Reactome | p-Y151-WASF3 [cytosol]

p-Y151-WASF3 [cytosol]

Stable Identifier

R-HSA-2029006

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y151-WAVE3

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - ABL phosphorylates WAVEs (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
      - p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)
        
        p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPY6 WASF3

Gene Names

WASF3, KIAA0900, SCAR3, WAVE3

Chain

chain:1-502

Reference Genes

BioGPS Gene:10810 WASF3

COSMIC (genes):WASF3 WASF3

CTD Gene:10810 WASF3

dbSNP Gene:10810 WASF3

ENSEMBL:ENSG00000132970 WASF3

HGNC:12734 WASF3

KEGG:hsa:10810 WASF3

Monarch:10810 WASF3

NCBI Gene:10810 WASF3

OMIM:605068 WASF3

UCSC:Q9UPY6 WASF3

Reference Transcript

Participates

as a candidate of

p-Y-WAVE [cytosol] (Homo sapiens)

Other forms of this molecule

p-Y151,S,T-WASF3 [cytosol]

WASF3 [cytosol]

Inferred To

phospho-SCAR [cytosol] (Drosophila melanogaster)

phospho-wasf3 [cytosol] (Xenopus tropicalis)

Homologues of p-Y151-WASF3 [cytosol] (Drosophila melanogaster)

phospho-gukh [cytosol] (Drosophila melanogaster)

phospho-wve-1 [cytosol] (Caenorhabditis elegans)

phospho-Wasf3 [cytosol] (Mus musculus)

phospho-Wasf3 [cytosol] (Rattus norvegicus)

phospho-scrA [cytosol] (Dictyostelium discoideum)

phospho-WASF3 [cytosol] (Bos taurus)

phospho-WASF3 [cytosol] (Canis familiaris)

phospho-WASF3 [cytosol] (Gallus gallus)

phospho-WASF3 [cytosol] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 151

Coordinate

151

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_006637.2, NP_001278894.1, XP_011533192.1, XP_011533191.1, XP_024305083.1, XP_054230021.1, XP_054230020.1, XP_054230025.1, XP_054230024.1, XP_047286020.1, XP_047286018.1, XP_047286019.1, XP_047286015.1, XP_054230022.1, XP_054230023.1, XP_047286016.1, XP_054230019.1, XP_054230026.1

OpenTargets

ENSG00000132970

ENSEMBL

ENSP00000335055, ENST00000335327, ENSG00000132970, ENSP00000354325, ENST00000361042

HPA

ENSG00000132970-WASF3

GeneCards

WASF3

PRO

Q9UPY6

Pharos - Targets

Q9UPY6

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.653	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.643	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.553	6