA-1963569)
p-6Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864081)
p-Y-ERBB2 [plasma membrane]
(R-HSA-1678589)
p-Y,Y877-ERBB2 [plasma membrane]
(R-HSA-1810446)
p-7Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864079)
p-7Y-ERBB2 [plasma membrane]
(R-HSA-1248698)
0.748
7
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.743
6
UniProt:Q15303 ERBB4
0.589
3
UniProt:Q6UXM1 LRIG3
0.524
7
UniProt:P22681 CBL
39
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL del366-409 [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
CBL G375fs*16 [cytosol]
(R-HSA-9706211)
CBL R420* [cytosol]
(R-HSA-9706208)
CBL H398D [cytosol]
(R-HSA-9706631)
CBL Y371C [cytosol]
(R-HSA-9706694)
CBL G375S [cytosol]
(R-HSA-9706214)
CBL Y371D [cytosol]
(R-HSA-9706687)
CBL Y371S [cytosol]
(R-HSA-9706674)
CBL P417S [cytosol]
(R-HSA-9706642)
CBL H398N [cytosol]
(R-HSA-9706641)
CBL R420P [cytosol]
(R-HSA-9706193)
CBL Y371N [cytosol]
(R-HSA-9706679)
CBL R499Q [cytosol]
(R-HSA-9706677)
CBL R420L [cytosol]
(R-HSA-9706197)
CBL P417H [cytosol]
(R-HSA-9706644)
p-Y371-CBL [plasma membrane]
(R-HSA-182923)
p-Y-CBL [cytosol]
(R-HSA-8875457)
p-Y371-CBL [cytosol]
(R-HSA-182940)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
CBL [cytosol]
(R-HSA-112199)
0.524
2
UniProt:Q9UPQ0-1 LIMCH1
0.463
2
UniProt:Q8WWI1-3 LMO7
0.463
2
UniProt:P00533-4 EGFR
0.463
2
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