Reactome | LRIG1 [plasma membrane]

LRIG1 [plasma membrane]

Stable Identifier

R-HSA-197745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor, LIG1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96JA1 LRIG1

Gene Names

LRIG1, LIG1

Chain

signal peptide:1-34, chain:35-1093

Reference Genes

BioGPS Gene:26018 LRIG1

COSMIC (genes):LIG1 LIG1

COSMIC (genes):LRIG1 LRIG1

CTD Gene:26018 LRIG1

dbSNP Gene:26018 LRIG1

ENSEMBL:ENSG00000144749 LRIG1

HGNC:17360 LRIG1

KEGG:hsa:26018 LRIG1

Monarch:26018 LRIG1

NCBI Gene:26018 LRIG1

OMIM:608868 LRIG1

UCSC:Q96JA1 LRIG1

Reference Transcript

RefSeq:NM_015541.3 LRIG1

Other Identifiers

11750405_a_at

11755110_a_at

16955939

211596_PM_s_at

211596_s_at

238339_PM_x_at

238339_x_at

240140_PM_s_at

240140_s_at

26018

2680602

2680603

2680604

2680605

2680606

2680607

2680610

2680612

2680613

2680614

2680617

2680620

2680621

2680622

2680625

2680630

2680631

2680633

2680634

2680636

2680637

2680640

2680641

2680642

2680644

2680645

2680646

2680660

2680661

2680669

2680672

2680683

2680684

2680685

34800_at

63691_at

70503_at

8088642

A_23_P109636

GE56536

GO:0005515

GO:0005615

GO:0005886

GO:0007605

GO:0022405

GO:0030312

GO:0031012

GO:0032474

GO:0050877

GO:0060384

HMNXSV003006438

Hs.121706.1.S1_3p_s_at

Hs.207432.0.A1_3p_s_at

ILMN_1707342

ILMN_2128795

PH_hs_0022789

PH_hs_0034614

TC03001532.hg

g13537354_3p_s_at

Participates

as a protein marker of

keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)

as a component of

MET:LRIG1 [plasma membrane] (Homo sapiens)

as an input of

MET binds LRIG1 (Homo sapiens)

This entity regulates

Negatively

EGFR binds EGF ligand (Homo sapiens)

Other forms of this molecule

Ub-LRIG1 [plasma membrane]

Inferred To

sma-10 [plasma membrane] (Caenorhabditis elegans)

Lrig1 [plasma membrane] (Mus musculus)

Lrig1 [plasma membrane] (Rattus norvegicus)

LRIG1 [plasma membrane] (Bos taurus)

LRIG1 [plasma membrane] (Canis familiaris)

LRIG1 [plasma membrane] (Gallus gallus)

LRIG1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_056356.2

OpenTargets

ENSG00000144749

ENSEMBL

ENSP00000373208, ENSG00000144749, ENST00000383703, ENSP00000273261, ENST00000273261

HPA

ENSG00000144749-LRIG1

GeneCards

LRIG1

PRO

Q96JA1

Pharos - Targets

Q96JA1

GlyGen

Q96JA1

PDB

4U7M, 4U7L

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.748	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.743	6
UniProt:Q6UXM1 LRIG3			0.641	9
UniProt:Q15303 ERBB4			0.589	3
UniProt:P20338 RAB4A	5	GGC-RAB4A [cytoplasmic vesicle membrane] (R-HSA-1458526) GGC-RAB4A [cytosol] (R-HSA-8874045) RAB4A [cytosol] (R-HSA-8873709) RAB4A [early endosome membrane] (R-HSA-8871356) GGC-RAB4A [recycling endosome membrane] (R-HSA-8875666)	0.527	2
UniProt:O14967 CLGN			0.527	2
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.527	2
UniProt:Q9BT09 CNPY3	1	CNPY3 [endoplasmic reticulum lumen] (R-HSA-1678932)	0.527	3
UniProt:O94898 LRIG2			0.527	3
UniProt:Q3ZCM7 TUBB8	3	Polyglycyl-TUBB8 [cytosol] (R-HSA-8867423) Polyglutamyl-TUBB8 [cytosol] (R-HSA-8867387) TUBB8 [cytosol] (R-HSA-6805243)	0.527	2
UniProt:P13747 HLA-E	7	HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (R-HSA-197643) HLA class I histocompatibility antigen, E alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983090) HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane] (R-HSA-1236744) HLA class I histocompatibility antigen, E alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236793) HLA class I histocompatibility antigen, E alpha chain precursor [recycling endosome membrane] (R-HSA-8863974) HLA class I histocompatibility antigen, E alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983407) HLA class I histocompatibility antigen, E alpha chain precursor [Golgi membrane] (R-HSA-983339)	0.527	2
UniProt:Q99445 GML			0.527	2
UniProt:Q8WVQ1 CANT1	4	CANT1 [ficolin-1-rich granule lumen] (R-HSA-6800998) CANT1 [extracellular region] (R-HSA-6800464) CANT1 [specific granule lumen] (R-HSA-6799706) CANT1 [tertiary granule lumen] (R-HSA-6800976)	0.527	2
UniProt:Q99999 GAL3ST1	1	GAL3ST1 [Golgi membrane] (R-HSA-1631586)	0.527	3
UniProt:Q9H9A6 LRC40			0.527	2
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.524	2
UniProt:Q8WWI1-3 LMO7			0.463	2
UniProt:P00533-4 EGFR			0.463	2
UniProt:Q9UPQ0-1 LIMCH1			0.463	2

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