Reactome | p-Y151-WASF3 [cytosol]

p-Y151-WASF3 [cytosol]

Stable Identifier

R-HSA-2029006

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y151-WAVE3

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Parasite infection (Homo sapiens)
      - Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - ABL phosphorylates WAVEs (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases (Homo sapiens)
  - RHO GTPase Effectors (Homo sapiens)
    - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - ABL phosphorylates WAVEs (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPY6 WASF3

Gene Names

WASF3, KIAA0900, SCAR3, WAVE3

Chain

chain:1-502

Reference Genes

BioGPS Gene:10810 WASF3

COSMIC (genes):WASF3 WASF3

CTD Gene:10810 WASF3

dbSNP Gene:10810 WASF3

ENSEMBL:ENSG00000132970 WASF3

HGNC:12734 WASF3

KEGG Gene (Homo sapiens):10810 WASF3

Monarch:10810 WASF3

NCBI Gene:10810 WASF3

OMIM:605068 WASF3

UCSC:Q9UPY6 WASF3

Reference Transcript

Other Identifiers

0006770411

1058_at

10810

11719975_at

11719976_at

11757981_s_at

16773453

204042_at

3482588

3482589

3482590

3482608

3482610

3482617

3482618

3482622

3482623

3482624

3482627

3482629

3482630

3482631

3482632

3482633

3482634

3482635

3482636

3482637

3482638

3482639

7968212

A_14_P108815

A_24_P176079

GE53572

GE81664

GO:0000902

GO:0003674

GO:0003779

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005856

GO:0007010

GO:0008092

GO:0008150

GO:0008360

GO:0014003

GO:0022607

GO:0030027

GO:0030032

GO:0030036

GO:0030041

GO:0030154

GO:0031209

GO:0031643

GO:0032991

GO:0034237

GO:0043226

GO:0048856

GO:0050877

GO:0065003

GO:0070062

GO:0071933

GO:0098794

GO:2000601

Hs.82318.0.A3_3p_at

ILMN_1810797

PH_hs_0004713

S69790_at

TC13000070.hg

Participant Of

hasCandidate

p-Y-WAVE [cytosol]

Other forms of this molecule

WASF3 [cytosol]

p-Y151,S,T-WASF3 [cytosol]

Inferred To

phospho-SCAR [cytosol] (Drosophila melanogaster)

Homologues of p-Y151-WASF3 [cytosol] (Drosophila melanogaster)

phospho-gukh [cytosol] (Drosophila melanogaster)

phospho-p-Y151-WASF3 [cytosol] (Xenopus tropicalis)

phospho-wasf3b [cytosol] (Danio rerio)

phospho-wve-1 [cytosol] (Caenorhabditis elegans)

phospho-Wasf3 [cytosol] (Mus musculus)

phospho-Wasf3 [cytosol] (Rattus norvegicus)

phospho-scrA [cytosol] (Dictyostelium discoideum)

phospho-WASF3 [cytosol] (Canis familiaris)

phospho-WASF3 [cytosol] (Gallus gallus)

phospho-WASF3 [cytosol] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 151

Coordinate

151

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001278894.1, NP_006637.2, XP_011533191.1, XP_011533192.1

OpenTargets

ENSG00000132970

HPA

ENSG00000132970-WASF3

GeneCards

Q9UPY6

Ensembl

ENST00000335327, ENSP00000354325, ENSG00000132970, ENST00000361042, ENSP00000335055

PRO

Q9UPY6

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2

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